LOCUS       NM_020123               6100 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane 9 superfamily member 3 (TM9SF3), mRNA.
ACCESSION   NM_020123
VERSION     NM_020123.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6100)
  AUTHORS   Shen,L., Du,X., Ma,H. and Mei,S.
  TITLE     miR-1193 Suppresses the Proliferation and Invasion of Human T-Cell
            Leukemia Cells Through Directly Targeting the Transmembrane 9
            Superfamily 3 (TM9SF3)
  JOURNAL   Oncol Res 25 (9), 1643-1651 (2017)
   PUBMED   28390114
  REMARK    GeneRIF: Authors confirmed that TM9SF3 was a target gene of
            miR-1193 by luciferase reporter gene assay. Gene overexpression and
            knockdown experiments in Jurkat cells revealed that TM9SF3
            positively regulated cell proliferation and invasion.
REFERENCE   2  (bases 1 to 6100)
  AUTHORS   Oo,H.Z., Sentani,K., Sakamoto,N., Anami,K., Naito,Y., Oshima,T.,
            Yanagihara,K., Oue,N. and Yasui,W.
  TITLE     Identification of novel transmembrane proteins in scirrhous-type
            gastric cancer by the Escherichia coli ampicillin secretion trap
            (CAST) method: TM9SF3 participates in tumor invasion and serves as
            a prognostic factor
  JOURNAL   Pathobiology 81 (3), 138-148 (2014)
   PUBMED   24642718
  REMARK    GeneRIF: TM9SF3 participates in tumor invasion and serves as a
            prognostic factor.
REFERENCE   3  (bases 1 to 6100)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 6100)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 6100)
  AUTHORS   Sugasawa,T., Lenzen,G., Simon,S., Hidaka,J., Cahen,A.,
            Guillaume,J.L., Camoin,L., Strosberg,A.D. and Nahmias,C.
  TITLE     The iodocyanopindolol and SM-11044 binding protein belongs to the
            TM9SF multispanning membrane protein superfamily
  JOURNAL   Gene 273 (2), 227-237 (2001)
   PUBMED   11595169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC136788.1 and AL138765.18.
            
            On Nov 22, 2018 this sequence version replaced NM_020123.3.
            
            Sequence Note: This RefSeq was created from transcript and genomic
            sequence data becuase transcript sequence consistent with the
            reference genome assembly was not available for all regions of the
            RefSeq transcript. The extent of this transcript is supported by
            transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK008789.1, BC136788.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371142.9/ ENSP00000360184.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3488              BC136788.1         41-3528
            3489-6100           AL138765.18        29407-32018         c
FEATURES             Location/Qualifiers
     source          1..6100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..6100
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /note="transmembrane 9 superfamily member 3"
                     /db_xref="GeneID:56889"
                     /db_xref="HGNC:HGNC:21529"
                     /db_xref="MIM:616872"
     exon            1..279
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1947
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /note="endomembrane protein emp70 precursor isolog;
                     dinucleotide oxidase disulfide thiol exchanger 3
                     superfamily member 3; SM-11044-binding protein"
                     /codon_start=1
                     /product="transmembrane 9 superfamily member 3 precursor"
                     /protein_id="NP_064508.3"
                     /db_xref="CCDS:CCDS7450.1"
                     /db_xref="GeneID:56889"
                     /db_xref="HGNC:HGNC:21529"
                     /db_xref="MIM:616872"
                     /translation="MRPLPGALGVAAAAALWLLLLLLPRTRADEHEHTYQDKEEVVLW
                     MNTVGPYHNRQETYKYFSLPFCVGSKKSISHYHETLGEALQGVELEFSGLDIKFKDDV
                     MPATYCEIDLDKEKRDAFVYAIKNHYWYQMYIDDLPIWGIVGEADENGEDYYLWTYKK
                     LEIGFNGNRIVDVNLTSEGKVKLVPNTKIQMSYSVKWKKSDVKFEDRFDKYLDPSFFQ
                     HRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKEEEMDDMDRDLGDEYGWKQ
                     VHGDVFRPSSHPLIFSSLIGSGCQIFAVSLIVIIVAMIEDLYTERGSMLSTAIFVYAA
                     TSPVNGYFGGSLYARQGGRRWIKQMFIGAFLIPAMVCGTAFFINFIAIYYHASRAIPF
                     GTMVAVCCICFFVILPLNLVGTILGRNLSGQPNFPCRVNAVPRPIPEKKWFMEPAVIV
                     CLGGILPFGSIFIEMYFIFTSFWAYKIYYVYGFMMLVLVILCIVTVCVTIVCTYFLLN
                     AEDYRWQWTSFLSAASTAIYVYMYSFYYYFFKTKMYGLFQTSFYFGYMAVFSTALGIM
                     CGAIGYMGTSAFVRKIYTNVKID"
     exon            280..475
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            476..598
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            599..759
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            760..837
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            838..969
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1136
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1231
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1362
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1502
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1571
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1718
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1802
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1879
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..6100
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3206..3211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /note="hexamer: AATAAA"
     polyA_site      3225
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /note="major polyA site"
     regulatory      3511..3516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /note="hexamer: AATAAA"
     polyA_site      3537
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
     regulatory      5278..5283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /note="hexamer: AATAAA"
     polyA_site      5305
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
     regulatory      6083..6088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
                     /note="hexamer: AATAAA"
     polyA_site      6100
                     /gene="TM9SF3"
                     /gene_synonym="EP70-P-iso; SMBP"
ORIGIN      
        1 aggagcgggc ggtgacggcg acggcggcgg cagaggaggc agcggctggg ccgggccccg
       61 tgcgtctgtc cgcgccccgt ggatgcgaat cggccgcggc ggaggcggcg gcggcggagg
      121 aggcggcggc gggaggagga gtcggtgagc cggctccggg ccggaggggc gcggaggatg
      181 aggccgctgc ctggcgctct tggcgtggcg gcggccgccg cgctgtggct gctgctgctg
      241 ctgctgcccc ggacccgggc ggacgagcac gaacacacgt atcaagataa agaggaagtt
      301 gtcttatgga tgaatactgt tgggccctac cataatcgtc aagaaacata taagtacttt
      361 tcacttccat tctgtgtggg gtcaaaaaaa agtatcagtc attaccatga aactctggga
      421 gaagcacttc aaggggttga attggaattt agtggtctgg atattaaatt taaagatgat
      481 gtgatgccag ccacttactg tgaaattgat ttagataaag aaaagagaga tgcatttgta
      541 tatgccataa aaaatcatta ctggtaccag atgtacatag atgatttacc aatatggggt
      601 attgttggtg aggctgatga aaatggagaa gattactatc tttggaccta taaaaaactt
      661 gaaataggtt ttaatggaaa tcgaattgtt gatgttaatc taactagtga aggaaaggtg
      721 aaactggttc caaatactaa aatccagatg tcatattcag taaaatggaa aaagtcagat
      781 gtgaaatttg aagatcgatt tgacaaatat cttgatccgt ccttttttca acatcggatt
      841 cattggtttt caattttcaa ctccttcatg atggtgatct tcttggtggg cttagtttca
      901 atgattttaa tgagaacatt aagaaaagat tatgctcggt acagtaaaga ggaagaaatg
      961 gatgatatgg atagagacct aggagatgaa tatggatgga aacaggtgca tggagatgta
     1021 tttagaccat caagtcaccc actgatattt tcctctctga ttggttctgg atgtcagata
     1081 tttgctgtgt ctctcatcgt tattattgtt gcaatgatag aagatttata tactgagagg
     1141 ggatcaatgc tcagtacagc catatttgtc tatgctgcta cgtctccagt gaatggttat
     1201 tttggaggaa gtctgtatgc tagacaagga ggaaggagat ggataaagca gatgtttatt
     1261 ggggcattcc ttatcccagc tatggtgtgt ggcactgcct tcttcatcaa tttcatagcc
     1321 atttattacc atgcttcaag agccattcct tttggaacaa tggtggccgt ttgttgcatc
     1381 tgtttttttg ttattcttcc tctaaatctt gttggtacaa tacttggccg aaatctgtca
     1441 ggtcagccca actttccttg tcgtgtcaat gctgtgcctc gtcctatacc ggagaaaaaa
     1501 tggttcatgg agcctgcggt tattgtttgc ctgggtggaa ttttaccttt tggttcaatc
     1561 tttattgaaa tgtatttcat cttcacgtct ttctgggcat ataagatcta ttatgtctat
     1621 ggcttcatga tgctggtgct ggttatcctg tgcattgtga ctgtctgtgt gactattgtg
     1681 tgcacatatt ttctactaaa tgcagaagat taccggtggc aatggacaag ttttctctct
     1741 gctgcatcaa ctgcaatcta tgtttacatg tattcctttt actactattt tttcaaaaca
     1801 aagatgtatg gcttatttca aacatcattt tactttggat atatggcggt atttagcaca
     1861 gccttgggga taatgtgtgg agcgattggt tacatgggaa caagtgcctt tgtccgaaaa
     1921 atctatacta atgtgaaaat tgactagaga cccaagaaaa cctggaactt tggatcaatt
     1981 tctttttcat aggggtggaa cttgcacagc aaaaacaaac aaacgcaaga agagatttgg
     2041 gctttaacac actgggtact ttgtgggtct ctctttcgtc ggtggcttaa agtaacatct
     2101 atttccattg atcctaggtt cttcctgact gctttctcca actgttcaca gcaaatgctt
     2161 ggattttatg cagtaggcat tactacagta catggctaat cttcccaaaa actagctcat
     2221 taaagatgaa atagaccagc tctcttcagt gaagaggaca aatagtttat ttaaagcatt
     2281 tgttccaata aaataaatag agggaaactt ggatgctaaa attacatgaa taggaatctt
     2341 cctggcactt agtgtttcta tgttattgaa aaatgatgtt ccagaaagat tacttttttc
     2401 ctcttatttt tactgccatt gtcgacctat tgtgggacat ttttatatat tgaatctggg
     2461 ttcttttttg actttttttt tttcccaatc caacagcatc ctttttttta aaagagagaa
     2521 ttagaaaata ttaaatcctg catgtaatat atctgctgtc atcttagttg gaccaacttc
     2581 ccatttattt atcttaaaac tatacagtta catcttaatt ccatccaaag aagatacagt
     2641 ttgaagacag aagtgtactc tctacaatgc aatttactgt acagttagaa agcaaagtgt
     2701 taaatggaga agatacttgt ttttattaaa cattttgaga tttagataaa ctacatttta
     2761 actgaatgtc taaagtgatt atcttttttc cccccaagtt agtcttaaat cttttgggtt
     2821 tgaatgaagg ttttacataa gaaattatta aaaacaaggg gggtgggtaa taaatgtata
     2881 taacattaaa taatgtaacg taggtgtaga ttcccaaatg catttggatg tacagatcga
     2941 ctacagagta cttttttctt atgatgattg gtgtagaaat gtgtgatttg ggtgggcttt
     3001 tacatcttgc ctaccattgc atgaaacatt ggggtttctt caaaatgtgt gtgtcatact
     3061 tcttttggga ggggggttgt tttcttctgt ttattttctg agactcctac aggagccaaa
     3121 tttgtaattt agagacactt aattttgtta atcctgtctg ggacacttaa gtaacatcta
     3181 aagcattatt gctttagaat gttcaaataa aatttcctga ccaaattgtt ttgtggaaat
     3241 agatgtgttt gcaatttgaa gatatctttc tgtccagaag gcaaaattac cgaatgccat
     3301 ttttaaaagt atgctataaa ctatgctact ctcatacagg ggacccgtat tttaaaatct
     3361 ccagacttgc ttacatctag attatccagc acaatcataa agtgaatgac aaaccctttg
     3421 aatgaaattg tggcacaaaa tctgttcagg ttggtgtacc gtgtaaagtg gggatggggt
     3481 aaaagtggtt aacgtactgt tggatcaaca aataaaggtt acagttttgt aagagaagtg
     3541 atttgaatac atttttctgg aactattcat aatatgaagt tttcctagaa ccactgagtt
     3601 tctagtttaa tagtttgcta tgcaaatgac cacctaaaac aatactttat attgttattt
     3661 ttagaaagac tcaaaacacc tgtatttaaa ccttaatatg aaaatcatgc aattaatagt
     3721 tacacaagat gttttcatta caaaatatgt acctatctat tgatggactc tacatcctat
     3781 attgtgacat gtaagtcctt taaaaggtga aaagtatgat ttcttaccac ttaagtatga
     3841 ttgatatgat ccaacaaatt tgatcagaag ctgtaggtaa atcctcttct gaagccaaaa
     3901 tggtatatta aatataattt attggtactt ccattttctc ttccttctta cttgccttta
     3961 agatcttata aaaaagaaac taaaagttaa tatttagttg cctatattat gtaacctttt
     4021 aactatatat aaagtacttt tttggtttct ttctcaccac ttttattcaa aagtactttt
     4081 aacataccaa tacatagtct gtctgatggg agtataaatt ggacagtaag gttttgtctt
     4141 aataaaatga aatttgtttc tcatgatatg aatcttgcag gtaagatgta gggtttattg
     4201 aaaatgtgtg ggttaaatgc tttcaggtac accaattctt tctactaaat tgagctctat
     4261 ttgaagttct ttggaatctg tggtgaaaaa taattttctg atttccaaat acattaagag
     4321 cattaaatga atattaatca cctttaaagt cttttagaaa aggacttgta ttggtttttg
     4381 gctgcataga ggggttgaat aagtgtatgt atgtgtgtgc gtgtgtgtgt gtcttcttaa
     4441 agaagatgta attcacaaat agtttagctc cctagcgctc agttgtagaa tagaaaatag
     4501 aacattattc aagttaattg aaaggtgagg tttttatacc cccactaatg ctgtgtatct
     4561 gtctttcgtt tgttaacatt atttgcttaa tttctttcaa ctcacacttt ggataatact
     4621 atcaaaaact aaggctaaac attccttgtg tatctttaag catgcttctc ctgaaattta
     4681 actacattag tagttgacat ttgtatacat atatcctaat acaagagtag gataaggtgg
     4741 aaatgtaatg gcctgaggga tggtgaagca ttcttttagt atttttcatc atgttgggct
     4801 cctagattgt actggggttg cccataaatc aaaccccata ctcttagaat tcattatatt
     4861 atggtgatat ccgaacctag tgaatggtat gcttgggtgt tttccattga gagtggatgg
     4921 acctctttat aaagttggtt gctgcaaaat ccagttcttc caaaagccac tttatttagg
     4981 gtttattcac aagtcatatc cattttggta cagtgtttgt ttcctaatat ttattaacca
     5041 ccttatacca aatgtcttgc aaagaaatgt tattaaaacc ttgaattttt acaaatgtaa
     5101 aaaacaaaaa gtgtattaat gtatttgttc aggaaaagct acataccgaa gggcttttgt
     5161 atatgaattc tgtggtgggg agacccattt gtaatctata tggcagttcc atctgggttt
     5221 taagtttaga tttcaccgtg tcttagtgct tcattctatt ggtttattgg aacatgtaat
     5281 aaataggagt agtgatgtat taaaacacaa gtattcatta atgttttata tcttcactaa
     5341 aattctatag ttatgaaact atcaatcaag gtgttatatt tcagtcagaa gtgaaaattt
     5401 atgaagagta tttggaagtg tgtacagaaa taaactagac ttacaggtag gctagatcag
     5461 aacgttaaca tatgaacctg cagaaatctg gtaagactta aattcagtgt gaggaataac
     5521 tctagttctc tcctatgagc atttcctaaa agccatctga tttggcattc ttactggagc
     5581 tgcagacaga aatctacaaa gacaaaagta aacaaaatta agttattatt ccactgttag
     5641 gaatggaaat aaacttgtga agtctgttta ttttgaagta ttggtgaact aggcttgcta
     5701 attgataact gcagcagttt gtgtttactc cagttcatca gcttaggtca tttgaaagat
     5761 ataagagctt aaggcaagaa agaaataaca tggaattcta tttgaaggac aacagaacat
     5821 tcttggaaaa gcagctccag ttggtttttc aactgtcaaa cttgaatgtg taagtcccca
     5881 cagagcatgg acagtcggtg cagagttcca aggaaacaat tattgcctga tgaccacttc
     5941 cattttgtat acactctttg gttcgtatag gccatattcc aactggcttt ttagtaatag
     6001 aaatccagta tataatgtat caaatacaat tgaggttcta acctagtgtg ttaatttatc
     6061 tgaatttgga tttttaaaaa gtaataaaaa gttaaatgta
//
