LOCUS       NM_020698               5874 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane and coiled-coil domain family 3 (TMCC3),
            transcript variant 1, mRNA.
ACCESSION   NM_020698
VERSION     NM_020698.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5874)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5874)
  AUTHORS   Wang,Y.H., Chan,Y.T., Hung,T.H., Hung,J.T., Kuo,M.W., Wang,S.H.,
            Huang,Y., Lin,Y.J., Chen,S.C., Yu,J.C., Wu,J.C., Yu,J. and Yu,A.L.
  TITLE     Transmembrane and coiled-coil domain family 3 (TMCC3) regulates
            breast cancer stem cell and AKT activation
  JOURNAL   Oncogene 40 (16), 2858-2871 (2021)
   PUBMED   33742122
  REMARK    GeneRIF: Transmembrane and coiled-coil domain family 3 (TMCC3)
            regulates breast cancer stem cell and AKT activation.
REFERENCE   3  (bases 1 to 5874)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5874)
  AUTHORS   Wisesa,S., Yamamoto,Y. and Sakisaka,T.
  TITLE     TMCC3 localizes at the three-way junctions for the proper tubular
            network of the endoplasmic reticulum
  JOURNAL   Biochem J 476 (21), 3241-3260 (2019)
   PUBMED   31696206
  REMARK    GeneRIF: A TMCC3 mutant lacking the N-terminal coiled-coil domain
            abolished localization to tubular network of the endoplasmic
            reticulum, suggesting that TMCC3 localized independently of binding
            to atlastins.
REFERENCE   5  (bases 1 to 5874)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5874)
  AUTHORS   Sohn,W.J., Kim,J.Y., Kim,D., Park,J.A., Lee,Y. and Kwon,H.J.
  TITLE     Expression and characterization of transmembrane and coiled-coil
            domain family 3
  JOURNAL   BMB Rep 49 (11), 629-634 (2016)
   PUBMED   27697108
  REMARK    GeneRIF: TMCC3 proteins are localized in endoplasmic reticulum
            through transmembrane domains and polymerized with other TMCC3
            protein an 1-3-3 proteins.
REFERENCE   7  (bases 1 to 5874)
  AUTHORS   Zhang,C., Kho,Y.S., Wang,Z., Chiang,Y.T., Ng,G.K., Shaw,P.C.,
            Wang,Y. and Qi,R.Z.
  TITLE     Transmembrane and coiled-coil domain family 1 is a novel protein of
            the endoplasmic reticulum
  JOURNAL   PLoS One 9 (1), e85206 (2014)
   PUBMED   24454821
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5874)
  AUTHORS   Davis,O.S., Butcher,L.M., Docherty,S.J., Meaburn,E.L., Curtis,C.J.,
            Simpson,M.A., Schalkwyk,L.C. and Plomin,R.
  TITLE     A three-stage genome-wide association study of general cognitive
            ability: hunting the small effects
  JOURNAL   Behav Genet 40 (6), 759-767 (2010)
   PUBMED   20306291
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026672.44.
            
            On Nov 23, 2018 this sequence version replaced NM_020698.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.221159.1,
                                           SRR1660805.4038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261226.9/ ENSP00000261226.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC026672.44        87263-87467         c
            206-1122            AC026672.44        18532-19448         c
            1123-1258           AC026672.44        15304-15439         c
            1259-5874           AC026672.44        4032-8647           c
FEATURES             Location/Qualifiers
     source          1..5874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     gene            1..5874
                     /gene="TMCC3"
                     /note="transmembrane and coiled-coil domain family 3"
                     /db_xref="GeneID:57458"
                     /db_xref="HGNC:HGNC:29199"
                     /db_xref="MIM:617459"
     exon            1..205
                     /gene="TMCC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1561
                     /gene="TMCC3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane and coiled-coil domains 3; transmembrane and
                     coiled-coil domains protein 3; transmembrane and
                     coiled-coil domain protein 3"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domain protein 3
                     isoform 1"
                     /protein_id="NP_065749.3"
                     /db_xref="CCDS:CCDS31877.1"
                     /db_xref="GeneID:57458"
                     /db_xref="HGNC:HGNC:29199"
                     /db_xref="MIM:617459"
                     /translation="MPGSDTALTVDRTYSYPGRHHRCKSRVERHDMNTLSLPLNIRRG
                     GSDTNLNFDVPDGILDFHKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNN
                     ADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHL
                     KDIHRSLKDAHVKSRTAPHCMESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSAD
                     NIAHLKNSLEEFRPEASARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAG
                     GASTLDSQGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYE
                     RLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLEL
                     HQQEQQALQTDTVNAKVLLGRCINVILAFMTVILVCVSTIAKFVSPMMKSRCHILGTF
                     FAVTLLAIFCKNWDHILCAIERMIIPR"
     exon            206..1122
                     /gene="TMCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1258
                     /gene="TMCC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..5874
                     /gene="TMCC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3437..3442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCC3"
                     /note="hexamer: AATAAA"
     polyA_site      3457
                     /gene="TMCC3"
                     /note="major polyA site"
     regulatory      4405..4410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCC3"
                     /note="hexamer: ATTAAA"
     polyA_site      4429
                     /gene="TMCC3"
     regulatory      5816..5821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCC3"
                     /note="hexamer: AATAAA"
     regulatory      5846..5851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCC3"
                     /note="hexamer: AATAAA"
     polyA_site      5847
                     /gene="TMCC3"
     polyA_site      5874
                     /gene="TMCC3"
ORIGIN      
        1 agaggcaaca gctgcagcag ccgcgccgcc ccctcgcccg cggctcccag ggtgatcccg
       61 agcacagccg gtggctcgcg gcgcggcagc cccagaagac gggaaagttc gcggccggag
      121 cgcggagatg ccgggcagcg acacggcgct caccgtggac cggacctact cgtaccccgg
      181 ccggcaccac cgctgcaaga gccgggtaga acgtcatgac atgaatacct taagcctgcc
      241 cctgaacata cgccgagggg ggtcagacac caacctcaac tttgatgtcc cggatggcat
      301 cctggacttc cacaaggtca aactcactgc agacagcctg aagcaaaaaa ttctaaaggt
      361 aacagagcag ataaaaattg agcaaacatc gcgcgatggg aatgttgcgg agtatctgaa
      421 actagtgaac aacgcagaca agcagcaggc gggacgtatc aagcaagtct ttgagaagaa
      481 gaatcagaaa tcagctcact ccatcgccca gctgcagaag aagttagagc agtatcatcg
      541 aaagctcaga gagatcgagc agaatggagc ctctaggagc tcaaaggaca tttccaaaga
      601 ccacctgaag gatatacatc gctctttgaa agatgcccac gtgaaatctc gaactgcccc
      661 ccattgcatg gagagcagca aatcgggcat gccaggggtc tcacttactc cacctgtgtt
      721 cgttttcaat aagtccagag agtttgccaa cctgatccgg aataagtttg gcagcgccga
      781 caacattgct cacttgaaaa attccttaga ggagtttagg ccagaggcga gtgccagggc
      841 ctacgggggc agcgctacca tcgtgaacaa acccaagtat ggcagtgatg atgaatgttc
      901 gagtggcacg tcaggctcgg ccgacagtaa cggaaaccag tcgtttgggg ctggtggagc
      961 cagcacactg gacagccagg gcaagctcgc cgtgatcctg gaggaactga gggagatcaa
     1021 ggatacccaa gctcagctgg ctgaggacat cgaggcactg aaggtgcagt ttaagagaga
     1081 atatggtttt atttctcaga ccctgcaaga ggaaagatac aggtatgagc gactggagga
     1141 ccagctgcat gacctgacgg acctgcatca gcatgagaca gccaacctga agcaggagct
     1201 ggccagcatt gaggagaagg tggcctacca ggcctacgag cgctcgcggg acatccagga
     1261 agccttggaa tcctgccaga ctcgcatttc taagctggag ctccaccagc aagagcagca
     1321 agctctgcag acagacaccg tgaatgctaa agttctcctg gggaggtgca tcaacgtgat
     1381 cctggccttc atgactgtca tcttagtgtg tgtgtccacc atcgcgaagt tcgtctcacc
     1441 catgatgaag agtcgctgcc acattcttgg caccttcttt gccgtgactc ttcttgctat
     1501 attttgtaaa aactgggacc atatcctgtg tgccatagaa aggatgataa taccaagatg
     1561 aagccactgg ttcctgcctt caagttcttt caagttttta ttttaaagaa aactctgtgc
     1621 atactaccaa attttacagt gaatgattgt gcggactcgt gtgtaagaaa aactaggact
     1681 gtgtggtgta aataactaca attctcttaa ctccgtagca gttgccaact cagtccttgt
     1741 acttcgttaa cacgaatctg tttcagagct ctcctacctt gctcactgcc ttaatcagac
     1801 cgatttcctg cccacctgac cagcccagcg tggtaaacct ctgtatattg agaccttggc
     1861 ataattggtg atcctgaaga aagaggtctc tctcctaagt ctctgtcaga attgagcttc
     1921 acaattgcta atggttgttt tctgtgagtc ctataaaaag caaggatatg catgattcag
     1981 ggaatgaaga atcacaggct tgggcagtgt taaacactgt ggcctatggt ccccgtgtga
     2041 tccaccctgc ttctctccag gggaccatag gtcccgtcat gtactcagtg tccacagcag
     2101 tcagtcgtgt atgaccctgt aacgtggaaa tcttatcaca cacctgttat ccaacaagtc
     2161 tacctgaggg gttttgttac actttaaatg ggaaggcata gggatttatg aatggggctt
     2221 tcaccttctc atacccaggc aaccaacacc tgattttgtc tcaactggct agcaaatgcc
     2281 cagccttcag agtgtgcagg aatgttttca aatccctcat cagactgtga ctttaacatt
     2341 aatttggaat cctgtgagca ctactctgaa ggtttgtgtt ttggcaaatc ttttttcttt
     2401 tttgagacag ggctctgcta aatattgctc aggctggttg caaactcctt gcttcaaggg
     2461 atcctcccac ctcagcctcc caagcagccg ggactgcagg cacaagccac catgcctggc
     2521 tgttttttgg caaatcttga ttgtgataag cccccctgga ggatatgatt cactttatgt
     2581 gattcatctt attcacaggt ctgtgaggga ctgcaaagct tactcaggaa atgaaaacaa
     2641 atgatggtca tgttgcagtt ttttccttga aggacaaccg aaccatagcc tctaaagttc
     2701 aagtgcactg aggtgtcgga acgctgaaag catgaggaaa cgaggacgta gggtgtgact
     2761 gaatggtggc tagattagtg ggagcagttc acctggatga agattgagag catcgtcttt
     2821 gagaagtgaa agactagcaa gaataaaata aattaagtcc agtgtttgag ccaaggttgc
     2881 cacctgtctc ttaacatctc actgaacata agtcctgagg tattaggacg accatactgc
     2941 ctctgagctg aaaacattca aaagttcaca tccctgtttg ggggatacca ttcaccgcct
     3001 tcagcccaga tgatactttc ctttaaatct gtgtctctgt gtgtataaca aagaggaaga
     3061 tggaaacaat gttcatggaa actgctgttg agccccttgt cccaccactc ccgccatctg
     3121 ctgcaggcag gaaggcatgt gagtgtacgt tttcttccag gagacatcag gtccccctgg
     3181 attcaaatta agtgcaatat tttgcaaaca gctcttctta gggaaatctc ctgaaggaaa
     3241 aaaatgtgac agaatgttcc atagtctgag agaatggaat cgttgagcat ttagtacaag
     3301 tccagtgtgt gtgagcggga cttaggcagc tcaagcttgc tttttttttt aagcgtacaa
     3361 ttgagtggtt ttagtaaatt cacaaacttg ttcaaccatc accactatct aattccagac
     3421 tcacgctttt ttaaacaata aatgtcattt catgaaatct ttggtgataa agtattttgg
     3481 attcagagaa gagctccctt accagtccca ccctgatctc atggctgtct ctcctttcat
     3541 tgtcagactc cccctggtct accgcgttga tgtgtataca ctgatctttc aagtctggga
     3601 gacagataag gaggccaggt gcaaggcagg gaggcagaga gaatgttgtg cttcctttag
     3661 cttttgtatt tcgatggcca gcattaccct ttacctgtgg gcatcagact cagcgtgggc
     3721 tgagtgctga gtgtaactta cactcctaaa tcaagctggg gcctgggtgg gcccctcttg
     3781 gtatctgtga atctttccaa gcaccacttc ggacacacca gggattgagt gctgctgtta
     3841 gtttagagaa ggagagatgt ctaacccttg aggtgaaggg ctctgggagg gtccaagaag
     3901 acgtaggctt cattttcaca ccagcccaca ccattccagt gctcagccta gcaaatgtgc
     3961 tttaatgcac acttctcaga cctgtgatcc gtgtatcttc tccccagtga cagaagtaga
     4021 gaagagaatg gaaagcagca cactccgtcc cctctagtct ggagctgtta acagaatctg
     4081 ctagaaacta gctttattct aacataccgt aggatctaaa tcctcctacc tggatcatga
     4141 attcctttga aataattcat attttcattg actctcacta aatgtcaaat aaccttgttt
     4201 tcacttggat aggctcaacc tacctggcat atttattttg cagtcttgtt gaaagttcat
     4261 gaaactttgt actttttaat aagatgatac actcgaagga aacttttaat ctctgcagtt
     4321 tattctctct taaggaataa acactcccac tgtttgttct cttcaatgtg taaggagatt
     4381 aaatgacatt ttagaaatat tacaattaaa aatagtgatg tagctgtaac atatgctgga
     4441 attggatatt taatttatgt ttgtgtcaac tataatcctt tccccacccc tttcatttat
     4501 ggtaaacatc ttgggcaaac ccaaagatgg aaagtgcttg ttgggtgggt aagcaccacc
     4561 tggtctctca gcaaacactc ctgagtggtt gaagatgctg gacattggat tctagcactg
     4621 ggtttatctg gtgacatagt ctcctgtggg tcttgagttg gttatttcaa gctcaaactc
     4681 tgaatatgat taaaccagaa caccccaccc ccaactgcca aaaaaaaaaa aaaaaaatgg
     4741 aaatccataa tgaaacagca aaaaagtact ccgttgctgg gtttggacaa tgaacatggg
     4801 attagtccca agtttgtagc ttggaacggt agcatttttg cctgcgtgat ccttgtcagc
     4861 tattcacaga aggaaatctt ccgaaactcc gtctttcatt tcagccggtg aggctgttat
     4921 ccttctctgt caattagcat tcatgtggtt ttcgctcttt ccagctctgt cactcttgtt
     4981 ttcatttaaa tattgcccca ctctgtgttt attgccttgc catttctcta gcatatcagg
     5041 tttaattatg ggctcagtaa taatgaggaa ctagcttccc tcaggcaact aattactttt
     5101 gtcttttttg gtcggattgt accaaattat tttgcattga atgggaatgt ttttgcagtg
     5161 aatccagata tagttgtatt ggtttggaaa aacatttaaa tatatttatt catatgaaca
     5221 tgtgtgatta aacaacctat tttacatatt tctgtaattc tgaggagtgg gctgggggta
     5281 ggaagaaatg gcaccactta aaattcaggg cttatatgaa gaggtgtttt aaggttagca
     5341 catgcacaaa ggaacgagtt ggtttaaaaa gataaatcac tgcaaagaat gaaattggct
     5401 tattcacatc aaaactagat aagatgctaa aaaaaaaaga tatgaaacag aactaaccta
     5461 tagtttcctg aaatcagtac agtttaattt ataagaagct agaaagtaat gcaccttgat
     5521 tgttttagga atgatttatg tgttgcaatt ttaatttatt taaagcatgt ctactgtgtt
     5581 tgtcctaaga gaaatatttc aacaaaacgt gctctgtgtt taagatatgt ttaggcagta
     5641 gttagcaact ctgaaagtag aaactggaaa tgtttattgt gaggcttgtt gcagaatttc
     5701 cattttgtga gttactactt agtttcatgt cagcctaaaa ttgtaaattc cctgtagatc
     5761 ttcaccccat tgtggtgtca tcaatgaatc caaagcaggt gccattattt ttttaaataa
     5821 acacttgatg ttagctttgg tgttaaataa agaggtagat ttcttaaatt ttca
//
