LOCUS       NM_001353880            1906 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane 6 superfamily member 1 (TM6SF1),
            transcript variant 6, mRNA.
ACCESSION   NM_001353880
VERSION     NM_001353880.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1906)
  AUTHORS   Huang,S., Zhao,H., Lou,X., Chen,D., Shi,C. and Ren,Z.
  TITLE     TM6SF1 suppresses the progression of lung adenocarcinoma and M2
            macrophage polarization by inactivating the PI3K/AKT/mtor pathway
  JOURNAL   Biochem Biophys Res Commun 718, 149983 (2024)
   PUBMED   38718735
  REMARK    GeneRIF: TM6SF1 suppresses the progression of lung adenocarcinoma
            and M2 macrophage polarization by inactivating the PI3K/AKT/mtor
            pathway.
REFERENCE   2  (bases 1 to 1906)
  AUTHORS   Li,T.T., Cui,Y.T., Li,T.H., Xiang,Q., Chen,Y.Y., Zheng,X.L.,
            Peng,J. and Tang,Z.H.
  TITLE     TM6SF2 reduces lipid accumulation in vascular smooth muscle cells
            by inhibiting LOX-1 and CD36 expression
  JOURNAL   Exp Cell Res 429 (2), 113666 (2023)
   PUBMED   37271250
  REMARK    GeneRIF: TM6SF2 reduces lipid accumulation in vascular smooth
            muscle cells by inhibiting LOX-1 and CD36 expression.
REFERENCE   3  (bases 1 to 1906)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1906)
  AUTHORS   Tam,W.Y., Jiang,L. and Kwan,K.M.
  TITLE     Transmembrane 6 superfamily 1 (Tm6sf1) is a novel lysosomal
            transmembrane protein
  JOURNAL   Protoplasma 252 (4), 977-983 (2015)
   PUBMED   25422095
REFERENCE   5  (bases 1 to 1906)
  AUTHORS   de Groot,J.S., Pan,X., Meeldijk,J., van der Wall,E., van Diest,P.J.
            and Moelans,C.B.
  TITLE     Validation of DNA promoter hypermethylation biomarkers in breast
            cancer--a short report
  JOURNAL   Cell Oncol (Dordr) 37 (4), 297-303 (2014)
   PUBMED   25123395
  REMARK    GeneRIF: Data conclude that AKR1B1 and TM6SF1 may serve as
            candidate methylation biomarkers for early breast cancer detection.
REFERENCE   6  (bases 1 to 1906)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     Cloning of the novel gene TM6SF1 reveals conservation of clusters
            of paralogous genes between human chromosomes 15q24-->q26 and
            19p13.3-->p12
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 255-260 (2000)
   PUBMED   11124529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024270.6 and BC063487.1.
            
            On May 31, 2019 this sequence version replaced NM_001353880.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.378326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AC024270.6         90028-90269
            243-346             AC024270.6         95180-95283
            347-444             AC024270.6         98228-98325
            445-548             AC024270.6         101961-102064
            549-631             AC024270.6         104304-104386
            632-753             AC024270.6         105140-105261
            754-858             AC024270.6         107055-107159
            859-978             AC024270.6         109741-109860
            979-1856            AC024270.6         118864-119741
            1857-1857           BC063487.1         1589-1589
            1858-1906           AC024270.6         119743-119791
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..1906
                     /gene="TM6SF1"
                     /note="transmembrane 6 superfamily member 1"
                     /db_xref="GeneID:53346"
                     /db_xref="HGNC:HGNC:11860"
                     /db_xref="MIM:606562"
     exon            1..242
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            243..346
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..444
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..1170
                     /gene="TM6SF1"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="transmembrane 6 superfamily member 1 isoform 6"
                     /protein_id="NP_001340809.1"
                     /db_xref="GeneID:53346"
                     /db_xref="HGNC:HGNC:11860"
                     /db_xref="MIM:606562"
                     /translation="MTHYLREGEPYLNTAYGHMICYWDGSAHYLMYLVMVAAIAWEET
                     YRTIGLYWVGSIIMSVVVFVPGNIVGKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPS
                     ENYNYPSKVIQEAQAKDLLRRPFDLMLVVCLLLATGFCLFRGLMLAYMFYSVPYFVTA
                     LYGLVVPGCSWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEAKILFLALNI
                     AYGVLPQLLAYRCIYKPEFFIKTKAEEKVE"
     exon            445..548
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..631
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..753
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..858
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..978
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1906
                     /gene="TM6SF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1399..1404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM6SF1"
                     /note="hexamer: AATAAA"
     polyA_site      1422
                     /gene="TM6SF1"
                     /note="major polyA site"
     regulatory      1834..1839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM6SF1"
                     /note="hexamer: AATAAA"
     polyA_site      1857
                     /gene="TM6SF1"
                     /note="major polyA site"
     regulatory      1872..1877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM6SF1"
                     /note="hexamer: ATTAAA"
     polyA_site      1906
                     /gene="TM6SF1"
ORIGIN      
        1 gggatgcggt gaagggcgag cggcgcggcg gctgcgatga gtgcctctgc ggccaccggg
       61 gtcttcgtgc tgtccctctc ggccatcccg gtcacctatg tcttcaacca cctggcggcc
      121 cagcatgagt gagtgagccg gcgcggcggg ggtcgcgccg aggggcggcg ggagttggct
      181 cgccgcgacg ggagcctcgc aacttttccg agggggctgg gaccgtccgc cgcgggacag
      241 agttcctgga ctattgtagg ggttgctgcc ctcatcctgt tcctggtagc actgctggct
      301 cgtgtcctcg tcaaaagaaa accaccccgg gacccactgt tctatgtgta tgcagttttt
      361 ggatttacca gcgtggtgaa cctcatcata ggactggagc aagatggaat cattgacggg
      421 ttcatgacac actacttgag agagggtgaa ccgtatctga acaccgcata tgggcacatg
      481 atctgctact gggatggctc tgctcattat ctgatgtacc tggtgatggt ggcagccata
      541 gcatgggagg aaacttatag aaccattggc ctatattggg ttggatctat tattatgagt
      601 gttgttgttt ttgtgccagg aaacattgta gggaagtatg gaacacgaat ttgccctgct
      661 tttttcttaa gcataccata tacttgtctt cctgtctggg ctggtttcag aatctataat
      721 cagccatcag aaaattataa ttacccctca aaggttattc aagaagccca agcgaaagac
      781 ctgctgagaa gaccatttga tttaatgttg gttgtgtgtc tcctcctggc aactggattt
      841 tgcctgttca gaggtttgat gctggcatat atgttctatt ctgttcctta ctttgtgact
      901 gcactgtatg gcttagtggt tcctggatgt tcctggatgc ctgacatcac attgatacat
      961 gctggaggtc tggctcaggc tcagttttct cacattggtg catctcttca tgctagaact
     1021 gcttatgtct acagagtccc tgaagaagca aaaatccttt ttttagcatt aaacatagca
     1081 tatggagttc ttcctcagct cttggcctat cgttgtatct acaaaccaga gttcttcata
     1141 aaaacaaagg cagaagaaaa agtggaataa aaatattact tcatgttcct cctttctaaa
     1201 ttactaactt ttgttatact ggtactgata ttttgtccca tttcactctc ttctcatacg
     1261 tgagtactta agaatatgta cattcttgct ctgcactgta tgtgtgagct atatggtatt
     1321 gtgtaaattt tttttgaagg aaaatggaaa ttcttgagaa acagtttgtt taaagaaata
     1381 tattcaaaat catttgtgaa taaacttgat catccatctc aatattgttt gacatataaa
     1441 ataattataa gtgtaaaaaa ttacaattta gtgccaacag tagtgagcat gaaatgaaac
     1501 tattcaaaag agaatatggc ctgtgcatat taaaaaattc aaaacagtga atgcagactg
     1561 gaggagtaac ttttgcaaat aagatgaata tgcttcatta ttaaactcaa tataaaaggc
     1621 aaatcatcag aatattttta aatgttgttt gaaaaatgtt ttcccaagga aagtttatta
     1681 tttgctgctg tttcaagaaa attactttta ctaaattttt ttgtgtgaat ttaaacagct
     1741 aaatagggat cagtaacttt atctctatcc ttaatgaaca tttgttttat tggtggctgg
     1801 aaatatttct attgtatttc tgtgtatatt tttaataaaa ttatttttgg cctcttataa
     1861 agacaaatct tattaaattt gaaacatttc atatatacac ataaaa
//
