LOCUS       NM_144676                913 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane p24 trafficking protein 6 (TMED6), mRNA.
ACCESSION   NM_144676
VERSION     NM_144676.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 913)
  AUTHORS   Xu,Y., Rao,Q., Xia,Q., Shi,S., Shi,Q., Ma,H., Lu,Z., Chen,H. and
            Zhou,X.
  TITLE     TMED6-COG8 is a novel molecular marker of TFE3 translocation renal
            cell carcinoma
  JOURNAL   Int J Clin Exp Pathol 8 (3), 2690-2699 (2015)
   PUBMED   26045774
  REMARK    GeneRIF: TMED6-COG8 chimera might act as a novel diagnostic marker
            in TFE3 translocation renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 913)
  AUTHORS   Wang,X., Yang,R., Jadhao,S.B., Yu,D., Hu,H., Glynn-Cunningham,N.,
            Sztalryd,C., Silver,K.D. and Gong,D.W.
  TITLE     Transmembrane emp24 protein transport domain 6 is selectively
            expressed in pancreatic islets and implicated in insulin secretion
            and diabetes
  JOURNAL   Pancreas 41 (1), 10-14 (2012)
   PUBMED   22129529
REFERENCE   3  (bases 1 to 913)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI600655.1, AY358268.1, BC020827.1 and AA804957.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144676.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020827.1, BI600655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288025.4/ ENSP00000288025.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BI600655.1         31-49
            20-827              AY358268.1         1-808
            828-906             BC020827.1         828-906
            907-913             AA804957.1         5-11                c
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..913
                     /gene="TMED6"
                     /gene_synonym="p24g5; PRO34237; SPLL9146"
                     /note="transmembrane p24 trafficking protein 6"
                     /db_xref="GeneID:146456"
                     /db_xref="HGNC:HGNC:28331"
     exon            1..246
                     /gene="TMED6"
                     /gene_synonym="p24g5; PRO34237; SPLL9146"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..756
                     /gene="TMED6"
                     /gene_synonym="p24g5; PRO34237; SPLL9146"
                     /note="transmembrane emp24 domain-containing protein 6;
                     p24gamma5; p24 family protein gamma-5; transmembrane emp24
                     protein transport domain containing 6"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 6
                     precursor"
                     /protein_id="NP_653277.2"
                     /db_xref="CCDS:CCDS10878.1"
                     /db_xref="GeneID:146456"
                     /db_xref="HGNC:HGNC:28331"
                     /translation="MSPLLFGAGLVVLNLVTSARSQKTEPLSGSGDQPLFRGADRYDF
                     AIMIPPGGTECFWQFAHQTGYFYFSYEVQRTVGMSHDRHVAATAHNPQGFLIDTSQGV
                     RGQINFSTQETGFYQLCLSNQHNHFGSVQVYLNFGVFYEGPETDHKQKERKQLNDTLD
                     AIEDGTQKVQNNIFHMWRYYNFARMRKMADFFLIQSNYNYVNWWSTAQSLVIILSGIL
                     QLYFLKRLFNVPTTTDTKKPRC"
     exon            247..373
                     /gene="TMED6"
                     /gene_synonym="p24g5; PRO34237; SPLL9146"
                     /inference="alignment:Splign:2.1.0"
     exon            374..522
                     /gene="TMED6"
                     /gene_synonym="p24g5; PRO34237; SPLL9146"
                     /inference="alignment:Splign:2.1.0"
     exon            523..913
                     /gene="TMED6"
                     /gene_synonym="p24g5; PRO34237; SPLL9146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      891..896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED6"
                     /gene_synonym="p24g5; PRO34237; SPLL9146"
                     /note="hexamer: AATAAA"
     polyA_site      913
                     /gene="TMED6"
                     /gene_synonym="p24g5; PRO34237; SPLL9146"
                     /note="major polyA site"
ORIGIN      
        1 agttcacctg cagaggaggc tccagaaagc ggcatgtccc ctttgctctt tggggctggg
       61 ctggtcgttc tgaatctagt gacgtctgcc aggagccaga agacagaacc tctaagtggc
      121 tctggggacc agccactctt ccgtggagct gatcgatatg actttgccat catgatacct
      181 ccaggaggca cggaatgctt ttggcaattt gcccaccaga ctggatactt ctatttcagt
      241 tacgaggttc agcggacagt ggggatgtca catgaccggc atgttgctgc cacggcacat
      301 aacccacagg gatttctcat agacacctcc cagggtgttc ggggccagat taacttctct
      361 acccaagaga caggttttta tcagctttgt ctaagtaatc agcataatca cttcggttct
      421 gtgcaagtgt acctcaactt tggggtcttc tatgaggggc ctgagactga tcacaaacag
      481 aaggaaagaa aacaactgaa tgatactctg gatgcaattg aggacggcac acaaaaggtg
      541 cagaacaata tctttcacat gtggcgatac tacaactttg cccggatgag gaaaatggct
      601 gactttttcc ttatccaatc aaactataac tacgtgaact ggtggtcgac agcccagagc
      661 cttgttatta ttctttctgg gatcctgcaa ctgtatttct tgaagcgtct cttcaatgtt
      721 ccaacaacta cagatacaaa gaagccaaga tgctaagcta aggtgactat agcaccctgg
      781 ctgttttctt ctggggctta gtcgaatcag ctttgtaatg ttatgggaca aaaatcaatt
      841 atctcattaa tgttttagtc tgctgcacac atctaaaaaa gcaaaatggc aataaaatca
      901 taacagtgaa aaa
//
