LOCUS       NM_138691               5340 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens transmembrane channel like 1 (TMC1), mRNA.
ACCESSION   NM_138691
VERSION     NM_138691.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5340)
  AUTHORS   Zhang,L., Zhu,Q., Wu,Y. and Shi,P.
  TITLE     Heterozygous variants in transmembrane channel-like 1 gene cause
            autosomal recessive nonsyndromic hearing loss
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (7), 134-142 (2024)
   PUBMED   39097884
  REMARK    GeneRIF: Heterozygous variants in transmembrane channel-like 1 gene
            cause autosomal recessive nonsyndromic hearing loss.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5340)
  AUTHORS   Cho,S.H., Yun,Y., Lee,D.H., Cha,J.H., Lee,S.M., Lee,J., Suh,M.H.,
            Lee,J.H., Oh,S.H., Park,M.K. and Lee,S.Y.
  TITLE     Novel autosomal dominant TMC1 variants linked to hearing loss:
            insight into protein-lipid interactions
  JOURNAL   BMC Med Genomics 16 (1), 320 (2023)
   PUBMED   38066485
  REMARK    GeneRIF: Novel autosomal dominant TMC1 variants linked to hearing
            loss: insight into protein-lipid interactions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5340)
  AUTHORS   Wu,J., Wang,L., Ervin,J.F., Wang,S.J., Soderblom,E., Ko,D. and
            Yan,D.
  TITLE     GABA signaling triggered by TMC-1/Tmc delays neuronal aging by
            inhibiting the PKC pathway in C. elegans
  JOURNAL   Sci Adv 8 (51), eadc9236 (2022)
   PUBMED   36542715
  REMARK    GeneRIF: GABA signaling triggered by TMC-1/Tmc delays neuronal
            aging by inhibiting the PKC pathway in C. elegans.
REFERENCE   4  (bases 1 to 5340)
  AUTHORS   Zeng,B., Xu,H., Tian,Y., Lin,Q., Feng,H., Zhang,Z., Li,S. and
            Tang,W.
  TITLE     A novel splicing variant in the TMC1 gene causes non-syndromic
            hearing loss in a Chinese family
  JOURNAL   Chin Med J (Engl) 135 (21), 2631-2633 (2022)
   PUBMED   35089886
  REMARK    GeneRIF: A novel splicing variant in the TMC1 gene causes
            non-syndromic hearing loss in a Chinese family.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5340)
  AUTHORS   Nishio,S.Y. and Usami,S.I.
  TITLE     Prevalence and clinical features of autosomal dominant and
            recessive TMC1-associated hearing loss
  JOURNAL   Hum Genet 141 (3-4), 929-937 (2022)
   PUBMED   34523024
  REMARK    GeneRIF: Prevalence and clinical features of autosomal dominant and
            recessive TMC1-associated hearing loss.
REFERENCE   6  (bases 1 to 5340)
  AUTHORS   Meyer,C.G., Gasmelseed,N.M., Mergani,A., Magzoub,M.M., Muntau,B.,
            Thye,T. and Horstmann,R.D.
  TITLE     Novel TMC1 structural and splice variants associated with
            congenital nonsyndromic deafness in a Sudanese pedigree
  JOURNAL   Hum Mutat 25 (1), 100 (2005)
   PUBMED   15605408
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5340)
  AUTHORS   Keresztes,G., Mutai,H. and Heller,S.
  TITLE     TMC and EVER genes belong to a larger novel family, the TMC gene
            family encoding transmembrane proteins
  JOURNAL   BMC Genomics 4 (1), 24 (2003)
   PUBMED   12812529
REFERENCE   8  (bases 1 to 5340)
  AUTHORS   Vreugde,S., Erven,A., Kros,C.J., Marcotti,W., Fuchs,H., Kurima,K.,
            Wilcox,E.R., Friedman,T.B., Griffith,A.J., Balling,R., Hrabe De
            Angelis,M., Avraham,K.B. and Steel,K.P.
  TITLE     Beethoven, a mouse model for dominant, progressive hearing loss
            DFNA36
  JOURNAL   Nat Genet 30 (3), 257-258 (2002)
   PUBMED   11850623
REFERENCE   9  (bases 1 to 5340)
  AUTHORS   Kurima,K., Peters,L.M., Yang,Y., Riazuddin,S., Ahmed,Z.M., Naz,S.,
            Arnaud,D., Drury,S., Mo,J., Makishima,T., Ghosh,M., Menon,P.S.,
            Deshmukh,D., Oddoux,C., Ostrer,H., Khan,S., Riazuddin,S.,
            Deininger,P.L., Hampton,L.L., Sullivan,S.L., Battey,J.F. Jr.,
            Keats,B.J., Wilcox,E.R., Friedman,T.B. and Griffith,A.J.
  TITLE     Dominant and recessive deafness caused by mutations of a novel
            gene, TMC1, required for cochlear hair-cell function
  JOURNAL   Nat Genet 30 (3), 277-284 (2002)
   PUBMED   11850618
  REMARK    GeneRIF: role of mutations causing dominant and recessive deafness
REFERENCE   10 (bases 1 to 5340)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY031448.1, AF417578.1,
            AL591662.6, BC114449.1 and AL162416.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 3, 2019 this sequence version replaced NM_138691.2.
            
            Summary: This gene is considered a member of a gene family
            predicted to encode transmembrane proteins. The specific function
            of this gene is unknown; however, it is known to be required for
            normal function of cochlear hair cells. Mutations in this gene have
            been associated with progressive postlingual hearing loss and
            profound prelingual deafness. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297784.10/ ENSP00000297784.6
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               HY031448.1         2-194
            194-514             AF417578.1         1-321
            515-537             AL591662.6         22144-22166
            538-969             AF417578.1         345-776
            970-974             BC114449.1         277-281
            975-3394            AF417578.1         782-3201
            3395-5340           AL162416.13        41056-43001
FEATURES             Location/Qualifiers
     source          1..5340
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.13"
     gene            1..5340
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /note="transmembrane channel like 1"
                     /db_xref="GeneID:117531"
                     /db_xref="HGNC:HGNC:16513"
                     /db_xref="MIM:606706"
     exon            1..306
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            307..428
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            429..538
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            539..681
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            682..749
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     CDS             734..3016
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /note="transmembrane, cochlear expressed, 1; transmembrane
                     cochlear-expressed protein 1"
                     /codon_start=1
                     /product="transmembrane channel-like protein 1"
                     /protein_id="NP_619636.2"
                     /db_xref="CCDS:CCDS6643.1"
                     /db_xref="GeneID:117531"
                     /db_xref="HGNC:HGNC:16513"
                     /db_xref="MIM:606706"
                     /translation="MSPKKVQIKVEEKEDETEESSSEEEEEVEDKLPRRESLRPKRKR
                     TRDVINEDDPEPEPEDEETRKAREKERRRRLKRGAEEEEIDEEELERLKAELDEKRQI
                     IATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKRWFAFKMMMAKKWAKFLRDF
                     ENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWG
                     LPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLS
                     YFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNK
                     FNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQE
                     FAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALL
                     LGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSENSTGPPFFVHPA
                     DVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYP
                     SYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEA
                     RVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLE
                     HDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMQALE
                     NKMRNKKMAAARAAAAAGRQ"
     exon            750..797
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            798..969
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1095
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1186
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1268
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1375
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1474
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1617
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1762
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1957
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2137
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2299
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2428
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2496
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2736
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2862
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2941
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..2993
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..5340
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5146..5151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /note="hexamer: AATAAA"
     polyA_site      5171
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /note="major polyA site"
     regulatory      5312..5317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /note="hexamer: AATAAA"
     polyA_site      5340
                     /gene="TMC1"
                     /gene_synonym="DFNA36; DFNB11; DFNB7"
                     /note="major polyA site"
ORIGIN      
        1 gatggcgcgc gactgtttcc catctactca gaggctgagg cgggagaatc gcttgaaccc
       61 ggaaggcgga ggttgcagtg agctgaaatc acgccattgc gctccagcct gggtgacaga
      121 gcaagactcc gtcacaaaaa aaaaaagaaa aaagaaacac cagttttctg atttcaccga
      181 agacctactg cctcagaaac tatgagggca gaacccagca atctgtgctt tctttcacaa
      241 gccctccagg agttgctgaa atttaggaat cattgcccca aaaagtggcc ctcataatga
      301 tgccagatgg gatcttactc tgttgcccag gctggagtgc agtggtgcga tctcggctct
      361 ctgcaacctc cgcctcccag gttcaagtga ttctcctgcc tcggcctcct gagtagctgg
      421 gatttcaggc catgaaagat cactgtttta gtctgcgtgg tgcagtggaa cagatagacc
      481 tcggtttgaa tctcagctct actgtttact agacatgaaa tggggaaatc taaaatgaga
      541 tgccagaagc ctcaaaaatg gaaaaccccc tgtgcttcac atctgaaaat ctctgctggg
      601 ggcagcaact ttgagcctgt ggggaaggaa ctgtccacgt ggagtggtct ggtgaatgct
      661 taaggagctg cagaagggaa gtccctctcc aaactagcca gccactgaga ccttctgaca
      721 ggacaccccc aggatgtcac ccaaaaaagt acaaatcaaa gtggaggaaa aagaagacga
      781 gactgaggaa agctcaagtg aagaggaaga ggaggtggaa gataagctac ctcgaagaga
      841 gagcttgaga ccaaagagga aacggaccag agatgttatc aatgaggatg acccagaacc
      901 tgaaccagag gatgaagaaa caaggaaggc aagagaaaaa gagaggagga ggaggctaaa
      961 gagaggagca gaagaagaag aaattgatga agaggaattg gaaagattga aggcagagtt
     1021 agatgagaaa agacaaataa ttgctactgt caaatgcaaa ccatggaaga tggagaagaa
     1081 aattgaagtt ctcaaggagg caaaaaaatt tgtgagtgaa aatgaagggg ctcttgggaa
     1141 aggaaaagga aaacggtggt ttgcatttaa gatgatgatg gccaagaaat gggcaaaatt
     1201 cctccgtgat tttgagaact tcaaagctgc gtgtgtccca tgggaaaata aaatcaaggc
     1261 tattgaaagt cagtttggct cctcagtggc ctcatacttc ctcttcttga gatggatgta
     1321 tggagtcaat atggttctct ttatcctgac atttagcctc atcatgttgc cagagtacct
     1381 ctggggtttg ccatatggca gtttacctag gaaaaccgtt cccagagccg aagaggcatc
     1441 ggcagcaaac tttggtgtgt tgtacgactt caatggtttg gcacaatatt ccgttctctt
     1501 ttatggctat tatgacaata aacgaacaat tggatggatg aatttcaggt tgccgctctc
     1561 ctattttcta gtggggatta tgtgcattgg atacagcttt ctggttgtcc tcaaagcaat
     1621 gaccaaaaac attggtgatg atggaggtgg agatgacaac actttcaatt tcagctggaa
     1681 ggtctttacc agctgggact acctgatcgg caatcctgaa acagcagaca acaaatttaa
     1741 ttctatcaca atgaacttta aggaagctat cacagaagaa aaagcagccc aagtagaaga
     1801 aaacgtccac ttgatcagat tcctgaggtt tctggctaac ttcttcgtgt ttctaacact
     1861 tggagggagt ggatacctca tcttttgggc tgtgaagcga tcccaggaat ttgcacagca
     1921 agatcctgac acccttgggt ggtgggaaaa aaatgaaatg aacatggtta tgtccctcct
     1981 agggatgttc tgtccaacat tgtttgactt atttgctgaa ttagaagact accatcctct
     2041 catcgctttg aaatggctac tgggacgcat ttttgctctt cttttaggca atttatacgt
     2101 atttattctt gcattaatgg atgagattaa caacaagatt gaagaggaga agctagtaaa
     2161 ggccaatatt accctttggg aagccaatat gatcaaggcc tacaatgcat cattctctga
     2221 aaatagcact ggaccaccct tttttgttca ccctgcagat gtacctcgag gaccttgctg
     2281 ggaaacaatg gtgggacagg agtttgtgag gctgacagtc tctgatgttc tgaccaccta
     2341 cgtcacaatc ctcattgggg actttctaag ggcatgtttt gtgaggtttt gcaattattg
     2401 ctggtgctgg gacttggagt atggatatcc ttcatacacc gaattcgaca tcagtggcaa
     2461 cgtcctcgct ctgatcttca accaaggcat gatctggatg ggctccttct ttgctcccag
     2521 cctcccaggc atcaatatcc ttcgactcca tacatccatg tacttccagt gctgggccgt
     2581 tatgtgctgc aatgttcctg aggccagggt cttcaaagct tccagatcaa ataacttcta
     2641 cctgggcatg ctactgctca tcctcttcct gtccacaatg cctgtcttgt acatgatcgt
     2701 gtccctccca ccatcttttg attgtggtcc attcagtggc aaaaatagaa tgtttgaagt
     2761 cattggagag accctggagc acgatttccc aagctggatg gcgaagatct tgagacagct
     2821 ttcaaaccct gggctggtca ttgctgtcat tttggtgatg gttttggcca tctattatct
     2881 caatgctact gccaagggcc agaaggcagc gaatctggat ctcaaaaaga agatgaaaat
     2941 gcaagctttg gagaacaaaa tgcgaaacaa gaaaatggca gctgcacgag cagctgcagc
     3001 tgctggtcgc cagtaataag tatcctgaga gcccagaaaa ggtacacttt gccttgctgt
     3061 ttaaaagtaa tgcaatatgt gaacgcccag agaacaagca ctgtggaact gctattttcc
     3121 tgttctaccc ttgatggatt ttcaaggtca tgctggccaa ttaaggcatc atcagtccta
     3181 cctgagcaac aagaatctaa actttattcc aagtcagaaa ctgtttctgc agagccactc
     3241 tctcccctgc tccatttcgt gacttttttt ttttttttaa caaattgagt ttagaagtga
     3301 gtgtaatcca gcaatacagt ttactggttt agttggtggg ttaattaaaa aaaatttgct
     3361 catatgaact ttcattttat atgtttcttt tgcctgagtt tccttaaact gagagcagaa
     3421 atatttcacc ctttttcctc taagttcaga aatatttgca aaaagtactc attgtaatca
     3481 ttcattaact cactttttga aaccaatacc ttattttctc tttttttcta cctgtctccc
     3541 caaccacgcg ccccacaaat atattcctaa aacctttgta tttggtgctg gattcagtat
     3601 gaaaagaaat agggttttta gaagaaaaaa aaatcctata tgaattgggg cctggatagc
     3661 actgagttga agatcttgaa gatctcttac tttgagaagg tacatgagtc ttacacaacc
     3721 tagcttttta tgagataaaa ttaaaaaaaa aaggaaagac atcataaatg actgttgttc
     3781 tctcacagtc tgctcatttg tcttccaatg atcatgttat cagtggtgaa tccatacagg
     3841 tctgcatcaa actcgataca attcttgcct ccttggaggg aagaattcag ctgaggggca
     3901 gaagtaggtt tatggcagag ggagagaatg aggcaagttt tagagcagga gtgtaggttt
     3961 attaaaaagt tttacagcag gaacaaaagg aaataaaata tacttggaag agagccaagt
     4021 gggcaaattg agagttccaa gtgccctgtt cagctttgac ctgggtttct atacactggc
     4081 atggttctgg agtttgcatc tctccccgct tgattttttt ggcggatggg ctgtccgtgt
     4141 ggatggtggc ctgccggcag ttggaaggag ctatgtgtac aatgtgttac tgaagttgtg
     4201 tgcctgctca cttgtgacgt tttcccttac catccagcgt tcctggagga aggtcatata
     4261 ctagttaaac tctgccattt tgcttagtgg gcatgcttga gcccacttgc ccaactccta
     4321 agatctccgg ctcaggtgtt ttctatctat tgggagactg tctttcccta gcactggttg
     4381 ccactaatta ttattttaga gagatagttt aaccaccacc tgaccatcac caaatggtca
     4441 cctgacattc ctgtgggatg ggtggtgggg ggcctctctt gccctgctta tgtttttatg
     4501 tttgcctaac tacctactct aacaatcata tcctgtaagc ttggattcta atgttctata
     4561 atttttttct ttgctttttt tgttaaggtc aggaaaacac acttctgttg ggggccttaa
     4621 tttatagata tgtttaagca ttattatgga tttacagttt gaattgactt taagtagtaa
     4681 cactcagtgc cctcactagc cttgttgtgc gactttaatt gcatagctta actcagtgtg
     4741 cctttccaaa actaagccaa tttgcttgcc attccctgca gttgacttac tgatttctat
     4801 tatcctgtct ctgagtttct cattcttttt gatcaccaaa aggcagccat agaataatcg
     4861 cactgtttcc ctgccagttc taaactttat tcctctggtt gtctttttca gattgacttc
     4921 cattctcaat cttatcactc cctttttagg attccttggg ctcttatgtc tgtaattcag
     4981 agtctattat ttatattgat tttcatgtga cttgtaatgg ttccttatta ttttttgatg
     5041 catggattat ctttcttgtc cttattgtaa attctctgtg agcaggggtt gtatcttcta
     5101 actcttttgt atgcctagta tagtgctgtg cacaagtagg cgctgaataa atgcttgcta
     5161 attaaattga atcaatttaa cttacagcaa ttgtgttatg agacaaaaac ttctgttacc
     5221 tgcatgaaaa cattttacta tgatgtaaga aatggattat ctgttgatag gctgagttta
     5281 ttgtttaatt agattataat gcagatgagt aaataaagct agtgtttatt tctacttgga
//
