LOCUS       NP_055673                709 aa            linear   PRI 03-OCT-2024
DEFINITION  transmembrane and coiled-coil domains protein 2 isoform 1 [Homo
            sapiens].
ACCESSION   NP_055673
VERSION     NP_055673.2
DBSOURCE    REFSEQ: accession NM_014858.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 709)
  AUTHORS   Zhang,C., Kho,Y.S., Wang,Z., Chiang,Y.T., Ng,G.K., Shaw,P.C.,
            Wang,Y. and Qi,R.Z.
  TITLE     Transmembrane and coiled-coil domain family 1 is a novel protein of
            the endoplasmic reticulum
  JOURNAL   PLoS One 9 (1), e85206 (2014)
   PUBMED   24454821
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 709)
  AUTHORS   Shameer,K., Denny,J.C., Ding,K., Jouni,H., Crosslin,D.R., de
            Andrade,M., Chute,C.G., Peissig,P., Pacheco,J.A., Li,R.,
            Bastarache,L., Kho,A.N., Ritchie,M.D., Masys,D.R., Chisholm,R.L.,
            Larson,E.B., McCarty,C.A., Roden,D.M., Jarvik,G.P. and Kullo,I.J.
  TITLE     A genome- and phenome-wide association study to identify genetic
            variants influencing platelet count and volume and their
            pleiotropic effects
  JOURNAL   Hum Genet 133 (1), 95-109 (2014)
   PUBMED   24026423
REFERENCE   3  (residues 1 to 709)
  AUTHORS   Gieger,C., Radhakrishnan,A., Cvejic,A., Tang,W., Porcu,E.,
            Pistis,G., Serbanovic-Canic,J., Elling,U., Goodall,A.H.,
            Labrune,Y., Lopez,L.M., Magi,R., Meacham,S., Okada,Y., Pirastu,N.,
            Sorice,R., Teumer,A., Voss,K., Zhang,W., Ramirez-Solis,R.,
            Bis,J.C., Ellinghaus,D., Gogele,M., Hottenga,J.J., Langenberg,C.,
            Kovacs,P., O'Reilly,P.F., Shin,S.Y., Esko,T., Hartiala,J.,
            Kanoni,S., Murgia,F., Parsa,A., Stephens,J., van der Harst,P.,
            Ellen van der Schoot,C., Allayee,H., Attwood,A., Balkau,B.,
            Bastardot,F., Basu,S., Baumeister,S.E., Biino,G., Bomba,L.,
            Bonnefond,A., Cambien,F., Chambers,J.C., Cucca,F., D'Adamo,P.,
            Davies,G., de Boer,R.A., de Geus,E.J., Doring,A., Elliott,P.,
            Erdmann,J., Evans,D.M., Falchi,M., Feng,W., Folsom,A.R.,
            Frazer,I.H., Gibson,Q.D., Glazer,N.L., Hammond,C.,
            Hartikainen,A.L., Heckbert,S.R., Hengstenberg,C., Hersch,M.,
            Illig,T., Loos,R.J., Jolley,J., Khaw,K.T., Kuhnel,B.,
            Kyrtsonis,M.C., Lagou,V., Lloyd-Jones,H., Lumley,T., Mangino,M.,
            Maschio,A., Mateo Leach,I., McKnight,B., Memari,Y., Mitchell,B.D.,
            Montgomery,G.W., Nakamura,Y., Nauck,M., Navis,G., Nothlings,U.,
            Nolte,I.M., Porteous,D.J., Pouta,A., Pramstaller,P.P., Pullat,J.,
            Ring,S.M., Rotter,J.I., Ruggiero,D., Ruokonen,A., Sala,C.,
            Samani,N.J., Sambrook,J., Schlessinger,D., Schreiber,S.,
            Schunkert,H., Scott,J., Smith,N.L., Snieder,H., Starr,J.M.,
            Stumvoll,M., Takahashi,A., Tang,W.H., Taylor,K., Tenesa,A., Lay
            Thein,S., Tonjes,A., Uda,M., Ulivi,S., van Veldhuisen,D.J.,
            Visscher,P.M., Volker,U., Wichmann,H.E., Wiggins,K.L.,
            Willemsen,G., Yang,T.P., Hua Zhao,J., Zitting,P., Bradley,J.R.,
            Dedoussis,G.V., Gasparini,P., Hazen,S.L., Metspalu,A., Pirastu,M.,
            Shuldiner,A.R., Joost van Pelt,L., Zwaginga,J.J., Boomsma,D.I.,
            Deary,I.J., Franke,A., Froguel,P., Ganesh,S.K., Jarvelin,M.R.,
            Martin,N.G., Meisinger,C., Psaty,B.M., Spector,T.D., Wareham,N.J.,
            Akkerman,J.W., Ciullo,M., Deloukas,P., Greinacher,A., Jupe,S.,
            Kamatani,N., Khadake,J., Kooner,J.S., Penninger,J., Prokopenko,I.,
            Stemple,D., Toniolo,D., Wernisch,L., Sanna,S., Hicks,A.A.,
            Rendon,A., Ferreira,M.A., Ouwehand,W.H. and Soranzo,N.
  TITLE     New gene functions in megakaryopoiesis and platelet formation
  JOURNAL   Nature 480 (7376), 201-208 (2011)
   PUBMED   22139419
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 709)
  AUTHORS   Hopkins,P.C., Sainz-Fuertes,R. and Lovestone,S.
  TITLE     The impact of a novel apolipoprotein E and amyloid-beta protein
            precursor-interacting protein on the production of amyloid-beta
  JOURNAL   J Alzheimers Dis 26 (2), 239-253 (2011)
   PUBMED   21593558
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB007950.3, T51366.1 and BM674135.1.
            
            On Oct 29, 2004 this sequence version replaced NP_055673.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007950.3, SRR1803611.27869.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358024.8/ ENSP00000350718.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..709
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     Protein         1..709
                     /product="transmembrane and coiled-coil domains protein 2
                     isoform 1"
                     /note="cerebral protein 11; transmembrane and coiled-coil
                     domains protein 2"
                     /calculated_mol_wt=77318
     Region          1..143
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75069.3)"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80W04; propagated from
                     UniProtKB/Swiss-Prot (O75069.3)"
     Region          158..202
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75069.3)"
     Site            163
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q80W04; propagated from
                     UniProtKB/Swiss-Prot (O75069.3)"
     Region          285..695
                     /region_name="Tmemb_cc2"
                     /note="Predicted transmembrane and coiled-coil 2 protein;
                     pfam10267"
                     /db_xref="CDD:463036"
     Site            438
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80W04; propagated from
                     UniProtKB/Swiss-Prot (O75069.3)"
     Region          444..500
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75069.3)"
     Site            464
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O75069.3)"
     Site            470
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80W04; propagated from
                     UniProtKB/Swiss-Prot (O75069.3)"
     Site            503
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q80W04; propagated from
                     UniProtKB/Swiss-Prot (O75069.3)"
     Site            649..669
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O75069.3)"
     Site            682..702
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O75069.3)"
     CDS             1..709
                     /gene="TMCC2"
                     /gene_synonym="HUCEP11"
                     /coded_by="NM_014858.4:620..2749"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS30984.1"
                     /db_xref="GeneID:9911"
                     /db_xref="HGNC:HGNC:24239"
                     /db_xref="MIM:619429"
ORIGIN      
        1 mkrcrsdelq qqqgeedgag ledaashlpg adlrpgettg ansaggptsd agaaaapnpg
       61 prskppdlkk iqqlsegsmf ghglkhlfhs rrrsrerehq tsqdsqqhqq qqgmsdhdsp
      121 dekerspemh rvsyamslhd lparptafnr vlqqirsrps ikrgaslhss sgggssgsss
      181 rrtkssslep qrgsphllrk apqdsslaai lhqhqcrprs ssttdtalll adgsnvylla
      241 eeaegigdkv dkgdlvalsl paghgdtdgp isldvpdgap dpqrtkaaid hlhqkilkit
      301 eqikieqear ddnvaeylkl annadkqqvs rikqvfekkn qksaqtiaql hkklehyrrr
      361 lkeieqngps rqpkdvlrdm qqglkdvgan vragisgfgg gvvegvkgsl sglsqathta
      421 vvskprefas lirnkfgsad niahlkdple dgppeeaara lsgsatlvss pkygsddecs
      481 sasassagag snsgagpgga lgspksnaly gapgnldall eelreikegq shledsmedl
      541 ktqlqrdyty mtqclqeery ryerleeqln dltelhqnem tnlkqelasm eekvayqsye
      601 rardiqeave scltrvtkle lqqqqqqvvq legvenanar allgkfinvi lalmavllvf
      661 vstianfitp lmktrlrits ttllvlvlfl lwkhwdslty llehvllps
//
