LOCUS       NM_017510               2546 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens transmembrane p24 trafficking protein 9 (TMED9), mRNA.
ACCESSION   NM_017510
VERSION     NM_017510.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2546)
  AUTHORS   Xiao,L., Pi,X., Goss,A.C., El-Baba,T., Ehrmann,J.F., Grinkevich,E.,
            Bazua-Valenti,S., Padovano,V., Alper,S.L., Carey,D., Udeshi,N.D.,
            Carr,S.A., Pablo,J.L., Robinson,C.V., Greka,A. and Wu,H.
  TITLE     Molecular basis of TMED9 oligomerization and entrapment of
            misfolded protein cargo in the early secretory pathway
  JOURNAL   Sci Adv 10 (38), eadp2221 (2024)
   PUBMED   39303030
  REMARK    GeneRIF: Molecular basis of TMED9 oligomerization and entrapment of
            misfolded protein cargo in the early secretory pathway.
REFERENCE   2  (bases 1 to 2546)
  AUTHORS   Li,S., Yan,R., Xu,J., Zhao,S., Ma,X., Sun,Q., Zhang,M., Li,Y.,
            Liu,J.G., Chen,L., Li,S., Xu,K. and Ge,L.
  TITLE     A new type of ERGIC-ERES membrane contact mediated by TMED9 and
            SEC12 is required for autophagosome biogenesis
  JOURNAL   Cell Res 32 (2), 119-138 (2022)
   PUBMED   34561617
REFERENCE   3  (bases 1 to 2546)
  AUTHORS   Ju,G., Xu,C., Zeng,K., Zhou,T. and Zang,L.
  TITLE     High expression of transmembrane P24 trafficking protein 9 predicts
            poor prognosis in breast carcinoma
  JOURNAL   Bioengineered 12 (1), 8965-8979 (2021)
   PUBMED   34635011
  REMARK    GeneRIF: High expression of transmembrane P24 trafficking protein 9
            predicts poor prognosis in breast carcinoma.
REFERENCE   4  (bases 1 to 2546)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2546)
  AUTHORS   Mishra,S., Bernal,C., Silvano,M., Anand,S. and Ruiz I Altaba,A.
  TITLE     The protein secretion modulator TMED9 drives CNIH4/TGFalpha/GLI
            signaling opposing TMED3-WNT-TCF to promote colon cancer metastases
  JOURNAL   Oncogene 38 (29), 5817-5837 (2019)
   PUBMED   31253868
  REMARK    GeneRIF: TMED9/TMED3 antagonism impacts WNT-TCF and GLI signaling,
            where TMED9 primacy over TMED3 leads to the establishment of a
            positive feedback loop together with CNIH4, TGFalpha, and GLI1 that
            enhances metastases
REFERENCE   6  (bases 1 to 2546)
  AUTHORS   Zhang,H., Li,X.J., Martin,D.B. and Aebersold,R.
  TITLE     Identification and quantification of N-linked glycoproteins using
            hydrazide chemistry, stable isotope labeling and mass spectrometry
  JOURNAL   Nat Biotechnol 21 (6), 660-666 (2003)
   PUBMED   12754519
REFERENCE   7  (bases 1 to 2546)
  AUTHORS   Jenne,N., Frey,K., Brugger,B. and Wieland,F.T.
  TITLE     Oligomeric state and stoichiometry of p24 proteins in the early
            secretory pathway
  JOURNAL   J Biol Chem 277 (48), 46504-46511 (2002)
   PUBMED   12237308
REFERENCE   8  (bases 1 to 2546)
  AUTHORS   Renz,M., Tomlinson,E., Hultgren,B., Levin,N., Gu,Q., Shimkets,R.A.,
            Lewin,D.A. and Stewart,T.A.
  TITLE     Quantitative expression analysis of genes regulated by both obesity
            and leptin reveals a regulatory loop between leptin and
            pituitary-derived ACTH
  JOURNAL   J Biol Chem 275 (14), 10429-10436 (2000)
   PUBMED   10744732
REFERENCE   9  (bases 1 to 2546)
  AUTHORS   Shevchenko,A., Keller,P., Scheiffele,P., Mann,M. and Simons,K.
  TITLE     Identification of components of trans-Golgi network-derived
            transport vesicles and detergent-insoluble complexes by
            nanoelectrospray tandem mass spectrometry
  JOURNAL   Electrophoresis 18 (14), 2591-2600 (1997)
   PUBMED   9527489
REFERENCE   10 (bases 1 to 2546)
  AUTHORS   Wada,I., Rindress,D., Cameron,P.H., Ou,W.J., Doherty,J.J. 2nd,
            Louvard,D., Bell,A.W., Dignard,D., Thomas,D.Y. and Bergeron,J.J.
  TITLE     SSR alpha and associated calnexin are major calcium binding
            proteins of the endoplasmic reticulum membrane
  JOURNAL   J Biol Chem 266 (29), 19599-19610 (1991)
   PUBMED   1918067
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP290332.1, BC001123.2 and
            AC139795.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_017510.5.
            
            Summary: This gene is a member of a family of genes encoding
            transport proteins located in the endoplasmic reticulum and the
            Golgi. A similar gene in mouse is the target of microRNA miR-296,
            which is part of an imprinted cluster. [provided by RefSeq, Jul
            2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.164109.1,
                                           SRR7410570.255187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332598.7/ ENSP00000330945.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BP290332.1         58-66
            10-730              BC001123.2         1-721
            731-955             AC139795.3         117634-117858
            956-1411            BC001123.2         947-1402
            1412-2546           AC139795.3         118315-119449
FEATURES             Location/Qualifiers
     source          1..2546
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2546
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
                     /note="transmembrane p24 trafficking protein 9"
                     /db_xref="GeneID:54732"
                     /db_xref="HGNC:HGNC:24878"
                     /db_xref="MIM:620436"
     exon            1..196
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..720
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
                     /note="glycoprotein 25L2; p24 family protein alpha-2;
                     transmembrane emp24 protein transport domain containing 9"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 9
                     precursor"
                     /protein_id="NP_059980.2"
                     /db_xref="CCDS:CCDS4428.1"
                     /db_xref="GeneID:54732"
                     /db_xref="HGNC:HGNC:24878"
                     /db_xref="MIM:620436"
                     /translation="MAVELGVLLVRPRPGTGLGRVMRTLLLVLWLATRGSALYFHIGE
                     TEKKCFIEEIPDETMVIGNYRTQLYDKQREEYQPATPGLGMFVEVKDPEDKVILARQY
                     GSEGRFTFTSHTPGEHQICLHSNSTKFSLFAGGMLRVHLDIQVGEHANDYAEIAAKDK
                     LSELQLRVRQLVEQVEQIQKEQNYQRWREERFRQTSESTNQRVLWWSILQTLILVAIG
                     VWQMRHLKSFFEAKKLV"
     exon            197..297
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
                     /inference="alignment:Splign:2.1.0"
     exon            298..423
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
                     /inference="alignment:Splign:2.1.0"
     exon            424..570
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
                     /inference="alignment:Splign:2.1.0"
     exon            571..2546
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1367..1372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
                     /note="hexamer: AATAAA"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
                     /note="hexamer: AATAAA"
     polyA_site      1428
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
                     /note="major polyA site"
     polyA_site      1431
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
     regulatory      1608..1613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
                     /note="hexamer: AGTAAA"
     polyA_site      1641
                     /gene="TMED9"
                     /gene_synonym="GMP25; HSGP25L2G; p24a2; p24alpha2; p25"
ORIGIN      
        1 aggtggagca agatggctgt ggagctgggc gtgctgctcg tccggccccg gcccggaacc
       61 gggctgggta gagtgatgcg gaccctcctg ctggtgctgt ggctggcgac gcgcggaagc
      121 gcgctctact ttcacatcgg agagacggag aagaagtgct ttattgagga gatcccggac
      181 gagaccatgg tcataggaaa ctaccggacg cagctgtatg acaagcagcg ggaggagtac
      241 cagccggcca ccccggggct tggcatgttt gtggaggtga aggacccaga ggacaaggtc
      301 atcctggccc ggcagtatgg ctccgagggc aggttcactt tcacttccca tacccctggt
      361 gagcaccaga tctgtcttca ctccaattcc accaagttct ccctctttgc tggaggcatg
      421 ctgagagttc acctggacat ccaggtaggt gaacatgcca atgactatgc agaaattgct
      481 gctaaagaca agttgagtga gttgcagcta cgagtgcgac agctggtgga acaagtggag
      541 cagatccaga aagagcagaa ctaccagcgg tggcgagagg agcgcttccg gcagaccagt
      601 gagagcacca accagcgggt gctgtggtgg tccattctgc agaccctcat cctcgtggcc
      661 atcggtgtct ggcagatgcg gcacctcaag agcttctttg aagccaagaa gcttgtgtag
      721 ctgtcccagg cgtcacaacc catcctccca ggctggggga gaaaggacct cctggaactg
      781 acttcttctg tcaggaggac tggtttccag ccatacctgt tctggaaggg agaggggctg
      841 gaggcaccca caggcacaag ctgaaggcag cagcttggct aatactgagc aggtagtggg
      901 gcaaattcct gccctctctc tctggcctct gggccgtttg gtagtaatca cccaagggct
      961 ggtaaagccc ctcctcttgg cacctcagaa tcacagtgtt actgatcagg gatgtgaggc
     1021 tgctgttggg ggtgggggga ggggaatggg caggcaagcc agtcttctgt cttcctttgc
     1081 taacttaggg ttttgagcag gttggggtat ggtgcctgtc atacccacct gccaccctgg
     1141 gaacctcact gttctctctt tcagcctaga cctgctgatc cagggtgtgt gtgagttgag
     1201 ggtgggtgga ggggtttgca gtgtgggaat gtggccctgc agttgacctg agctgcttca
     1261 catggttgtc cattctgggg cttaaagaac tgggaccaga ccaagtagag gccttggtgc
     1321 tggttggggt ggggcctgca gagtcttagt tactgatttc attttcaata aatgtaggtt
     1381 tgttacatga gtttcccaat aaaaaaaaaa atgacttctt gtccagtgca agtgactcag
     1441 tcatcagtgg gcacacactg cagggtgcct cagggaatgc cagttcttcc aaagagcaaa
     1501 gcacttcaca ttccaaagtg aattcccacc agtcagcttc attctttcct tcttctccag
     1561 gccttcctgt ggcagggaat agtgggtttg tccaagatta tacaacaagt aaattgggct
     1621 ggggctcaaa tttacaccct ttcctctgtg ccagctccct ggtgaagttc cctctttcta
     1681 gagtcagtaa gcaggattgt catggatgct gccaggaagt gcctggtaag gaggtgcatt
     1741 gagcagggga gtgctacagg acagccaccc tgggctggca gggacaagga tgttgatggg
     1801 ctaaaccaac agcaagtgat ttcaaccagg accatgaagg agaggaagga ttctgctgga
     1861 aggagatggc aggacagggg tggttggaga agtggaggca aacagctgga atggaggtgg
     1921 gtgggtgttt aatttcagct gcagagggtg ttgtgaggaa gctggaaagg aaggttggat
     1981 tagagaagcc tcgagctcca ggtaagcgat ttggacatgc ccacctttca agaggggctg
     2041 caggcaccca caggcacaag ctgaaggcag cagcttggct ggcttaatac tgagcaggtg
     2101 gtggggtaaa tgcctgcccc cctccctctg gcctctgggc cctttgcagt aatcacccag
     2161 ggtctggtaa agccactgag agccctactg gcacctcaga atcacagtgt tattgatcag
     2221 ggatgtgagg ctgctgttgg gggttggggg aggcaaatgg gcaggcagtt ttgagaagaa
     2281 ccttctaata agaaatgtga gggaggttac agcagtgtgt gagaaagacc aggaagaagg
     2341 agacaagttt gggggctgct tcccctaatg ggatgatgca atctgggctc atgctgccaa
     2401 ctaattcttc cacatgaaaa aaaaaagttt tttggcgggc acggtggttc acacctgtaa
     2461 tcccagcact ttgggaggct gaggtaggtg gatggcctga ggccaggagt ttgagaccag
     2521 cctggccaac atggtgaaac ctcatc
//
