LOCUS       NM_014742               3768 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane 9 superfamily member 4 (TM9SF4),
            transcript variant 1, mRNA.
ACCESSION   NM_014742
VERSION     NM_014742.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3768)
  AUTHORS   Meng,Z., Li,Z., Xie,M., Yu,H., Jiang,L. and Yao,X.
  TITLE     TM9SF4 is an F-actin disassembly factor that promotes tumor
            progression and metastasis
  JOURNAL   Nat Commun 13 (1), 5728 (2022)
   PUBMED   36175399
  REMARK    GeneRIF: TM9SF4 is an F-actin disassembly factor that promotes
            tumor progression and metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3768)
  AUTHORS   Xie,M., Mak,J.W.Y., Yu,H., Cheng,C.T.Y., Chan,H.C.H., Chan,T.T.,
            Lau,L.H.S., Wong,M.T.L., Ko,W.H., Jiang,L. and Yao,X.
  TITLE     TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in
            Inflammatory Bowel Disease
  JOURNAL   Cell Mol Gastroenterol Hepatol 14 (2), 245-270 (2022)
   PUBMED   35398597
  REMARK    GeneRIF: TM9SF4 Is a Crucial Regulator of Inflammation and ER
            Stress in Inflammatory Bowel Disease.
REFERENCE   3  (bases 1 to 3768)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3768)
  AUTHORS   Zhu,Y., Xie,M., Meng,Z., Leung,L.K., Chan,F.L., Hu,X., Chi,K.,
            Liu,C. and Yao,X.
  TITLE     Knockdown of TM9SF4 boosts ER stress to trigger cell death of
            chemoresistant breast cancer cells
  JOURNAL   Oncogene 38 (29), 5778-5791 (2019)
   PUBMED   31249383
  REMARK    GeneRIF: results uncovered a novel role of TM9SF4 proteins in
            alleviating endoplasmic reticulum stress and protecting
            chemoresistant breast cancer cells from apoptotic/necrotic cell
            death
REFERENCE   5  (bases 1 to 3768)
  AUTHORS   Vernay,A., Lamrabet,O., Perrin,J. and Cosson,P.
  TITLE     TM9SF4 levels determine sorting of transmembrane domains in the
            early secretory pathway
  JOURNAL   J Cell Sci 131 (21) (2018)
   PUBMED   30301779
  REMARK    GeneRIF: Results show that TM9SF4 controls the sorting of TMDs at
            the ER-Golgi interface. Remarkably, sorting of T-R1 in HCT116 cells
            was different from that in HEK cells: in HCT116 cells, a
            substantial fraction of T-R1 was localized to the Golgi complex,
            and it was relocated to the ER by genetic ablation of TM9SF4.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3768)
  AUTHORS   Lozupone,F., Borghi,M., Marzoli,F., Azzarito,T., Matarrese,P.,
            Iessi,E., Venturi,G., Meschini,S., Canitano,A., Bona,R., Cara,A.
            and Fais,S.
  TITLE     TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor
            pH alterations associated with drug resistance and invasiveness of
            colon cancer cells
  JOURNAL   Oncogene 34 (40), 5163-5174 (2015)
   PUBMED   25659576
  REMARK    GeneRIF: Our study shows for the first time the important role of
            TM9SF4 in the aberrant constitutive activation of the V-ATPase, and
            the development of a malignant phenotype.
REFERENCE   7  (bases 1 to 3768)
  AUTHORS   Paolillo,R., Spinello,I., Quaranta,M.T., Pasquini,L., Pelosi,E., Lo
            Coco,F., Testa,U. and Labbaye,C.
  TITLE     Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved
            in Cell Adhesion of Leukemic Cells
  JOURNAL   PLoS One 10 (5), e0126968 (2015)
   PUBMED   25961573
  REMARK    GeneRIF: TM9SF4 is a direct target of HIF-1alpha, down-regulated in
            leukemic cells by hypoxia and involved in cell adhesion.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3768)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   9  (bases 1 to 3768)
  AUTHORS   Lozupone,F., Perdicchio,M., Brambilla,D., Borghi,M., Meschini,S.,
            Barca,S., Marino,M.L., Logozzi,M., Federici,C., Iessi,E., de
            Milito,A. and Fais,S.
  TITLE     The human homologue of Dictyostelium discoideum phg1A is expressed
            by human metastatic melanoma cells
  JOURNAL   EMBO Rep 10 (12), 1348-1354 (2009)
   PUBMED   19893578
  REMARK    GeneRIF: TM9SF4 is a new marker of malignancy, representing a
            potential new target for anti-tumour strategies with a specific
            role in tumour cannibalism and in the establishment of a metastatic
            phenotype.
REFERENCE   10 (bases 1 to 3768)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC381660.1, BC021107.1, D87444.1 and BM976438.1.
            
            On May 17, 2019 this sequence version replaced NM_014742.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.112811.1,
                                           SRR1803612.622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398022.7/ ENSP00000381104.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DC381660.1         209-224
            17-2064             BC021107.1         1-2048
            2065-3766           D87444.1           2327-4028
            3767-3768           BM976438.1         21-22               c
FEATURES             Location/Qualifiers
     source          1..3768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..3768
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /note="transmembrane 9 superfamily member 4"
                     /db_xref="GeneID:9777"
                     /db_xref="HGNC:HGNC:30797"
                     /db_xref="MIM:617727"
     exon            1..42
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1956
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; dinucleotide oxidase disulfide thiol exchanger
                     3 superfamily member 4; transmembrane 9 superfamily
                     protein member 4; tumor cannibalism associated protein 1"
                     /codon_start=1
                     /product="transmembrane 9 superfamily member 4 isoform 1
                     precursor"
                     /protein_id="NP_055557.2"
                     /db_xref="CCDS:CCDS13196.2"
                     /db_xref="GeneID:9777"
                     /db_xref="HGNC:HGNC:30797"
                     /db_xref="MIM:617727"
                     /translation="MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKA
                     VKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEV
                     LCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKD
                     VQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLED
                     LKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDV
                     QIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDV
                     FRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVF
                     GGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
                     ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGI
                     LPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYR
                     WWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPSLLYFGYTALMVLSFWLLTGTIG
                     FYAAYMFVRKIYAAVKID"
     exon            43..156
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            157..256
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            257..425
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..555
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..679
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..798
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            799..910
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..981
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1114
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1196
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1272
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1356
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1532
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1596
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1716
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1806
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..3768
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2033..2038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /note="hexamer: AATAAA"
     polyA_site      2064
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
     regulatory      3747..3752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /note="hexamer: AATAAA"
     polyA_site      3768
                     /gene="TM9SF4"
                     /gene_synonym="dJ836N17.2"
                     /note="major polyA site"
ORIGIN      
        1 gtcattacgg cgacacgtgg atccaagatg gcgacggcga tggattggtt gccgtggtct
       61 ttactgcttt tctccctgat gtgtgaaaca agcgccttct atgtgcctgg ggtcgcgcct
      121 atcaacttcc accagaacga tcccgtagaa atcaaggctg tgaagctcac cagctctcga
      181 acccagctac cttatgaata ctattcactg cccttctgcc agcccagcaa gataacctac
      241 aaggcagaga atctgggaga ggtgctgaga ggggaccgga ttgtcaacac ccctttccag
      301 gttctcatga acagcgagaa gaagtgtgaa gttctgtgca gccagtccaa caagccagtg
      361 accctgacag tggagcagag ccgactcgtg gccgagcgga tcacagaaga ctactacgtc
      421 cacctcattg ctgacaacct gcctgtggcc acccggctgg agctctactc caaccgagac
      481 agcgatgaca agaagaagga aaaagatgtg cagtttgaac acggctaccg gctcggcttc
      541 acagatgtca acaagatcta cctgcacaac cacctctcat tcatccttta ctatcatcgg
      601 gaggacatgg aagaggacca ggagcacacg taccgtgtcg tccgcttcga ggtgattccc
      661 cagagcatca ggctggagga cctcaaagca gatgagaaga gttcgtgcac tctgcctgag
      721 ggtaccaact cctcgcccca agaaattgac cccaccaagg agaatcagct gtacttcacc
      781 tactctgtcc actgggagga aagtgatatc aaatgggcct ctcgctggga cacttacctg
      841 accatgagtg acgtccagat ccactggttt tctatcatta actccgttgt tgtggtcttc
      901 ttcctgtcag gtatcctgag catgattatc attcggaccc tccggaagga cattgccaac
      961 tacaacaagg aggatgacat tgaagacacc atggaggagt ctgggtggaa gttggtgcac
     1021 ggcgacgtct tcaggccccc ccagtacccc atgatcctca gctccctgct gggctcaggc
     1081 attcagctgt tctgtatgat cctcatcgtc atctttgtag ccatgcttgg gatgctgtcg
     1141 ccctccagcc ggggagctct catgaccaca gcctgcttcc tcttcatgtt catgggggtg
     1201 tttggcggat tttctgctgg ccgtctgtac cgcactttaa aaggccatcg gtggaagaaa
     1261 ggagccttct gtacggcaac tctgtaccct ggtgtggttt ttggcatctg cttcgtattg
     1321 aattgcttca tttggggaaa gcactcatca ggagcggtgc cctttcccac catggtggct
     1381 ctgctgtgca tgtggttcgg gatctccctg cccctcgtct acttgggcta ctacttcggc
     1441 ttccgaaagc agccatatga caaccctgtg cgcaccaacc agattccccg gcagatcccc
     1501 gagcagcggt ggtacatgaa ccgatttgtg ggcatcctca tggctgggat cttgcccttc
     1561 ggcgccatgt tcatcgagct cttcttcatc ttcagtgcta tctgggagaa tcagttctat
     1621 tacctctttg gcttcctgtt ccttgttttc atcatcctgg tggtatcctg ttcacaaatc
     1681 agcatcgtca tggtgtactt ccagctgtgt gcagaggatt accgctggtg gtggagaaat
     1741 ttcctagtct ccgggggctc tgcattctac gtcctggttt atgccatctt ttatttcgtt
     1801 aacaagctgg acatcgtgga gttcatcccc tctctcctct actttggcta cacggccctc
     1861 atggtcttgt ccttctggct gctaacgggt accatcggct tctatgcagc ctacatgttt
     1921 gttcgcaaga tctatgctgc tgtgaagata gactgattgg agtggaccac ggccaagctt
     1981 gctccgtcct cggacaggaa gccaccctgc gtgggggact gcaggcacgc aaaataaaat
     2041 aactcctgct cgtttggaat gtaactcctg gcacagtgtt cctggatcct ggggctgcgt
     2101 ggggggcggg agggcctgta gataatcttg cgtttttcgt catcttattc cagttctgtg
     2161 ggggatgagt ttttttgtgg gttgcttttt cttcagtgct aagaaagttc cctccaacag
     2221 gaactctctg acctgtttat tcaggtgtat ttctggtttg gatttttttt tccttctttg
     2281 ttttaacaaa tggatccagg atggataaat ccaccgagat aagggttttg gtcactgtct
     2341 ccacctcagt tcctcagggc tgttggccac cctatgacta actggaagag gacacgccag
     2401 agcttcagtg aggtttccga gcctctccct gcccatcctc accactgagg ccacgacaaa
     2461 gcacagctcc agctcggaca gcaccctcag tgccagccag cctctgccag acctctcttt
     2521 ccctcttctc cccagcctcc tccagggctg cccaaggcag ggtttccagc caggcctcgg
     2581 ggtcatcttt tcaccaggag caaacccaag tcttagttgc tacaagaaaa tcccctggaa
     2641 gtactggggg ccaggttccc cagacagcag gaattgcccc tgttcagagc agccggagtt
     2701 tgctggacca caaggaagaa gagaagagac ttgcagtgaa ctgtttttgt gccaagaaac
     2761 cctggacctg gggccaagta tttcccaagc caagcatcca cttgtctgtg tctgggaagg
     2821 gatggccaag gccgctaggg tccttacccc tcaggatcac tccccagccc tttcctcagg
     2881 aggtaccgct ctccaaggtg tgctagcagt gggccctgcc caacttcagg cagaacaggg
     2941 aggcccagag attacagatc ccctcctgta agtggccagg cattctctcc ctgccctctc
     3001 tggcctctgg ggtcatactc acttctttag ccagccccat cccctccacc ccacacctga
     3061 gttcttgcct cctccttttg gggacaccca aaacactgct tgtgagaagg aagatggaag
     3121 gtaagttctg tcgttctttc cccaatcccc aggaatggac aagaagccaa cttagaaaga
     3181 agggtctcac gtggctggcc tggctcctcc gtagacccct gttcttttca acctctgccc
     3241 acccgtgcat gtcatcacaa acatttgctc ttaagttaca agagaccaca tccacccagg
     3301 gattagggtt caagtagcag ctgctaaccc ttgcaccagc ccttgtggga ctcccaacac
     3361 aagacaaagc tcaggatgct ggtgatgcta ggaagatgtc cctcccctca ctgccccaca
     3421 ttctcccagt ggctctacca gcctcaccca tcaaaccagt gaatttctca atcttgcctc
     3481 acagtgactg cagcgccaag cggcatccac caagcatcaa gttggagaaa agggaaccca
     3541 agcagtagag agcgatattg gagtcttttg ttcattcaaa tcttggattt ttttttttcc
     3601 ctaagagatt ctctttttag ggggaatggg aaacggacac ctcataaagg gttcaaagat
     3661 catcaatttt tctgactttt taaatcatta tcattattat ttttaattaa aaaaatgcct
     3721 gtatgccttt ttttggtcgg attgtaaata aatataccat tgtcctac
//
