LOCUS       NM_001349268            6052 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane and coiled-coil domain family 1 (TMCC1),
            transcript variant 9, mRNA.
ACCESSION   NM_001349268 XM_011512579
VERSION     NM_001349268.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6052)
  AUTHORS   Hoyer,M.J., Chitwood,P.J., Ebmeier,C.C., Striepen,J.F., Qi,R.Z.,
            Old,W.M. and Voeltz,G.K.
  TITLE     A Novel Class of ER Membrane Proteins Regulates ER-Associated
            Endosome Fission
  JOURNAL   Cell 175 (1), 254-265 (2018)
   PUBMED   30220460
REFERENCE   2  (bases 1 to 6052)
  AUTHORS   Zhang,C., Kho,Y.S., Wang,Z., Chiang,Y.T., Ng,G.K., Shaw,P.C.,
            Wang,Y. and Qi,R.Z.
  TITLE     Transmembrane and coiled-coil domain family 1 is a novel protein of
            the endoplasmic reticulum
  JOURNAL   PLoS One 9 (1), e85206 (2014)
   PUBMED   24454821
  REMARK    GeneRIF: roles of TMCC1 in ER organization
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6052)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL449209.2, AC083799.17, AC117492.17 and AC023162.41.
            
            On Jun 2, 2019 this sequence version replaced NM_001349268.1.
            
            Transcript Variant: This variant (9) encodes the longest isoform
            (a). Variants 1 and 5-9 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.158880.1,
                                           SRR18074967.3321127.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AL449209.2         19811-20028
            219-271             AC083799.17        148044-148096       c
            272-977             AC083799.17        143073-143778       c
            978-1912            AC117492.17        11957-12891         c
            1913-2048           AC023162.41        5275-5410
            2049-6052           AC023162.41        8583-12586
FEATURES             Location/Qualifiers
     source          1..6052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..6052
                     /gene="TMCC1"
                     /note="transmembrane and coiled-coil domain family 1"
                     /db_xref="GeneID:23023"
                     /db_xref="HGNC:HGNC:29116"
                     /db_xref="MIM:616242"
     exon            1..218
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..271
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..977
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..2363
                     /gene="TMCC1"
                     /note="isoform a is encoded by transcript variant 9"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domains protein 1
                     isoform a"
                     /protein_id="NP_001336197.1"
                     /db_xref="CCDS:CCDS33855.1"
                     /db_xref="GeneID:23023"
                     /db_xref="HGNC:HGNC:29116"
                     /db_xref="MIM:616242"
                     /translation="MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALEN
                     INVIGQGLKHLFQHQRRRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTAL
                     NRVLQQIRVPPKMKRGTSLHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTT
                     DAPTSSAMMEIACAAAAAAAACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHT
                     DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAAR
                     IKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGA
                     KVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDS
                     LEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTN
                     TLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERL
                     EEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQ
                     QQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFST
                     LFLVVFIAFLWKHWDALFSYVERFFSSPR"
     exon            978..1912
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2048
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..6052
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3265..3270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCC1"
                     /note="hexamer: AATAAA"
     polyA_site      3291
                     /gene="TMCC1"
                     /note="major polyA site"
     regulatory      6032..6037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCC1"
                     /note="hexamer: AATAAA"
     polyA_site      6052
                     /gene="TMCC1"
                     /note="major polyA site"
ORIGIN      
        1 ctctcgcgcc ggttcgccct cccgcgccgg ggctgaggcg gcggcggcgg tggcggtgac
       61 tgaggcggcg gcggctgagg cggcgcgggg ggagggtcgg gagggggggg tggttgtggg
      121 ggatggaccg ggtgcggcgg ccgcagtgga aggagcaggc gcttgagctc gagcgacggc
      181 gctggcggag acgccggctg ctcctcccct ccccgccgct tttcctaaaa ggattgtaca
      241 ccttagaagt gcttaaggaa gagtgatgaa gataggcatg aagccttcgt ctcacagctg
      301 catgcgtagt cactgttgaa gcaaatgcct acctaatttg acactcttgg tgtgtttaaa
      361 aaattttttt gagtttgcaa ataagcatat taagtctact gatggagcct tcgggcagtg
      421 aacagttatt tgaggaccct gatcctggag gcaaatccca agatgcagag gccagaaagc
      481 agacagaatc agaacaaaaa ttgtctaaaa tgacccacaa tgctttggag aacattaacg
      541 tgattggcca aggcttgaag catctcttcc agcaccagcg caggaggtca tcagtgtctc
      601 cacatgatgt gcagcaaatt caggcagatc cagaacctga aatggatctg gaaagccaga
      661 acgcatgtgc tgagattgat ggtgtcccca cccaccccac agctctgaat cgtgtcctgc
      721 agcagattcg agtgccaccc aagatgaaga gagggacaag cttgcatagt aggcggggca
      781 agccagaggc cccaaaggga agtccccaaa tcaacaggaa gtctggtcag gagatgacag
      841 ctgttatgca gtcaggccga cccaggtctt catccacaac tgatgcacct accagctctg
      901 ctatgatgga aatagcttgt gctgctgctg ctgctgctgc tgcatgtcta ccaggagagg
      961 agggaactgc ggagcggatc gaacggttgg aagtaagcag ccttgcccaa acatccagtg
     1021 cagtggcctc cagtaccgat ggcagcatcc acacagactc tgtggatgga acaccagacc
     1081 ctcagcgcac aaaggctgcc attgctcacc tgcagcagaa gatcctgaag ctcacagaac
     1141 aaatcaagat tgcacaaaca gcccgggacg acaacgttgc tgaatacttg aagcttgcca
     1201 acagtgcaga caaacagcag gctgcccgca tcaagcaagt ctttgagaag aagaaccaga
     1261 aatctgccca aactatcctc cagctgcaaa agaaacttga gcactaccac aggaagctca
     1321 gagaggtaga gcagaatggg atcccccggc agccaaagga tgtcttcagg gacatgcacc
     1381 agggtctgaa ggatgtagga gcaaaggtga ctggcttcag tgaaggtgtg gtggatagtg
     1441 tcaaaggtgg gttttccagc ttctcccagg ccacccattc agcagcaggc gctgtagtct
     1501 caaagcccag agagattgcc tcactcattc ggaacaaatt tggcagtgca gacaacatcc
     1561 ccaacctgaa ggactcttta gaggaagggc aagtggatga tgcggggaag gctttgggag
     1621 tgatttcaaa ctttcagtct agcccaaaat atggtagtga agaagattgt tctagtgcca
     1681 cttcaggctc agtgggagcc aacagcacca cagggggcat cgctgtagga gcatccagct
     1741 ccaaaacaaa caccctggac atgcagagct caggatttga tgcactacta catgagatcc
     1801 aggagatccg ggaaacccag gccagactag aggaatcctt tgagactctc aaggaacatt
     1861 atcagaggga ctattcctta ataatgcaga ccttacagga ggagcgatat agatgtgaac
     1921 gattggaaga acagctaaat gacctaacag agctccacca gaatgaaatc ttgaacttga
     1981 agcaggaact ggcaagcatg gaagaaaaaa tcgcgtatca gtcctatgaa cgggcccggg
     2041 acatccagga ggccctggag gcatgccaga cgcgcatctc caagatggag ctgcagcagc
     2101 agcagcagca ggtggtgcag ctagaagggc tggagaatgc cactgcccgg aaccttctgg
     2161 gcaaactcat caacatcctc ctggctgtca tggcagtcct tttggtcttt gtctccactg
     2221 tagccaactg tgtggtcccc ctcatgaaga ctcgcaacag gacgttcagc actttattcc
     2281 ttgtggtttt tattgccttt ctctggaagc actgggacgc cctcttcagc tatgtggaac
     2341 ggttcttttc atcccctaga tgatgctggc acagaaggca ttgttcccta ccctctggcg
     2401 agtgcatgca gcagagagtt agacagcaac ttacctactc tgaagttttc tacaacaaaa
     2461 aaagagttga gtgaatctgt ttacatttag aataatgttt ttttcttcaa gagacgcaat
     2521 tgcaatagta ttttttagat tttatccaag aagttttttg ggcgaaaatc ttggatcatt
     2581 tttatgtagc atgattttcc ttgggatgca aatcttaaaa cagtccttta atatgaacca
     2641 acaatctgga gcacaccgaa gggcaatcta aattgtggct tgaaggactg cactaaaacc
     2701 cactaaaaag atgcgaaaac ctgatgaggg caaaccagtt aaacctaaca ccctgccttg
     2761 tctgggctca tcacctctcc ctatcccaga ctaactttac tgtgaaatcc taccacattc
     2821 catgtctgaa tttttggatt cggggtggat tttcgttgtc cgtggaagaa cacatggatc
     2881 tctctggctt tctcacccaa gttggccact tacgctaatc ctggaagtat gatcactttt
     2941 gaacctgccc cttaaccttg acgaggatac aaaagtgaaa gcatcatccc ccaaaggatc
     3001 actgcacagt cctactacag tatttttaag tagccctcta aatacttaat tttaagcaaa
     3061 atcccttggc cgcactttta aggttttttt atatgtgtat agttaccaac ctaaaaataa
     3121 aaaatccgaa cagcatactt gaagaatgta atactcaaac tctcagtgct tccttatggt
     3181 ttctaatagg attttttatt attgttatta ttattattgg gtttttttgg acagggttgg
     3241 gagggtcttt tatttttcct ttgaaataaa gaagtgatgt ttttaaatga agaaatgtgt
     3301 ggatatttaa gtgtgctgct ccctcttgtc ttgaaacagt ttgagtaaga aagtcttgct
     3361 gtaaatgctg ccctctgccg cctttgtttt gagatgcagt ttaaactccc tctggctgct
     3421 gctgctgctt tttggtgtcc cgacatacct acgcccccgt tttatgggtt tggcttagtt
     3481 gaagaggaaa gggttgtgca aggagagcag gaggctgttt ccaaaaacca gtgtagtagg
     3541 atagggattt tttttttttt tttttgcccc aagaaaacgt tcacccagtg atcttgggct
     3601 ggggttgtct ttaggaaaag ttgagactat aagagtcata aataagtcct tgtgtttcct
     3661 taatttattt tgttaacacc cctaattaca accaaagtga tgatgtggag tcttctgtct
     3721 tcattttggc cccagcattc ttaatttcaa agctttattc tgtctgccta agagaatcaa
     3781 ccaaaggtga ttctcctaaa gagcagtgaa ggaaatgtca ggttagcagg acccaagttt
     3841 tgggtgtgaa atgttgccag cttcctataa tgtaaacgga cttgttaacc taacctaatt
     3901 atgctcagtg gacttctata gatggttttg aaaaatgaac tgagctgcct tcccccgtcg
     3961 cataaccagt tccatcatcc tggtggaact tgaacattta gagtttatct agagagcttg
     4021 gttaatcttt ccatattatt tgtagtattg gtcacaaatg ctgttccctc ttagcctcat
     4081 tctgtgcaac caagtgcata taagatgccc tgaaaagagt aacaaagtat gctttgcctg
     4141 tttccactta ccaggaaatt ccttcagaac tagattagca ttgccctgcc tgtctgaaag
     4201 gacagtttac ctaatggtgc cagcctcctt ttgctttggc aagctggatt tctcagagcc
     4261 agcatgttgt ttccataact actttgatat tttaactcag gtactccagt cttcacccca
     4321 acctcagctg attgtagtac acctgctagc tctgttgccc cctcaaaact gcacccagag
     4381 cagggccaca agggtgcttt ttttctttaa aaaaaaaaaa attagaacca attcatgttc
     4441 atgccaaaaa caaattgtcc ccaagcctat atgtattaaa atgttaactt tgcctaaaaa
     4501 tattgcagtg actttttagg caggagtgcc aaaggacact atgaactttt tgaactgaca
     4561 gtttctccta actttctgct ttagcgtaat tgctcagagt agagagcccc cacaaagtta
     4621 tttaaaagat gccctagcag caatccacca gtttttctaa gctagaacct ttgagtcccc
     4681 caaactgcct gaagacttaa gttttgtggg cactggaagt cactttgata gatggattga
     4741 aactgttcct atttgccctg ggacggtttc tatctatcaa aggaaggttt tcacctgtag
     4801 aaagccccct gcctccagcc aaatagtccc atgctgactt tctatcttcc tttctcaaac
     4861 tgtcttagga aggaccttca gtgcagatca ggtgcagtaa tggctttctt gtcccttaat
     4921 tattcaccag acccagaagt tgtacgcatt taatgctgtt tgtaaccatg catctgtttt
     4981 cattctttgc tgtacctttt gctgcccatc ctgttacttt tgagtttctt tcattgtggt
     5041 tgttcttggg ttcttttgtc ttgtcagagc tcttctataa cctcgctcta atggcttaac
     5101 agttgttctg ggtggaaacg tcccctcatt tgaatgctcc tctaaaaaaa aaagaaaaga
     5161 aaactgtatt cattcccttt aaaatgaaac attcctggtt tatttgtcca tgcctctagc
     5221 ctgggtgagt gaagctggct gtgttggcct gggtgattgt tcaggttgta gaatgcgcat
     5281 tttacattgt ttatgataat tgaagggtac ttctgtctgc tccaatttcc attccttggt
     5341 atactcagta tgtcctagta aggaaggctt tccactctac tggctcctta agaagcaaaa
     5401 gtaggttaaa ttttatactt cactgactag ggtcttctct ctcccctgtt ctgaatggag
     5461 taaaagtctg atgccaagac aaatattggg agcgagcctt cctcactagc catgtccaaa
     5521 taatgagcgt attttcatgt ggtcttcact gcatttggtt ttgtttctga tttcatgttc
     5581 ctttgaggta cagtcagatg aaaatgctga gttctgagag agttccaatg aggagctgcc
     5641 tttcagcttt ggaaaatatg caactaaaac aaaaccaaac attattgtaa tctgacacag
     5701 gcaaaattat ggttcccaca ccccaacccc aaatgaaacc tgggattttg aatgtggctc
     5761 taagagttaa cattgctgtc tgtatgtcgt gtatgctagg tgatatcctc agtagggatt
     5821 gactactaga ctgtgtgttt tatcaaagtg tgtaagaata aaaactcact tgcacgaatt
     5881 gaaacgtaaa gaaatgacac ttgtgaacgt gtgaacgtta acactgtagt tgatagatct
     5941 taagctgcta attgttgaga gagatttaaa tttatgttct gtctggtcgc tgcagattct
     6001 cagcagcact tttactgtat atagaaattg aaataaagac ctcagctatt aa
//
