LOCUS       NM_023003               1885 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane 6 superfamily member 1 (TM6SF1),
            transcript variant 1, mRNA.
ACCESSION   NM_023003
VERSION     NM_023003.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Huang,S., Zhao,H., Lou,X., Chen,D., Shi,C. and Ren,Z.
  TITLE     TM6SF1 suppresses the progression of lung adenocarcinoma and M2
            macrophage polarization by inactivating the PI3K/AKT/mtor pathway
  JOURNAL   Biochem Biophys Res Commun 718, 149983 (2024)
   PUBMED   38718735
  REMARK    GeneRIF: TM6SF1 suppresses the progression of lung adenocarcinoma
            and M2 macrophage polarization by inactivating the PI3K/AKT/mtor
            pathway.
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   Li,T.T., Cui,Y.T., Li,T.H., Xiang,Q., Chen,Y.Y., Zheng,X.L.,
            Peng,J. and Tang,Z.H.
  TITLE     TM6SF2 reduces lipid accumulation in vascular smooth muscle cells
            by inhibiting LOX-1 and CD36 expression
  JOURNAL   Exp Cell Res 429 (2), 113666 (2023)
   PUBMED   37271250
  REMARK    GeneRIF: TM6SF2 reduces lipid accumulation in vascular smooth
            muscle cells by inhibiting LOX-1 and CD36 expression.
REFERENCE   3  (bases 1 to 1885)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1885)
  AUTHORS   Tam,W.Y., Jiang,L. and Kwan,K.M.
  TITLE     Transmembrane 6 superfamily 1 (Tm6sf1) is a novel lysosomal
            transmembrane protein
  JOURNAL   Protoplasma 252 (4), 977-983 (2015)
   PUBMED   25422095
REFERENCE   5  (bases 1 to 1885)
  AUTHORS   de Groot,J.S., Pan,X., Meeldijk,J., van der Wall,E., van Diest,P.J.
            and Moelans,C.B.
  TITLE     Validation of DNA promoter hypermethylation biomarkers in breast
            cancer--a short report
  JOURNAL   Cell Oncol (Dordr) 37 (4), 297-303 (2014)
   PUBMED   25123395
  REMARK    GeneRIF: Data conclude that AKR1B1 and TM6SF1 may serve as
            candidate methylation biomarkers for early breast cancer detection.
REFERENCE   6  (bases 1 to 1885)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     Cloning of the novel gene TM6SF1 reveals conservation of clusters
            of paralogous genes between human chromosomes 15q24-->q26 and
            19p13.3-->p12
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 255-260 (2000)
   PUBMED   11124529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024270.6, AK292100.1 and BC063487.1.
            
            On May 17, 2019 this sequence version replaced NM_023003.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.201509.1,
                                           SRR1660805.128509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322019.14/ ENSP00000317000.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC024270.6         90028-90029
            3-1490              AK292100.1         1-1488
            1491-1835           AC024270.6         119397-119741
            1836-1836           BC063487.1         1589-1589
            1837-1885           AC024270.6         119743-119791
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..1885
                     /gene="TM6SF1"
                     /note="transmembrane 6 superfamily member 1"
                     /db_xref="GeneID:53346"
                     /db_xref="HGNC:HGNC:11860"
                     /db_xref="MIM:606562"
     exon            1..128
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1149
                     /gene="TM6SF1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane 6 superfamily member 1 isoform 1"
                     /protein_id="NP_075379.2"
                     /db_xref="CCDS:CCDS10323.1"
                     /db_xref="GeneID:53346"
                     /db_xref="HGNC:HGNC:11860"
                     /db_xref="MIM:606562"
                     /translation="MSASAATGVFVLSLSAIPVTYVFNHLAAQHDSWTIVGVAALILF
                     LVALLARVLVKRKPPRDPLFYVYAVFGFTSVVNLIIGLEQDGIIDGFMTHYLREGEPY
                     LNTAYGHMICYWDGSAHYLMYLVMVAAIAWEETYRTIGLYWVGSIIMSVVVFVPGNIV
                     GKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPSENYNYPSKVIQEAQAKDLLRRPFDL
                     MLVVCLLLATGFCLFRGLIALDCPSELCRLYTQFQEPYLKDPAAYPKIQMLAYMFYSV
                     PYFVTALYGLVVPGCSWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEAKIL
                     FLALNIAYGVLPQLLAYRCIYKPEFFIKTKAEEKVE"
     exon            129..232
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..330
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..434
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..517
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..639
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..744
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..837
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..957
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1885
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1378..1383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM6SF1"
                     /note="hexamer: AATAAA"
     polyA_site      1401
                     /gene="TM6SF1"
                     /note="major polyA site"
     regulatory      1813..1818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM6SF1"
                     /note="hexamer: AATAAA"
     polyA_site      1836
                     /gene="TM6SF1"
                     /note="major polyA site"
     regulatory      1851..1856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM6SF1"
                     /note="hexamer: ATTAAA"
     polyA_site      1885
                     /gene="TM6SF1"
ORIGIN      
        1 gggatgcggt gaagggcgag cggcgcggcg gctgcgatga gtgcctctgc ggccaccggg
       61 gtcttcgtgc tgtccctctc ggccatcccg gtcacctatg tcttcaacca cctggcggcc
      121 cagcatgatt cctggactat tgtaggggtt gctgccctca tcctgttcct ggtagcactg
      181 ctggctcgtg tcctcgtcaa aagaaaacca ccccgggacc cactgttcta tgtgtatgca
      241 gtttttggat ttaccagcgt ggtgaacctc atcataggac tggagcaaga tggaatcatt
      301 gacgggttca tgacacacta cttgagagag ggtgaaccgt atctgaacac cgcatatggg
      361 cacatgatct gctactggga tggctctgct cattatctga tgtacctggt gatggtggca
      421 gccatagcat gggaggaaac ttatagaacc attggcctat attgggttgg atctattatt
      481 atgagtgttg ttgtttttgt gccaggaaac attgtaggga agtatggaac acgaatttgc
      541 cctgcttttt tcttaagcat accatatact tgtcttcctg tctgggctgg tttcagaatc
      601 tataatcagc catcagaaaa ttataattac ccctcaaagg ttattcaaga agcccaagcg
      661 aaagacctgc tgagaagacc atttgattta atgttggttg tgtgtctcct cctggcaact
      721 ggattttgcc tgttcagagg tttgattgct ttggattgcc catctgagct ctgccgatta
      781 tatacgcaat ttcaagagcc ctatctaaag gatcctgctg cttatcctaa aattcagatg
      841 ctggcatata tgttctattc tgttccttac tttgtgactg cactgtatgg cttagtggtt
      901 cctggatgtt cctggatgcc tgacatcaca ttgatacatg ctggaggtct ggctcaggct
      961 cagttttctc acattggtgc atctcttcat gctagaactg cttatgtcta cagagtccct
     1021 gaagaagcaa aaatcctttt tttagcatta aacatagcat atggagttct tcctcagctc
     1081 ttggcctatc gttgtatcta caaaccagag ttcttcataa aaacaaaggc agaagaaaaa
     1141 gtggaataaa aatattactt catgttcctc ctttctaaat tactaacttt tgttatactg
     1201 gtactgatat tttgtcccat ttcactctct tctcatacgt gagtacttaa gaatatgtac
     1261 attcttgctc tgcactgtat gtgtgagcta tatggtattg tgtaaatttt ttttgaagga
     1321 aaatggaaat tcttgagaaa cagtttgttt aaagaaatat attcaaaatc atttgtgaat
     1381 aaacttgatc atccatctca atattgtttg acatataaaa taattataag tgtaaaaaat
     1441 tacaatttag tgccaacagt agtgagcatg aaatgaaact attcaaaaga gaatatggcc
     1501 tgtgcatatt aaaaaattca aaacagtgaa tgcagactgg aggagtaact tttgcaaata
     1561 agatgaatat gcttcattat taaactcaat ataaaaggca aatcatcaga atatttttaa
     1621 atgttgtttg aaaaatgttt tcccaaggaa agtttattat ttgctgctgt ttcaagaaaa
     1681 ttacttttac taaatttttt tgtgtgaatt taaacagcta aatagggatc agtaacttta
     1741 tctctatcct taatgaacat ttgttttatt ggtggctgga aatatttcta ttgtatttct
     1801 gtgtatattt ttaataaaat tatttttggc ctcttataaa gacaaatctt attaaatttg
     1861 aaacatttca tatatacaca taaaa
//
