LOCUS       NM_001346131            7776 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens transmembrane p24 trafficking protein family member 8
            (TMED8), transcript variant 1, mRNA.
ACCESSION   NM_001346131 XM_017021223
VERSION     NM_001346131.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7776)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 7776)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007954.7.
            
            On May 31, 2019 this sequence version replaced NM_001346131.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.143191.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AC007954.7         163915-164073       c
            160-238             AC007954.7         138652-138730       c
            239-368             AC007954.7         133328-133457       c
            369-510             AC007954.7         130676-130817       c
            511-816             AC007954.7         130157-130462       c
            817-7776            AC007954.7         122008-128967       c
FEATURES             Location/Qualifiers
     source          1..7776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..7776
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /note="transmembrane p24 trafficking protein family member
                     8"
                     /db_xref="GeneID:283578"
                     /db_xref="HGNC:HGNC:18633"
     exon            1..159
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1034
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /note="isoform a is encoded by transcript variant 1;
                     transmembrane emp24 domain containing 8; family with
                     sequence similarity 15, member B; protein TMED8;
                     transmembrane emp24 protein transport domain containing 8"
                     /codon_start=1
                     /product="protein TMED8 isoform a"
                     /protein_id="NP_001333060.1"
                     /db_xref="GeneID:283578"
                     /db_xref="HGNC:HGNC:18633"
                     /translation="MSDLQAAEGPGSWSPTARPGSAGGVGDCQGVEGSQAAASENEDL
                     ENKDTSLLASATDPEPCSSPHRPQMVSPVSKDATEDLRKATGPLEAQALVKQDLLPAD
                     QAQVLNESSVVQMAKYQVPQRSGDIVMIQSEHTGAIDVLSADLESADLLGDHRKVSPP
                     LMAPPCIWTFAKVKEFKSKLGKEKNSRLVVKRGEVVTIRVPTHPEGKRVCWEFATDDY
                     DIGFGVYFDWTPVTSTDITVQVSDSSDDEDEEEEEEEEIEEPVPAGDVERGSRSSLRG
                     RYGEVMPVYRRDSHRDVQAGSHDYPGEGIYLLKFDNSYSLLRNKTLYFHIYYTS"
     exon            160..238
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
     exon            239..368
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
     exon            369..510
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
     exon            511..816
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
     exon            817..7776
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgcggct ggcagcggag agctccgtgc gcgggctgca gatgtctgac ctgcaggcgg
       61 ctgaggggcc gggctcctgg agccccacag cccgcccagg gtcggctggc ggcgtcgggg
      121 actgccaggg agtggagggg agccaggcgg ccgcctcaga gaatgaagat ctagaaaaca
      181 aggatacctc tttattggct tctgccaccg atccagaacc ctgctcctca ccccacaggc
      241 cacagatggt atctccagtg agtaaggatg ccacggaaga tctgcggaaa gcaactggtc
      301 ctttggaggc tcaggccttg gtgaaacagg atttgctgcc tgcagaccag gcccaggtcc
      361 tcaatgagag ttctgttgtg cagatggcta agtatcaagt tccacagagg tctggggaca
      421 tcgttatgat ccagtctgaa catacaggag ctatagatgt tctttcagct gatttggaat
      481 ctgcagatct tctgggggac cacaggaaag tctccccacc tctgatggct cctccatgca
      541 tctggacctt tgccaaggtg aaggaattca aaagcaagct gggcaaagag aagaacagcc
      601 gtctggtggt gaagcgtggt gaggtggtga ccatccgggt acctactcat ccagagggga
      661 agcgtgtctg ctgggagttt gcgaccgatg actatgacat tggctttgga gtttattttg
      721 actggacccc tgtaactagc actgacataa ctgtgcaggt cagtgattcc agtgacgatg
      781 aggatgaaga agaggaagag gaggaagaga ttgaagaacc cgttccagct ggagatgtgg
      841 agagaggctc caggagctcc ttgcggggtc gctatgggga ggtcatgcct gtgtaccggc
      901 gggacagcca ccgagacgtg caggctggca gccatgacta ccctggtgag ggcatctacc
      961 tgctcaagtt cgacaactcc tactccctgc tgcgcaacaa gactctctac ttccacatct
     1021 actacaccag ctgaaggact gctgggacag gggcaggctg tatttgctgg ctgaagcagg
     1081 ctgccagctg gtgcctcttg tttgggatag gcaagagcca aaggttcatg gggggctgct
     1141 gagcctcaca ccctgtctgg catgcctgac tgttggccca cgtagctttt tccccttctt
     1201 ggcttctgca ggtggtggtg tagtgcccct gttctgtagt ccctgactca tacccttctt
     1261 gcttcagact ccagcaaatt ccctcttgaa ggcacctatg gggcacaagc ctaaaaggaa
     1321 gcagggcgat gttttttaaa aatagattca tcttggcaca ggtttatcat tcagattgct
     1381 gccctctcct ctcccacagc ccttattgcc agtgcattta gtggcaccca ctctcttcag
     1441 ttgttgaggt gccagaagag ggaaaagcac attgcccatg aaggagcccc atcttttggt
     1501 tggagaaagc tctatccagc ctgtcaccac tgccatattc ctgcctgctg gttattcttg
     1561 gtctctgcat agctgggaga ccacactgcc tttggagggc tattactatt cctgatggta
     1621 gacaccccct cctttctctt tcctaagtct atgtttttgc cattacagca agaacattca
     1681 tgcaatctca agtgatgatc aatgtaacct aagatcttgt gggaagaaaa actgccccca
     1741 ttatttccta ttccaagagc tggtttccct tactatgggc actggcagtc aaagtggaga
     1801 gagtggaaat taggtactga attgatgtca gaacccacat atttgaaagt cgtgttactt
     1861 tttttttttt ttttggtata atcaaagaag gaatggtatc atctgacaga gaagatgaaa
     1921 aacaaaaaac actccagagt ccccaccgct tttttttgtc tttagagtag gagtgctgtt
     1981 tagaaatgtt gctttggaat caaatgcagt gaaacccaat caggtttcca aagtttctgc
     2041 atttagcttt cttgcattga gggcttaaag cttttggtgt tcaaagtccc ttagtttagg
     2101 tgataatgaa gcttcactat tgctgctgat tgtatttgtt ctttacctga ccaaagcttg
     2161 catttccctg gtgacagcat ttcctactgt gtcacccctg aggctcagga gtgccacaga
     2221 gtgcaggtag tgctgcagcc agtggtcacc agagcaccag ctgctgggcc cccaggcgga
     2281 ggaggagacg gaggtgagat gggacctcag cagtctctgt gtttgtacct ccctgtctct
     2341 tactcctcgt gttatgtctg ttactgccta cgaattctga agaataatta gatttattta
     2401 ttactgtatt tattttttta gcacatttca ttttgccttt gaaacagttt ccatctgttt
     2461 ctcagaaggc ttcccatctg ttctgagcca ctgaagcccc ctcttttatg gagttaaaga
     2521 tgatattttt aggagaattt gggaagcgat gatgttttat ttctgtaggt cagtcctgtg
     2581 acggctttgc gaggagtatg gcccttcaga gatggatgat gccaccttac tccatgtttg
     2641 gggtacagtc cagcactccc catgaaaaat tctaagttgt gagggaatct gcccatttgc
     2701 tggagattga gtgcagagga attccctaac caatcagaga tatcccgtga ttccaggatt
     2761 tcagagtcct ttgtctcctc tgaggtgtca ccttctttgt gatgtttcct ttgactcatt
     2821 gttagattcc tcacaccaag ggtctatccc tacagtagca taactcaagg aacgggactc
     2881 ttcccagtgg gtccctagta gcatctacat cacatcaaag ggcaatatat cctgcacctg
     2941 ctcttcccct cggagcaaag ccccaagtgg gataggatgt tggggactgc cagagcattc
     3001 ccattctctg agcagcatca tacctccatt attttatatt tgcaaatgtg ttttgtagag
     3061 gattacactg gccaacattt atataccttt aaagaaatta ttttagtgac tgtctgttga
     3121 ggcagtgaag agctgatttg ctgtgtgtca tcccattgga tagctgagtg accgctcttg
     3181 catcattgaa gttgaatcat gccttagcta actgaatata atctttgtaa aataattttc
     3241 tactgagctg ttttctagtc agctaaagcc ttgcttattt ttcctgttta ttattaactt
     3301 ctgcctttct ctcaaattga aacagtcagg ccatacacag caagctccca aggataacac
     3361 ttgttattat ttattttcac catgagattc tctgcttatt ttctttggaa tcctagttct
     3421 gttgcatcag ggaagcctaa gggacttgtt cccctcacct ctgtgtgcct cttagggtct
     3481 ggtcactttt gaagtcctgg gcatggttac atttcattca tactggtttt tcaccaactg
     3541 tcagggtttc tgtgttccat tagcacaaaa tagctaaaag aagatatttt cactgtctaa
     3601 ttcactattt tcatgttaca tttctgaaat aattgaactt taggggcaag atactactta
     3661 ctgaagcaca ggtaattact gagaacccac agcccagcaa attctaagag acagtcattt
     3721 cctcagcccc tcccagtcca aatttataga cccaaacaat gaaatgaaaa ccgtttgctt
     3781 tgatcctcac cctgttctct agagcacaaa caaatagtaa caaacaattg aaagaaagtg
     3841 cttcatagta ggagagagat tggaattctc tatagtgact gagttcttaa atttctttag
     3901 ttttagtttt gccactttgt tgagagatgg gccttttaga aaggaagaca tatttaaagt
     3961 attgatttct tttcccccag tgttttattg tgaaaaaatt tcagcaaaca gcttaaaaga
     4021 aatataaata tattgtaaac caaaaagtat ctgagacagg tctcaataca tttagaggtt
     4081 tattttgcca aggttcagag cccatgatgg ggcctcagga ggttcttaga acatgtgccc
     4141 gaggtagtcg ggttacagtt ttatacattt gagggagaca gaaggtccag gcaaagccat
     4201 aaatcaatac atgtaaggta tacactggtt tggcctggaa aggcaggaca tcttgaagat
     4261 gggggtttcc aggtcagagg tagatcaaag agttcctgac tggcagttgg ttgagagagt
     4321 taaactttac ctgaaaagat gaagtcagct taagttaaag taagggaggc ttggcttaag
     4381 tcatgtagat gaagcctcca ggtagcaggc ttcagagaga acagatgatg aatttttctt
     4441 tttaggcctt aaaaggtgtc agactctcca gaaaagacct aataagagaa ggagattctc
     4501 tacagaatgc agtttccccc acaagagaca gctttgtagg gccatttcaa aatacgtcaa
     4561 ataaatatat tggggggtaa atttcctttg gggcctgctg tcatgtgatg ctataccaga
     4621 gtcaggttgg gatttggtat tttattgcca caaagggtct gtttggttag tcttaagatc
     4681 tctgttttaa tgttaatgct ggtcagttgt atttaaattc caaagggaag agggtaatat
     4741 gaggcaccct gtaatctgac cataatatga ggcaccctgt cttcccatca tggactagtt
     4801 tttcaggttc ctttgagatc ccctgggcca agacaggggt ccattcagcc ggttggggga
     4861 tttagaattt atttttggtt tgctgtatat atatgtatac acacactccc cgcataaatg
     4921 taaaaatttt aaactaccaa ttcctaggca aagatgattc taacattctg ttccttttga
     4981 caagtgtcca attagagaat gctgagaatg tcccctgcat atcggctctg ttggagagcc
     5041 cctgattttt agcagacctg tttcattcaa catgggttac ccaggaggtg gtcttcataa
     5101 aaatgtttct tggaggccag gcgccgtggc ccacgcctgt aatcccagca ctttgggagg
     5161 ccaaggtggg cagaccacct taggccagga gttcgagacc agcctggcca acatagtgaa
     5221 actccgtcgc tactaaaaat acaaaaaatt agctgggcgt ggtggcgggc atctgtaatc
     5281 ccagctactc tggaggcaga agcagggaga atttcttgag cccaggaggc agaggttgca
     5341 gcgagccgag atcatgccac tgcactccag actgggcaac agagcaagat tccgtctcaa
     5401 aaaaaaaaaa attgtttctt ggtctccatc tttcaagaaa atacatctgt gctgtatttt
     5461 ccccttccct caggccatga tctctgctgt tttccttact aactggcatg tcagtacaag
     5521 agtgattgtg aagctgctcc ggaagggctt tatgctaacc tctgttgctt gatgacatgt
     5581 cctcaggact ctgatattaa aactcaatcc ttagataaca ggtagcttta tcatggaagt
     5641 aggtagcaat ttggaattag accattctta gttatttttt tcttaatgaa ttgatacatg
     5701 cactttaaaa aatatttttg ttattttggg aagaaaaact cagactttta aaaaagtgta
     5761 tattgtccca ttataatatg tatatggaag agtgaaatct gaacgctgtc ttatattaag
     5821 cagtagaatt aggtattatc ataaaaagtc ttaatctgta gggaatatga gtttatgttt
     5881 atgagtcctg ctcagtccct ctttgagaga attagttgaa acccagactc taaagtctgc
     5941 ttttatattt gtttgttaag accacttatc tgcagaaggt tgccttttaa ccccagtggt
     6001 tctaaggtgt ggaattgagt gaccctaata tttacataag agacttgttt tagtggagca
     6061 taagggaggg gcataagtta caccgttttg tgctgcttga gaactgtctt ttaaaattga
     6121 tcacaacgag ggaaaacaaa ataaaattag ggggcaaagg gtaggagtat ggggggaggg
     6181 gagagcaaac ctatcgaata tatcttagaa ttttgctcag aaatcactgc tgcctctcaa
     6241 gtgttgcatt gtccctgcct aaaccaagaa ggctaaacaa agcccctcct gtttgaattc
     6301 ttaaggtaag aaatttctaa gctaagaaaa cactattgcc taaaaccaat gatagtggag
     6361 ctcatttaca aataggcatg cctcacacac acagtccaaa ggcaagacac tggctttgaa
     6421 attaggctca tgatgtgatt cctattatat gtacctgatt tttttaggcc ccaggtatgt
     6481 ggaccagagt taatgtcatg actcttcaaa gatatgatga aaagttgccc tagaaatcta
     6541 gagatgcatg tttatttaat tccatagttt aaaaaaaaat ttaagcaggt agttgtggct
     6601 tatctggggg caaaataata tatgtgaaat tgcttccaga ggacaaagta tattttctaa
     6661 agtcctgaaa taggatcatg aacccttctg aagttttggt ttgaaatatt atagtatatg
     6721 atattaccaa agagccctta attcagagtt taaggggctc tcttcctgaa ctctcttcat
     6781 cactcagggt tgaatgtgta atgttccttg ctattgattg ttattgttga ttcttaggat
     6841 caggccaaga atcatctgga aaacattatc ttaattccgt ctctcatatc ctaaacagta
     6901 cattttacta agaaattcca tatgaaaaac tccactcatg tctcctgaga ttatcctgta
     6961 agtgaagtag ctttcattta accaagctaa attatttcca tttagccatg ttaaagagaa
     7021 gccaagtcta gagaaagcaa tcctgtaacc catgaatctg gtgtacccat tttcccttaa
     7081 cgtaacggga agtgttttga aattcccaga agagagctgt tttgtaatca aagtgatgga
     7141 ttataagaaa gccagacttt ggaaaaggat aattggaata aagggaggtg cttgaagatt
     7201 ttccaaacta ctttatgtca tttagcttct attttctgaa gggctttctt tggtgccatg
     7261 tactcagatc agtcagttga ctgaaagatg atcatgtttt cttcgtaaag atttaagcaa
     7321 ttggcaacta caaagacatt attttcttac tgttctatat catgtactgt tgctgacatt
     7381 acaaaaaggg tctggaaggg aaaccgtgtc actgttttat cttttttctt taaaatacaa
     7441 aagtatccca actaatcatt tattatggtc agcttgtttt acatgtcccc tatcatgaga
     7501 aatgctatca acatctgtga tttctaagag tcttaccaaa ttgttacttt aattcttgtg
     7561 tcctgctgag tggtttttct tttaaaatac catttttatc accctgtggc actgggtgtg
     7621 ttactgcgat tacactgatg attctgagct gtgcttcttc aagtagctca gttcttgcgt
     7681 tttatattag gtaacagttt tgtgatgctt ttgtgcattc tttgtcatct cttctgagtt
     7741 ttcgaatctg tcataaataa actttttcac tatgca
//
