LOCUS       NM_018352               1749 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens translation machinery associated 16 homolog (TMA16),
            mRNA.
ACCESSION   NM_018352
VERSION     NM_018352.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1749)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU159489.1, BC011842.2, BX370094.1, AW518118.1 and AA772718.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018352.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002046.1, SRR5189655.168471.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358572.10/ ENSP00000351380.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               BU159489.1         170-625
            457-638             BC011842.2         443-624
            639-1179            BX370094.1         61-601
            1180-1622           AW518118.1         7-449               c
            1623-1749           AA772718.1         6-132               c
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.2"
     gene            1..1749
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /note="translation machinery associated 16 homolog"
                     /db_xref="GeneID:55319"
                     /db_xref="HGNC:HGNC:25638"
     exon            1..115
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..724
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /note="UPF0534 protein C4orf43"
                     /codon_start=1
                     /product="translation machinery-associated protein 16"
                     /protein_id="NP_060822.2"
                     /db_xref="CCDS:CCDS43278.1"
                     /db_xref="GeneID:55319"
                     /db_xref="HGNC:HGNC:25638"
                     /translation="MPKAPKGKSAGREKKVIHPYSRKAAQITREAHKQEKKEKLKNEK
                     ALRLNLVGEKLQWFQNHLDPQKKRYSKKDACELIERYLNRFSSELEQIELHNSIRDRQ
                     GRRHCSRETVIKQTMERERQQFEGYGLEIPDILNASNLKTFREWDFDLKKLPNIKMRK
                     ICANDAIPKTCKRKTIITVDQDLGELELNDESSDSDEEMTAVA"
     exon            116..228
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /inference="alignment:Splign:2.1.0"
     exon            229..266
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /inference="alignment:Splign:2.1.0"
     exon            267..351
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /inference="alignment:Splign:2.1.0"
     exon            352..500
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /inference="alignment:Splign:2.1.0"
     exon            501..543
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1749
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      749..754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /note="hexamer: AATAAT"
     polyA_site      771
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /note="major polyA site"
     regulatory      1725..1730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
                     /note="hexamer: AATAAA"
     polyA_site      1749
                     /gene="TMA16"
                     /gene_synonym="C4orf43"
ORIGIN      
        1 aggcgccacg tgggattcgg cccgggtgct cttgtgagct gctgctcctg cggttggtga
       61 gattacctgg gtctagagtg cggagctgct ccgtggccac gaggacgtca ccatgcccaa
      121 agcaccaaag ggaaaaagtg caggacggga aaaaaaagtc atccatccat atagtagaaa
      181 agcagctcaa attacgagag aggcccacaa acaagaaaaa aaggaaaaat tgaagaatga
      241 aaaggccttg cgtctcaacc ttgttggtga aaaactgcaa tggtttcaaa atcatcttga
      301 tccccaaaaa aagagatatt caaagaaaga tgcttgtgaa ctaattgaaa ggtacttaaa
      361 tcgattcagc agtgagctgg agcagattga gttacataac agtatcaggg acaggcaggg
      421 gaggcggcac tgttcccggg agaccgtcat caagcagacg atggagcggg agcgacagca
      481 gtttgaggga tatggccttg agattccaga cattctaaat gcaagtaatc tgaaaacatt
      541 tagggaatgg gactttgatc tgaagaaatt accaaacatt aaaatgagaa aaatttgcgc
      601 taatgatgca attcccaaga cgtgcaagag gaaaactatt ataactgtag accaagattt
      661 gggggaattg gaactaaacg atgaatcaag tgattcagat gaggaaatga ctgcagtggc
      721 ctaattgtct tcacttgaat tgaaaataaa taatttgaga gcttcaaatt atattcattg
      781 attatggtac ctaattgtca tgatacaaaa atttgatact gacattctct tatatgatga
      841 gagtttcatt tgcgtttcaa aaatggtgtt atgatactta ttttaaaatg aagattgctt
      901 ttcatttcca ttaagttgct aaaatagata gatgtgatct gcagaagttg tttagtcttc
      961 atctgaattt caggctggga gggagcaata taactaagga caaaaaatgt tttgtttttc
     1021 ttgtgtattt atgatcacct aatttcacgt tttgtgaaat ggacagtaac ctgtttcctg
     1081 aaagattcct gtgggtactt tttgagctgt gataatagca aaattgtttt tcggtaataa
     1141 tatcacacta atgcttcttt taaacattaa acctattttc cttttttaca gaataaggga
     1201 aaatgtgata agaagtttgt atacatttct ggattataga ttattattta tcttttgaac
     1261 cagagctaaa tggtaaaaga aaaaaaatca gtgatgattg ttatgttgat ctcccacaat
     1321 taatttatct tttgacaaag gggataaaga gtttcagttt agctcctttt gattgtatat
     1381 tattttttgc ttttttattg tgaaaagagg taggttttat ttgtggagag agagttgaag
     1441 attagggaac cagtgatttt aattatgcta ctttttcttc taagagataa attgatatat
     1501 cattcagtgt catgaaaaac atgaatgttg tacaattttc ttcctcaaaa aactttttaa
     1561 atgtaagtat ccttattttt tttttaaaag agcacaatgt aggtgtattt gagtattttc
     1621 aagaaaagaa taaaaacatt aatgcagtat taggttaact ggatatcaac taagccttgt
     1681 taacagttaa agtattataa ctttttttac ttctgaaaat taaaaataaa atttatttct
     1741 gcaatttca
//
