LOCUS       NM_006827               4109 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane p24 trafficking protein 10 (TMED10),
            mRNA.
ACCESSION   NM_006827
VERSION     NM_006827.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4109)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4109)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4109)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4109)
  AUTHORS   Zhang,M., Liu,L., Lin,X., Wang,Y., Li,Y., Guo,Q., Li,S., Sun,Y.,
            Tao,X., Zhang,D., Lv,X., Zheng,L. and Ge,L.
  TITLE     A Translocation Pathway for Vesicle-Mediated Unconventional Protein
            Secretion
  JOURNAL   Cell 181 (3), 637-652 (2020)
   PUBMED   32272059
REFERENCE   5  (bases 1 to 4109)
  AUTHORS   Yang,X., Li,S., Wu,Y., Ge,F., Chen,Y. and Xiong,Q.
  TITLE     The circular RNA CDR1as regulate cell proliferation via TMED2 and
            TMED10
  JOURNAL   BMC Cancer 20 (1), 312 (2020)
   PUBMED   32293333
  REMARK    GeneRIF: The circular RNA CDR1as regulate cell proliferation via
            TMED2 and TMED10.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4109)
  AUTHORS   Fullekrug,J., Suganuma,T., Tang,B.L., Hong,W., Storrie,B. and
            Nilsson,T.
  TITLE     Localization and recycling of gp27 (hp24gamma3): complex formation
            with other p24 family members
  JOURNAL   Mol Biol Cell 10 (6), 1939-1955 (1999)
   PUBMED   10359607
REFERENCE   7  (bases 1 to 4109)
  AUTHORS   Bremser,M., Nickel,W., Schweikert,M., Ravazzola,M., Amherdt,M.,
            Hughes,C.A., Sollner,T.H., Rothman,J.E. and Wieland,F.T.
  TITLE     Coupling of coat assembly and vesicle budding to packaging of
            putative cargo receptors
  JOURNAL   Cell 96 (4), 495-506 (1999)
   PUBMED   10052452
REFERENCE   8  (bases 1 to 4109)
  AUTHORS   Horer,J., Blum,R., Feick,P., Nastainczyk,W. and Schulz,I.
  TITLE     A comparative study of rat and human Tmp21 (p23) reveals the
            pseudogene-like features of human Tmp21-II
  JOURNAL   DNA Seq 10 (2), 121-126 (1999)
   PUBMED   10376215
REFERENCE   9  (bases 1 to 4109)
  AUTHORS   Blum,R., Feick,P., Puype,M., Vandekerckhove,J., Klengel,R.,
            Nastainczyk,W. and Schulz,I.
  TITLE     Tmp21 and p24A, two type I proteins enriched in pancreatic
            microsomal membranes, are members of a protein family involved in
            vesicular trafficking
  JOURNAL   J Biol Chem 271 (29), 17183-17189 (1996)
   PUBMED   8663407
REFERENCE   10 (bases 1 to 4109)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX504393.1, X97442.1,
            BX248754.1, AK056156.1, BG675810.1, CN420777.1, AL832012.2 and
            DB528262.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006827.5.
            
            Summary: This gene is a member of the EMP24/GP25L/p24 family and
            encodes a protein with a GOLD domain. This type I membrane protein
            is localized to the plasma membrane and golgi cisternae and is
            involved in vesicular protein trafficking. The protein is also a
            member of a heteromeric secretase complex and regulates the
            complex's gamma-secretase activity without affecting its
            epsilon-secretase activity. Mutations in this gene have been
            associated with early-onset familial Alzheimer's disease. This gene
            has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.111188.1,
                                           SRR1660803.120772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303575.9/ ENSP00000303145.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BX504393.1         36-57
            23-524              X97442.1           1-502
            525-1699            BX248754.1         510-1684
            1700-2633           AK056156.1         179-1112
            2634-3125           BG675810.1         98-589
            3126-3689           CN420777.1         25-588
            3690-4108           AL832012.2         3669-4087
            4109-4109           DB528262.1         288-288
FEATURES             Location/Qualifiers
     source          1..4109
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..4109
                     /gene="TMED10"
                     /gene_synonym="p23; P24(DELTA); p24d1; S31I125; S31III125;
                     Tmp-21-I; TMP21"
                     /note="transmembrane p24 trafficking protein 10"
                     /db_xref="GeneID:10972"
                     /db_xref="HGNC:HGNC:16998"
                     /db_xref="MIM:605406"
     exon            1..258
                     /gene="TMED10"
                     /gene_synonym="p23; P24(DELTA); p24d1; S31I125; S31III125;
                     Tmp-21-I; TMP21"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..693
                     /gene="TMED10"
                     /gene_synonym="p23; P24(DELTA); p24d1; S31I125; S31III125;
                     Tmp-21-I; TMP21"
                     /note="21 kDa transmembrane trafficking protein;
                     transmembrane emp24 domain-containing protein 10;
                     p24delta; transmembrane protein Tmp21; p24delta1; p24
                     family protein delta-1; transmembrane emp24-like
                     trafficking protein 10; testicular tissue protein Li 206"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 10
                     precursor"
                     /protein_id="NP_006818.3"
                     /db_xref="CCDS:CCDS9840.1"
                     /db_xref="GeneID:10972"
                     /db_xref="HGNC:HGNC:16998"
                     /db_xref="MIM:605406"
                     /translation="MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCL
                     REEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDATKGKFAFTTEDY
                     DMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSES
                     IVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLI
                     E"
     exon            259..370
                     /gene="TMED10"
                     /gene_synonym="p23; P24(DELTA); p24d1; S31I125; S31III125;
                     Tmp-21-I; TMP21"
                     /inference="alignment:Splign:2.1.0"
     exon            371..444
                     /gene="TMED10"
                     /gene_synonym="p23; P24(DELTA); p24d1; S31I125; S31III125;
                     Tmp-21-I; TMP21"
                     /inference="alignment:Splign:2.1.0"
     exon            445..571
                     /gene="TMED10"
                     /gene_synonym="p23; P24(DELTA); p24d1; S31I125; S31III125;
                     Tmp-21-I; TMP21"
                     /inference="alignment:Splign:2.1.0"
     exon            572..4109
                     /gene="TMED10"
                     /gene_synonym="p23; P24(DELTA); p24d1; S31I125; S31III125;
                     Tmp-21-I; TMP21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1306..1311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED10"
                     /gene_synonym="p23; P24(DELTA); p24d1; S31I125; S31III125;
                     Tmp-21-I; TMP21"
                     /note="hexamer: ATTAAA"
     polyA_site      1334
                     /gene="TMED10"
                     /gene_synonym="p23; P24(DELTA); p24d1; S31I125; S31III125;
                     Tmp-21-I; TMP21"
                     /note="major polyA site"
     regulatory      4089..4094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED10"
                     /gene_synonym="p23; P24(DELTA); p24d1; S31I125; S31III125;
                     Tmp-21-I; TMP21"
                     /note="hexamer: AATAAA"
     polyA_site      4109
                     /gene="TMED10"
                     /gene_synonym="p23; P24(DELTA); p24d1; S31I125; S31III125;
                     Tmp-21-I; TMP21"
                     /note="major polyA site"
ORIGIN      
        1 gaggccttcg gtggtgaacg agtctccagc accatgtctg gtttgtctgg cccaccagcc
       61 cggcgcggcc cttttccgtt agcgttgctg cttttgttcc tgctcggccc cagattggtc
      121 cttgccatct ccttccatct gcccattaac tctcgcaagt gcctccgtga ggagattcac
      181 aaggacctgc tagtgactgg cgcgtacgag atctccgacc agtctggggg cgctggcggc
      241 ctgcgcagcc acctcaagat cacagattct gctggccata ttctctactc caaagaggat
      301 gcaaccaagg ggaaatttgc ctttaccact gaagattatg acatgtttga agtgtgtttt
      361 gagagcaagg gaacagggcg gatacctgac caactcgtga tcctagacat gaagcatgga
      421 gtggaggcga aaaattacga agagattgca aaagttgaga agctcaaacc attagaggta
      481 gagctgcgac gcctagaaga cctttcagaa tctattgtta atgattttgc ctacatgaag
      541 aagagagaag aggagatgcg tgataccaac gagtcaacaa acactcgggt cctatacttc
      601 agcatctttt caatgttctg tctcattgga ctagctacct ggcaggtctt ctacctgcga
      661 cgcttcttca aggccaagaa attgattgag taatgaatga ggcatattct cctcccacct
      721 tgtacctcag ccagcagaac atcgctggga cgtgcctggc ctaaggcatc ctaccaacag
      781 caccatcaag gcacgttgga gctttcttgc cagaactgat ctcttttggt gtgggaggac
      841 atggggtacc acctacaccc aacaagtcaa tgagggactt ctttttaatt tggtaggatt
      901 ttgactggtt ttgcaacaat aggtctatta ttagagtcac ctatgacaaa aaataggggt
      961 tacctagata atgccaaagt cagcatttgt cctgggttcc cttgtgtgat ctgtttggac
     1021 tatgttttct tttcttctcc cacttgctca gcagcttggg cttccattct agttctttta
     1081 ccaagatttt tgtgtgacca tgttgacttc atttggattg ccctctttca atttccttgt
     1141 gaaaacaccc ttaactttct ctttaccctt agctgaaatg tttacatagc ttctggtgat
     1201 atcttttcat gattttatat ctcttaaaat ggtgatggat gtgacacctc ataaaagtga
     1261 gctttgaact gtagataact cttaaagaaa atgtcatttt agacaattaa aatatttgtg
     1321 ctcaactgct tgaacttttt tcgtgtatgt gtatttaatt ctatgcaata ttatcacatg
     1381 tgtagattca tgtgaccacc atcacaagag acagaacagt tctgtcacat ggatcccttg
     1441 cactgccctt ttacagccgc agccacatcc ctttcttata ccctcacccc aacctgtggc
     1501 taccactgtt ctgtcctcca tctctgtaat tttgtcattt caagaatgtt gtatgaatgg
     1561 aatcatacag aatgtaatct tacgaggctg atcttttttc attcagcata attcccttga
     1621 aatccatcca agttgttgca tgtatgaata gtttcttcct ttttttcttt taaaaatgtt
     1681 ttatatattt agggggtata agtacagatt tcttacatgc atatattgca tcgtggtgaa
     1741 gtgggggcag ttccttttga ttgctgagta gtattccatg gtatggatgt accacagttt
     1801 gcttaaccat tcacccacta aaggacataa gagttgtttt cagttttttg ccctaataaa
     1861 gctgctgtga acattcatgt acaggttttt atgtgaacat acattttcat tttctgggat
     1921 aaatgctcaa aagggcaact gttgggttgt atggtaaaca catatatttt tgtaagaaac
     1981 taccctactc tttttccaga gtggctctac tttttacata cagccactca tacaattcag
     2041 acagcaatgt atgattgatc cagtttcttc acatcctcac cagcatttgg tattactact
     2101 attttttatc ttaaccattc acatagatgt gtgtaatgat accacatgtg gttttaattt
     2161 gcatttccaa tggctaatga tgttgagtat ctttttgtgt gctaatttgc catctatgta
     2221 tcctcttcgg tgaaatgtct tcatgtcttt tgtctatttt ctatttaggt catttgttct
     2281 ttttactatt gagttttgag aggtttttta tatatcctag ataaaattcc tctgttagat
     2341 atgtggttgc ttgaattttt aacataactt ctaccaagga aaaataagta aaatttccaa
     2401 cccttgcatg gccagtcact tacttaattc ctgtccttca gtgttccatc tagagaatta
     2461 agagatatga tgtataaaat agacatcgag ggccattaag agagtaaata cttaaaaata
     2521 catgttatga aagcaaagcc aataatcact gtaggagtat gagttgccta agggccaaaa
     2581 ctaatgtaaa taagagaaag tgtggatata aatgaccatt gtttataaac agttatgaaa
     2641 aatgctgtga cttgaaatct ttcccacatc tcccaagaaa gtaggtagga gtttatcctt
     2701 tccgtaatct ctttttaacc ctgctgacta ttacagggct tgtttaatca cagtggcaag
     2761 aattacatgt atcttacagt aaagaaacag aatactggaa tcgttagaga accctgatgt
     2821 gttgacctgg ataaagtaca aaggtggaag agggaatgag ttatgctgtt aaaatctcag
     2881 gctattctgt taatgttcct gctactatga acccaaactt tttttttccc ccttttgact
     2941 ccttgtgtct tcctctcctg tggcataaaa gtagttctgt cgttaacttg tacaacattg
     3001 ccatctgctg ttgagaattg gtaggtactg cttctgagaa cctggctgca gatccttagc
     3061 ataggcagca aatgttgaga aagtctatct gtagtattac atatactaag ttacagagga
     3121 tgcatccaag tagagaaaat aatatgtggg ttaagataca tccttaaact tttttttttt
     3181 tggggggggg gggacggagt cttgctgcaa cgcccaggct ggagtgcaat ggcactatct
     3241 cagctcgctg caaccttcac ctcctgggtt caagcaattc tcctgcctca gcctcctgag
     3301 tagctgggaa tataggtgca caccaccatg cctggctaat ttttgtattt tcagtagaag
     3361 cagagtttca ccatattggc caggttggtc tcgaactcct gacctcaagt gatctgcctg
     3421 cctcagcctc ccaaagtgct gggattacac gcgtgagcca ccacacccag cctccatctt
     3481 taaactttta aatgtgaaat ttctatcatg taccgttagc ctaacaagat tttctttcct
     3541 atttctgact ggtgcctttc ccctttttag gagcaacgaa agctactctc ttagttatgt
     3601 tcttgtgatg tgacaaaatg tcaagaagat aggagaagag aatattttat ttcgttgatg
     3661 cttttgttcc caagtgtgac cctaaactta agctttgtag gagttgacat tctttcatgt
     3721 cccttccctt tactcatgcc gaaactatca actgggacat tttgtgcttt tggtttaaaa
     3781 gttaattgat attatacttt ggttttatct aaaaagtaaa tgtatttgcc tttgacaaaa
     3841 gactgacaca agagcaaata agctttaaaa tcgggtgtta tgtgctttcc tccatttttg
     3901 agcatattat ccaaaatggt ctgtataata taaatgagaa tgatgcagtt taagtaagcc
     3961 ttgttatacc attgtcatgg acccctgtca taaagccatt tcttggtttg tttgggaaag
     4021 aggcatatgg gatttataca gattcacttg taaatgttgg attggggatt tttgtgtaaa
     4081 ttttctcaaa taaaggctag cagaaacca
//
