LOCUS       NM_152453               1212 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens transmembrane and coiled-coil domains 5A (TMCO5A),
            transcript variant 1, mRNA.
ACCESSION   NM_152453
VERSION     NM_152453.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1212)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1212)
  AUTHORS   Kaneko,T., Minohara,T., Shima,S., Yoshida,K., Fukuda,A.,
            Iwamori,N., Inai,T. and Iida,H.
  TITLE     A membrane protein, TMCO5A, has a close relationship with manchette
            microtubules in rat spermatids during spermiogenesis
  JOURNAL   Mol Reprod Dev 86 (3), 330-341 (2019)
   PUBMED   30632224
REFERENCE   3  (bases 1 to 1212)
  AUTHORS   Bauerschlag,D.O., Ammerpohl,O., Brautigam,K., Schem,C., Lin,Q.,
            Weigel,M.T., Hilpert,F., Arnold,N., Maass,N., Meinhold-Heerlein,I.
            and Wagner,W.
  TITLE     Progression-free survival in ovarian cancer is reflected in
            epigenetic DNA methylation profiles
  JOURNAL   Oncology 80 (1-2), 12-20 (2011)
   PUBMED   21577013
  REMARK    GeneRIF: Longer survival was associated with hypomethylation at
            specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation
            in other genes (e.g. TMCO5, PTPRN and GUCY2C).
REFERENCE   4  (bases 1 to 1212)
  AUTHORS   Lanktree,M.B., Hegele,R.A., Yusuf,S. and Anand,S.S.
  TITLE     Multi-ethnic genetic association study of carotid intima-media
            thickness using a targeted cardiovascular SNP microarray
  JOURNAL   Stroke 40 (10), 3173-3179 (2009)
   PUBMED   19679847
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI561792.1, BI826726.1 and BC029221.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2020 this sequence version replaced NM_152453.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.26886.1,
                                           SRR5189667.174726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319669.5/ ENSP00000327234.4
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BI561792.1         37-39
            4-779               BI826726.1         1-776
            780-1212            BC029221.2         726-1158
FEATURES             Location/Qualifiers
     source          1..1212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..1212
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /note="transmembrane and coiled-coil domains 5A"
                     /db_xref="GeneID:145942"
                     /db_xref="HGNC:HGNC:28558"
     exon            1..55
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     exon            56..147
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     exon            148..297
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1024
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane and coiled-coil domains 5; transmembrane and
                     coiled-coil domain-containing protein 5A; testicular
                     tissue protein Li 205"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domain-containing
                     protein 5A isoform 1"
                     /protein_id="NP_689666.2"
                     /db_xref="CCDS:CCDS10046.1"
                     /db_xref="GeneID:145942"
                     /db_xref="HGNC:HGNC:28558"
                     /translation="MEISRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQEREDK
                     IQRLESEIIQTRGLVEDEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITEL
                     QQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLC
                     EDQALYIKKYQETLKKIEEELEALFLEREVSKLVSMNPVEKEHTSQNNEGTPTQKTAR
                     LFSKKIFCCLFFITLFFIRLLSYMFFHVRFINPDLLVNVLPKVLGRSTLWKLRCFFFP
                     SLTLETEDMLPH"
     exon            298..421
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     exon            422..472
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     exon            473..544
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     exon            545..601
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     exon            602..661
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     exon            662..726
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     exon            727..784
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     exon            785..825
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1212
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /note="hexamer: AGTAAA"
     polyA_site      1212
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /note="major polyA site"
ORIGIN      
        1 agaagctaat tgactaggga aggatcagga agacaagaca catcaaaaag gggagggaat
       61 ctacaatgga aggacacaag aaagatcagc tggattaagt agtcatgatt atgcaaagcc
      121 atatccagag accaaggtgt aaagcaggtc ggagaaaatg gaaatctcaa gattggctca
      181 gtcaaaaaga aacattatca gtttgaacat ggaccttgaa agggatacgc agagaataga
      241 tgaagcaaat cagaaacttc ttctcaaaat ccaagagagg gaagataaga ttcagaggct
      301 ggaaagtgag atcattcaga cgcggggcct ggtggaagat gaagagtggg agaaggagaa
      361 ccgcaccacg atggaaaggg aaagagcctt gcaggagctg gaggaagaaa cagccagact
      421 tgaaaggaag aataagacgt tggtccacag tataacagaa cttcaacaaa agcttacaag
      481 gaaatcacaa aagataacca attgtgaaca aagcagtcca gatggagccc tagaagagac
      541 aaaggttaag ttacaacagc tggaagcttc ctatgcatgc caagagaagg agctgctcaa
      601 ggtaatgaag gagtatgcat ttgtgaccca gctctgtgaa gatcaagccc tctacataaa
      661 gaagtaccag gaaacgttga agaaaataga agaagaacta gaggctctgt tccttgagag
      721 agaagtatca aaactcgtga gcatgaaccc tgtggaaaaa gagcatacca gccaaaataa
      781 tgagggtact cctacccaaa agacagcaag attattcagt aaaaagattt tttgctgtct
      841 ctttttcatc accctatttt tcatcagact gctgagctac atgttttttc atgtaagatt
      901 cataaatcca gatctcctcg tcaatgtact gcccaaggta ctgggcagga gcaccttgtg
      961 gaagctcaga tgcttcttct ttccatctct cacacttgag acagaggaca tgttacccca
     1021 ctgattccct aagaaatatc cttgagcaat agaagggaag tgggatccga gcctgtagaa
     1081 gggaggcatg aaacttgtgg aggaaagaga tttgcttcag ttttttcctc accgtttgcc
     1141 tgcttgacta ccttctgtca ccacgtcatc tttccaggat taaccttgac cagtaaaaag
     1201 ctctgtaata ga
//
