LOCUS       NM_006405               2200 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens transmembrane 9 superfamily member 1 (TM9SF1),
            transcript variant 1, mRNA.
ACCESSION   NM_006405
VERSION     NM_006405.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2200)
  AUTHORS   He,P., Peng,Z., Luo,Y., Wang,L., Yu,P., Deng,W., An,Y., Shi,T. and
            Ma,D.
  TITLE     High-throughput functional screening for autophagy-related genes
            and identification of TM9SF1 as an autophagosome-inducing gene
  JOURNAL   Autophagy 5 (1), 52-60 (2009)
   PUBMED   19029833
  REMARK    GeneRIF: The results of transmission electron microscopy and
            immunoblotting to examine LC3-II levels further confirmed the
            ability of TM9SF1 to induce autophagy.
REFERENCE   2  (bases 1 to 2200)
  AUTHORS   Sugasawa,T., Lenzen,G., Simon,S., Hidaka,J., Cahen,A.,
            Guillaume,J.L., Camoin,L., Strosberg,A.D. and Nahmias,C.
  TITLE     The iodocyanopindolol and SM-11044 binding protein belongs to the
            TM9SF multispanning membrane protein superfamily
  JOURNAL   Gene 273 (2), 227-237 (2001)
   PUBMED   11595169
REFERENCE   3  (bases 1 to 2200)
  AUTHORS   Chluba-de Tapia,J., de Tapia,M., Jaggin,V. and Eberle,A.N.
  TITLE     Cloning of a human multispanning membrane protein cDNA: evidence
            for a new protein family
  JOURNAL   Gene 197 (1-2), 195-204 (1997)
   PUBMED   9332367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX161390.1 and AW452952.1.
            
            On Nov 24, 2018 this sequence version replaced NM_006405.6.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.72143.1,
                                           SRR5189652.90010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261789.9/ ENSP00000261789.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2139              BX161390.1         216-2354
            2140-2200           AW452952.1         23-83               c
FEATURES             Location/Qualifiers
     source          1..2200
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..2200
                     /gene="TM9SF1"
                     /gene_synonym="HMP70; MP70"
                     /note="transmembrane 9 superfamily member 1"
                     /db_xref="GeneID:10548"
                     /db_xref="HGNC:HGNC:11864"
                     /db_xref="MIM:618965"
     exon            1..96
                     /gene="TM9SF1"
                     /gene_synonym="HMP70; MP70"
                     /inference="alignment:Splign:2.1.0"
     exon            97..458
                     /gene="TM9SF1"
                     /gene_synonym="HMP70; MP70"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1934
                     /gene="TM9SF1"
                     /gene_synonym="HMP70; MP70"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; multispanning membrane protein (70kD);
                     transmembrane protein 9 superfamily member 1; MP70 protein
                     family member"
                     /codon_start=1
                     /product="transmembrane 9 superfamily member 1 isoform a
                     precursor"
                     /protein_id="NP_006396.2"
                     /db_xref="CCDS:CCDS9617.1"
                     /db_xref="GeneID:10548"
                     /db_xref="HGNC:HGNC:11864"
                     /db_xref="MIM:618965"
                     /translation="MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVIL
                     YVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVE
                     KRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLW
                     THLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSD
                     RRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTS
                     AGSGDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFN
                     VHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWS
                     VVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNI
                     AREIPPQPWYKSTVIHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAIL
                     LSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQT
                     VEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD"
     exon            459..1080
                     /gene="TM9SF1"
                     /gene_synonym="HMP70; MP70"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1266
                     /gene="TM9SF1"
                     /gene_synonym="HMP70; MP70"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1540
                     /gene="TM9SF1"
                     /gene_synonym="HMP70; MP70"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..2200
                     /gene="TM9SF1"
                     /gene_synonym="HMP70; MP70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2180..2185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM9SF1"
                     /gene_synonym="HMP70; MP70"
                     /note="hexamer: AATAAA"
     polyA_site      2200
                     /gene="TM9SF1"
                     /gene_synonym="HMP70; MP70"
                     /note="major polyA site"
ORIGIN      
        1 accgcgccgc tgtgggagag accccagcag gagcccaaag gcagctacgg gggcgcgaag
       61 gccgctggcg ccgcctcggc cagcccttcc cgcgcggttc cactgcctta aggatgacag
      121 tcgtagggaa ccctcgaagt tggagctgcc agtggttgcc aatcctgata ctgttgctgg
      181 gcacaggcca tgggccaggg gtggaaggcg tgacacacta caaggccggc gaccctgtta
      241 ttctgtatgt caacaaagtg ggaccctacc ataaccctca ggaaacttac cactactatc
      301 agcttccagt ctgctgccct gagaagatac gtcacaaaag ccttagcctg ggtgaagtgc
      361 tggatgggga ccgaatggct gagtctttgt atgagatccg ctttcgggaa aacgtggaga
      421 agagaattct gtgccacatg cagctcagtt ctgcacaggt ggagcagctg cgccaggcca
      481 ttgaagaact gtactacttt gaatttgtgg tagatgactt gccaatccgg ggctttgtgg
      541 gctacatgga ggagagtggt ttcctgccac acagccacaa gataggactc tggacccatt
      601 tggacttcca cctagaattc catggagacc gaattatatt tgccaatgtt tcagtgcggg
      661 acgtcaagcc ccacagcttg gatgggttac gacctgacga gttcctaggc cttacccaca
      721 cttatagcgt gcgctggtct gagacttcag tggagcgtcg gagtgacagg cgccgtggtg
      781 acgatggtgg tttctttcct cgaacactgg aaatccattg gttgtccatc atcaactcca
      841 tggtgcttgt gtttttactg gtgggttttg tggctgtcat tctaatgcgt gtgcttcgga
      901 atgacctggc tcggtacaac ttagatgagg agaccacctc tgcaggttct ggtgatgact
      961 ttgaccaggg tgacaatggc tggaaaatta tccatacaga tgtcttccgc ttccccccat
     1021 accgtggtct gctctgtgct gtgcttggcg tgggtgccca gttcctggcc cttggcactg
     1081 gcattattgt catggcactg ctgggcatgt tcaatgtgca ccgtcatggg gccattaact
     1141 cagcagccat cttgttgtat gccctgacct gctgcatctc tggctacgtg tccagccact
     1201 tctaccggca gattggaggc gagcgttggg tgtggaacat cattctcacc accagtctct
     1261 tctctgtgcc tttcttcctg acgtggagtg tggtgaactc agtgcattgg gccaatggtt
     1321 cgacacaggc tctgccagcc acaaccatcc tgctgcttct gacggtttgg ctgctggtgg
     1381 gctttcccct cactgtcatt ggaggcatct ttgggaagaa caacgccagc ccctttgatg
     1441 caccctgtcg caccaagaac atcgcccggg agattccacc ccagccctgg tacaagtcta
     1501 ctgtcatcca catgactgtt ggaggcttcc tgcctttcag tgccatctct gtggagctgt
     1561 actacatctt tgccacagta tggggtcggg agcagtacac tttgtacggc atcctcttct
     1621 ttgtcttcgc catcctgctg agtgtggggg cttgcatctc cattgcactc acctacttcc
     1681 agttgtctgg ggaggattac cgctggtggt ggcgatctgt gctgagtgtt ggctccaccg
     1741 gcctcttcat cttcctctac tcagttttct attatgcccg gcgctccaac atgtctgggg
     1801 cagtacagac agtagagttc ttcggctact ccttactcac tggttatgtc ttcttcctca
     1861 tgctgggcac catctccttt ttttcttccc taaagttcat ccggtatatc tatgttaacc
     1921 tcaagatgga ctgagttctg tatggcagaa ctattgctgt tctctccctt tcttcatgcc
     1981 ctgttgaact ctcctaccag cttctcttct gattgactga attgtgtgat ggcattgttg
     2041 ccttcccttt tgccctttgg gcattccttc cccagagagg gcctggaaat tataaatctc
     2101 tatcacataa ggattatata tttgaacttt ttaagttgcc tttagttttg gtcctgattt
     2161 ttctttttac aattaccaaa ataaaattta ttaagaaaaa
//
