LOCUS       NM_001127198            8387 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens transmembrane channel like 6 (TMC6), transcript
            variant 1, mRNA.
ACCESSION   NM_001127198
VERSION     NM_001127198.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8387)
  AUTHORS   Godfred,A.C., Thomas,Z., Peter,D., Joseph,A., Ravichandran,L.,
            George,A.A., Pulimood,S.A., Gaikwad,P., Babu,R., Thomas,M.,
            Thomas,N. and Chapla,A.
  TITLE     A Novel Large Deletion in the EVER1 Gene in a Family With
            Epidermodysplasia Verruciformis From India
  JOURNAL   Am J Dermatopathol 46 (6), 373-376 (2024)
   PUBMED   38574087
  REMARK    GeneRIF: A Novel Large Deletion in the EVER1 Gene in a Family With
            Epidermodysplasia Verruciformis From India.
REFERENCE   2  (bases 1 to 8387)
  AUTHORS   Wu,C.J., Li,X., Sommers,C.L., Kurima,K., Huh,S., Bugos,G., Dong,L.,
            Li,W., Griffith,A.J. and Samelson,L.E.
  TITLE     Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in
            lymphocytes is regulated by each of the components
  JOURNAL   J Biol Chem 295 (47), 16086-16099 (2020)
   PUBMED   32917726
  REMARK    GeneRIF: Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in
            lymphocytes is regulated by each of the components.
REFERENCE   3  (bases 1 to 8387)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 8387)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 8387)
  AUTHORS   Zhang,Q., Chao,T.C., Patil,V.S., Qin,Y., Tiwari,S.K., Chiou,J.,
            Dobin,A., Tsai,C.M., Li,Z., Dang,J., Gupta,S., Urdahl,K., Nizet,V.,
            Gingeras,T.R., Gaulton,K.J. and Rana,T.M.
  TITLE     The long noncoding RNA ROCKI regulates inflammatory gene expression
  JOURNAL   EMBO J 38 (8) (2019)
   PUBMED   30918008
REFERENCE   6  (bases 1 to 8387)
  AUTHORS   Kurima,K., Yang,Y., Sorber,K. and Griffith,A.J.
  TITLE     Characterization of the transmembrane channel-like (TMC) gene
            family: functional clues from hearing loss and epidermodysplasia
            verruciformis
  JOURNAL   Genomics 82 (3), 300-308 (2003)
   PUBMED   12906855
REFERENCE   7  (bases 1 to 8387)
  AUTHORS   Keresztes,G., Mutai,H. and Heller,S.
  TITLE     TMC and EVER genes belong to a larger novel family, the TMC gene
            family encoding transmembrane proteins
  JOURNAL   BMC Genomics 4 (1), 24 (2003)
   PUBMED   12812529
REFERENCE   8  (bases 1 to 8387)
  AUTHORS   Ramoz,N., Rueda,L.A., Bouadjar,B., Montoya,L.S., Orth,G. and
            Favre,M.
  TITLE     Mutations in two adjacent novel genes are associated with
            epidermodysplasia verruciformis
  JOURNAL   Nat Genet 32 (4), 579-581 (2002)
   PUBMED   12426567
  REMARK    GeneRIF: Mutations in EVER1 are associated with epidermodysplasia
            verruciformis.
REFERENCE   9  (bases 1 to 8387)
  AUTHORS   Ramoz,N., Taieb,A., Rueda,L.A., Montoya,L.S., Bouadjar,B., Favre,M.
            and Orth,G.
  TITLE     Evidence for a nonallelic heterogeneity of epidermodysplasia
            verruciformis with two susceptibility loci mapped to chromosome
            regions 2p21-p24 and 17q25
  JOURNAL   J Invest Dermatol 114 (6), 1148-1153 (2000)
   PUBMED   10844558
REFERENCE   10 (bases 1 to 8387)
  AUTHORS   Ramoz,N., Rueda,L.A., Bouadjar,B., Favre,M. and Orth,G.
  TITLE     A susceptibility locus for epidermodysplasia verruciformis, an
            abnormal predisposition to infection with the oncogenic human
            papillomavirus type 5, maps to chromosome 17qter in a region
            containing a psoriasis locus
  JOURNAL   J Invest Dermatol 112 (3), 259-263 (1999)
   PUBMED   10084299
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY100488.1, AK074065.1 and
            AC021593.15.
            
            On Jan 3, 2020 this sequence version replaced NM_001127198.4.
            
            Summary: Epidermodysplasia verruciformis (EV) is an autosomal
            recessive dermatosis characterized by abnormal susceptibility to
            human papillomaviruses (HPVs) and a high rate of progression to
            squamous cell carcinoma on sun-exposed skin. EV is caused by
            mutations in either of two adjacent genes located on chromosome
            17q25.3. Both of these genes encode integral membrane proteins that
            localize to the endoplasmic reticulum and are predicted to form
            transmembrane channels. This gene encodes a transmembrane
            channel-like protein with 10 transmembrane domains and 2 leucine
            zipper motifs. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.13125.1,
                                           SRR11853563.15013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590602.6/ ENSP00000465261.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                HY100488.1         40-97
            59-2865             AK074065.1         1-2807
            2866-8387           AC021593.15        73691-79212
FEATURES             Location/Qualifiers
     source          1..8387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..8387
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /note="transmembrane channel like 6"
                     /db_xref="GeneID:11322"
                     /db_xref="HGNC:HGNC:18021"
                     /db_xref="MIM:605828"
     exon            1..144
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..274
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2636
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     epidermodysplasia verruciformis 1; expressed in activated
                     T/LAK lymphocytes; transmembrane channel-like protein 6;
                     protein LAK-4; TNRC6C antisense RNA 1; epidermodysplasia
                     verruciformis protein 1"
                     /codon_start=1
                     /product="transmembrane channel-like protein 6 isoform 1"
                     /protein_id="NP_001120670.1"
                     /db_xref="CCDS:CCDS32748.1"
                     /db_xref="GeneID:11322"
                     /db_xref="HGNC:HGNC:18021"
                     /db_xref="MIM:605828"
                     /translation="MAQPLAFILDVPETPGDQGQGPSPYDESEVHDSFQQLIQEQSQC
                     TAQEGLELQQREREVTGSSQQTLWRPEGTQSTATLRILASMPSRTIGRSRGAIISQYY
                     NRTVQLRCRSSRPLLGNFVRSAWPSLRLYDLELDPTALEEEEKQSLLVKELQSLAVAQ
                     RDHMLRGMPLSLAEKRSLREKSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGL
                     ALLSALQALMPWRYALKRIGGQFGSSVLSYFLFLKTLLAFNALLLLLLVAFIMGPQVA
                     FPPALPGPAPVCTGLELLTGAGCFTHTVMYYGHYSNATLNQPCGSPLDGSQCTPRVGG
                     LPYNMPLAYLSTVGVSFFITCITLVYSMAHSFGESYRVGSTSGIHAITVFCSWDYKVT
                     QKRASRLQQDNIRTRLKELLAEWQLRHSPRSVCGRLRQAAVLGLVWLLCLGTALGCAV
                     AVHVFSEFMIQSPEAAGQEAVLLVLPLVVGLLNLGAPYLCRVLAALEPHDSPVLEVYV
                     AICRNLILKLAILGTLCYHWLGRRVGVLQGQCWEDFVGQELYRFLVMDFVLMLLDTLF
                     GELVWRIISEKKLKRRRKPEFDIARNVLELIYGQTLTWLGVLFSPLLPAVQIIKLLLV
                     FYVKKTSLLANCQAPRRPWLASHMSTVFLTLLCFPAFLGAAVFLCYAVWQVKPSSTCG
                     PFRTLDTMYEAGRVWVRHLEAAGPRVSWLPWVHRYLMENTFFVFLVSALLLAVIYLNI
                     QVVRGQRKVICLLKEQISNEGEDKIFLINKLHSIYERKEREERSRVGTTEEAAAPPAL
                     LTDEQDA"
     exon            275..399
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..489
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..648
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..754
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..851
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1109
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1300
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1445
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1601
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1753
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1933
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2029
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2105
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2239
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2416
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2495
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2572
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..8387
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2844..2849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /note="hexamer: ATTAAA"
     polyA_site      2865
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /note="major polyA site"
     regulatory      8361..8366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
                     /note="hexamer: AATAAA"
     polyA_site      8387
                     /gene="TMC6"
                     /gene_synonym="EV1; EVER1; EVIN1; LAK-4P; lnc; TNRC6C-AS1"
ORIGIN      
        1 agacctgcga ctggcccagt cgcccctggg gccctttgcc actcccttgg caaggagagc
       61 cgagacctca gttcccggcg gctcttgcgg ggcacaggtg agccctggct gcgcgcgcgg
      121 cccctcctcc ccggcgcctc ccagatgggg gctccggagg tggcgcccag gctctgagct
      181 accctaggtc tgcagactag cgggcattgg ccagagacat ggcccagcca ctggccttca
      241 tcctcgatgt ccctgagacc ccaggggacc agggccaggg ccccagcccc tatgatgaaa
      301 gcgaagtgca cgactccttc cagcagctca tccaggagca gagccagtgc acggcccagg
      361 aggggctgga gctgcagcag agagagcggg aggtgacagg aagtagccag cagacactct
      421 ggcggcccga gggcacccag agcacggcca cactccgcat cctggccagc atgcccagcc
      481 gcaccattgg ccgcagccga ggtgccatca tctcccagta ctacaaccgc acggtgcagc
      541 ttcggtgcag gagcagccgg cccctgctcg ggaactttgt ccgctccgcc tggcccagcc
      601 tccgcctgta cgacctggag ctggacccca cggccctgga ggaggaggag aagcagagcc
      661 tcctggtgaa ggagctccag agcctggcag tggcacagcg ggaccacatg cttcgcggga
      721 tgcccttaag cctggctgag aaacgcagcc tgcgagagaa gagcaggacc ccgaggggga
      781 agtggagggg ccagccgggc agcggcgggg tctgctcctg ctgtggccgg ctcagatatg
      841 cctgcgtgct ggccttgcac agcctgggcc tggcgctgct ctccgccctg caggccctga
      901 tgccgtggcg ctacgccctg aagcgcatcg ggggccagtt cggctccagc gtgctctcct
      961 acttcctctt tctcaagacc ctgctggctt tcaatgccct cctgctgctg ctgctggtgg
     1021 ccttcatcat gggccctcag gtcgccttcc cacccgccct gccgggccct gcccccgtct
     1081 gcacaggcct ggagctcctc acaggcgcgg gttgcttcac ccacaccgtc atgtactacg
     1141 gccactacag taacgccacg ctgaaccagc cgtgtggcag ccccctggat ggcagccagt
     1201 gcacacccag ggtgggtggc ctgccctaca acatgcccct ggcctacctc tccactgtgg
     1261 gcgtgagctt ctttatcacc tgcatcaccc tggtgtacag catggctcac tctttcgggg
     1321 agagctaccg ggtgggcagc acctctggca tccacgccat caccgtcttc tgctcctggg
     1381 actacaaggt gacgcagaag cgggcctccc gcctccagca ggacaatatt cgcacccggc
     1441 tgaaggagct gctggccgag tggcagctgc ggcacagccc caggagcgtg tgcgggaggc
     1501 tgcggcaggc ggctgtgctg gggcttgtgt ggctgctgtg tctggggacc gcgctgggct
     1561 gcgccgtggc cgtccacgtc ttctcggagt tcatgatcca gagtccagag gctgctggcc
     1621 aggaggctgt gctgctggtc ctgcccctgg tggttggcct cctcaacctg ggggccccct
     1681 acctgtgccg tgtcctggcc gccctggagc cgcatgactc cccggtactg gaggtgtacg
     1741 tggccatctg caggaacctc atcctcaagc tggccatcct ggggacactg tgctaccact
     1801 ggctgggccg cagggtgggc gtcctgcagg gccagtgctg ggaggatttt gtgggccagg
     1861 agctgtaccg gttcctggtg atggacttcg tcctcatgtt gctggacacg ctttttgggg
     1921 aactggtgtg gaggattatc tccgagaaga agctgaagag gaggcggaag ccggagtttg
     1981 acattgcccg gaatgtcctg gagctgattt atgggcagac tctgacctgg ctgggggtgc
     2041 tcttctcgcc cctcctcccc gccgtgcaga tcatcaagct gctgctcgtc ttctatgtca
     2101 agaagaccag ccttctggcc aactgccagg cgccgcgccg gccctggctg gcctcacaca
     2161 tgagcaccgt cttcctcacg ctgctctgct tccccgcctt cctgggcgcc gctgtcttcc
     2221 tctgctacgc cgtctggcag gtgaagccct cgagcacctg cggccccttc cggaccctgg
     2281 acaccatgta cgaggccggc agggtgtggg tgcgccacct ggaggcggca ggccccaggg
     2341 tctcctggct gccctgggtg caccggtacc tgatggaaaa caccttcttt gtcttcctgg
     2401 tgtcagccct gctgctggcc gtgatctacc tcaacatcca ggtggtgcgg ggccagcgca
     2461 aggtcatctg cctgctcaag gagcagatca gcaatgaggg tgaggacaaa atcttcttaa
     2521 tcaacaagct tcactccatc tacgagagga aggagaggga ggagaggagc agggttggga
     2581 caaccgagga ggctgcggca ccccctgccc tgctcacaga tgaacaggat gcctaggggg
     2641 acggcgatgg gcctcacggg cccgcccagc accctgagac cacactgttg cctcccagtg
     2701 accctgctgg gacaccagga caaggaagac agtttcgcct ctcgaaagcc gcagctgcgc
     2761 ctaggctgga gctggaaggg tgggtgaatc cggcttgggc atccccaatg aactctgccc
     2821 tgcctgggac tctatttatt ctgattaaag gggttttgca aatgggcttg tcccttgggg
     2881 ctctgtgtct gtgaccacac ccggggcctg cttcccgctg ccctggggcc acctccaggc
     2941 gcaggtctgg gtcctgggaa cctcagctgg agtgggggcg ccctctgctg gccaagcccc
     3001 agatggcagg ggctggaccg cgccagggct tgattcgctt gctgcctttg accagcctga
     3061 actcgcgccc aggaggggct tacacctgca caagtgagcc gagcaggcac ggattgtgac
     3121 cagagcgatg cgtcaaccat tgggtgatgc tgtagcatct actggagcag gagacaaatt
     3181 tagagaggga cttggagggg agacatatca gttgcaaatg agttgtgggg acagttgcct
     3241 cccaggcata ggtaaccagc acctgtgctt ggaggcgaac agggcttggt gaggtggggc
     3301 tggccccctg cttctggctg ccagcagctg gctggggggt ggtgatcctg ggtctgactg
     3361 ggctgagttt gaggagcccg tgggataccg aaaaccgtag gctgtggggg gtgggcacag
     3421 ggattcgggg accagcccgt catgaccccg tgctccaggt ctgcagggac cagcccatga
     3481 cagcccaggg ctccaggtct gcggggacca gcccatcaca gcccagggct ccaggcctgc
     3541 ggggaccagc ccgtcagcct cagttctcca ggcctgcggg gaccagcccg tcatgacccc
     3601 agtgctccag gtctgtgggg accagcccgt cagcctgtgc tccaggcctg caggaaccag
     3661 cccgtcagcc tcagtgctcc aggcctgcgg ggaccagccc gtcagcctgt gctccaggcc
     3721 tgcggggacc agcccgtcat gaccccagtg ctccaggtct gtggggacca gcccgtcagc
     3781 ctgtgctcca ggcctgcggg aaccagcccg tcatgacccc agtgctccag gcctgcgggg
     3841 accagcccgt catgacccca gtgctccagg tctgtgggga ccagcccgtc acggcgcagg
     3901 gttccaggct tgtggggacc agcctgtcac agcccagggc tccaggcctg caggagctgc
     3961 gcttgggatt gggggaatga acccaggtgg ggaaatggtc aaagagcgat gggcccagaa
     4021 aagggtcaga cccagatgga gatgccactg gctgctagca gacccccacg ctgggtctag
     4081 cccacccaat cccatgggga tgctcctgtg ctctgcagac atctgggtgc tgccacaggg
     4141 gcccgacaga gttggcatct gggtggatct gagccaagtg gtgcttctgg gcctcagcaa
     4201 gtagctggtg ctgattctgg gcagccaact gtggcagcat cttcaggtgc gagtgctgct
     4261 gggtgaagct gcgtgggcag tccagaaagt gacgtgacag tccacaggga ccgacgtagg
     4321 gtttccagcc cctatctgtg cagatgctgt cctccaaacc atcacggtcc ctctctggct
     4381 ggggacgtgc gcctgccact gctggcttgc cagcatgatc attggttgtg acctgttgag
     4441 cccatcttgc cagcctcaca aaggacagta ctagctgctt atgacaggaa agtggaagaa
     4501 cttggcctgg atatttctgg agaattaccg tgtgtgctag tcagtctttc gtgtcaacca
     4561 ggccaggctg tggggcccag tgatctcatc gagaggggcc gaggtgttgc tgtgatcgtg
     4621 tgctgctgga atgtggtgaa cacctacagt cgatttcacc taaagatcat ccttgagaat
     4681 gtgggtgggc ctcatcctat cagctgaaag ctttaagagc aaaacccgag gtgtcccaga
     4741 gagggaattc tgccttgaga cggcggcttc ccactcccac tggatgtcca gcccgcggcc
     4801 ccacggctgg gtgagcccgt cctctcctcg tttctgtctc cggacccacc gtgtggcccc
     4861 agaccctcca gtgaggacct cccgtatttc ttcagagcag cccttgcgtg ctggaggcct
     4921 gggcttcagt gtgtccctgg gtgccctggg gcatgttctg tgacctccca gctcctcgcc
     4981 tcatggggcc gctgtatcaa gtgacacagt ttgtgtgctg cgtaccatgc ctggcaccca
     5041 tttgaggtgt tgcaaggagg ccatgtttgc tcgatgagag cagcctaaga tctacaaact
     5101 gttgttcgag tggatgggaa cttgatgcta ttttcaggct gaatgacaag actccgcgat
     5161 gcttctcggc ctgggctgca caacggaatc taccagggag gttttaaaaa cactggtact
     5221 tgctggaggt ggtggcgcct gtctgtaatt gcagctgctc cagaggctga ggcggaggat
     5281 tgcttgagcc caagagtttc ggtttatttg ctttttcaga gtcttgctct tgcccaggct
     5341 ggagtgcagt tccatgatct cggctcactg cctcagcctc ccaagtagct gggattacag
     5401 gtgcatacaa ccaggcctgg ctgatcttcg tatttttagt agagatgggg tttcaccatg
     5461 atggtcaggc tggtcaagat ctcctgacct caagtgatct gcccgcctcg gcctcccaaa
     5521 gtgctgggat tacagacatg aaccacaaca cctgccgagc ccaggtgttt tgaatccagc
     5581 acgggcaatg gcaagaccct gtcccaacaa acaaaaaaac actggtgcct gaggcccacc
     5641 ccgagagatt ctgattgagt tgatttggat ttgaattatc tttaaaattt tggatgtgaa
     5701 tttttttttt ttttcttgga atggagtttc actcttgttc cccaggctgg agtgcaacgg
     5761 gacgatcttg gctcaccgca acctccgcct actgggttca agccattctc ctgcctcagc
     5821 ttcccaagta gctgggatta caggcatgtg ctaccatgcc cagctaattt tgtattttta
     5881 gtagagacag ggtttctcca tgttgctcag gctggtcttg aactcctgac ctcaggtgat
     5941 ccgcccgcct cggactccca aagtgctggg attacaggca tgagccacca tgcctggccg
     6001 gatgtgaatt atcttaaaaa ttttcaggta attctaatgg gccaaggttg agaacccctg
     6061 ctctgggccc atccgagcac caggctgtca caaacgcatg catgcactca cgcccgtggg
     6121 cttggggggc ttcggaaatg tgcttctgct tttttgagat ggggtctttc tgttgcccat
     6181 cccggagcac agtggcacga tcacagctca ctgcagcctc gacctcctgg gctcaggtga
     6241 tcctcccgcc tcagcctcct gagtgtctgc ttctggtttt catgatgacc tggggcccag
     6301 gcatactaca cttgtgctgt tcaggggcca gtcctgcacc aggagcccat cagccacagc
     6361 tccgccgaga agcactgata tgcagagcta agcagctttg tttccacgtg gatcctgcgt
     6421 aggttttctt ggtccatccg tagacaccgc actcctgcag aggatcttct cgggatgccc
     6481 cactgtctct gttttccctc ttcactgaac actcagtcgg ggctcgccat gatgcctctg
     6541 tgtctgctgg cttctccccc attggaacag ccttcttggc acgccacact gctagctgct
     6601 gggcactgtg ctttctgcct ttaccgttct gccgtgatgt tgccaaaata gcagcaacaa
     6661 caacaacaac aaaggctggg cacctggctc atgcctgtat tcccagcagt tcgagatcag
     6721 cctgggcaac atggtgagac cctatctcta caaaaataaa aaatgaaatg agctgggtgg
     6781 ggtggcgcat gcatgcctgt ggtcccagct acttgggagg ctgaggtcgg aagatcgctg
     6841 gagcttaacc ttgaggtcaa ggttgcagtg agccgagatt acatcactgc actccagcgt
     6901 gggagacaga gaccctgtat taacaaacaa aaacacaaac cacaaagggc aggtctgaaa
     6961 ctgccattta aaaaaaaatt taataaactt aaaaaaatat atatccacag atgcaggtga
     7021 agaacctgtt gtcttcctca agcctctttt tcacccatgg gtggaaatgg tgccctggac
     7081 acccaggccc acgaggtctt tgcgtggggt ccctacacag ggctttagct tacactgtgc
     7141 tgccctcctg tcccccgagt tcccagtctg tcaaaatcca acctggtctc ccaggcccag
     7201 ggcaaatgcc acctcctcca tgaagcctgc cacatccttt gcacaccctt gggcgctgac
     7261 cttgttctcc cagcgcacag gcacgggtac agtttgcccc tgtagtagta actcaggcac
     7321 aaaacgaact cttgctgagg ctcggccgcg cagagctgag ggttgccgct tccaggttca
     7381 agtgcatttt gagtttcatt cccagcttcc ttctttttct ggtctttaat ttcttctccg
     7441 gattaggtcc cactcaatgc tttccttctc aatttccaaa agagtatggt cagagccagc
     7501 agcacaccac cttccccatg ggtggggggg ggccagcctg tggcgggggt gcgggtccca
     7561 tcttttcgaa ggaattgacc cacagtgggc gggtccacct ttgaccttgc cccagggagc
     7621 gcagacagaa aaaagatcct tgcttagttt gaggggccgc tggggtgctc ggtttgtctt
     7681 cagaggcctg tctgtaacac caatgccaac ccggtggcac tgactggtca ccctgaaggc
     7741 cacggccagt gtcctaggaa gggactcaat ttctagctgt gccacctgag attctggggt
     7801 taggctggtt gtgcttctga agttccactg tgctcaaagt gcttggtgaa agttagcgaa
     7861 ggtgatttta caaaaataga tgcataaaat gtctaggaaa cacaaaaaat cctcattact
     7921 cttctctcca aatatttttt aagccccaac tggaccctag gcaaaagtga gtggcactcc
     7981 tctgccagga ctccaggcaa gccccggcat cttcttgctg ccgtcccaga caacagaagt
     8041 taccagatga acagacttgg atgggccacg ggggtggaga gctggaaagc ttggctgtgc
     8101 ctctcgatga tgattaagat ttcaatattt acagcaaaac cacaaagcaa atgatagaat
     8161 aaagcaaaac aatggaaaat ctgagttcac tcgtgagaga ggtacgtatg tgagctctga
     8221 ggaaattaca gagggaacgc atgcagcggg acagctctcc caatcgcagc gtgcaaagta
     8281 gacatccata gtgtcttttg aaaaatgaaa aacacattac tttgaacagc caagaaaaaa
     8341 attgcaattt attaagattc aataaagcgt tgtactttcg aaagcaa
//
