LOCUS       NM_007364               1418 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens transmembrane p24 trafficking protein 3 (TMED3),
            transcript variant 1, mRNA.
ACCESSION   NM_007364
VERSION     NM_007364.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1418)
  AUTHORS   Chen,X., Zhang,W., Han,X., Li,X., Xia,L., Wu,Y. and Zhou,Y.
  TITLE     TMED3 stabilizes SMAD2 by counteracting NEDD4-mediated
            ubiquitination to promote ovarian cancer
  JOURNAL   Mol Carcinog 63 (5), 803-816 (2024)
   PUBMED   38411267
  REMARK    GeneRIF: TMED3 stabilizes SMAD2 by counteracting NEDD4-mediated
            ubiquitination to promote ovarian cancer.
REFERENCE   2  (bases 1 to 1418)
  AUTHORS   Liao,G., Zhang,M. and Wang,C.
  TITLE     Analysis and Validation of TMED3 correlates with poor prognosis and
            tumor immune infiltration of glioma
  JOURNAL   J Cancer Res Clin Oncol 149 (7), 3485-3494 (2023)
   PUBMED   35951089
  REMARK    GeneRIF: Analysis and Validation of TMED3 correlates with poor
            prognosis and tumor immune infiltration of glioma.
REFERENCE   3  (bases 1 to 1418)
  AUTHORS   Yang,Y., Liu,S., Xie,C., Li,Q., Gao,T., Liu,M., Xi,M. and Zhao,L.
  TITLE     Trafficking protein TMED3 promotes esophageal squamous cell
            carcinoma
  JOURNAL   Biomed J 46 (2), 100528 (2023)
   PUBMED   35358714
  REMARK    GeneRIF: Trafficking protein TMED3 promotes esophageal squamous
            cell carcinoma.
REFERENCE   4  (bases 1 to 1418)
  AUTHORS   Zhang,D., Sun,L. and Zhang,J.
  TITLE     TMED3 exerts a protumor function in non-small cell lung cancer by
            enhancing the Wnt/beta-catenin pathway via regulation of AKT
  JOURNAL   Toxicol Appl Pharmacol 433, 115793 (2021)
   PUBMED   34758370
  REMARK    GeneRIF: TMED3 exerts a protumor function in non-small cell lung
            cancer by enhancing the Wnt/beta-catenin pathway via regulation of
            AKT.
REFERENCE   5  (bases 1 to 1418)
  AUTHORS   Xie,A., Xu,X., Kuang,P., Zhang,L. and Yu,F.
  TITLE     TMED3 promotes the progression and development of lung squamous
            cell carcinoma by regulating EZR
  JOURNAL   Cell Death Dis 12 (9), 804 (2021)
   PUBMED   34429402
  REMARK    GeneRIF: TMED3 promotes the progression and development of lung
            squamous cell carcinoma by regulating EZR.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1418)
  AUTHORS   Zheng,H., Yang,Y., Han,J., Jiang,W.H., Chen,C., Wang,M.C., Gao,R.,
            Li,S., Tian,T., Wang,J., Ma,L.J., Ren,H. and Zhou,W.P.
  TITLE     TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3
            signaling
  JOURNAL   Sci Rep 6, 37070 (2016)
   PUBMED   27901021
  REMARK    GeneRIF: Study demonstrates that transmembrane p24 trafficking
            protein 3 (TMED3) promotes hepatocellular carcinoma (HCC)
            metastasis and is a potential prognostic biomarker in
            hepatocellular carcinoma. Study propose that TMED3 promotes HCC
            metastasis through IL-11/STAT3 signaling.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1418)
  AUTHORS   Duquet,A., Melotti,A., Mishra,S., Malerba,M., Seth,C., Conod,A. and
            Ruiz i Altaba,A.
  TITLE     A novel genome-wide in vivo screen for metastatic suppressors in
            human colon cancer identifies the positive WNT-TCF pathway
            modulators TMED3 and SOX12
  JOURNAL   EMBO Mol Med 6 (7), 882-901 (2014)
   PUBMED   24920608
  REMARK    GeneRIF: This genome-wide screen has identified two novel
            metastatic suppressors: TMED3 and SOX12, the knockdown of which
            increases metastatic growth after direct seeding.
REFERENCE   8  (bases 1 to 1418)
  AUTHORS   Vainio,P., Mpindi,J.P., Kohonen,P., Fey,V., Mirtti,T., Alanen,K.A.,
            Perala,M., Kallioniemi,O. and Iljin,K.
  TITLE     High-throughput transcriptomic and RNAi analysis identifies AIM1,
            ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer
  JOURNAL   PLoS One 7 (6), e39801 (2012)
   PUBMED   22761906
  REMARK    GeneRIF: AIM1, ERGIC1, and TPX2 were shown to be highly expressed
            especially in prostate cancer tissues, and high mRNA expression of
            ERGIC1 and TMED3 associated with AR and ERG oncogene expression
REFERENCE   9  (bases 1 to 1418)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 1418)
  AUTHORS   Jenne,N., Frey,K., Brugger,B. and Wieland,F.T.
  TITLE     Oligomeric state and stoichiometry of p24 proteins in the early
            secretory pathway
  JOURNAL   J Biol Chem 277 (48), 46504-46511 (2002)
   PUBMED   12237308
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011797.8, KF459564.1 and AC027811.9.
            
            On Nov 23, 2018 this sequence version replaced NM_007364.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.519148.1,
                                           SRR3476690.664899.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299705.10/ ENSP00000299705.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC011797.8         148887-149192
            307-534             KF459564.1         1-228               c
            535-555             AC011797.8         151760-151780
            556-1418            AC027811.9         104774-105636       c
FEATURES             Location/Qualifiers
     source          1..1418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..1418
                     /gene="TMED3"
                     /gene_synonym="C15orf22; P24B; p24g4; p24gamma4; p26"
                     /note="transmembrane p24 trafficking protein 3"
                     /db_xref="GeneID:23423"
                     /db_xref="HGNC:HGNC:28889"
                     /db_xref="MIM:620437"
     exon            1..306
                     /gene="TMED3"
                     /gene_synonym="C15orf22; P24B; p24g4; p24gamma4; p26"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..792
                     /gene="TMED3"
                     /gene_synonym="C15orf22; P24B; p24g4; p24gamma4; p26"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; integral type I protein; transmembrane emp24
                     domain-containing protein 3; membrane protein p24B; p24
                     family protein gamma-4; transmembrane emp24 protein
                     transport domain containing 3; testis tissue sperm-binding
                     protein Li 48e"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 3
                     isoform a precursor"
                     /protein_id="NP_031390.1"
                     /db_xref="CCDS:CCDS10310.1"
                     /db_xref="GeneID:23423"
                     /db_xref="HGNC:HGNC:28889"
                     /db_xref="MIM:620437"
                     /translation="MGSTVPRSASVLLLLLLLRRAEQPCGAELTFELPDNAKQCFHEE
                     VEQGVKFSLDYQVITGGHYDVDCYVEDPQGNTIYRETKKQYDSFTYRAEVKGVYQFCF
                     SNEFSTFSHKTVYFDFQVGDEPPILPDMGNRVTALTQMESACVTIHEALKTVIDSQTH
                     YRLREAQDRARAEDLNSRVSYWSVGETIALFVVSFSQVLLLKSFFTEKRPISRAVHS"
     exon            307..555
                     /gene="TMED3"
                     /gene_synonym="C15orf22; P24B; p24g4; p24gamma4; p26"
                     /inference="alignment:Splign:2.1.0"
     exon            556..1418
                     /gene="TMED3"
                     /gene_synonym="C15orf22; P24B; p24g4; p24gamma4; p26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1396..1401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED3"
                     /gene_synonym="C15orf22; P24B; p24g4; p24gamma4; p26"
                     /note="hexamer: AATAAA"
     polyA_site      1418
                     /gene="TMED3"
                     /gene_synonym="C15orf22; P24B; p24g4; p24gamma4; p26"
                     /note="major polyA site"
ORIGIN      
        1 cctcccggaa gcgcagagct ccgctggtgc cacgtctatc cccttacatc ctcctaggac
       61 ccggtcggta gtcgtcgccc cagcccgccg ggggcgcagc gcccgagccg cggccctcga
      121 gacgggaccg agagcatcat gggcagcact gtcccgcgct ccgcctccgt gctgcttctg
      181 ctgctgctcc tgcgccgggc cgagcagccc tgcggggccg agctcacctt cgagctgccg
      241 gacaacgcca agcagtgctt ccacgaggag gtggagcagg gcgtgaagtt ctccctggat
      301 taccaggtca tcactggagg ccactacgat gttgactgct atgtagagga cccccagggg
      361 aacaccatct acagagaaac gaagaagcag tacgacagct tcacgtaccg ggctgaagtc
      421 aagggcgttt atcagttttg cttcagtaat gagttttcca ccttctctca caagaccgtc
      481 tactttgact ttcaagtggg cgatgagcct cccattctcc cagacatggg gaacagggtc
      541 acagctctca cccagatgga gtccgcctgc gtgaccatcc atgaggctct gaaaacggtg
      601 attgactccc agacgcatta ccggctgcgg gaggcccagg accgggcccg agcagaagac
      661 cttaatagcc gagtctctta ctggtctgtt ggcgagacga ttgccctgtt cgtggtcagc
      721 ttcagtcagg tgctactgtt gaaaagcttc ttcacagaaa aacgacccat cagcagggca
      781 gtccactcct agccccggca tcctgctcta gggcccctca tgccccaggc tggagcagct
      841 ctcctaggtc acagcctgct gggctgggtc gcgtagccca gggtggaggc agaacgatgc
      901 tgctgtggta gccctttgcc tttcatgccc atgcttgatt cttgcacctc agcagctgaa
      961 ggtctcagag accagtaatc agaaggcatc cgactgcatt aagtgtgcag cgctgaaaag
     1021 acatttacaa ctaggccagg gattagccac tgtgggaggg tggacaggca atggttcagt
     1081 ggcctggctg ttggcaggaa ctccaagtgc ccaggcctct tgggcagctt agggccctgc
     1141 ctctgtttca tgatgcatgg gtcatttgtc ttgggtgtcc tatcccatat ggagaagaaa
     1201 ggggctctaa gttctggctc ttctttcttt ggggttctct gtacctgagg aaaccaggcc
     1261 ctgggtgact ttgcagatct gctcaccctc ggtgagcaac agtgtcagcc atgcaagcag
     1321 gacagaatgg tgactgggtg cccttggtga gctgtgtatt tcctaggagg tagaaaactg
     1381 tgggaaactg tggctaataa aaactaagtg tgagcgtc
//
