LOCUS       NM_006815               2544 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane p24 trafficking protein 2 (TMED2),
            transcript variant 1, mRNA.
ACCESSION   NM_006815
VERSION     NM_006815.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2544)
  AUTHORS   Sun,C., Zhang,Y., Wang,Z., Chen,J., Zhang,J. and Gu,Y.
  TITLE     TMED2 promotes glioma tumorigenesis by being involved in EGFR
            recycling transport
  JOURNAL   Int J Biol Macromol 262 (Pt 2), 130055 (2024)
   PUBMED   38354922
  REMARK    GeneRIF: TMED2 promotes glioma tumorigenesis by being involved in
            EGFR recycling transport.
REFERENCE   2  (bases 1 to 2544)
  AUTHORS   Liang,C., Zhang,H.Y., Wang,Y.Q., Yang,L.A., Du,Y.S., Luo,Y.,
            Zhang,T.C. and Xu,Y.
  TITLE     TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting
            the KEAP1-Nrf2 Pathway
  JOURNAL   Curr Med Sci 43 (5), 1023-1032 (2023)
   PUBMED   37615927
  REMARK    GeneRIF: TMED2 Induces Cisplatin Resistance in Breast Cancer via
            Targeting the KEAP1-Nrf2 Pathway.
REFERENCE   3  (bases 1 to 2544)
  AUTHORS   Xu,H., Lin,X., Li,Z., He,X., Li,Y., Qiu,L., Lu,L., Liu,B., Zhan,M.
            and He,K.
  TITLE     VIRMA facilitates intrahepatic cholangiocarcinoma progression
            through epigenetic augmentation of TMED2 and PARD3B mRNA
            stabilization
  JOURNAL   J Gastroenterol 58 (9), 925-944 (2023)
   PUBMED   37391589
  REMARK    GeneRIF: VIRMA facilitates intrahepatic cholangiocarcinoma
            progression through epigenetic augmentation of TMED2 and PARD3B
            mRNA stabilization.
REFERENCE   4  (bases 1 to 2544)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2544)
  AUTHORS   Feng,L., Cheng,P., Feng,Z. and Zhang,X.
  TITLE     Transmembrane p24 trafficking protein 2 regulates inflammation
            through the TLR4/NF-kappaB signaling pathway in lung adenocarcinoma
  JOURNAL   World J Surg Oncol 20 (1), 32 (2022)
   PUBMED   35135563
  REMARK    GeneRIF: Transmembrane p24 trafficking protein 2 regulates
            inflammation through the TLR4/NF-kappaB signaling pathway in lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2544)
  AUTHORS   Goldberg,J.
  TITLE     Decoding of sorting signals by coatomer through a GTPase switch in
            the COPI coat complex
  JOURNAL   Cell 100 (6), 671-679 (2000)
   PUBMED   10761932
REFERENCE   7  (bases 1 to 2544)
  AUTHORS   Fullekrug,J., Suganuma,T., Tang,B.L., Hong,W., Storrie,B. and
            Nilsson,T.
  TITLE     Localization and recycling of gp27 (hp24gamma3): complex formation
            with other p24 family members
  JOURNAL   Mol Biol Cell 10 (6), 1939-1955 (1999)
   PUBMED   10359607
REFERENCE   8  (bases 1 to 2544)
  AUTHORS   Gommel,D., Orci,L., Emig,E.M., Hannah,M.J., Ravazzola,M.,
            Nickel,W., Helms,J.B., Wieland,F.T. and Sohn,K.
  TITLE     p24 and p23, the major transmembrane proteins of COPI-coated
            transport vesicles, form hetero-oligomeric complexes and cycle
            between the organelles of the early secretory pathway
  JOURNAL   FEBS Lett 447 (2-3), 179-185 (1999)
   PUBMED   10214941
REFERENCE   9  (bases 1 to 2544)
  AUTHORS   Fiedler,K., Veit,M., Stamnes,M.A. and Rothman,J.E.
  TITLE     Bimodal interaction of coatomer with the p24 family of putative
            cargo receptors
  JOURNAL   Science 273 (5280), 1396-1399 (1996)
   PUBMED   8703076
REFERENCE   10 (bases 1 to 2544)
  AUTHORS   Blum,R., Feick,P., Puype,M., Vandekerckhove,J., Klengel,R.,
            Nastainczyk,W. and Schulz,I.
  TITLE     Tmp21 and p24A, two type I proteins enriched in pancreatic
            microsomal membranes, are members of a protein family involved in
            vesicular trafficking
  JOURNAL   J Biol Chem 271 (29), 17183-17189 (1996)
   PUBMED   8663407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055713.29, BI086507.1 and BC025957.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006815.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.972817.1,
                                           SRR1660805.248900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262225.8/ ENSP00000262225.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC055713.29        23372-23485         c
            115-366             BI086507.1         66-317
            367-1654            BC025957.1         305-1592
            1655-2103           AC055713.29        9896-10344          c
            2104-2544           AC055713.29        9455-9895           c
FEATURES             Location/Qualifiers
     source          1..2544
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..2544
                     /gene="TMED2"
                     /gene_synonym="p24; P24A; p24b1; p24beta1; RNP24"
                     /note="transmembrane p24 trafficking protein 2"
                     /db_xref="GeneID:10959"
                     /db_xref="HGNC:HGNC:16996"
                     /db_xref="MIM:619642"
     exon            1..265
                     /gene="TMED2"
                     /gene_synonym="p24; P24A; p24b1; p24beta1; RNP24"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..691
                     /gene="TMED2"
                     /gene_synonym="p24; P24A; p24b1; p24beta1; RNP24"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; coated vesicle membrane protein; membrane
                     protein p24A; p24 family protein beta-1; transmembrane
                     emp24 domain trafficking protein 2"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 2
                     isoform 1 precursor"
                     /protein_id="NP_006806.1"
                     /db_xref="CCDS:CCDS9250.1"
                     /db_xref="GeneID:10959"
                     /db_xref="HGNC:HGNC:16996"
                     /db_xref="MIM:619642"
                     /translation="MVTLAELLVLLAALLATVSGYFVSIDAHAEECFFERVTSGTKMG
                     LIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMT
                     PKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRA
                     INDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV"
     exon            266..458
                     /gene="TMED2"
                     /gene_synonym="p24; P24A; p24b1; p24beta1; RNP24"
                     /inference="alignment:Splign:2.1.0"
     exon            459..566
                     /gene="TMED2"
                     /gene_synonym="p24; P24A; p24b1; p24beta1; RNP24"
                     /inference="alignment:Splign:2.1.0"
     exon            567..2544
                     /gene="TMED2"
                     /gene_synonym="p24; P24A; p24b1; p24beta1; RNP24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2080..2085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED2"
                     /gene_synonym="p24; P24A; p24b1; p24beta1; RNP24"
                     /note="hexamer: AATAAA"
     polyA_site      2101
                     /gene="TMED2"
                     /gene_synonym="p24; P24A; p24b1; p24beta1; RNP24"
                     /note="major polyA site"
     regulatory      2520..2525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED2"
                     /gene_synonym="p24; P24A; p24b1; p24beta1; RNP24"
                     /note="hexamer: AATAAA"
     polyA_site      2544
                     /gene="TMED2"
                     /gene_synonym="p24; P24A; p24b1; p24beta1; RNP24"
ORIGIN      
        1 gagaaggcag cggggcggcg gcggcggcgg cggcggcggc tgtggaggcc gcagtccggg
       61 tcctggcttc ggcctcagcc ccaccatggt gacgcttgct gaactgctgg tgcttctggc
      121 cgctctcctg gccacggtct cgggctattt cgttagcatc gacgcccatg ctgaagagtg
      181 cttctttgag cgggtcacct cgggcaccaa gatgggcctc atcttcgagg tggcggaggg
      241 cggcttcctg gacatcgacg tggagattac aggaccagat aacaaaggaa tttacaaagg
      301 agacagagaa tccagtggga aatacacatt tgctgctcac atggatggaa catacaaatt
      361 ttgttttagt aaccggatgt ccaccatgac tccaaaaata gtgatgttca ccattgatat
      421 tggggaggct ccaaaaggac aagatatgga aacagaagct caccagaaca agctagaaga
      481 aatgatcaat gagctagcag tggcgatgac agctgtaaag cacgaacagg aatacatgga
      541 agtccgggag agaatacaca gagccatcaa cgacaacaca aacagcagag tggtcctttg
      601 gtccttcttt gaagctcttg ttctagttgc catgacattg ggacagatct actacctgaa
      661 gagatttttt gaagtccgga gagttgttta aaaagcctct tcctgatgat cccaactcag
      721 aattcactgt ttaccaaaca ccttggtcat aataatgtca ttagtttctc catttttatt
      781 ttctgaactg tacattcaca acttatgttt ctttgagatt aatagatatt gggggaaaaa
      841 cgccttttta ggaaaattat agtgaaaatt tgacagttga ttggcataat ttcttgtttg
      901 aatgctgcct ccattatata ggtccttcca ggaactcaaa cactgtaagt gaaatatggg
      961 agtatagttt ttattatttc ttcttttcct tttgttttca taatataatg cagtttgttc
     1021 aggaaatcag cacaaagcct gatagtactt tactaaaatg actgcattct ttggattcct
     1081 tcagtctatg gttcaagtca ctaaagattc atttttgttg agtccttatg agaaacagca
     1141 gtatgaatct tgacggtttc tgcccgtcct aatggcagag ctctctgact tgggtgtatg
     1201 ctgccaggct gggtactttc atactttgtt ttcttgtttt gctttaaaac tacgactcag
     1261 catacatttt cccacataca tttttacatt gtaccttagg actcagtcat ctccacttaa
     1321 attgatgaca caagcagcta ataaccattt ctgggtttct gcctaacccc ctaattgtct
     1381 gttaaagcca attctctggg tgtcccagtg agtggtggct ttttttcttt ccacattggc
     1441 acattcactt ctcccactct tggcatgtaa gaaataagca tttacataat tggaaaaatc
     1501 tggatttctg atgccaaagg gttaaagctt cttggatttc atttcattga tatacagcca
     1561 ctattttatt tttgatcagt ggcctttggg ccactgttca gggtactgac catcagtgtc
     1621 agcattaggg ttttggtttt tgtttctttt gggtctttct tttttggcac atgtgaatct
     1681 tgttttgtgt aaaatgaaat tactttctct tgttctctga tgatgggttt aaaattaaaa
     1741 gagcatccgg ttttggtatg gggatgatcc aggattatgt tgtgactgat acatattagt
     1801 tacttgtgct tttttttttt tttttggatc tttgcaaggg caaaactaca agtaacgagt
     1861 tttatataat taatttaaat ttgttacagg ttttcatgtt caggataaac catacttcca
     1921 ccttgggtga gaacacttgc aacagtttat taatgaggtg actttcacct taggacaact
     1981 gttgcatgcc aagttttttg tgtgtgtgaa acacttcaaa actgatttaa aagatgtaaa
     2041 tttaaaattg gttgtatcta atatgcccca ggttcggtaa ataaacaatt ctttttaaaa
     2101 acagtattct gtgttttata tattgacagc taatccacat tttttacaca ccaactttct
     2161 gttcttattt gacatgagac atgttcatgt tttctgagta tttataccta ttacgtctgt
     2221 tactttttaa ttctataaac ttgaggatag tgaatggtac caagttttag tttctgcgta
     2281 ggttttccag tgtggcttct ctgatggatc agtgctaaaa tcttaagtat ttttctattt
     2341 gggaaaaaag ggttgaatta ttttcacttg cccacgtagt ttatgaatgt gggaaatagc
     2401 ttcaaagaca gattaaatga tttgcccaag gccacagaaa agagtgaaag gtggaaccgg
     2461 agactagatc accacctgta gaaactgttc ttcctctgtg aaactaacgg cctgctggta
     2521 ataaaagtag ctaccatttc ttga
//
