LOCUS       NM_001080532            4770 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens transmembrane channel like 3 (TMC3), mRNA.
ACCESSION   NM_001080532 XM_930010
VERSION     NM_001080532.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4770)
  AUTHORS   Tang,W., Kowgier,M., Loth,D.W., Soler Artigas,M., Joubert,B.R.,
            Hodge,E., Gharib,S.A., Smith,A.V., Ruczinski,I., Gudnason,V.,
            Mathias,R.A., Harris,T.B., Hansel,N.N., Launer,L.J., Barnes,K.C.,
            Hansen,J.G., Albrecht,E., Aldrich,M.C., Allerhand,M., Barr,R.G.,
            Brusselle,G.G., Couper,D.J., Curjuric,I., Davies,G., Deary,I.J.,
            Dupuis,J., Fall,T., Foy,M., Franceschini,N., Gao,W., Glaser,S.,
            Gu,X., Hancock,D.B., Heinrich,J., Hofman,A., Imboden,M.,
            Ingelsson,E., James,A., Karrasch,S., Koch,B., Kritchevsky,S.B.,
            Kumar,A., Lahousse,L., Li,G., Lind,L., Lindgren,C., Liu,Y.,
            Lohman,K., Lumley,T., McArdle,W.L., Meibohm,B., Morris,A.P.,
            Morrison,A.C., Musk,B., North,K.E., Palmer,L.J.,
            Probst-Hensch,N.M., Psaty,B.M., Rivadeneira,F., Rotter,J.I.,
            Schulz,H., Smith,L.J., Sood,A., Starr,J.M., Strachan,D.P.,
            Teumer,A., Uitterlinden,A.G., Volzke,H., Voorman,A., Wain,L.V.,
            Wells,M.T., Wilk,J.B., Williams,O.D., Heckbert,S.R., Stricker,B.H.,
            London,S.J., Fornage,M., Tobin,M.D., O'Connor,G.T., Hall,I.P. and
            Cassano,P.A.
  TITLE     Large-scale genome-wide association studies and meta-analyses of
            longitudinal change in adult lung function
  JOURNAL   PLoS One 9 (7), e100776 (2014)
   PUBMED   24983941
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4770)
  AUTHORS   Beurg,M., Kim,K.X. and Fettiplace,R.
  TITLE     Conductance and block of hair-cell mechanotransducer channels in
            transmembrane channel-like protein mutants
  JOURNAL   J Gen Physiol 144 (1), 55-69 (2014)
   PUBMED   24981230
REFERENCE   3  (bases 1 to 4770)
  AUTHORS   Davis,M.F., Cummings,A.C., D'Aoust,L.N., Jiang,L., Velez
            Edwards,D.R., Laux,R., Reinhart-Mercer,L., Fuzzell,D., Scott,W.K.,
            Pericak-Vance,M.A., Lee,S.L. and Haines,J.L.
  TITLE     Parkinson disease loci in the mid-western Amish
  JOURNAL   Hum Genet 132 (11), 1213-1221 (2013)
   PUBMED   23793441
REFERENCE   4  (bases 1 to 4770)
  AUTHORS   Dong,C., Beecham,A., Wang,L., Slifer,S., Wright,C.B., Blanton,S.H.,
            Rundek,T. and Sacco,R.L.
  TITLE     Genetic loci for blood lipid levels identified by linkage and
            association analyses in Caribbean Hispanics
  JOURNAL   J Lipid Res 52 (7), 1411-1419 (2011)
   PUBMED   21558551
REFERENCE   5  (bases 1 to 4770)
  AUTHORS   Ahmad,J., Khan,S.N., Khan,S.Y., Ramzan,K., Riazuddin,S.,
            Ahmed,Z.M., Wilcox,E.R., Friedman,T.B. and Riazuddin,S.
  TITLE     DFNB48, a new nonsyndromic recessive deafness locus, maps to
            chromosome 15q23-q25.1
  JOURNAL   Hum Genet 116 (5), 407-412 (2005)
   PUBMED   15711797
REFERENCE   6  (bases 1 to 4770)
  AUTHORS   Kurima,K., Yang,Y., Sorber,K. and Griffith,A.J.
  TITLE     Characterization of the transmembrane channel-like (TMC) gene
            family: functional clues from hearing loss and epidermodysplasia
            verruciformis
  JOURNAL   Genomics 82 (3), 300-308 (2003)
   PUBMED   12906855
REFERENCE   7  (bases 1 to 4770)
  AUTHORS   Keresztes,G., Mutai,H. and Heller,S.
  TITLE     TMC and EVER genes belong to a larger novel family, the TMC gene
            family encoding transmembrane proteins
  JOURNAL   BMC Genomics 4 (1), 24 (2003)
   PUBMED   12812529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103858.2, AY236490.1, BC157874.1 and AY263163.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001080532.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC157874.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359440.6/ ENSP00000352413.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC103858.2         189826-189882       c
            58-95               AY236490.1         1-38
            96-1773             BC157874.1         9-1686
            1774-1980           AY263163.1         1677-1883
            1981-3170           BC157874.1         1894-3083
            3171-4753           AY263163.1         3164-4746
            4754-4770           AC103858.2         146757-146773       c
FEATURES             Location/Qualifiers
     source          1..4770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..4770
                     /gene="TMC3"
                     /note="transmembrane channel like 3"
                     /db_xref="GeneID:342125"
                     /db_xref="HGNC:HGNC:22995"
                     /db_xref="MIM:617196"
     exon            1..225
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..3439
                     /gene="TMC3"
                     /codon_start=1
                     /product="transmembrane channel-like protein 3"
                     /protein_id="NP_001074001.1"
                     /db_xref="CCDS:CCDS45324.1"
                     /db_xref="GeneID:342125"
                     /db_xref="HGNC:HGNC:22995"
                     /db_xref="MIM:617196"
                     /translation="MKTSKASQRYRGIRRNASQCYLYQESLLLSNLDDSFSADETGDS
                     NDPEQIFQNIQFQKDLMANIRCRPWTMGQKLRALRQAKNIVLKFEGRLTRTRGYQAAG
                     AELWRKFARLACNFVVIFIPWEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTG
                     AFIVIPELIAGQPFGSTARKTIPKEQVSSAQDLDTVWSLGGYLQYSVLFYGYYGRERK
                     IGRAGYRLPLAYFLVGMAVFAYSFIILLKKMAKNSRTSLASASNENYTFCWRVFCAWD
                     YLIGNPEAAESKTAAIVNSIREAILEEQEKKKSKNLAVTICLRIIANILVLLSLAGSI
                     YLIYFVVDRSQKLEQSKKELTLWEKNEVSVVVSLVTMIAPSAFDLIAALEMYHPRTTL
                     RFQLARVLVLYLGNLYSLIIALLDKVNSMSIEEMATKNNTSHWIDSTTFFATRTAPEE
                     EKWSTSRPGMGLRRNNTWALEETSISAYTMPLIKANKTSLHTQSPQDQCWETYVGQEM
                     LKLSIIDMLFTVASILLIDFFRGLFVRYLSDYWCWDLESKFPEYGEFKIAENVLHLVY
                     NQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRSNNFYLAML
                     LFMLFLCMLPTIFAIVRYKPSLNCGPFSGQEKIYDIVSETIEKDFPVWFGSVVGHISS
                     PVVILPAVLLLFMLIYYLQSIARSLKLSNHQLKMQIQNARSEDKKKVAQMVEARIQTQ
                     EESTKKLPNDSDLTSQLSSAHSGTPQNNGNVAHFDSGSSKSGRIETVAQSMPQSPRPG
                     DRAPSSPLPGVPKSRLEHETNRYLHGLCASTSDLHRNRSRTPMTFTTHIEDVHSEPLF
                     RKDFQQINPPHRGPQASTLLAQGPRPHAPRYYVINECDSYKKKHLNVWPERHFKIDAS
                     GDIVELYPRNVRQYASRVPRQPPSPQLSEEEEETPSRDWIKRSLPPRSLIDLRRAPHF
                     YIGERSESQTRDPEHQGRVHYKSWNEDFEGHLERPAYVPRKPRSRNFQYPQPPLKPRG
                     KPRFEPSLTESDSVSAASSSDQQNSSADQYLQVTHSQGRFPRSVGQPSRRKAKSGQEL
                     TVDLDDLICSDV"
     exon            226..372
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            373..448
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            449..530
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            531..637
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            638..736
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            737..879
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1027
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1071
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1219
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1329
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1408
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1654
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1783
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1851
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1980
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2091
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2217
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2296
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2339
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2595
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..4770
                     /gene="TMC3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacagtctt cttcctgaga actagcgggc agagcaaact ccgctgcttc cattcagaaa
       61 cctcggaaca gacctttgcc tgccaacttc ctagctctct ggccagcttc tgattgttag
      121 cagtgggtta gctcccatga aaacctcgaa ggcatcccag cgctatagag gcatccggag
      181 aaatgccagc cagtgctacc tctaccagga atctctgctg ctcagcaact tggatgacag
      241 ctttagtgct gatgaaacag gggacagcaa tgatccggaa caaatcttcc agaatataca
      301 gttccagaaa gatctcatgg caaacattcg ctgcagaccc tggactatgg gacagaagct
      361 gagggcattg agacaagcga agaacattgt gctgaagttt gaagggaggc tgaccaggac
      421 ccgaggctac caagcagcag gtgcagagct ctggcggaaa tttgctcgtc tcgcctgtaa
      481 ctttgtggtc atcttcattc cctgggaaat gaggataaag aaaatcgaga gtcattttgg
      541 atctggcgtt gcctcctatt tcatattctt gagatggtta tttggaatta atattgtgct
      601 caccattatg acaggtgctt ttattgtcat tccagagctg attgcaggcc agccctttgg
      661 aagcacagcc aggaagacca tccccaagga gcaggtttcg tctgcccaag acctggacac
      721 cgtctggtct ctggggggct acctccagta ctctgtcctc ttctacggat attacggcag
      781 ggagaggaag atcgggagag ctggctaccg gctgcccttg gcgtatttcc tagtggggat
      841 ggcagtgttt gcttacagct tcatcattct tttaaaaaag atggctaaga actcccgcac
      901 gagtcttgcc agtgcttcca atgaaaacta taccttctgc tggcgggtgt tctgtgcctg
      961 ggattacctc attggaaacc cagaggctgc agagagcaaa acagctgcca tagtgaacag
     1021 catcagggaa gctatattgg aagaacagga gaaaaagaaa agcaaaaacc tggcagtgac
     1081 catctgcctg aggattattg ccaacatcct ggtgcttctc tcactggctg ggagcattta
     1141 tctcatctac tttgtggtgg accggtccca gaagctggag cagtcgaaga aggagctgac
     1201 actttgggaa aagaatgagg tcagtgtggt ggtctccctc gtcaccatga tagcaccatc
     1261 agcctttgac ctcattgctg ccttagagat gtaccacccc aggaccacgc tgcgcttcca
     1321 gcttgcaagg gtccttgtgc tgtatttggg aaatctctac agcctgatca ttgctctcct
     1381 ggacaaagtt aacagcatga gcattgagga aatggctacc aaaaataaca caagtcattg
     1441 gatagattcc accaccttct ttgcaaccag gacagcccct gaagaagaga aatggtccac
     1501 atctcggcct ggaatggggc tcaggagaaa caacacatgg gccttggaag agaccagcat
     1561 ttcagcttat accatgcctc ttataaaggc caacaagact agcctccaca ctcagagtcc
     1621 acaagaccag tgctgggaga catacgttgg tcaggagatg ctgaagctct ccatcattga
     1681 catgctcttc accgtggcga gcattctgct catagacttc ttccgaggac ttttcgtgcg
     1741 gtacttaagt gactactggt gttgggatct ggagagcaag tttcctgaat atggagaatt
     1801 caaaatagct gagaatgtgc tacatttagt ctacaaccaa ggaatgattt ggatgggggc
     1861 cttcttctcc ccatgtctcc cagcgttcaa cgttctcaaa ctcattgggc tcatgtacct
     1921 gagaagctgg gctgtgctga cctgcaatgt gccccaccag caagtatttc gagcctcaag
     1981 atccaacaac ttctacttgg caatgctcct gtttatgctg tttctgtgca tgctgccaac
     2041 catttttgct attgtccgat acaagccatc tctaaactgt gggccattca gtggacaaga
     2101 gaaaatttat gacattgtgt cagaaacgat tgagaaagac tttcctgtgt ggtttggctc
     2161 cgtggttgga cacatcagta gccccgtggt catcctgccc gcagtactcc tgcttttcat
     2221 gctcatctat tatctccaga gcatcgcacg gtctctaaag ctcagcaacc accagctcaa
     2281 aatgcagatc caaaacgcaa gatcagagga taagaaaaag gttgcccaga tggtagaagc
     2341 ccgaatccag acccaggaag aaagcaccaa gaagcttcca aacgacagtg atcttaccag
     2401 ccagctgtcc tcagcgcact cgggcacacc ccaaaacaac ggcaacgtgg cccattttga
     2461 ctcagggagc agcaagagtg gcaggataga gacagtcgca cagtccatgc cccagagccc
     2521 gaggccaggg gacagggctc ctagctcacc tctccctggg gtccccaaat ccaggctaga
     2581 gcatgaaact aacaggtatc tgcacggtct gtgtgcaagc accagtgacc ttcacaggaa
     2641 cagatcgcgc acacctatga catttacaac gcacatcgaa gatgtacact cagaacctct
     2701 tttccgaaaa gactttcagc aaatcaaccc tcctcaccgt ggaccacagg cctcgacttt
     2761 gctggcacag ggtcccaggc cccacgcccc cagatactat gtcattaatg aatgtgactc
     2821 ttacaagaaa aaacatctaa atgtctggcc agaaagacat ttcaagatag atgcttcagg
     2881 tgacattgtg gagctgtacc ccaggaacgt gcgacaatat gcatcccggg tcccccgcca
     2941 gcctccctcc ccacagctga gtgaagaaga ggaggagacg ccaagcagag attggatcaa
     3001 acggtctctt cccccacgct ccctgataga cctccgtcgg gctcctcatt tttatattgg
     3061 ggagaggtcc gaaagtcaga cccgggatcc cgagcaccag gggagggtgc actacaagtc
     3121 gtggaatgaa gattttgagg gtcaccttga gaggccagcc tatgtgccca gaaagccacg
     3181 atcccggaat ttccaatacc cacagccccc tctgaagccc agagggaagc ccaggttcga
     3241 gccatccctc acggaatctg actccgtgtc ggcagcatcc agcagtgacc agcagaacag
     3301 cagcgctgac cagtacctgc aggtcaccca cagccagggc aggttcccga ggtccgtggg
     3361 ccagcccagc aggaggaagg ccaagtcggg gcaggagctg accgtggatc tggatgactt
     3421 gatttgttca gatgtctagg cttcctccag tgtcccgttc ctagaggtca ggcccctgtt
     3481 ggagtgctgg gccagcacat ggcatctccc tttctggaaa aagaggtgaa caagtgtgtt
     3541 agagacctga ggggcatggt cagcggctgc tagctgaggc cctgaggctg acagggctac
     3601 agatacctat tctacagcta ctgttagcca aatttatccg agttaggtgg caccaaagta
     3661 tgtcaccagc agtgaatcat cacgggtctg cagcaatctc aatacttgcc tcctcggaag
     3721 aaagaatttg gcagaggggc tcaagacaga aggagagact gaggcaagtt ttagagcagg
     3781 catgaaagtt tactgaaaag ctttaaagca ggaatgaaag aacgtaaaac atacttagta
     3841 gagggccaag caggcgactt gagagatcca gtgcactgtt tgacctttga cttggggttt
     3901 tacacgttgg catgcttccg gggtcttgcg ttgcttctcc ccacgattct tccctttctt
     3961 cccttggggt gggctgtccg catgcgcagt agtggcctgc tagcgctggg gaggggagca
     4021 tgcgcagtgt gtttactgga gttgtgcacg cgctcactcg aggttcttcc cttaccaggg
     4081 gaatgctcca ttttgtctct tagtgcgcat gtttgagccc actcgcccaa ctcctgacat
     4141 tttatgggga agctgccgat caccagtttc aggttttttc tatctattgg gagactgtcg
     4201 ttccctggtg ccagctgtga ccaattatta ttttagagag acaatcagca gccacctgac
     4261 catcacctga tggtcgcctg acattcctgg gggttgtgtt gaagaaggaa ttcatgaatt
     4321 ttacaagtat aatcaaagac aaccaaaaat ttttactttt tccttcaaaa gctaagtgta
     4381 gtgtagctcc cccatagtct aagttaaaga agaacactaa ctgcctgttt ttccttctgt
     4441 gctcagcaag ccttatctgt acttgctagt ttcacattcc ttgaggctca gcgagttcct
     4501 gcttcaccac cctagcgcag ctgcaaagtt acaaggttga tgcagaaaca tggtttccca
     4561 gggatgtgga acatgtagta tagataaatg taaaagactg aacaactgcc tttgctctcg
     4621 cttctgtaag tacgcttcct gcctcgcgta ctcccggcca ccgactgctt aaaaggtggc
     4681 tgctttcttt atccagggct cagactttcc tggacgctag tcctactgag ccaggtgatc
     4741 accttttaat aaagaccttt cctgaactca
//
