LOCUS       NP_001017395             653 aa            linear   PRI 08-JUN-2024
DEFINITION  transmembrane and coiled-coil domains protein 1 isoform a [Homo
            sapiens].
ACCESSION   NP_001017395 XP_006713606
VERSION     NP_001017395.2
DBSOURCE    REFSEQ: accession NM_001017395.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 653)
  AUTHORS   Hoyer,M.J., Chitwood,P.J., Ebmeier,C.C., Striepen,J.F., Qi,R.Z.,
            Old,W.M. and Voeltz,G.K.
  TITLE     A Novel Class of ER Membrane Proteins Regulates ER-Associated
            Endosome Fission
  JOURNAL   Cell 175 (1), 254-265 (2018)
   PUBMED   30220460
REFERENCE   2  (residues 1 to 653)
  AUTHORS   Zhang,C., Kho,Y.S., Wang,Z., Chiang,Y.T., Ng,G.K., Shaw,P.C.,
            Wang,Y. and Qi,R.Z.
  TITLE     Transmembrane and coiled-coil domain family 1 is a novel protein of
            the endoplasmic reticulum
  JOURNAL   PLoS One 9 (1), e85206 (2014)
   PUBMED   24454821
  REMARK    GeneRIF: roles of TMCC1 in ER organization
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 653)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL449209.2, AC083799.17, AC117492.17 and AC023162.41.
            
            On or before Mar 10, 2017 this sequence version replaced
            XP_006713606.1, NP_001017395.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 5-9 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.133359.1,
                                           SRR7346977.1582085.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393238.8/ ENSP00000376930.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     Protein         1..653
                     /product="transmembrane and coiled-coil domains protein 1
                     isoform a"
                     /calculated_mol_wt=71952
     Region          1..35
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O94876.3)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (O94876.3)"
     Region          58..78
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O94876.3)"
     Region          112..165
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O94876.3)"
     Region          204..227
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O94876.3)"
     Region          230..638
                     /region_name="Tmemb_cc2"
                     /note="Predicted transmembrane and coiled-coil 2 protein;
                     pfam10267"
                     /db_xref="CDD:463036"
     Site            382
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (O94876.3)"
     Site            414
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O94876.3)"
     Region          415..437
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O94876.3)"
     Site            592..612
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O94876.3)"
     Site            625..645
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O94876.3)"
     CDS             1..653
                     /gene="TMCC1"
                     /coded_by="NM_001017395.5:653..2614"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS33855.1"
                     /db_xref="GeneID:23023"
                     /db_xref="HGNC:HGNC:29116"
                     /db_xref="MIM:616242"
ORIGIN      
        1 mepsgseqlf edpdpggksq daearkqtes eqklskmthn aleninvigq glkhlfqhqr
       61 rrssvsphdv qqiqadpepe mdlesqnaca eidgvpthpt alnrvlqqir vppkmkrgts
      121 lhsrrgkpea pkgspqinrk sgqemtavmq sgrprssstt daptssamme iacaaaaaaa
      181 aclpgeegta erierlevss laqtssavas stdgsihtds vdgtpdpqrt kaaiahlqqk
      241 ilklteqiki aqtarddnva eylklansad kqqaarikqv fekknqksaq tilqlqkkle
      301 hyhrklreve qngiprqpkd vfrdmhqglk dvgakvtgfs egvvdsvkgg fssfsqaths
      361 aagavvskpr eiaslirnkf gsadnipnlk dsleegqvdd agkalgvisn fqsspkygse
      421 edcssatsgs vgansttggi avgasssktn tldmqssgfd allheiqeir etqarleesf
      481 etlkehyqrd yslimqtlqe eryrcerlee qlndltelhq neilnlkqel asmeekiayq
      541 syerardiqe aleacqtris kmelqqqqqq vvqleglena tarnllgkli nillavmavl
      601 lvfvstvanc vvplmktrnr tfstlflvvf iaflwkhwda lfsyverffs spr
//
