LOCUS       NM_001008740             696 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane and coiled-coil domains 2 (TMCO2), mRNA.
ACCESSION   NM_001008740 XM_059140
VERSION     NM_001008740.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 696)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 696)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU567634.1 and BC108666.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001008740.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX416836.2, HM005658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372766.4/ ENSP00000361852.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BU567634.1         40-70
            32-696              BC108666.1         1-665
FEATURES             Location/Qualifiers
     source          1..696
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..696
                     /gene="TMCO2"
                     /gene_synonym="dJ39G22.2"
                     /note="transmembrane and coiled-coil domains 2"
                     /db_xref="GeneID:127391"
                     /db_xref="HGNC:HGNC:23312"
     exon            1..294
                     /gene="TMCO2"
                     /gene_synonym="dJ39G22.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..606
                     /gene="TMCO2"
                     /gene_synonym="dJ39G22.2"
                     /note="testis tissue sperm-binding protein Li 35a"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domain-containing
                     protein 2"
                     /protein_id="NP_001008740.1"
                     /db_xref="CCDS:CCDS30684.1"
                     /db_xref="GeneID:127391"
                     /db_xref="HGNC:HGNC:23312"
                     /translation="MSTSSSSSWDNLLESLSLSTVWNWIQASFLGETSAPQQTSLGLL
                     DNLAPAVQIILRISFLILLGIGIYALWKRSIQSIQKTLLFVITLYKLYKKGSHIFEAL
                     LANPEGSGLRIQDNNNLFLSLGLQEKILKKLKTVENKMKNLEGIIVAQKPATKRDCSS
                     EPYCSCSDCQSPLSTSGFTSPI"
     exon            295..696
                     /gene="TMCO2"
                     /gene_synonym="dJ39G22.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      671..676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCO2"
                     /gene_synonym="dJ39G22.2"
                     /note="hexamer: AATAAA"
     polyA_site      696
                     /gene="TMCO2"
                     /gene_synonym="dJ39G22.2"
                     /note="major polyA site"
ORIGIN      
        1 atatttagat tcctgaagct tctgcacatg tagttcctag agctgctgct tattaaaatg
       61 tcaacatctt catcttctag ctgggacaac ctcttagagt ctctctctct cagcacagta
      121 tggaattgga tacaagcaag ttttttggga gagactagtg cacctcagca aacaagtttg
      181 ggactattag ataatcttgc tccagctgtg caaatcatct tgaggatttc tttcttgatt
      241 ttattgggaa taggaatata tgccttatgg aaacgaagta ttcagtcaat tcagaaaaca
      301 ttgttgtttg taatcacact ctacaaactt tacaagaagg gctcacatat ttttgaggct
      361 ttgctagcca acccagaagg aagtggtctc cgaattcaag acaataataa tcttttcctg
      421 tccttgggtc tgcaagagaa aattttgaaa aaacttaaga cagtggaaaa caaaatgaag
      481 aacctagaag ggataatcgt tgctcaaaaa cctgccacga agagggattg ctcctctgag
      541 ccctactgca gctgctctga ctgccagagt cccttgtcca catcagggtt tacttccccc
      601 atttgaaatg tgatggactc caatcttttc caggaaagca ctgtttccct catgtgtgca
      661 gtggtgtatc aataaagata gagaacgcta ttgaaa
//
