LOCUS       NM_003963                714 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane 4 L six family member 5 (TM4SF5), mRNA.
ACCESSION   NM_003963
VERSION     NM_003963.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 714)
  AUTHORS   Sun,H., Kim,E., Ryu,J., Lee,H., Shin,E.A., Lee,M., Lee,H.,
            Lee,J.H., Yoon,J.H., Song,D.G., Kim,S. and Lee,J.W.
  TITLE     TM4SF5-mediated liver malignancy involves NK cell exhaustion-like
            phenotypes
  JOURNAL   Cell Mol Life Sci 79 (1), 49 (2021)
   PUBMED   34921636
  REMARK    GeneRIF: TM4SF5-mediated liver malignancy involves NK cell
            exhaustion-like phenotypes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 714)
  AUTHORS   Park,D., Kim,E., Lee,H., Shin,E.A., Lee,H. and Lee,J.W.
  TITLE     Tetraspanin TM4SF5 in hepatocytes negatively modulates SLC27A
            transporters during acute fatty acid supply
  JOURNAL   Arch Biochem Biophys 710, 109004 (2021)
   PUBMED   34364885
  REMARK    GeneRIF: Tetraspanin TM4SF5 in hepatocytes negatively modulates
            SLC27A transporters during acute fatty acid supply.
REFERENCE   3  (bases 1 to 714)
  AUTHORS   Choi,C., Son,Y., Kim,J., Cho,Y.K., Saha,A., Kim,M., Im,H., Kim,K.,
            Han,J., Lee,J.W., Seong,J.K. and Lee,Y.H.
  TITLE     TM4SF5 Knockout Protects Mice From Diet-Induced Obesity Partly by
            Regulating Autophagy in Adipose Tissue
  JOURNAL   Diabetes 70 (9), 2000-2013 (2021)
   PUBMED   34187836
  REMARK    GeneRIF: TM4SF5 Knockout Protects Mice From Diet-Induced Obesity
            Partly by Regulating Autophagy in Adipose Tissue.
REFERENCE   4  (bases 1 to 714)
  AUTHORS   Song,H.E., Lee,Y., Kim,E., Cho,C.Y., Jung,O., Lee,D., Lee,E.G.,
            Nam,S.H., Kang,M., Macalino,S.J.Y., Kim,J.E., Jung,J.W., Kwon,S.W.,
            Choi,S. and Lee,J.W.
  TITLE     N-terminus-independent activation of c-Src via binding to a
            tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by
            the TM4SF5 C-terminal peptide application
  JOURNAL   Theranostics 11 (16), 8092-8111 (2021)
   PUBMED   34335982
  REMARK    GeneRIF: N-terminus-independent activation of c-Src via binding to
            a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by
            the TM4SF5 C-terminal peptide application.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 714)
  AUTHORS   Kim,H.J., Kim,E., Lee,H., Jung,J.W., Kim,J.E., Pack,C.G. and
            Lee,J.W.
  TITLE     SLAC2B-dependent microtubule acetylation regulates extracellular
            matrix-mediated intracellular TM4SF5 traffic to the plasma
            membranes
  JOURNAL   FASEB J 35 (3), e21369 (2021)
   PUBMED   33554392
  REMARK    GeneRIF: SLAC2B-dependent microtubule acetylation regulates
            extracellular matrix-mediated intracellular TM4SF5 traffic to the
            plasma membranes.
REFERENCE   6  (bases 1 to 714)
  AUTHORS   Kaneko,R., Tsuji,N., Kamagata,C., Endoh,T., Nakamura,M.,
            Kobayashi,D., Yagihashi,A. and Watanabe,N.
  TITLE     Amount of expression of the tumor-associated antigen L6 gene and
            transmembrane 4 superfamily member 5 gene in gastric cancers and
            gastric mucosa
  JOURNAL   Am J Gastroenterol 96 (12), 3457-3458 (2001)
   PUBMED   11774983
REFERENCE   7  (bases 1 to 714)
  AUTHORS   Berditchevski,F.
  TITLE     Complexes of tetraspanins with integrins: more than meets the eye
  JOURNAL   J Cell Sci 114 (Pt 23), 4143-4151 (2001)
   PUBMED   11739647
  REMARK    Review article
REFERENCE   8  (bases 1 to 714)
  AUTHORS   Wright,M.D., Ni,J. and Rudy,G.B.
  TITLE     The L6 membrane proteins--a new four-transmembrane superfamily
  JOURNAL   Protein Sci 9 (8), 1594-1600 (2000)
   PUBMED   10975581
REFERENCE   9  (bases 1 to 714)
  AUTHORS   Muller-Pillasch,F., Wallrapp,C., Lacher,U., Friess,H., Buchler,M.,
            Adler,G. and Gress,T.M.
  TITLE     Identification of a new tumour-associated antigen TM4SF5 and its
            expression in human cancer
  JOURNAL   Gene 208 (1), 25-30 (1998)
   PUBMED   9479038
REFERENCE   10 (bases 1 to 714)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Geng,M., Zimmerhackl,F.,
            Zehetner,G., Friess,H., Buchler,M., Adler,G. and Lehrach,H.
  TITLE     A pancreatic cancer-specific expression profile
  JOURNAL   Oncogene 13 (8), 1819-1830 (1996)
   PUBMED   8895530
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091153.10 and AC233723.2.
            
            On Nov 25, 2018 this sequence version replaced NM_003963.2.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            This encoded protein is a cell surface glycoprotein and is highly
            similar in sequence and structure to transmembrane 4 superfamily
            member 1. It may play a role in cell proliferation, and
            overexpression of this protein may be associated with the
            uncontrolled growth of tumour cells. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.117107.1,
                                           SRR5189664.21184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270560.4/ ENSP00000270560.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC091153.10        9935-10148          c
            215-295             AC091153.10        1165-1245           c
            296-432             AC233723.2         153032-153168       c
            433-616             AC233723.2         152634-152817       c
            617-714             AC233723.2         152460-152557       c
FEATURES             Location/Qualifiers
     source          1..714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..714
                     /gene="TM4SF5"
                     /note="transmembrane 4 L six family member 5"
                     /db_xref="GeneID:9032"
                     /db_xref="HGNC:HGNC:11857"
                     /db_xref="MIM:604657"
     exon            1..214
                     /gene="TM4SF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..631
                     /gene="TM4SF5"
                     /note="transmembrane 4 superfamily member 5; tetraspan
                     transmembrane protein L6H"
                     /codon_start=1
                     /product="transmembrane 4 L6 family member 5"
                     /protein_id="NP_003954.2"
                     /db_xref="CCDS:CCDS11054.1"
                     /db_xref="GeneID:9032"
                     /db_xref="HGNC:HGNC:11857"
                     /db_xref="MIM:604657"
                     /translation="MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLS
                     LQVWLMGGFIGGGLMVLCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAI
                     YCLSVSGAGLRNGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFS
                     LLVAASCLEIVLCGIQLVNATIGVFCGDCRKKQDTPH"
     exon            215..295
                     /gene="TM4SF5"
                     /inference="alignment:Splign:2.1.0"
     exon            296..432
                     /gene="TM4SF5"
                     /inference="alignment:Splign:2.1.0"
     exon            433..616
                     /gene="TM4SF5"
                     /inference="alignment:Splign:2.1.0"
     exon            617..714
                     /gene="TM4SF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      694..699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM4SF5"
                     /note="hexamer: AATAAA"
     polyA_site      714
                     /gene="TM4SF5"
                     /note="major polyA site"
ORIGIN      
        1 actttcactc accgcctgtc cttcctgaca cctcaccatg tgtacgggaa aatgtgcccg
       61 ctgtgtgggg ctctccctca ttaccctctg cctcgtctgc attgtggcca acgccctcct
      121 gctggtacct aatggggaga cctcctggac caacaccaac catctcagct tgcaagtctg
      181 gctcatgggc ggcttcattg gcgggggcct aatggtactg tgtccgggga ttgcagccgt
      241 tcgggcaggg ggcaagggct gctgtggtgc tgggtgctgt ggaaaccgct gcaggatgct
      301 gcgctcggtc ttctcctcgg cgttcggggt gcttggtgcc atctactgcc tctcggtgtc
      361 tggagctggg ctccgaaatg gacccagatg cttaatgaac ggcgagtggg gctaccactt
      421 cgaagacacc gcgggagctt acttgctcaa ccgcactcta tgggatcggt gcgaggcgcc
      481 ccctcgcgtg gtcccctgga atgtgacgct cttctcgctg ctggtggccg cctcctgcct
      541 ggagatagta ctgtgtggga tccagctggt gaacgcgacc attggtgtct tctgcggcga
      601 ttgcaggaaa aaacaggaca cacctcactg aggctccact gaccgccggg ttacacctgc
      661 tccttcctgg acgctcactc ccttgctcgc tagaataaac tgctttgcgc tctc
//
