LOCUS       NM_001017395            6303 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane and coiled-coil domain family 1 (TMCC1),
            transcript variant 1, mRNA.
ACCESSION   NM_001017395 XM_006713543
VERSION     NM_001017395.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6303)
  AUTHORS   Hoyer,M.J., Chitwood,P.J., Ebmeier,C.C., Striepen,J.F., Qi,R.Z.,
            Old,W.M. and Voeltz,G.K.
  TITLE     A Novel Class of ER Membrane Proteins Regulates ER-Associated
            Endosome Fission
  JOURNAL   Cell 175 (1), 254-265 (2018)
   PUBMED   30220460
REFERENCE   2  (bases 1 to 6303)
  AUTHORS   Zhang,C., Kho,Y.S., Wang,Z., Chiang,Y.T., Ng,G.K., Shaw,P.C.,
            Wang,Y. and Qi,R.Z.
  TITLE     Transmembrane and coiled-coil domain family 1 is a novel protein of
            the endoplasmic reticulum
  JOURNAL   PLoS One 9 (1), e85206 (2014)
   PUBMED   24454821
  REMARK    GeneRIF: roles of TMCC1 in ER organization
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6303)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL449209.2, AC083799.17, AC117492.17 and AC023162.41.
            
            On Jun 2, 2019 this sequence version replaced NM_001017395.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 5-9 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.133359.1,
                                           SRR7346977.1582085.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393238.8/ ENSP00000376930.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AL449209.2         19811-20028
            219-469             AL449209.2         32963-33213
            470-522             AC083799.17        148044-148096       c
            523-1228            AC083799.17        143073-143778       c
            1229-2163           AC117492.17        11957-12891         c
            2164-2299           AC023162.41        5275-5410
            2300-6303           AC023162.41        8583-12586
FEATURES             Location/Qualifiers
     source          1..6303
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..6303
                     /gene="TMCC1"
                     /note="transmembrane and coiled-coil domain family 1"
                     /db_xref="GeneID:23023"
                     /db_xref="HGNC:HGNC:29116"
                     /db_xref="MIM:616242"
     exon            1..218
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..469
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..522
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..1228
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             653..2614
                     /gene="TMCC1"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domains protein 1
                     isoform a"
                     /protein_id="NP_001017395.2"
                     /db_xref="CCDS:CCDS33855.1"
                     /db_xref="GeneID:23023"
                     /db_xref="HGNC:HGNC:29116"
                     /db_xref="MIM:616242"
                     /translation="MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALEN
                     INVIGQGLKHLFQHQRRRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTAL
                     NRVLQQIRVPPKMKRGTSLHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTT
                     DAPTSSAMMEIACAAAAAAAACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHT
                     DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAAR
                     IKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGA
                     KVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDS
                     LEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTN
                     TLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERL
                     EEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQ
                     QQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFST
                     LFLVVFIAFLWKHWDALFSYVERFFSSPR"
     exon            1229..2163
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2299
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..6303
                     /gene="TMCC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3516..3521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCC1"
                     /note="hexamer: AATAAA"
     polyA_site      3542
                     /gene="TMCC1"
                     /note="major polyA site"
     regulatory      6283..6288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMCC1"
                     /note="hexamer: AATAAA"
     polyA_site      6303
                     /gene="TMCC1"
                     /note="major polyA site"
ORIGIN      
        1 ctctcgcgcc ggttcgccct cccgcgccgg ggctgaggcg gcggcggcgg tggcggtgac
       61 tgaggcggcg gcggctgagg cggcgcgggg ggagggtcgg gagggggggg tggttgtggg
      121 ggatggaccg ggtgcggcgg ccgcagtgga aggagcaggc gcttgagctc gagcgacggc
      181 gctggcggag acgccggctg ctcctcccct ccccgccggt attaatctct ggagaagaca
      241 catccacagt tagcactttc ttcagatgct gacgctcggt gaacagttgc ctttggtcac
      301 aagatttaga agacacagtg tccatcctcc cagattggat ctctttttca tatggatctt
      361 ctgtttctat gtctttttaa aaaataactt tttgggaaac cttttggatt acaactgttc
      421 atcctcacct atgcaaagaa agggaagcta ttgctgggat tttgaggagc ttttcctaaa
      481 aggattgtac accttagaag tgcttaagga agagtgatga agataggcat gaagccttcg
      541 tctcacagct gcatgcgtag tcactgttga agcaaatgcc tacctaattt gacactcttg
      601 gtgtgtttaa aaaatttttt tgagtttgca aataagcata ttaagtctac tgatggagcc
      661 ttcgggcagt gaacagttat ttgaggaccc tgatcctgga ggcaaatccc aagatgcaga
      721 ggccagaaag cagacagaat cagaacaaaa attgtctaaa atgacccaca atgctttgga
      781 gaacattaac gtgattggcc aaggcttgaa gcatctcttc cagcaccagc gcaggaggtc
      841 atcagtgtct ccacatgatg tgcagcaaat tcaggcagat ccagaacctg aaatggatct
      901 ggaaagccag aacgcatgtg ctgagattga tggtgtcccc acccacccca cagctctgaa
      961 tcgtgtcctg cagcagattc gagtgccacc caagatgaag agagggacaa gcttgcatag
     1021 taggcggggc aagccagagg ccccaaaggg aagtccccaa atcaacagga agtctggtca
     1081 ggagatgaca gctgttatgc agtcaggccg acccaggtct tcatccacaa ctgatgcacc
     1141 taccagctct gctatgatgg aaatagcttg tgctgctgct gctgctgctg ctgcatgtct
     1201 accaggagag gagggaactg cggagcggat cgaacggttg gaagtaagca gccttgccca
     1261 aacatccagt gcagtggcct ccagtaccga tggcagcatc cacacagact ctgtggatgg
     1321 aacaccagac cctcagcgca caaaggctgc cattgctcac ctgcagcaga agatcctgaa
     1381 gctcacagaa caaatcaaga ttgcacaaac agcccgggac gacaacgttg ctgaatactt
     1441 gaagcttgcc aacagtgcag acaaacagca ggctgcccgc atcaagcaag tctttgagaa
     1501 gaagaaccag aaatctgccc aaactatcct ccagctgcaa aagaaacttg agcactacca
     1561 caggaagctc agagaggtag agcagaatgg gatcccccgg cagccaaagg atgtcttcag
     1621 ggacatgcac cagggtctga aggatgtagg agcaaaggtg actggcttca gtgaaggtgt
     1681 ggtggatagt gtcaaaggtg ggttttccag cttctcccag gccacccatt cagcagcagg
     1741 cgctgtagtc tcaaagccca gagagattgc ctcactcatt cggaacaaat ttggcagtgc
     1801 agacaacatc cccaacctga aggactcttt agaggaaggg caagtggatg atgcggggaa
     1861 ggctttggga gtgatttcaa actttcagtc tagcccaaaa tatggtagtg aagaagattg
     1921 ttctagtgcc acttcaggct cagtgggagc caacagcacc acagggggca tcgctgtagg
     1981 agcatccagc tccaaaacaa acaccctgga catgcagagc tcaggatttg atgcactact
     2041 acatgagatc caggagatcc gggaaaccca ggccagacta gaggaatcct ttgagactct
     2101 caaggaacat tatcagaggg actattcctt aataatgcag accttacagg aggagcgata
     2161 tagatgtgaa cgattggaag aacagctaaa tgacctaaca gagctccacc agaatgaaat
     2221 cttgaacttg aagcaggaac tggcaagcat ggaagaaaaa atcgcgtatc agtcctatga
     2281 acgggcccgg gacatccagg aggccctgga ggcatgccag acgcgcatct ccaagatgga
     2341 gctgcagcag cagcagcagc aggtggtgca gctagaaggg ctggagaatg ccactgcccg
     2401 gaaccttctg ggcaaactca tcaacatcct cctggctgtc atggcagtcc ttttggtctt
     2461 tgtctccact gtagccaact gtgtggtccc cctcatgaag actcgcaaca ggacgttcag
     2521 cactttattc cttgtggttt ttattgcctt tctctggaag cactgggacg ccctcttcag
     2581 ctatgtggaa cggttctttt catcccctag atgatgctgg cacagaaggc attgttccct
     2641 accctctggc gagtgcatgc agcagagagt tagacagcaa cttacctact ctgaagtttt
     2701 ctacaacaaa aaaagagttg agtgaatctg tttacattta gaataatgtt tttttcttca
     2761 agagacgcaa ttgcaatagt attttttaga ttttatccaa gaagtttttt gggcgaaaat
     2821 cttggatcat ttttatgtag catgattttc cttgggatgc aaatcttaaa acagtccttt
     2881 aatatgaacc aacaatctgg agcacaccga agggcaatct aaattgtggc ttgaaggact
     2941 gcactaaaac ccactaaaaa gatgcgaaaa cctgatgagg gcaaaccagt taaacctaac
     3001 accctgcctt gtctgggctc atcacctctc cctatcccag actaacttta ctgtgaaatc
     3061 ctaccacatt ccatgtctga atttttggat tcggggtgga ttttcgttgt ccgtggaaga
     3121 acacatggat ctctctggct ttctcaccca agttggccac ttacgctaat cctggaagta
     3181 tgatcacttt tgaacctgcc ccttaacctt gacgaggata caaaagtgaa agcatcatcc
     3241 cccaaaggat cactgcacag tcctactaca gtatttttaa gtagccctct aaatacttaa
     3301 ttttaagcaa aatcccttgg ccgcactttt aaggtttttt tatatgtgta tagttaccaa
     3361 cctaaaaata aaaaatccga acagcatact tgaagaatgt aatactcaaa ctctcagtgc
     3421 ttccttatgg tttctaatag gattttttat tattgttatt attattattg ggtttttttg
     3481 gacagggttg ggagggtctt ttatttttcc tttgaaataa agaagtgatg tttttaaatg
     3541 aagaaatgtg tggatattta agtgtgctgc tccctcttgt cttgaaacag tttgagtaag
     3601 aaagtcttgc tgtaaatgct gccctctgcc gcctttgttt tgagatgcag tttaaactcc
     3661 ctctggctgc tgctgctgct ttttggtgtc ccgacatacc tacgcccccg ttttatgggt
     3721 ttggcttagt tgaagaggaa agggttgtgc aaggagagca ggaggctgtt tccaaaaacc
     3781 agtgtagtag gatagggatt tttttttttt ttttttgccc caagaaaacg ttcacccagt
     3841 gatcttgggc tggggttgtc tttaggaaaa gttgagacta taagagtcat aaataagtcc
     3901 ttgtgtttcc ttaatttatt ttgttaacac ccctaattac aaccaaagtg atgatgtgga
     3961 gtcttctgtc ttcattttgg ccccagcatt cttaatttca aagctttatt ctgtctgcct
     4021 aagagaatca accaaaggtg attctcctaa agagcagtga aggaaatgtc aggttagcag
     4081 gacccaagtt ttgggtgtga aatgttgcca gcttcctata atgtaaacgg acttgttaac
     4141 ctaacctaat tatgctcagt ggacttctat agatggtttt gaaaaatgaa ctgagctgcc
     4201 ttcccccgtc gcataaccag ttccatcatc ctggtggaac ttgaacattt agagtttatc
     4261 tagagagctt ggttaatctt tccatattat ttgtagtatt ggtcacaaat gctgttccct
     4321 cttagcctca ttctgtgcaa ccaagtgcat ataagatgcc ctgaaaagag taacaaagta
     4381 tgctttgcct gtttccactt accaggaaat tccttcagaa ctagattagc attgccctgc
     4441 ctgtctgaaa ggacagttta cctaatggtg ccagcctcct tttgctttgg caagctggat
     4501 ttctcagagc cagcatgttg tttccataac tactttgata ttttaactca ggtactccag
     4561 tcttcacccc aacctcagct gattgtagta cacctgctag ctctgttgcc ccctcaaaac
     4621 tgcacccaga gcagggccac aagggtgctt tttttcttta aaaaaaaaaa aattagaacc
     4681 aattcatgtt catgccaaaa acaaattgtc cccaagccta tatgtattaa aatgttaact
     4741 ttgcctaaaa atattgcagt gactttttag gcaggagtgc caaaggacac tatgaacttt
     4801 ttgaactgac agtttctcct aactttctgc tttagcgtaa ttgctcagag tagagagccc
     4861 ccacaaagtt atttaaaaga tgccctagca gcaatccacc agtttttcta agctagaacc
     4921 tttgagtccc ccaaactgcc tgaagactta agttttgtgg gcactggaag tcactttgat
     4981 agatggattg aaactgttcc tatttgccct gggacggttt ctatctatca aaggaaggtt
     5041 ttcacctgta gaaagccccc tgcctccagc caaatagtcc catgctgact ttctatcttc
     5101 ctttctcaaa ctgtcttagg aaggaccttc agtgcagatc aggtgcagta atggctttct
     5161 tgtcccttaa ttattcacca gacccagaag ttgtacgcat ttaatgctgt ttgtaaccat
     5221 gcatctgttt tcattctttg ctgtaccttt tgctgcccat cctgttactt ttgagtttct
     5281 ttcattgtgg ttgttcttgg gttcttttgt cttgtcagag ctcttctata acctcgctct
     5341 aatggcttaa cagttgttct gggtggaaac gtcccctcat ttgaatgctc ctctaaaaaa
     5401 aaaagaaaag aaaactgtat tcattccctt taaaatgaaa cattcctggt ttatttgtcc
     5461 atgcctctag cctgggtgag tgaagctggc tgtgttggcc tgggtgattg ttcaggttgt
     5521 agaatgcgca ttttacattg tttatgataa ttgaagggta cttctgtctg ctccaatttc
     5581 cattccttgg tatactcagt atgtcctagt aaggaaggct ttccactcta ctggctcctt
     5641 aagaagcaaa agtaggttaa attttatact tcactgacta gggtcttctc tctcccctgt
     5701 tctgaatgga gtaaaagtct gatgccaaga caaatattgg gagcgagcct tcctcactag
     5761 ccatgtccaa ataatgagcg tattttcatg tggtcttcac tgcatttggt tttgtttctg
     5821 atttcatgtt cctttgaggt acagtcagat gaaaatgctg agttctgaga gagttccaat
     5881 gaggagctgc ctttcagctt tggaaaatat gcaactaaaa caaaaccaaa cattattgta
     5941 atctgacaca ggcaaaatta tggttcccac accccaaccc caaatgaaac ctgggatttt
     6001 gaatgtggct ctaagagtta acattgctgt ctgtatgtcg tgtatgctag gtgatatcct
     6061 cagtagggat tgactactag actgtgtgtt ttatcaaagt gtgtaagaat aaaaactcac
     6121 ttgcacgaat tgaaacgtaa agaaatgaca cttgtgaacg tgtgaacgtt aacactgtag
     6181 ttgatagatc ttaagctgct aattgttgag agagatttaa atttatgttc tgtctggtcg
     6241 ctgcagattc tcagcagcac ttttactgta tatagaaatt gaaataaaga cctcagctat
     6301 taa
//
