LOCUS       NM_016551               4315 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane 7 superfamily member 3 (TM7SF3), mRNA.
ACCESSION   NM_016551
VERSION     NM_016551.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4315)
  AUTHORS   Isaac,R., Bandyopadhyay,G., Rohm,T.V., Kang,S., Wang,J.,
            Pokhrel,N., Sakane,S., Zapata,R., Libster,A.M., Vinik,Y.,
            Berhan,A., Kisseleva,T., Borok,Z., Zick,Y., Telese,F.,
            Webster,N.J.G. and Olefsky,J.M.
  TITLE     TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver
            fibrosis
  JOURNAL   Cell Metab 36 (5), 1030-1043 (2024)
   PUBMED   38670107
  REMARK    GeneRIF: TM7SF3 controls TEAD1 splicing to prevent MASH-induced
            liver fibrosis.
REFERENCE   2  (bases 1 to 4315)
  AUTHORS   Isaac,R., Goldstein,I., Furth,N., Zilber,N., Streim,S.,
            Boura-Halfon,S., Elhanany,E., Rotter,V., Oren,M. and Zick,Y.
  TITLE     TM7SF3, a novel p53-regulated homeostatic factor, attenuates
            cellular stress and the subsequent induction of the unfolded
            protein response
  JOURNAL   Cell Death Differ 24 (1), 132-143 (2017)
   PUBMED   27740623
  REMARK    GeneRIF: Lack of TM7SF3 activates nitric oxide production and the
            PKR-like ER kinase arm of the unfolded protein response that
            involves inhibition of eIF2alpha activity, enhanced expression of
            ATF4 and ATF3, and induction of CHOP that culminates in apoptosis.
REFERENCE   3  (bases 1 to 4315)
  AUTHORS   Beck,A., Isaac,R., Lavelin,I., Hart,Y., Volberg,T.,
            Shatz-Azoulay,H., Geiger,B. and Zick,Y.
  TITLE     An siRNA screen identifies transmembrane 7 superfamily member 3
            (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of
            cytokine-induced death of pancreatic beta cells
  JOURNAL   Diabetologia 54 (11), 2845-2855 (2011)
   PUBMED   21853325
  REMARK    GeneRIF: Data indicate that TM7SF3 plays a role in inhibition of
            cytokine-induced cell death/apoptosis in pancreatic beta cells and
            in inhibition of insulin secretion from pancreatic beta cells.
REFERENCE   4  (bases 1 to 4315)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 4315)
  AUTHORS   Akashi,H., Han,H.J., Iizaka,M., Nakajima,Y., Furukawa,Y.,
            Sugano,S., Imai,K. and Nakamura,Y.
  TITLE     Isolation and characterization of a novel gene encoding a putative
            seven-span transmembrane protein, TM7SF3
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 305-309 (2000)
   PUBMED   10828615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA719107.1, BC005176.2 and AC024896.23.
            
            On Nov 22, 2018 this sequence version replaced NM_016551.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.40978.1,
                                           SRR1660809.171695.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343028.9/ ENSP00000342322.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                DA719107.1         23-75
            54-2246             BC005176.2         1-2193
            2247-4315           AC024896.23        13907-15975         c
FEATURES             Location/Qualifiers
     source          1..4315
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.23"
     gene            1..4315
                     /gene="TM7SF3"
                     /note="transmembrane 7 superfamily member 3"
                     /db_xref="GeneID:51768"
                     /db_xref="HGNC:HGNC:23049"
                     /db_xref="MIM:605181"
     exon            1..307
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1929
                     /gene="TM7SF3"
                     /note="seven transmembrane protein TM7SF3; seven span
                     transmembrane protein"
                     /codon_start=1
                     /product="transmembrane 7 superfamily member 3 precursor"
                     /protein_id="NP_057635.1"
                     /db_xref="CCDS:CCDS8710.1"
                     /db_xref="GeneID:51768"
                     /db_xref="HGNC:HGNC:23049"
                     /db_xref="MIM:605181"
                     /translation="MGFLQLLVVAVLASEHRVAGAAEVFGNSSEGLIEFSVGKFRYFE
                     LNRPFPEEAILHDISSNVTFLIFQIHSQYQNTTVSFSPTLLSNSSETGTASGLVFILR
                     PEQSTCTWYLGTSGIQPVQNMAILLSYSERDPVPGGCNLEFDLDIDPNIYLEYNFFET
                     TIKFAPANLGYARGVDPPPCDAGTDQDSRWRLQYDVYQYFLPENDLTEEMLLKHLQRM
                     VSVPQVKASALKVVTLTANDKTSVSFSSLPGQGVIYNVIVWDPFLNTSAAYIPAHTYA
                     CSFEAGEGSCASLGRVSSKVFFTLFALLGFFICFFGHRFWKTELFFIGFIIMGFFFYI
                     LITRLTPIKYDVNLILTAVTGSVGGMFLVAVWWRFGILSICMLCVGLVLGFLISSVTF
                     FTPLGNLKIFHDDGVFWVTFSCIAILIPVVFMGCLRILNILTCGVIGSYSVVLAIDSY
                     WSTSLSYITLNVLKRALNKDFHRAFTNVPFQTNDFIILAVWGMLAVSGITLQIRRERG
                     RPFFPPHPYKLWKQERERRVTNILDPSYHIPPLRERLYGRLTQIKGLFQKEQPAGERT
                     PLLL"
     exon            308..462
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     exon            463..613
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     exon            614..734
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     exon            735..906
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1084
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1171
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1252
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1405
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1503
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1666
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..4315
                     /gene="TM7SF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2226..2231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM7SF3"
                     /note="hexamer: ATTAAA"
     polyA_site      2256
                     /gene="TM7SF3"
                     /note="major polyA site"
     regulatory      4292..4297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM7SF3"
                     /note="hexamer: AATAAA"
     polyA_site      4315
                     /gene="TM7SF3"
ORIGIN      
        1 aggtgccgga agaggaaacc tctcgctggg gctaggagtt cggcggggcg cgcgccggcg
       61 gctgcggagc tggcaggtgc gaagcgtctg cacctggcgg gcgatggcgc ccgatgcggg
      121 cgccccggga tagcgtgggc gaggctgcgg ggccccggcg cgcacgcccg cacctctccc
      181 cagccctggc gtgggcccag cccggcccag gcagcaatgg ggttcctgca gctgctggtc
      241 gtagcggtgc tggcatccga acaccgggtg gctggtgcag ccgaggtctt cgggaattcc
      301 agcgagggtc ttattgaatt ttctgtgggg aaatttagat acttcgagct caataggccc
      361 tttccagagg aagctatttt gcatgatatt tcaagcaatg tgacttttct tattttccaa
      421 atacactcac agtatcagaa tacaactgtt tccttttctc cgactctcct ttccaattcc
      481 tcggaaacag gcactgccag tggactggtt ttcatcctta gaccagagca gagtacatgc
      541 acttggtact tggggacttc aggcatacag cctgtccaga atatggctat cctactctcc
      601 tactcagaaa gagatcctgt ccctggaggc tgtaatttgg agttcgattt agatattgat
      661 cccaacattt acttggagta taatttcttt gaaacgacta tcaagtttgc cccagcaaac
      721 ctaggctatg cgagaggcgt agatccccca ccatgtgacg ctgggacaga ccaggactcc
      781 aggtggaggt tgcagtatga tgtctatcag tattttctgc ctgagaatga cctcactgag
      841 gagatgttgc tgaagcatct gcagaggatg gtcagtgtgc cccaggtgaa ggccagtgct
      901 ctcaaggtgg ttaccctaac agctaatgat aagacaagtg tttccttctc ctccctcccg
      961 ggacaaggtg tcatatacaa tgtcattgtt tgggacccgt ttctaaatac atctgctgcc
     1021 tacattcctg ctcacacata cgcttgcagc tttgaggcag gagagggtag ttgtgcttcc
     1081 ctaggaagag tgtcttccaa agtgttcttc actctttttg ccctgcttgg tttcttcatt
     1141 tgtttctttg gacacagatt ctggaaaaca gaattattct tcataggctt tatcatcatg
     1201 ggattcttct tttatatact gattacaaga ctgacaccta tcaagtatga tgtgaatctg
     1261 attctgacag ctgtcactgg aagcgtcggt ggaatgttct tggtagctgt gtggtggcga
     1321 tttggaatcc tctcgatctg catgctctgt gttggactag tgctggggtt cctcatctcg
     1381 tcagtgactt tctttactcc actgggaaac ctaaagattt ttcatgatga tggtgtattc
     1441 tgggtcactt tctcttgcat agctatcctc attccagtag ttttcatggg ctgcctaaga
     1501 atactgaaca tactgacttg tggagtcatt ggctcctatt cggtggtttt agccattgac
     1561 agttactggt ccacaagcct ttcctacatc actttgaacg tactcaagag agcgctcaac
     1621 aaggatttcc acagagcttt cacaaatgtg ccttttcaaa ctaatgactt cattatcctg
     1681 gcagtatggg gcatgctggc tgtaagtgga attacgttac agattcgaag agagagagga
     1741 cgaccgttct tccctcccca cccatacaag ttatggaagc aagagagaga gcgccgagtg
     1801 acaaacattc tggaccctag ctaccacatt cctccattga gagagaggct ctatggccga
     1861 ttaacccaga ttaaagggct cttccagaag gagcagccag ctggagagag aacgcctttg
     1921 cttctgtaga tgcccagggg cttggtcagt gtgcctcagc tttggagttc atgcctggag
     1981 tggttcaaca gtctctggtg caagtctaat aagagatcag gcatatatat ctgttctttg
     2041 cataatatta tggtgccctt attgatatat ggtaagggtg tactagggga ttaggatgat
     2101 tgtaagagaa tgagaaagat gaccaaaagg ttggtggtag ggaggctttt tcttatttcc
     2161 aaatacttga gaaattacct tttggtttac aaatctatga tcaacttatt ccattaaata
     2221 gatacattaa aaaaattaaa aactgattct tctgcagagc actggtgttt ctttttataa
     2281 ccccttgaaa caagtctctc acctgagcct gtctaaactt tcggagggag tttattattg
     2341 agtctttatc tgtgacagta tttggagatt tagggatttg atacttaggc ctttgaattt
     2401 tagaatacaa aaagagaagc aagccagaca tggtggctca cacctgtaat cccaatactg
     2461 ggaagccaag gtgggagtat cgcttgagcc caggagtttg agaccgacat gggcaacatg
     2521 acaagacccc atctctacaa aaaaattaaa aaattagcca ggcatggtgg cacatgccta
     2581 ctcccagctc ccaaggagac tgagatggga ggatccctgg agccctgaag attgaggcta
     2641 cagtgagcct tgattgtgtc actgcactcc agcttgggtg acagagaccc tgtctcgaga
     2701 aattaaaaaa aaaaaaaact tattttctta ctaaaagcag tctgattact tagttgcatg
     2761 cccttcttag tatcatacat tatccaaaag ttaccctttg tttttttttc agtatttttt
     2821 aaaattttta agttgtgata aaatacacat gaaatttacc ttcttattca tgtttaagtg
     2881 tacaattcag taggttccct ttgtttttgc cttttattgc ttaaaatggt aattgaaata
     2941 gctaaattat tatttgaaaa taggccaatt tatatagata atagaatttt ataagggtga
     3001 tttatattcc aaataatggc cccctttttt ttttcaaggc cttttcaaat agtgtcaaca
     3061 ggtgatcttt aatttaactg cattagatga catatggatt acttttgttt ttaggaaata
     3121 acccccacct taatctatat tgccgaccag gtgcggtggc tcaaacctgt aatcccagca
     3181 ttttgggagg tcgaggcggg tggatcacct ggggtcagga gttcgagacc agcctggcca
     3241 acatagtggt ctctactata gtatagtaga atatatacta ctacaccctg tctctactaa
     3301 aaatacaaaa attagctggg tattgtggca ggtgcctgta atcccagcta ctcgggaggc
     3361 tgaggcagga gaatcgcttg aacccaggag gcagaggttg cagtgagcca agatcacgcc
     3421 actgcactcc accctgggca acagagcgag actccgtctc aaaaaaaaaa aaagtctgta
     3481 ttgccattaa taagaaaacc ttagaaaaat ttgtacttca tagttctttc tgctcaatta
     3541 gctgttagca ttagtgtaaa atatagtttt taataatttc tgtacaaagc ctttgtacag
     3601 aaaggcttca tccttaaagt gatgagaatg gagtcaaaaa ggattcaggt gtttagagga
     3661 gctgcttttc attaggacct tggagagtcc cctcagtttt gacacccttg tttcaccaca
     3721 agaaagcacc cgacaccctg ggttgcatac ttactactca ggggctttcc ccccagcttt
     3781 cagagcactg aattattgtg agctggtgac tctgcaggcc tgagtggtat tagggttgtg
     3841 gaatgttgtt gcatacacgt ttatgagtta accactattt aaatgatgct gctttttaaa
     3901 gttttttcaa agtacaatag atttttgaag tttcaggtaa ctggaaaaat atttaacttt
     3961 tgctttaagt gtttggggca ggataaaaca acatagaaaa tataaaacaa tttttgcttt
     4021 gaaaaataca gtgcaggtga ccatttactg cttattctgt aatccttact gtctataatt
     4081 aacttcagta acactgaaac ttgatgaaaa gttttaaaaa attatttact gtagggacaa
     4141 agttatatgg aatgtttgtt attttctata ctatctgaat gcactgccag tgaagactgt
     4201 aaagacagaa cacactattt tggagggagg atactaattg tttaaaattt ttcatcattt
     4261 gtgagtgata aaaagtttgt atagttttta taataaatcc ctattttgaa aaaaa
//
