LOCUS       NM_006858               1633 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane p24 trafficking protein 1 (TMED1),
            transcript variant 1, mRNA.
ACCESSION   NM_006858
VERSION     NM_006858.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1633)
  AUTHORS   Mota,D.C.A.M., Cardoso,I.A., Mori,R.M., Batista,M.R.B.,
            Basso,L.G.M., Nonato,M.C., Costa-Filho,A.J. and Mendes,L.F.S.
  TITLE     Structural and thermodynamic analyses of human TMED1 (p24gamma1)
            Golgi dynamics
  JOURNAL   Biochimie 192, 72-82 (2022)
   PUBMED   34634369
  REMARK    GeneRIF: Structural and thermodynamic analyses of human TMED1
            (p24gamma1) Golgi dynamics.
REFERENCE   2  (bases 1 to 1633)
  AUTHORS   Connolly,D.J., O'Neill,L.A. and McGettrick,A.F.
  TITLE     The GOLD domain-containing protein TMED1 is involved in
            interleukin-33 signaling
  JOURNAL   J Biol Chem 288 (8), 5616-5623 (2013)
   PUBMED   23319592
  REMARK    GeneRIF: The GOLD domain-containing protein TMED1 is involved in
            interleukin-33 signaling
REFERENCE   3  (bases 1 to 1633)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   4  (bases 1 to 1633)
  AUTHORS   Jenne,N., Frey,K., Brugger,B. and Wieland,F.T.
  TITLE     Oligomeric state and stoichiometry of p24 proteins in the early
            secretory pathway
  JOURNAL   J Biol Chem 277 (48), 46504-46511 (2002)
   PUBMED   12237308
REFERENCE   5  (bases 1 to 1633)
  AUTHORS   Gayle,M.A., Slack,J.L., Bonnert,T.P., Renshaw,B.R., Sonoda,G.,
            Taguchi,T., Testa,J.R., Dower,S.K. and Sims,J.E.
  TITLE     Cloning of a putative ligand for the T1/ST2 receptor
  JOURNAL   J Biol Chem 271 (10), 5784-5789 (1996)
   PUBMED   8621446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U41804.1, BC002443.1,
            AW389310.1 and BI793229.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006858.3.
            
            Summary: This gene belongs to the TMED (transmembrane emp24
            domain-containing) protein family, which is involved in the
            vesicular trafficking of proteins. The protein encoded by this gene
            was identified by its interaction with interleukin 1 receptor-like
            1 (IL1RL1) and may play a role in innate immunity. This protein
            lacks any similarity to other interleukin 1 ligands. Alternative
            splicing results in multiple transcript variants of this gene.
            [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein coding.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.311988.1,
                                           SRR5189667.15316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000214869.7/ ENSP00000214869.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1237              U41804.1           67-1303
            1238-1262           BC002443.1         1221-1245
            1263-1294           AW389310.1         1-32                c
            1295-1633           BI793229.1         24-362
FEATURES             Location/Qualifiers
     source          1..1633
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1633
                     /gene="TMED1"
                     /gene_synonym="Il1rl1l; IL1RL1LG; p24g1; Tp24"
                     /note="transmembrane p24 trafficking protein 1"
                     /db_xref="GeneID:11018"
                     /db_xref="HGNC:HGNC:17291"
                     /db_xref="MIM:605395"
     exon            1..204
                     /gene="TMED1"
                     /gene_synonym="Il1rl1l; IL1RL1LG; p24g1; Tp24"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..705
                     /gene="TMED1"
                     /gene_synonym="Il1rl1l; IL1RL1LG; p24g1; Tp24"
                     /note="interleukin 1 receptor-like 1 ligand; p24 family
                     protein gamma-1; IL1RL1-binding protein; transmembrane
                     emp24 domain-containing protein 1; putative T1/ST2
                     receptor-binding protein; transmembrane emp24 protein
                     transport domain containing 1"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 1
                     precursor"
                     /protein_id="NP_006849.1"
                     /db_xref="CCDS:CCDS12249.1"
                     /db_xref="GeneID:11018"
                     /db_xref="HGNC:HGNC:17291"
                     /db_xref="MIM:605395"
                     /translation="MMAAGAALALALWLLMPPVEVGGAGPPPIQDGEFTFLLPAGRKQ
                     CFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGD
                     YKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIET
                     MRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRF
                     FQDKRPVPT"
     exon            205..302
                     /gene="TMED1"
                     /gene_synonym="Il1rl1l; IL1RL1LG; p24g1; Tp24"
                     /inference="alignment:Splign:2.1.0"
     exon            303..486
                     /gene="TMED1"
                     /gene_synonym="Il1rl1l; IL1RL1LG; p24g1; Tp24"
                     /inference="alignment:Splign:2.1.0"
     exon            487..1633
                     /gene="TMED1"
                     /gene_synonym="Il1rl1l; IL1RL1LG; p24g1; Tp24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1240..1245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED1"
                     /gene_synonym="Il1rl1l; IL1RL1LG; p24g1; Tp24"
                     /note="hexamer: AATAAA"
     polyA_site      1262
                     /gene="TMED1"
                     /gene_synonym="Il1rl1l; IL1RL1LG; p24g1; Tp24"
                     /note="major polyA site"
     regulatory      1614..1619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMED1"
                     /gene_synonym="Il1rl1l; IL1RL1LG; p24g1; Tp24"
                     /note="hexamer: AGTAAA"
     polyA_site      1633
                     /gene="TMED1"
                     /gene_synonym="Il1rl1l; IL1RL1LG; p24g1; Tp24"
ORIGIN      
        1 gcagaccaga gggtgacccg gatgatggcg gccggcgcgg ccctagccct ggccttgtgg
       61 ctactaatgc caccagtgga ggtgggaggg gcggggcccc cgccaatcca ggacggtgag
      121 ttcacgttcc tgttgccggc ggggaggaag cagtgtttct accagtccgc gccggccaac
      181 gcaagcctcg agaccgaata ccaggtgatc ggaggtgctg gactggacgt ggacttcacg
      241 ctggagagcc ctcagggcgt gctgttggtc agcgagtccc gcaaggctga tggggtacac
      301 acggtggagc caacggaggc cggggactac aagctgtgct ttgacaactc cttcagcacc
      361 atctccgaga agctggtgtt ctttgaactg atctttgaca gcctccagga tgacgaggag
      421 gtcgaaggat gggcagaggc tgtggagccc gaggagatgc tggatgttaa aatggaggac
      481 atcaaggagt ccattgagac catgcggacc cggctggagc gcagcatcca gatgctcacg
      541 ctactgcggg ccttcgaggc acgtgaccgc aacctgcaag agggcaactt ggagcgggtc
      601 aacttctggt cagctgtcaa cgtggcggtg ctgctgctgg tggctgtgct gcaggtctgc
      661 acgctcaagc gcttcttcca ggacaagcgc ccggtgccca cgtagcccct gccatggaag
      721 gaagaacggg acaaaggagg ggcagcaggg tgtgtgcata tgagacttgg gggtccctcc
      781 ccaattttag tttcctgcca aaacgggagt gtgcagtcag ggcctgcggt ctggccccat
      841 gagtctcctt ccgtcctcag cgggcaggga acacctctgg cttgtagaag ggacggctca
      901 gtggctgcac cgacggtcct ggaaatctca catggtgggc actgcagcgt tggaacgtga
      961 gcctcggatt tcctggcccc tctactgtaa atgtgcctta gcctaagcct cccatcctgt
     1021 gttagcgttg cctggtgcgg ggcagggcct aacaaggaaa cctgggccct ccaagccagg
     1081 ttgaggtctg gtaacagaat gccaggaagg gggcctggaa gaccacctgc cccggcccct
     1141 ctcctgcagg ggccccacac aggcatgagg gatggcccgg ccaaagtcta ggcagaagcc
     1201 tcctataaca aagggtggtg tggcctgggc attggagtca ataaattatg gtcagaaaat
     1261 cacaagagcc tgctgattgg ggctcaggga caccagccag gacagaccgg cccccgaggg
     1321 ggcagccaga caggtgggag gggcctccca cgaagctcag aagaaaggtc gtgcgggagc
     1381 cgatggaggt ggtcgcctgg cacaagagaa aaatcagaaa gcaaagttta actgagcccc
     1441 agttgggcca cgaggcttgg gcttccccac gaggtgagag aagcagggcc tgagggtagg
     1501 aagggggtgg agcgctgggg tccccgcttc accaggcagc agccaggcct gtgcacgtgg
     1561 gggtgtgcag ggggtcagag aatatctgct cccactcctc acatgctaag gaaagtaaaa
     1621 gctctcccct gta
//
