LOCUS       NM_001261841            4685 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane channel like 5 (TMC5), transcript
            variant 4, mRNA.
ACCESSION   NM_001261841
VERSION     NM_001261841.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4685)
  AUTHORS   Zhang,W., Wang,S., Zhang,X., Liu,K., Song,J., Leng,X., Luo,R. and
            Ran,L.
  TITLE     Transmembrane Channel-Like 5 (TMC5) promotes prostate cancer cell
            proliferation through cell cycle regulation
  JOURNAL   Biochimie 165, 115-122 (2019)
   PUBMED   31356847
  REMARK    GeneRIF: This findings revealed that TMC5 promoted prostate cancer
            cell proliferation through cell cycle regulation and could be a
            powerful and hopeful target for prostate cancer treatment.
REFERENCE   2  (bases 1 to 4685)
  AUTHORS   Byrne,E.M., Gehrman,P.R., Medland,S.E., Nyholt,D.R., Heath,A.C.,
            Madden,P.A., Hickie,I.B., Van Duijn,C.M., Henders,A.K.,
            Montgomery,G.W., Martin,N.G. and Wray,N.R.
  CONSRTM   Chronogen Consortium
  TITLE     A genome-wide association study of sleep habits and insomnia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (5), 439-451 (2013)
   PUBMED   23728906
REFERENCE   3  (bases 1 to 4685)
  AUTHORS   Ng,D., Hu,N., Hu,Y., Wang,C., Giffen,C., Tang,Z.Z., Han,X.Y.,
            Yang,H.H., Lee,M.P., Goldstein,A.M. and Taylor,P.R.
  TITLE     Replication of a genome-wide case-control study of esophageal
            squamous cell carcinoma
  JOURNAL   Int J Cancer 123 (7), 1610-1615 (2008)
   PUBMED   18649358
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4685)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 4685)
  AUTHORS   Kurima,K., Yang,Y., Sorber,K. and Griffith,A.J.
  TITLE     Characterization of the transmembrane channel-like (TMC) gene
            family: functional clues from hearing loss and epidermodysplasia
            verruciformis
  JOURNAL   Genomics 82 (3), 300-308 (2003)
   PUBMED   12906855
REFERENCE   6  (bases 1 to 4685)
  AUTHORS   Keresztes,G., Mutai,H. and Heller,S.
  TITLE     TMC and EVER genes belong to a larger novel family, the TMC gene
            family encoding transmembrane proteins
  JOURNAL   BMC Genomics 4 (1), 24 (2003)
   PUBMED   12812529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK304431.1, DB222660.1, BC070101.1, AK023655.1 and CR749359.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001261841.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR and uses
            an alternate promoter, compared to variant 1. Variants 1 and 4
            encode the same isoform (A).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK304431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000542583.7/ ENSP00000446274.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AK304431.1         188-223
            37-37               DB222660.1         200-200
            38-608              AK304431.1         225-795
            609-879             BC070101.1         841-1111
            880-3582            AK304431.1         1067-3769
            3583-4328           AK023655.1         1068-1813
            4329-4685           CR749359.1         3216-3572
FEATURES             Location/Qualifiers
     source          1..4685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..4685
                     /gene="TMC5"
                     /note="transmembrane channel like 5"
                     /db_xref="GeneID:79838"
                     /db_xref="HGNC:HGNC:22999"
                     /db_xref="MIM:617197"
     exon            1..210
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            211..438
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            439..1305
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             518..3538
                     /gene="TMC5"
                     /note="isoform a is encoded by transcript variant 4;
                     transmembrane channel-like protein 5"
                     /codon_start=1
                     /product="transmembrane channel-like protein 5 isoform a"
                     /protein_id="NP_001248770.1"
                     /db_xref="CCDS:CCDS45431.1"
                     /db_xref="GeneID:79838"
                     /db_xref="HGNC:HGNC:22999"
                     /db_xref="MIM:617197"
                     /translation="MSAYYRNNWSEEDPDYPDYSGSQNRTQGYLKTQGYPDVPGPLNN
                     PDYPGTRSNPYSVASRTRPDYPGSLAEPNYPRSLSNPDYSGTRSNAYSAASRTSPDHP
                     TSLPEPDYSEFQSHPYHRASSRQPDYPGSQRNPDFAGSSSSGNYAGSRTHPDHFGSLE
                     PDYPGAQSNSDHPGPRANLNHPGSRKNLEHTSFRINPYADSLGKPDYPGADIQPNSPP
                     FFGEPDYPSAEDNQNLPSTWREPDYSDAENGHDYGSSETPKMTRGVLSRTSSIQPSFR
                     HRSDDPVGSLWGENDYPEGIEMASMEMANSYGHSLPGAPGSGYVNPAYVGESGPVHAY
                     GNPPLSECDWHKSPQGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSK
                     QTHRILQLNCCIQCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYF
                     NFLRWLLKFNIFSFILNFSFIIIPQFTVAKKNTLQFTGLEFFTGVGYFRDTVMYYGFY
                     TNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGIT
                     KLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWV
                     VSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRLVE
                     RYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEECWETLIGQDIYRLLLMD
                     FVFSLVNSFLGEFLRRIIGMQLITSLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLP
                     FIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITI
                     WRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVHFFFILTLI
                     VLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDMEKKANPSSLVLE
                     RREVEQQGFLHLGEHDGSLDLRSRRSVQEGNPRA"
     exon            1306..1475
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1565
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1665
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1753
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..2002
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2154
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2299
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2455
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2607
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2686
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2784
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2880
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..2956
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3090
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3264
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3343
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3448
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3491
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..4685
                     /gene="TMC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3950..3955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMC5"
                     /note="hexamer: AATAAA"
     polyA_site      3969
                     /gene="TMC5"
                     /note="major polyA site"
     regulatory      4662..4667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMC5"
                     /note="hexamer: ATTAAA"
     polyA_site      4685
                     /gene="TMC5"
ORIGIN      
        1 cccccttccc gtgatcttcg tggcttcccg cccagacgtg tgaccaagat agcaaggagc
       61 agtctttaag gcgacacggc agagaggcag aaaaagatgg gccttaccgg ttagttaaga
      121 aaaaaagagg acctgttgcc tgtccctcta gctttgaact acaaagtgga ggggaagttt
      181 gtctggattt tcctgtagaa ctgagggcag gacatgaggc tctgcctgca gtcagcaact
      241 tggaatattc agacttcaga ccagcatcac agattataac cctccgtaaa tcatctgcat
      301 cccagctccc atcaaaagcc agcctgaagg acccatggac acgtgactcc agtgttctca
      361 acaacatctt aagatcaagt tggtttgcac aacatttgca tctacttggg acaaagcaag
      421 aacaataagg gcaaaaaagt gaaaaaaaaa aaagatccct gagtaattgc aaatgctggg
      481 acagtttacc actccagggt gaagagtcca taccaacatg tctgcctact acaggaataa
      541 ctggtctgag gaagacccag attaccctga ctattcaggg tctcagaacc gtacgcaggg
      601 gtatttgaaa actcaaggtt atccagatgt tccaggtcct ctgaacaatc cagactaccc
      661 cggcaccagg agcaatccat actctgtagc ctccagaaca cgtccagact atcctgggtc
      721 tctggcagaa ccaaattatc ctagatctct gagtaatcca gactattctg gcaccagaag
      781 caatgcatac tctgcagcct ctagaacaag cccagaccat cctacctctc taccagagcc
      841 agattatagt gaatttcaga gtcatcccta ccaccgagca tcatccagac aaccagacta
      901 ccctggatct caacgaaatc ctgattttgc aggctccagc agcagtggaa actatgcagg
      961 ctccagaaca catccagatc attttggctc cttagaaccg gactaccctg gagctcagag
     1021 caactctgat catcctggac ccagagccaa tttgaaccat ccaggatcca gaaagaatct
     1081 ggaacataca agttttagaa tcaatccata cgcagactct ctgggaaagc ctgattatcc
     1141 aggcgctgac attcaaccta actctccacc cttttttggg gagccagact atcccagtgc
     1201 tgaggacaat cagaacttgc caagcacttg gagagaacct gattattcag atgctgagaa
     1261 tggtcatgat tatggctctt ctgagacccc aaagatgacc aggggggtgc tcagcagaac
     1321 atcttcaatc cagccctcat ttcgtcacag gagtgatgac cccgtgggca gtctttgggg
     1381 agagaatgat taccctgaag gcattgaaat ggcatccatg gagatggcaa actcatatgg
     1441 ccactctctg ccaggtgctc ctggaagtgg ctatgtgaac cctgcttatg taggtgaaag
     1501 tggtcctgtc catgcttatg gaaacccacc attgtctgaa tgtgattggc acaagtcacc
     1561 ccaaggacag aagttaatcg catcccttat acccatgaca tccagagaca gaattaaagc
     1621 catcaggaac cagccaagga ccatggaaga gaaaaggaac cttaggaaaa tagttgacaa
     1681 agaaaaaagc aaacagaccc atcgtatcct tcagctcaat tgctgtattc agtgtctgaa
     1741 ctccatttcc cgggcttatc ggagatccaa gaacagcctg tcggaaattc tgaattccat
     1801 cagcctgtgg cagaagacgc tgaagatcat tggaggcaag tttggaacca gcgtcctctc
     1861 ctatttcaac tttctgagat ggcttttgaa gttcaacatt ttctcattca tcctgaactt
     1921 cagcttcatc ataatccctc agtttaccgt ggccaaaaag aacaccctcc agttcactgg
     1981 gctggagttt ttcactgggg tgggttattt tagggacaca gtgatgtact atggctttta
     2041 caccaattcc accatccagc acgggaacag cggggcatcc tacaacatgc agctggccta
     2101 catcttcaca atcggagcat gcttgaccac ctgcttcttc agtttgctgt tcagcatggc
     2161 caagtatttc cggaacaact tcattaatcc ccacatttac tccggaggga tcaccaagct
     2221 gatcttttgc tgggacttca ctgtcactca tgaaaaagct gtgaagctaa aacagaagaa
     2281 tcttagcact gagataaggg agaacctgtc agagctccgt caggagaatt ccaagttgac
     2341 gttcaatcag ctgctgaccc gcttctctgc ctacatggta gcctgggttg tctctacagg
     2401 agtggccata gcctgctgtg cagccgttta ttacctggct gagtacaact tagagttcct
     2461 gaagacacac agtaaccctg gggcggtgct gttactgcct ttcgttgtgt cctgcattaa
     2521 tctggccgtg ccatgcatct actccatgtt caggcttgtg gagaggtacg agatgccacg
     2581 gcacgaagtc tacgttctcc tgatccgaaa catctttttg aaaatatcaa tcattggcat
     2641 tctttgttac tattggctca acaccgtggc cctgtctggt gaagagtgtt gggaaaccct
     2701 cattggccag gacatctacc ggctccttct gatggatttt gtgttctctt tagtcaattc
     2761 cttcctgggg gagtttctga ggagaatcat tgggatgcaa ctgatcacaa gtcttggcct
     2821 tcaggagttt gacattgcca ggaacgttct agaactgatc tatgcacaaa ctctggtgtg
     2881 gattggcatc ttcttctgcc ccctgctgcc ctttatccaa atgattatgc ttttcatcat
     2941 gttctactcc aaaaatatca gcctgatgat gaatttccag cctccgagca aagcctggcg
     3001 ggcctcacag atgatgactt tcttcatctt cttgctcttt ttcccatcct tcaccggggt
     3061 cttgtgcacc ctggccatca ccatctggag attgaagcct tcagctgact gtggcccttt
     3121 tcgaggtctg cctctcttca ttcactccat ctacagctgg atcgacaccc taagtacacg
     3181 gcctggctac ctgtgggttg tttggatcta tcggaacctc attggaagtg tgcacttctt
     3241 tttcatcctc accctcattg tgctaatcat cacctatctt tactggcaga tcacagaggg
     3301 aaggaagatt atgataaggc tgctccatga gcagatcatt aatgagggca aagataaaat
     3361 gttcctgata gaaaaattga tcaagctgca ggatatggag aagaaagcaa accccagctc
     3421 acttgttctg gaaaggagag aggtggagca acaaggcttt ttgcatttgg gggaacatga
     3481 tggcagtctt gacttgcgat ctagaagatc agttcaagaa ggtaatccaa gggcctgatg
     3541 actcttttgg taaccagaca ccaatcaaat aaggggagga gacgaaaatg gaatgatttc
     3601 ttccatgcca cctgtgcctt taggaactgc ccagaagaaa atccaaggct ttagccagga
     3661 gcggaaactg actaccatgt aattatcaaa gtaaaattgg gcattccatg ctatttttaa
     3721 tacctggatt gctgattttt caagacaaaa tacttggggt tttccaataa agattgttgt
     3781 aatattgaaa tgagcctaca aaaacctagg aagagataac tagggaataa tgtatattat
     3841 cttcaagaag tgtgtgcagg aatgattggt tcttagaaat ctctcctgcc agacttccca
     3901 gacctggcaa aggtttagaa actgttgcta agaaaagtgg tccatcctga ataaacatgt
     3961 aatactccag cagggatatg aagcctctga attgtagaac ctgcatttat ttgtgacttt
     4021 gaactaaaga catcccccat gtcccaaagg tggaatacaa ccagaggtct catctctgaa
     4081 ctttcttgcg tactgattac atgagtcttt ggagtcgggg atggaggagg ttctgcccct
     4141 gtgaggtgtt atacatgacc atcaaagtcc tacgtcaagc tagctttgca gtggcagtac
     4201 cgtagccaat gagatttatc cgagacgcga ttattgctaa ttggaaattt tcccaatacc
     4261 ccaccgtgat gacttgaaat ataatcagcg ctggcaattt ttgacagtct ctacggagac
     4321 tgaataagaa aaaagaaaag aaaagaaatt agctgggtgc gatggcttat gcctgtaatc
     4381 ccggcacttt gggaggctga ggcaagcgga tcacttaatg tcaggagttc aagaccagcc
     4441 tggccaacat ggtgaaaccc cgtctctact aaaaataaaa aaactagctg ggcgtggtgg
     4501 tacatgccta taatcccagc tactcgggag gctgaggcag gagaattgct tgaacctggg
     4561 aggcagaggt tgcagtgagg cgagattgta ccactgcatt ccagcctggg caacagtgag
     4621 actctgcctc aaaaaaataa ataaataaat aaataaagta aattaaaagt cttattcaaa
     4681 ccaaa
//
