LOCUS       NM_213601               7761 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens transmembrane p24 trafficking protein family member 8
            (TMED8), transcript variant 2, mRNA.
ACCESSION   NM_213601
VERSION     NM_213601.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7761)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 7761)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC101510.1 and AC007954.7.
            
            On Nov 23, 2018 this sequence version replaced NM_213601.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (b)
            has the same N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.53018.1,
                                           SRR1660809.57547.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216468.8/ ENSP00000216468.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1041              BC101510.1         16-1056
            1042-7761           AC007954.7         122008-128727       c
FEATURES             Location/Qualifiers
     source          1..7761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..7761
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /note="transmembrane p24 trafficking protein family member
                     8"
                     /db_xref="GeneID:283578"
                     /db_xref="HGNC:HGNC:18633"
     exon            1..159
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1019
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /note="isoform b is encoded by transcript variant 2;
                     transmembrane emp24 domain containing 8; family with
                     sequence similarity 15, member B; protein TMED8;
                     transmembrane emp24 protein transport domain containing 8"
                     /codon_start=1
                     /product="protein TMED8 isoform b"
                     /protein_id="NP_998766.1"
                     /db_xref="CCDS:CCDS32125.1"
                     /db_xref="GeneID:283578"
                     /db_xref="HGNC:HGNC:18633"
                     /translation="MSDLQAAEGPGSWSPTARPGSAGGVGDCQGVEGSQAAASENEDL
                     ENKDTSLLASATDPEPCSSPHRPQMVSPVSKDATEDLRKATGPLEAQALVKQDLLPAD
                     QAQVLNEMAKYQVPQRSGDIVMIQSEHTGAIDVLSADLESADLLGDHRKVSPPLMAPP
                     CIWTFAKVKEFKSKLGKEKNSRLVVKRGEVVTIRVPTHPEGKRVCWEFATDDYDIGFG
                     VYFDWTPVTSTDITVQVSDSSDDEDEEEEEEEEIEEPVPAGDVERGSRSSLRGRYGEV
                     MPVYRRDSHRDVQAGSHDYPGEGIYLLKFDNSYSLLRNKTLYFHIYYTS"
     exon            160..238
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
     exon            239..368
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
     exon            369..495
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
     exon            496..801
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
     exon            802..7761
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgcggct ggcagcggag agctccgtgc gcgggctgca gatgtctgac ctgcaggcgg
       61 ctgaggggcc gggctcctgg agccccacag cccgcccagg gtcggctggc ggcgtcgggg
      121 actgccaggg agtggagggg agccaggcgg ccgcctcaga gaatgaagat ctagaaaaca
      181 aggatacctc tttattggct tctgccaccg atccagaacc ctgctcctca ccccacaggc
      241 cacagatggt atctccagtg agtaaggatg ccacggaaga tctgcggaaa gcaactggtc
      301 ctttggaggc tcaggccttg gtgaaacagg atttgctgcc tgcagaccag gcccaggtcc
      361 tcaatgagat ggctaagtat caagttccac agaggtctgg ggacatcgtt atgatccagt
      421 ctgaacatac aggagctata gatgttcttt cagctgattt ggaatctgca gatcttctgg
      481 gggaccacag gaaagtctcc ccacctctga tggctcctcc atgcatctgg acctttgcca
      541 aggtgaagga attcaaaagc aagctgggca aagagaagaa cagccgtctg gtggtgaagc
      601 gtggtgaggt ggtgaccatc cgggtaccta ctcatccaga ggggaagcgt gtctgctggg
      661 agtttgcgac cgatgactat gacattggct ttggagttta ttttgactgg acccctgtaa
      721 ctagcactga cataactgtg caggtcagtg attccagtga cgatgaggat gaagaagagg
      781 aagaggagga agagattgaa gaacccgttc cagctggaga tgtggagaga ggctccagga
      841 gctccttgcg gggtcgctat ggggaggtca tgcctgtgta ccggcgggac agccaccgag
      901 acgtgcaggc tggcagccat gactaccctg gtgagggcat ctacctgctc aagttcgaca
      961 actcctactc cctgctgcgc aacaagactc tctacttcca catctactac accagctgaa
     1021 ggactgctgg gacaggggca ggctgtattt gctggctgaa gcaggctgcc agctggtgcc
     1081 tcttgtttgg gataggcaag agccaaaggt tcatgggggg ctgctgagcc tcacaccctg
     1141 tctggcatgc ctgactgttg gcccacgtag ctttttcccc ttcttggctt ctgcaggtgg
     1201 tggtgtagtg cccctgttct gtagtccctg actcataccc ttcttgcttc agactccagc
     1261 aaattccctc ttgaaggcac ctatggggca caagcctaaa aggaagcagg gcgatgtttt
     1321 ttaaaaatag attcatcttg gcacaggttt atcattcaga ttgctgccct ctcctctccc
     1381 acagccctta ttgccagtgc atttagtggc acccactctc ttcagttgtt gaggtgccag
     1441 aagagggaaa agcacattgc ccatgaagga gccccatctt ttggttggag aaagctctat
     1501 ccagcctgtc accactgcca tattcctgcc tgctggttat tcttggtctc tgcatagctg
     1561 ggagaccaca ctgcctttgg agggctatta ctattcctga tggtagacac cccctccttt
     1621 ctctttccta agtctatgtt tttgccatta cagcaagaac attcatgcaa tctcaagtga
     1681 tgatcaatgt aacctaagat cttgtgggaa gaaaaactgc ccccattatt tcctattcca
     1741 agagctggtt tcccttacta tgggcactgg cagtcaaagt ggagagagtg gaaattaggt
     1801 actgaattga tgtcagaacc cacatatttg aaagtcgtgt tacttttttt tttttttttg
     1861 gtataatcaa agaaggaatg gtatcatctg acagagaaga tgaaaaacaa aaaacactcc
     1921 agagtcccca ccgctttttt ttgtctttag agtaggagtg ctgtttagaa atgttgcttt
     1981 ggaatcaaat gcagtgaaac ccaatcaggt ttccaaagtt tctgcattta gctttcttgc
     2041 attgagggct taaagctttt ggtgttcaaa gtcccttagt ttaggtgata atgaagcttc
     2101 actattgctg ctgattgtat ttgttcttta cctgaccaaa gcttgcattt ccctggtgac
     2161 agcatttcct actgtgtcac ccctgaggct caggagtgcc acagagtgca ggtagtgctg
     2221 cagccagtgg tcaccagagc accagctgct gggcccccag gcggaggagg agacggaggt
     2281 gagatgggac ctcagcagtc tctgtgtttg tacctccctg tctcttactc ctcgtgttat
     2341 gtctgttact gcctacgaat tctgaagaat aattagattt atttattact gtatttattt
     2401 ttttagcaca tttcattttg cctttgaaac agtttccatc tgtttctcag aaggcttccc
     2461 atctgttctg agccactgaa gccccctctt ttatggagtt aaagatgata tttttaggag
     2521 aatttgggaa gcgatgatgt tttatttctg taggtcagtc ctgtgacggc tttgcgagga
     2581 gtatggccct tcagagatgg atgatgccac cttactccat gtttggggta cagtccagca
     2641 ctccccatga aaaattctaa gttgtgaggg aatctgccca tttgctggag attgagtgca
     2701 gaggaattcc ctaaccaatc agagatatcc cgtgattcca ggatttcaga gtcctttgtc
     2761 tcctctgagg tgtcaccttc tttgtgatgt ttcctttgac tcattgttag attcctcaca
     2821 ccaagggtct atccctacag tagcataact caaggaacgg gactcttccc agtgggtccc
     2881 tagtagcatc tacatcacat caaagggcaa tatatcctgc acctgctctt cccctcggag
     2941 caaagcccca agtgggatag gatgttgggg actgccagag cattcccatt ctctgagcag
     3001 catcatacct ccattatttt atatttgcaa atgtgttttg tagaggatta cactggccaa
     3061 catttatata cctttaaaga aattatttta gtgactgtct gttgaggcag tgaagagctg
     3121 atttgctgtg tgtcatccca ttggatagct gagtgaccgc tcttgcatca ttgaagttga
     3181 atcatgcctt agctaactga atataatctt tgtaaaataa ttttctactg agctgttttc
     3241 tagtcagcta aagccttgct tatttttcct gtttattatt aacttctgcc tttctctcaa
     3301 attgaaacag tcaggccata cacagcaagc tcccaaggat aacacttgtt attatttatt
     3361 ttcaccatga gattctctgc ttattttctt tggaatccta gttctgttgc atcagggaag
     3421 cctaagggac ttgttcccct cacctctgtg tgcctcttag ggtctggtca cttttgaagt
     3481 cctgggcatg gttacatttc attcatactg gtttttcacc aactgtcagg gtttctgtgt
     3541 tccattagca caaaatagct aaaagaagat attttcactg tctaattcac tattttcatg
     3601 ttacatttct gaaataattg aactttaggg gcaagatact acttactgaa gcacaggtaa
     3661 ttactgagaa cccacagccc agcaaattct aagagacagt catttcctca gcccctccca
     3721 gtccaaattt atagacccaa acaatgaaat gaaaaccgtt tgctttgatc ctcaccctgt
     3781 tctctagagc acaaacaaat agtaacaaac aattgaaaga aagtgcttca tagtaggaga
     3841 gagattggaa ttctctatag tgactgagtt cttaaatttc tttagtttta gttttgccac
     3901 tttgttgaga gatgggcctt ttagaaagga agacatattt aaagtattga tttcttttcc
     3961 cccagtgttt tattgtgaaa aaatttcagc aaacagctta aaagaaatat aaatatattg
     4021 taaaccaaaa agtatctgag acaggtctca atacatttag aggtttattt tgccaaggtt
     4081 cagagcccat gatggggcct caggaggttc ttagaacatg tgcccgaggt agtcgggtta
     4141 cagttttata catttgaggg agacagaagg tccaggcaaa gccataaatc aatacatgta
     4201 aggtatacac tggtttggcc tggaaaggca ggacatcttg aagatggggg tttccaggtc
     4261 agaggtagat caaagagttc ctgactggca gttggttgag agagttaaac tttacctgaa
     4321 aagatgaagt cagcttaagt taaagtaagg gaggcttggc ttaagtcatg tagatgaagc
     4381 ctccaggtag caggcttcag agagaacaga tgatgaattt ttctttttag gccttaaaag
     4441 gtgtcagact ctccagaaaa gacctaataa gagaaggaga ttctctacag aatgcagttt
     4501 cccccacaag agacagcttt gtagggccat ttcaaaatac gtcaaataaa tatattgggg
     4561 ggtaaatttc ctttggggcc tgctgtcatg tgatgctata ccagagtcag gttgggattt
     4621 ggtattttat tgccacaaag ggtctgtttg gttagtctta agatctctgt tttaatgtta
     4681 atgctggtca gttgtattta aattccaaag ggaagagggt aatatgaggc accctgtaat
     4741 ctgaccataa tatgaggcac cctgtcttcc catcatggac tagtttttca ggttcctttg
     4801 agatcccctg ggccaagaca ggggtccatt cagccggttg ggggatttag aatttatttt
     4861 tggtttgctg tatatatatg tatacacaca ctccccgcat aaatgtaaaa attttaaact
     4921 accaattcct aggcaaagat gattctaaca ttctgttcct tttgacaagt gtccaattag
     4981 agaatgctga gaatgtcccc tgcatatcgg ctctgttgga gagcccctga tttttagcag
     5041 acctgtttca ttcaacatgg gttacccagg aggtggtctt cataaaaatg tttcttggag
     5101 gccaggcgcc gtggcccacg cctgtaatcc cagcactttg ggaggccaag gtgggcagac
     5161 caccttaggc caggagttcg agaccagcct ggccaacata gtgaaactcc gtcgctacta
     5221 aaaatacaaa aaattagctg ggcgtggtgg cgggcatctg taatcccagc tactctggag
     5281 gcagaagcag ggagaatttc ttgagcccag gaggcagagg ttgcagcgag ccgagatcat
     5341 gccactgcac tccagactgg gcaacagagc aagattccgt ctcaaaaaaa aaaaaattgt
     5401 ttcttggtct ccatctttca agaaaataca tctgtgctgt attttcccct tccctcaggc
     5461 catgatctct gctgttttcc ttactaactg gcatgtcagt acaagagtga ttgtgaagct
     5521 gctccggaag ggctttatgc taacctctgt tgcttgatga catgtcctca ggactctgat
     5581 attaaaactc aatccttaga taacaggtag ctttatcatg gaagtaggta gcaatttgga
     5641 attagaccat tcttagttat ttttttctta atgaattgat acatgcactt taaaaaatat
     5701 ttttgttatt ttgggaagaa aaactcagac ttttaaaaaa gtgtatattg tcccattata
     5761 atatgtatat ggaagagtga aatctgaacg ctgtcttata ttaagcagta gaattaggta
     5821 ttatcataaa aagtcttaat ctgtagggaa tatgagttta tgtttatgag tcctgctcag
     5881 tccctctttg agagaattag ttgaaaccca gactctaaag tctgctttta tatttgtttg
     5941 ttaagaccac ttatctgcag aaggttgcct tttaacccca gtggttctaa ggtgtggaat
     6001 tgagtgaccc taatatttac ataagagact tgttttagtg gagcataagg gaggggcata
     6061 agttacaccg ttttgtgctg cttgagaact gtcttttaaa attgatcaca acgagggaaa
     6121 acaaaataaa attagggggc aaagggtagg agtatggggg gaggggagag caaacctatc
     6181 gaatatatct tagaattttg ctcagaaatc actgctgcct ctcaagtgtt gcattgtccc
     6241 tgcctaaacc aagaaggcta aacaaagccc ctcctgtttg aattcttaag gtaagaaatt
     6301 tctaagctaa gaaaacacta ttgcctaaaa ccaatgatag tggagctcat ttacaaatag
     6361 gcatgcctca cacacacagt ccaaaggcaa gacactggct ttgaaattag gctcatgatg
     6421 tgattcctat tatatgtacc tgattttttt aggccccagg tatgtggacc agagttaatg
     6481 tcatgactct tcaaagatat gatgaaaagt tgccctagaa atctagagat gcatgtttat
     6541 ttaattccat agtttaaaaa aaaatttaag caggtagttg tggcttatct gggggcaaaa
     6601 taatatatgt gaaattgctt ccagaggaca aagtatattt tctaaagtcc tgaaatagga
     6661 tcatgaaccc ttctgaagtt ttggtttgaa atattatagt atatgatatt accaaagagc
     6721 ccttaattca gagtttaagg ggctctcttc ctgaactctc ttcatcactc agggttgaat
     6781 gtgtaatgtt ccttgctatt gattgttatt gttgattctt aggatcaggc caagaatcat
     6841 ctggaaaaca ttatcttaat tccgtctctc atatcctaaa cagtacattt tactaagaaa
     6901 ttccatatga aaaactccac tcatgtctcc tgagattatc ctgtaagtga agtagctttc
     6961 atttaaccaa gctaaattat ttccatttag ccatgttaaa gagaagccaa gtctagagaa
     7021 agcaatcctg taacccatga atctggtgta cccattttcc cttaacgtaa cgggaagtgt
     7081 tttgaaattc ccagaagaga gctgttttgt aatcaaagtg atggattata agaaagccag
     7141 actttggaaa aggataattg gaataaaggg aggtgcttga agattttcca aactacttta
     7201 tgtcatttag cttctatttt ctgaagggct ttctttggtg ccatgtactc agatcagtca
     7261 gttgactgaa agatgatcat gttttcttcg taaagattta agcaattggc aactacaaag
     7321 acattatttt cttactgttc tatatcatgt actgttgctg acattacaaa aagggtctgg
     7381 aagggaaacc gtgtcactgt tttatctttt ttctttaaaa tacaaaagta tcccaactaa
     7441 tcatttatta tggtcagctt gttttacatg tcccctatca tgagaaatgc tatcaacatc
     7501 tgtgatttct aagagtctta ccaaattgtt actttaattc ttgtgtcctg ctgagtggtt
     7561 tttcttttaa aataccattt ttatcaccct gtggcactgg gtgtgttact gcgattacac
     7621 tgatgattct gagctgtgct tcttcaagta gctcagttct tgcgttttat attaggtaac
     7681 agttttgtga tgcttttgtg cattctttgt catctcttct gagttttcga atctgtcata
     7741 aataaacttt ttcactatgc a
//
