LOCUS       NM_181719               2946 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transmembrane and coiled-coil domains 4 (TMCO4),
            transcript variant 1, mRNA.
ACCESSION   NM_181719
VERSION     NM_181719.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2946)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX640987.1, AK127543.1 and BM974434.1.
            
            On Aug 14, 2020 this sequence version replaced NM_181719.6.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX640987.1, SRR18074968.3120455.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155751 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294543.11/ ENSP00000294543.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1673              BX640987.1         3-1675
            1674-2944           AK127543.1         452-1722
            2945-2946           BM974434.1         43-44               c
FEATURES             Location/Qualifiers
     source          1..2946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..2946
                     /gene="TMCO4"
                     /note="transmembrane and coiled-coil domains 4"
                     /db_xref="GeneID:255104"
                     /db_xref="HGNC:HGNC:27393"
     exon            1..62
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            63..141
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            142..233
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            234..420
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..2146
                     /gene="TMCO4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane and coiled-coil domain-containing protein 4"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domain-containing
                     protein 4 isoform 1"
                     /protein_id="NP_859070.3"
                     /db_xref="CCDS:CCDS198.1"
                     /db_xref="GeneID:255104"
                     /db_xref="HGNC:HGNC:27393"
                     /translation="MAMWNRPCQRLPQQPLVAEPTAEGEPHLPTGRELTEANRFAYAA
                     LCGISLSQLFPEPEHSSFCTEFMAGLVQWLELSEAVLPTMTAFASGLGGEGADVFVQI
                     LLKDPILKDDPTVITQDLLSFSLKDGHYDARARVLVCHMTSLLQVPLEELDVLEEMFL
                     ESLKEIKEEESEMAEASRKKKENRRKWKRYLLIGLATVGGGTVIGVTGGLAAPLVAAG
                     AATIIGSAGAAALGSAAGIAIMTSLFGAAGAGLTGYKMKKRVGAIEEFTFLPLTEGRQ
                     LHITIAVTGWLASGKYRTFSAPWAALAHSREQYCLAWEAKYLMELGNALETILSGLAN
                     MVAQEALKYTVLSGIVAALTWPASLLSVANVIDNPWGVCLHRSAEVGKHLAHILLSRQ
                     QGRRPVTLIGFSLGARVIYFCLQEMAQEKDCQGIIEDVILLGAPVEGEAKHWEPFRKV
                     VSGRIINGYCRGDWLLSFVYRTSSVQLRVAGLQPVLLQDRRVENVDLTSVVSGHLDYA
                     KQMDAILKAVGIRTKPGWDEKGLLLAPGCLPSEEPRQAAAAASSGETPHQVGQTQGPI
                     SGDTSKLAMSTDPSQAQVPVGLDQSEGASLPAAASPERPPICSHGMDPNPLGCPDCAC
                     KTQGPSTGLD"
     exon            421..595
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            596..623
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            624..756
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            757..854
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            855..998
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1118
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1283
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1420
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1505
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1623
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1741
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..2946
                     /gene="TMCO4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2926..2931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCO4"
                     /note="hexamer: AATAAA"
     regulatory      2930..2935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCO4"
                     /note="hexamer: AATAAT"
     polyA_site      2943
                     /gene="TMCO4"
     polyA_site      2946
                     /gene="TMCO4"
                     /note="major polyA site"
ORIGIN      
        1 gggcgggagg agccgctcgc cggttttgcc gcctccgcct ttgccttcgc agccgcctcc
       61 agtgttgtac attataaacc ggggctgctg atgaggagtg gggaactggc tctctggaac
      121 gtgtgacagc aggcagaagg gggcaatttg catatttctc caaagaacca tccagaacct
      181 gagcagcctg tcttcagaca gagagaggcc cacggctgtt tcttgaaatc tggcgctggg
      241 aatggccatg tggaacaggc catgccagag gctgcctcag cagcctctgg tagctgagcc
      301 cactgcagag ggggagccac acctgcccac gggccgggag ctgactgagg ccaaccgctt
      361 cgcctatgct gccctctgtg gcatctccct gtcccagtta tttcctgaac ccgaacacag
      421 ctccttctgc acagagttca tggcaggcct ggtgcagtgg ctggagttgt ctgaagctgt
      481 cttgccaacc atgactgctt ttgcgagcgg cctgggaggt gaaggagcag atgtgtttgt
      541 tcaaatttta ctgaaggacc ccatcttgaa ggacgacccg acggtgatca ctcaggacct
      601 tctgagcttc tcactcaagg atgggcacta tgacgcccgg gccagagtcc tcgtttgcca
      661 catgacctcc ctgctccaag tgcccttgga ggagctggat gtccttgaag agatgttcct
      721 ggagagcctg aaggaaatca aagaagagga atctgaaatg gccgaggcat cccgaaagaa
      781 gaaagaaaac cggaggaaat ggaagcgtta tctcctgata ggcctggcga ctgtcggagg
      841 cggaacggtg atcggtgtga ctggaggtct agctgcaccc cttgttgccg ctggagcagc
      901 gacgattatt ggcagcgccg gggcagcggc tctgggctca gcagccggca tagccatcat
      961 gacctcgctg tttggtgcag ctggagctgg cctgacagga tacaagatga agaagcgagt
     1021 gggagccatt gaagagttca cgtttctgcc tctgacggag ggcaggcagc tgcacatcac
     1081 catcgccgtc acggggtggc tcgcttctgg caaataccgc accttcagtg ccccgtgggc
     1141 tgccctggcc cacagccgtg agcagtactg cctggcctgg gaagccaagt acctgatgga
     1201 gctcggcaat gccctggaga ccatcctcag tggtctcgcc aacatggtgg cccaggaggc
     1261 cctaaagtac acagtgttgt ctggcattgt ggctgccctg acctggccag cctcactcct
     1321 cagtgtcgcc aatgtcatcg acaacccctg gggggtgtgt ctccatcgat cagcagaggt
     1381 tggcaagcac ctggcccaca tcctgctctc ccggcagcag gggcgacgac ctgtcacctt
     1441 gattggcttc agcctgggag ccagagtcat ctacttctgt ctgcaggaga tggctcaaga
     1501 gaaagattgc caaggaatca tcgaggacgt catcctgctg ggtgcgcctg tggagggaga
     1561 agccaagcat tgggagcctt tccggaaggt ggtgtccggg aggatcatca acggctactg
     1621 caggggagac tggctgctga gtttcgtgta ccgcacatcc tcggtgcagc tccgtgtcgc
     1681 cggcctacag cccgtgctgc tgcaggacag gagggtggag aacgtggacc tgacctctgt
     1741 ggtcagcggc cacctggact atgccaagca gatggatgcc atcctgaagg ccgtgggcat
     1801 ccgcaccaag ccaggctggg acgagaaggg gctcttgctg gccccaggct gcctgccctc
     1861 cgaggagcct cgccaggcag cagctgccgc ctcatcaggc gagacccccc accaggttgg
     1921 gcaaacccag ggtcccatat ccggagacac ctccaaattg gccatgtcca cagaccccag
     1981 ccaagcccag gtgccagtag ggctggacca gtctgaaggg gcctcccttc ctgctgctgc
     2041 cagccctgaa aggcccccca tctgcagcca tggcatggac cccaacccac tgggctgccc
     2101 cgattgtgcc tgcaagaccc agggccccag cacggggctg gactgaccac agcaggggac
     2161 ctgagccgtc ttccccagtc tccatatgca gctctctctt ataccctcgg gttcctccca
     2221 ggagctctgg aggtacagga tttccacagg cctctttcct aaatggaagg aattggaact
     2281 gaaagggaaa ggaaatggaa ggaaggggaa tttggaggag agaacacgcc cacccttggg
     2341 aagctgcctg tccccagagg agccccacca gggagcagct gccccctcat cagagacctg
     2401 cagagtcaac caagcacagg ttagagtccc aggaccggaa accaactgtg ggctttctgt
     2461 acttctcata gctttggagt ctggctgtcc atcaggaggt cccgagggct ctctggggcc
     2521 tgaggctccc acaccagctc tcccctggcc tcaataaaac caggtgcatg cctgttcttc
     2581 catccacact ccagggctgc ccaccagctg acaggcacca tcaactggca gcaacagagc
     2641 aggcgcaggt acaaagaagg cagctcactc ctgctcttag gagatccaat cagatctgcc
     2701 ctgtacagcc atgtaggctg tgcgctgcat aactccaggg acatgagtca cacagacaca
     2761 atgtgagtgt gctcccccgt catgcaacat ctggacacca ctaacagagc atggtgaata
     2821 catgctgaat tgcattcagt atggctgtga actaggcctg gggacaagaa tgaattttac
     2881 atggaaagaa tttcctgtag caggaacaga ggggataaca acagcaataa ataataataa
     2941 gaagaa
//
