LOCUS       NM_018502               1865 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transmembrane and coiled-coil domains 6 (TMCO6),
            transcript variant 2, mRNA.
ACCESSION   NM_018502
VERSION     NM_018502.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1865)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1865)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1865)
  AUTHORS   Han,S., Lan,Q., Park,A.K., Lee,K.M., Park,S.K., Ahn,H.S.,
            Shin,H.Y., Kang,H.J., Koo,H.H., Seo,J.J., Choi,J.E., Ahn,Y.O.,
            Chanock,S.J., Kim,H., Rothman,N. and Kang,D.
  TITLE     Polymorphisms in innate immunity genes and risk of childhood
            leukemia
  JOURNAL   Hum Immunol 71 (7), 727-730 (2010)
   PUBMED   20438785
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   4  (bases 1 to 1865)
  AUTHORS   Rajaraman,P., Brenner,A.V., Neta,G., Pfeiffer,R., Wang,S.S.,
            Yeager,M., Thomas,G., Fine,H.A., Linet,M.S., Rothman,N.,
            Chanock,S.J. and Inskip,P.D.
  TITLE     Risk of meningioma and common variation in genes related to innate
            immunity
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (5), 1356-1361 (2010)
   PUBMED   20406964
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1865)
  AUTHORS   Matarin,M., Brown,W.M., Dena,H., Britton,A., De Vrieze,F.W.,
            Brott,T.G., Brown,R.D. Jr., Worrall,B.B., Case,L.D., Chanock,S.J.,
            Metter,E.J., Ferrucci,L., Gamble,D., Hardy,J.A., Rich,S.S.,
            Singleton,A. and Meschia,J.F.
  TITLE     Candidate gene polymorphisms for ischemic stroke
  JOURNAL   Stroke 40 (11), 3436-3442 (2009)
   PUBMED   19729601
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1865)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB196005.1, AK097088.1 and BC065828.1.
            
            On Feb 27, 2020 this sequence version replaced NM_018502.4.
            
            Transcript Variant: This variant (2) has an alternate splice site
            in the central coding region but maintains the reading frame,
            compared to variant 1. The resulting isoform (2) lacks an internal
            segment, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK097088.1, SRR18074969.501060.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394671.8/ ENSP00000378166.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DB196005.1         25-36
            13-1863             AK097088.1         1-1851
            1864-1865           BC065828.1         1948-1949
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..1865
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /note="transmembrane and coiled-coil domains 6"
                     /db_xref="GeneID:55374"
                     /db_xref="HGNC:HGNC:28814"
     exon            1..162
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1559
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transmembrane and coiled-coil domain-containing protein 6"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domain-containing
                     protein 6 isoform 2"
                     /protein_id="NP_060972.3"
                     /db_xref="CCDS:CCDS4233.2"
                     /db_xref="GeneID:55374"
                     /db_xref="HGNC:HGNC:28814"
                     /translation="MWSRRQGRLRPTVCGVEELRRRRREREAALRKARREQQLVSKRL
                     LRNDAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPETQQT
                     FIRLEGSMRTLVGLLTSNQALLQLEAARCLHELSHSEQSTVAEACLPATSYLLTYLSS
                     HSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQSPHVAVLEALGYALSQL
                     LQAEEAPEKIIPSILASTLPQHMLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSNPLL
                     IGHGALSTLGLLLLDLAGAVQKTEDAGLELLACPVLRCLSNLLTEAAVETVGGQMQLR
                     DERVVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLP
                     VSNVVSVMVLTVLCNVAEKGPAYCQRLWPGPLLPALLHTLAFSDTEVVGQSLELLHLL
                     FLYQPEAVQVFLQQSGLQALERHQEEAQLQDRVYALQQTALQG"
     exon            163..275
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     exon            276..391
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     exon            392..575
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     exon            576..680
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     exon            681..766
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     exon            767..883
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     exon            884..995
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1182
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1277
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1445
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1865
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1842..1847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /note="hexamer: AATAAA"
     polyA_site      1865
                     /gene="TMCO6"
                     /gene_synonym="PRO1580"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcggtg ccatcttcta cgcccctggg agcgttgtgg ctgctgtttc cttcggcttt
       61 cctcctcctg ctccaccatg tggagccgac ggcagggccg cctcaggccc acggtctgcg
      121 gggtggagga gctacggcgc cgccggcggg agcgggaggc agcactgcgg aaggcgcgga
      181 gggagcagca gctggtcagc aagaggctgc tgagaaacga cgccccagag gaagctggag
      241 agggatgtgt ggctgcgatc ctcggggaaa ccgaggtgca gcagttcctg cggcaagccc
      301 agcgggggac agaggaaaag gagagagagg gggctctggt cagccttcgt cgaggcttgc
      361 agcaccctga aacacagcaa accttcatcc ggctggaggg cagcatgcgg accctggtcg
      421 ggctcctgac cagcaaccag gccctgctgc agcttgaggc ggctcggtgc ctgcatgagc
      481 tctctcactc cgagcagtcc actgttgctg aggcctgcct gccagccact tcttacctcc
      541 tcacctacct ctccagtcac agctcagact tcatagagct gtgtctgtat acactgggta
      601 acctgatcgt ggagagtgag gctgtgagaa ggcagctcct gccacagggc attgttccag
      661 ccttggctgc ctgcatccag tccccccatg tggctgtgct ggaagctctc ggatatgcct
      721 tgtcccagct tctacaggct gaggaagctc cagagaagat cattccctcc atcttggcct
      781 ccactctccc tcagcacatg ctacaaatgt tgcaacctgg cccaaagctc aaccctgggg
      841 tcgctgtgga gtttgcctgg tgccttcatt acatcatctg cagccaggtc agcaatcctc
      901 tgctcattgg ccatggggct ctgtctactc tggggttgct gctgttggac ttggctgggg
      961 ctgtccagaa aaccgaggat gcaggactgg agctgctggc atgccccgtg cttcgatgtc
     1021 taagcaacct gctaactgag gcagcagtgg agactgtggg agggcaaatg cagctcagag
     1081 atgagcgtgt tgtggcagcc ttatttatcc ttctgcagtt ctttttccag aaacagccca
     1141 gtctgctccc tgagggcctt tggctcctca acaacctcac tgcaaacagt cctagtttct
     1201 gtacctcctt gctctccctg gatctgattg agcctctctt acagctgttg ccagtatcta
     1261 acgtggtgag cgtaatggtg ctcacagttc tgtgcaatgt tgcagaaaag ggtcctgctt
     1321 actgccagcg gctgtggcca gggcccctgc ttcccgcctt gctgcacaca ctagcctttt
     1381 ctgacactga agtagtaggc cagagtttgg agctgctgca tctgctgttc ctgtatcagc
     1441 cagaggctgt tcaggtcttc ctgcagcagt cagggctgca agccctggaa aggcatcagg
     1501 aagaggccca gctccaggat cgtgtgtatg ctctccagca gacagctctt caagggtgat
     1561 cttgtttctc aatgtcactc attcccctct ctcttaacat caagcttgtt tgtccagtag
     1621 agcctttgga gatttaggac cataatgagg tctcatgttc tctgctccca cacctaagcc
     1681 aagacctttg ggtcccagct cctccccttc cactcagcac tatccaggca ggaggaccaa
     1741 aagggactca gtgtggtcta cttactctgg ggccctagaa tccctgcccc cccgccaccc
     1801 ttcatgtttg cttcagcagc tggtagcttt tgatgagaca gaataaagtt ttatttttat
     1861 attaa
//
