LOCUS       NM_181836               3918 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane p24 trafficking protein 7 (TMED7), mRNA.
ACCESSION   NM_181836
VERSION     NM_181836.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3918)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3918)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 3918)
  AUTHORS   Liaunardy-Jopeace,A., Bryant,C.E. and Gay,N.J.
  TITLE     The COP II adaptor protein TMED7 is required to initiate and
            mediate the delivery of TLR4 to the plasma membrane
  JOURNAL   Sci Signal 7 (336), ra70 (2014)
   PUBMED   25074978
  REMARK    GeneRIF: TMED7 is required to initiate and mediate the delivery of
            TLR4 to the plasma membrane
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3918)
  AUTHORS   Doyle,S.L., Husebye,H., Connolly,D.J., Espevik,T., O'Neill,L.A. and
            McGettrick,A.F.
  TITLE     The GOLD domain-containing protein TMED7 inhibits TLR4 signalling
            from the endosome upon LPS stimulation
  JOURNAL   Nat Commun 3, 707 (2012)
   PUBMED   22426228
  REMARK    GeneRIF: TMED7 is essential for TAG-mediated disruption of the
            TRAM/TRIF complex and the degradation of toll-like receptor 4
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3918)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 3918)
  AUTHORS   Jenne,N., Frey,K., Brugger,B. and Wieland,F.T.
  TITLE     Oligomeric state and stoichiometry of p24 proteins in the early
            secretory pathway
  JOURNAL   J Biol Chem 277 (48), 46504-46511 (2002)
   PUBMED   12237308
REFERENCE   7  (bases 1 to 3918)
  AUTHORS   Fullekrug,J., Suganuma,T., Tang,B.L., Hong,W., Storrie,B. and
            Nilsson,T.
  TITLE     Localization and recycling of gp27 (hp24gamma3): complex formation
            with other p24 family members
  JOURNAL   Mol Biol Cell 10 (6), 1939-1955 (1999)
   PUBMED   10359607
REFERENCE   8  (bases 1 to 3918)
  AUTHORS   Ueno,K., Kumagai,T., Kijima,T., Kishimoto,T. and Hosoe,S.
  TITLE     Cloning and tissue expression of cDNAs from chromosome 5q21-22
            which is frequently deleted in advanced lung cancer
  JOURNAL   Hum Genet 102 (1), 63-68 (1998)
   PUBMED   9490301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC321837.1, BC019349.2 and AC010226.5.
            
            On Nov 23, 2018 this sequence version replaced NM_181836.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.475859.1,
                                           SRR1660805.201572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000456936.4/ ENSP00000405926.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DC321837.1         144-154
            12-2182             BC019349.2         1-2171
            2183-3918           AC010226.5         57907-59642
FEATURES             Location/Qualifiers
     source          1..3918
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.3"
     gene            1..3918
                     /gene="TMED7"
                     /gene_synonym="CGI-109; p24g3; p24gamma3; p27; Tag"
                     /note="transmembrane p24 trafficking protein 7"
                     /db_xref="GeneID:51014"
                     /db_xref="HGNC:HGNC:24253"
                     /db_xref="MIM:619990"
     exon            1..436
                     /gene="TMED7"
                     /gene_synonym="CGI-109; p24g3; p24gamma3; p27; Tag"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..919
                     /gene="TMED7"
                     /gene_synonym="CGI-109; p24g3; p24gamma3; p27; Tag"
                     /note="transmembrane emp24 domain-containing protein 7;
                     p24 family protein gamma-3; transmembrane emp24 protein
                     transport domain containing 7"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 7
                     precursor"
                     /protein_id="NP_861974.1"
                     /db_xref="CCDS:CCDS4120.1"
                     /db_xref="GeneID:51014"
                     /db_xref="HGNC:HGNC:24253"
                     /db_xref="MIM:619990"
                     /translation="MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGASEITFELPDN
                     AKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASK
                     NGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKS
                     VIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTT
                     TTRVGS"
     exon            437..682
                     /gene="TMED7"
                     /gene_synonym="CGI-109; p24g3; p24gamma3; p27; Tag"
                     /inference="alignment:Splign:2.1.0"
     exon            683..3918
                     /gene="TMED7"
                     /gene_synonym="CGI-109; p24g3; p24gamma3; p27; Tag"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3602..3607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED7"
                     /gene_synonym="CGI-109; p24g3; p24gamma3; p27; Tag"
                     /note="hexamer: AATAAA"
     polyA_site      3625
                     /gene="TMED7"
                     /gene_synonym="CGI-109; p24g3; p24gamma3; p27; Tag"
                     /note="major polyA site"
     regulatory      3892..3897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED7"
                     /gene_synonym="CGI-109; p24g3; p24gamma3; p27; Tag"
                     /note="hexamer: AGTAAA"
     polyA_site      3918
                     /gene="TMED7"
                     /gene_synonym="CGI-109; p24g3; p24gamma3; p27; Tag"
ORIGIN      
        1 aatccccact tccgaccctc tcaggccttt tccgcttctc ttttacctcc ccaggtccgc
       61 ccgtctgcgc ccctcacagg aagccggagg gtcgctctga tcccgaatct cccacaggcg
      121 tgaacctgct ctgctgtgta tctttgcggg gtggcctgcg ctgaggcctg ccgcgcgcgg
      181 tgagtccgcg cagacctgac cctgcgtctc gcagctcggt tgaggccgcc gccgccttct
      241 cgggatgccg cggccggggt ccgcgcagcg ctgggcggcc gtcgcgggcc gttgggggtg
      301 caggctgctc gcactgctgc tactggtgcc tggacccggc ggcgcctctg agatcacctt
      361 cgagcttcct gacaacgcca agcagtgctt ctacgaggac atcgctcagg gcaccaagtg
      421 caccctggag ttccaggtga ttactggtgg tcactatgat gtagattgtc gattagaaga
      481 tcctgatggt aaagtgttat acaaagagat gaagaaacag tatgatagtt ttaccttcac
      541 agcctccaaa aatgggacat acaaattttg cttcagcaat gaattttcta ctttcacaca
      601 taaaactgta tattttgatt ttcaagttgg agaagaccca cctttgtttc ctagtgagaa
      661 ccgagtcagt gctcttaccc agatggaatc tgcctgtgtt tcaattcacg aagctctgaa
      721 gtctgtcatc gattatcaga ctcatttccg tttaagagaa gctcaaggcc gaagccgagc
      781 agaggatcta aatacaagag tggcctattg gtcagtagga gaagccctca ttcttctggt
      841 ggttagcata gggcaggtat ttcttttgaa aagctttttc tcagataaaa gaaccaccac
      901 aactcgtgtt ggatcataac tacgttttga gaattgatgc accattgcca ctgtaatatt
      961 gctgtcctct aattaatttt aggtactgaa gaacttaata ttggcaacat ttttaaatcc
     1021 ttactcatac acttgttggg agggatgtac aatgcatatt cccaaactgt ggaaaggaca
     1081 ccttttttta tttgtaaagg tggaaaaact ttggaactca ttttgggcta ttcatgttaa
     1141 atattcaaca ccaatgatct actctgttcg cagttgttta tatctactct tcgcacacta
     1201 aactttggta ttttgattcc ttttaaccat ttaagactac ttttcttata ggtagttgat
     1261 attttaaaaa ctttagattt aatgtctaca tgtgttaggg aggaagaaaa ttgcctttta
     1321 attgttaata agaaaaccaa atgtgatgaa ctgtagccca agccctattc tgcactgttc
     1381 agttttatgg aggaaaaata aatctaccat aggaatgtta gttaatattg atatatcatg
     1441 gtaaaattga tttctcacta gcttagaaaa tgtcagactt ttgtttttgg ggtttataat
     1501 ttaaaccagc tatgctattt tttcataaag gcatttgtag tacacagaaa acagtagttt
     1561 cagtagtgta aaagagttta tacaggcctt aaatatcaga ctttgtaaca ggtagaaata
     1621 ttacagaata atttaagaca ctacaatggg ggcaaatgaa ataggaaaat ttttagtgag
     1681 ttacacgtac tcattacatt ttcagtgctt ttacaaggaa aaaaggtgat atgtttaatt
     1741 ttaaaatttt aattggctag ctcttgccct tatatgactt taatgtctgt gagtcattcc
     1801 cagcttaaat taacaattgt tagtattagt ctcacacata agtgccatac attttatcct
     1861 catggatgtg atgcactgaa aagttagttg ctctcctttt ttcttttttt tgtcgtgcat
     1921 attttatttc tgtagtttct ggttagctac cctaaagtga tttaaaaatt tagaatgctt
     1981 tgtgtttcct atttggtaat cttcattgac ttttctttag ttaatgagta ttaaatagtg
     2041 catattctgt agactatagg gtttacattg tgttgcatct tataacttgt atagattgag
     2101 ctgattgaaa taagattttg ttccaagtat tatctgatag aatacaagat gattcaaaat
     2161 tatatagata tttaaagctt ttctgctgtt tttttttttt ttaattgcaa ctgcttttct
     2221 gccgtgcctc tcttccctac ccaaaagtga tgagttctga acaagacaag actgtcatat
     2281 tgtagagact ttggtatgtg ataccataga atactgattg gatagccatc ctagtcactt
     2341 accaatactg actagaagtt aactcttaat tctaagctat cttaaaatgc atatatatac
     2401 ttcttgcatg gaagagcaaa acaaattcaa gttgtcatgc ctgataattt cagatgccac
     2461 cgtatagcaa agggtgaaca tgttttcaac cctttaactt tttacggtgt ttgaagacca
     2521 gctactcctt aatatttatc aatggattaa gaagtttaag attttgcaga tttatcaatt
     2581 tgggtttttg tactgaagtt gtcttgcggc tttgcaagtg tccctttata tttaaatttg
     2641 aaagttgtaa gcactgatgt taatgtgatt gatcagcatg ggcatatgta aaatgtcctt
     2701 ttctggttgc ctctctatgc tattgtgttc agatacttac accataatta aacagtaagt
     2761 tatagacttg ctgagtttgg catagatagt gcactcattt aatctgtgcc tctcaaaact
     2821 tcagaatatt agcatattac cacaaataat ttttggtgaa actattgaga tattaaaatt
     2881 tttgaaatca ctactgttac ctgttataga aaatagtgtt ggcttagtct agtctctgtg
     2941 taactggtta cattttgatg gttgtctata ctcaactgga tatgtgtatg taaattagaa
     3001 aatacatacc tatccagaca taaatgctaa gtaacatttt tttcttcctc caactacata
     3061 atttgtagct catcattttt ccttaatcct ttcctaactt gttgcagcag tttgaatttc
     3121 ccagatattt atgtttgaac ataatggctc agaatacata tttgaacatc atagttgtat
     3181 atatttttaa agtagaataa ataatggaaa gcaacttgat atacaagttt atactaaaat
     3241 ttcaactgtg tgaagataca ttttaaggca ttactttgct aataatctac acattctttt
     3301 ttctattaaa taaacaaatg gtttgtggtt cacagctttc atccaagctt ggtgataatc
     3361 aattttgaaa atacagtgga ctgaaaagca aatttattct ttcgaagatt tcatttaaat
     3421 ctctgtacta tgcatttttg tttcagtttg taaatgtgta acatttatag ttaaatagga
     3481 caaagcaggc cctatgacta ttgttttcaa aaaattaata tataaataat tcagaggggt
     3541 ttttcattta cttttgaaaa gaaatttctt taacaggatt gcacctatca atttcttgta
     3601 gaataaaaaa aaatctttca acaaactgac tttacttgtt tctgtcagga tttaaatctt
     3661 tctaaagctc cttataaact taaagcctag agtacagttc tgtaatgaga gtgattattt
     3721 atttggtatt ttattaaaat atctgaggga ctgtccaaga aagaaggtga aagagaaata
     3781 ccacgtctgt actgcctaat ttgtaacctt ctctttgcat tccttactga aagtttgtgt
     3841 aggtgaaaag cagttaaatc atcagttgct ctaaagaggt cttaattttt aagtaaatta
     3901 cctttagttt gtatatta
//
