LOCUS       NM_004617               1491 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane 4 L six family member 4 (TM4SF4), mRNA.
ACCESSION   NM_004617
VERSION     NM_004617.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1491)
  AUTHORS   Mou,Y. and Ding,X.
  TITLE     LncRNA ST8SIA6-AS1 facilitates hepatocellular carcinoma progression
            by governing miR-651-5p/TM4SF4 axis
  JOURNAL   Anticancer Drugs 33 (8), 741-751 (2022)
   PUBMED   35946523
  REMARK    GeneRIF: LncRNA ST8SIA6-AS1 facilitates hepatocellular carcinoma
            progression by governing miR-651-5p/TM4SF4 axis.
REFERENCE   2  (bases 1 to 1491)
  AUTHORS   Jung,K., Choi,J.S., Koo,B.M., Kim,Y.J., Song,J.Y., Sung,M.,
            Chang,E.S., Noh,K.W., An,S., Lee,M.S., Song,K., Lee,H., Kim,R.N.,
            Shin,Y.K., Oh,D.Y. and Choi,Y.L.
  TITLE     TM4SF4 and LRRK2 Are Potential Therapeutic Targets in Lung and
            Breast Cancers through Outlier Analysis
  JOURNAL   Cancer Res Treat 53 (1), 9-24 (2021)
   PUBMED   32972043
  REMARK    GeneRIF: TM4SF4 and LRRK2 Are Potential Therapeutic Targets in Lung
            and Breast Cancers through Outlier Analysis.
REFERENCE   3  (bases 1 to 1491)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1491)
  AUTHORS   Cheong,J.G., Song,D.G., Song,H.E., Berditchevski,F., Nam,S.H.,
            Jung,J.W., Kim,H.J., Kim,J.E., Kim,S., Ryu,J., Cho,C.Y., Lee,K.M.
            and Lee,J.W.
  TITLE     Differential regulation of cellular functions by the C-termini of
            transmembrane 4 L six family proteins in 2- or 3-dimensional
            environment
  JOURNAL   Oncotarget 8 (8), 13277-13292 (2017)
   PUBMED   28129652
  REMARK    GeneRIF: Replacement of the transmembrane 4 L six family protein
            TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 increased spheroids
            growth, transwell migration, and invasive dissemination from
            spheroids in 3D collagen gels.
REFERENCE   5  (bases 1 to 1491)
  AUTHORS   Choi,S.I., Kim,S.Y., Lee,J., Cho,E.W. and Kim,I.G.
  TITLE     TM4SF4 overexpression in radiation-resistant lung carcinoma cells
            activates IGF1R via elevation of IGF1
  JOURNAL   Oncotarget 5 (20), 9823-9837 (2014)
   PUBMED   25344917
  REMARK    GeneRIF: TM4SF4 expression was correlated with the increased
            expression of IGF1, consequently resulting in IGF1R activation in
            lung adenocarcinoma.
REFERENCE   6  (bases 1 to 1491)
  AUTHORS   Qiao,J., Wang,L., Li,R. and Zhang,X.
  TITLE     Microarray evaluation of endometrial receptivity in Chinese women
            with polycystic ovary syndrome
  JOURNAL   Reprod Biomed Online 17 (3), 425-435 (2008)
   PUBMED   18765015
  REMARK    GeneRIF: expression of transmembrane 4 superfamily member 4
            (TM4SF4) and matrix metalloproteinase 26 (MMP26) was found to be
            significantly decreased during the implantation window in patients
            with polycystic ovary syndrome.
REFERENCE   7  (bases 1 to 1491)
  AUTHORS   Berditchevski,F.
  TITLE     Complexes of tetraspanins with integrins: more than meets the eye
  JOURNAL   J Cell Sci 114 (Pt 23), 4143-4151 (2001)
   PUBMED   11739647
  REMARK    Review article
REFERENCE   8  (bases 1 to 1491)
  AUTHORS   Wright,M.D., Ni,J. and Rudy,G.B.
  TITLE     The L6 membrane proteins--a new four-transmembrane superfamily
  JOURNAL   Protein Sci 9 (8), 1594-1600 (2000)
   PUBMED   10975581
REFERENCE   9  (bases 1 to 1491)
  AUTHORS   Ferrer,M., Yunta,M. and Lazo,P.A.
  TITLE     Pattern of expression of tetraspanin antigen genes in Burkitt
            lymphoma cell lines
  JOURNAL   Clin Exp Immunol 113 (3), 346-352 (1998)
   PUBMED   9737661
REFERENCE   10 (bases 1 to 1491)
  AUTHORS   Wice,B.M. and Gordon,J.I.
  TITLE     A tetraspan membrane glycoprotein produced in the human intestinal
            epithelium and liver that can regulate cell density-dependent
            proliferation
  JOURNAL   J Biol Chem 270 (37), 21907-21918 (1995)
   PUBMED   7665614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP294159.1, U31449.1 and
            BG656032.1.
            
            On May 17, 2019 this sequence version replaced NM_004617.3.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            This encoded protein is a cell surface glycoprotein that can
            regulate cell proliferation.[provided by RefSeq, Mar 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.75216.1,
                                           SRR5189664.128237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305354.5/ ENSP00000305852.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BP294159.1         117-132
            17-1378             U31449.1           1-1362
            1379-1491           BG656032.1         54-166
FEATURES             Location/Qualifiers
     source          1..1491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..1491
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
                     /note="transmembrane 4 L six family member 4"
                     /db_xref="GeneID:7104"
                     /db_xref="HGNC:HGNC:11856"
                     /db_xref="MIM:606567"
     exon            1..355
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..790
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
                     /note="transmembrane 4 superfamily member 4; intestinal
                     and liver (il) tetraspan membrane protein; intestine and
                     liver tetraspan membrane protein"
                     /codon_start=1
                     /product="transmembrane 4 L6 family member 4"
                     /protein_id="NP_004608.1"
                     /db_xref="CCDS:CCDS46932.1"
                     /db_xref="GeneID:7104"
                     /db_xref="HGNC:HGNC:11856"
                     /db_xref="MIM:606567"
                     /translation="MCTGGCARCLGGTLIPLAFFGFLANILLFFPGGKVIDDNDHLSQ
                     EIWFFGGILGSGVLMIFPALVFLGLKNNDCCGCCGNEGCGKRFAMFTSTIFAVVGFLG
                     AGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDEALWNKCREPLNVVPWNLTLF
                     SILLVVGGIQMVLCAIQVVNGLLGTLCGDCQCCGCCGGDGPV"
     exon            356..445
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
                     /inference="alignment:Splign:2.1.0"
     exon            446..582
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
                     /inference="alignment:Splign:2.1.0"
     exon            583..772
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1491
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      969..974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
                     /note="hexamer: AATAAA"
     polyA_site      993
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
                     /note="major polyA site"
     polyA_site      1251
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
     regulatory      1352..1357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
                     /note="hexamer: ATTAAA"
     polyA_site      1380
                     /gene="TM4SF4"
                     /gene_synonym="il-TMP; ILTMP"
                     /note="major polyA site"
ORIGIN      
        1 atttttgaga agctgaagca actccaagga cacagttcac agaaatttgg ttctcagccc
       61 caaaatactg attgaattgg agacaattac aaggactctc tggccaaaaa cccttgaaga
      121 ggccccgtga aggaggcagt gaggagcttt tgattgctga cctgtgtcgt accaccccag
      181 aatgtgcact gggggctgtg ccagatgcct gggggggacc ctcattcccc ttgctttttt
      241 tggcttcctg gctaacatcc tgttattttt tcctggagga aaagtgatag atgacaacga
      301 ccacctttcc caagagatct ggtttttcgg aggaatatta ggaagcggtg tcttgatgat
      361 cttccctgcg ctggtgttct tgggcctgaa gaacaatgac tgctgtgggt gctgcggcaa
      421 cgagggctgt gggaagcgat ttgcgatgtt cacctccacg atatttgctg tggttggatt
      481 cttgggagct ggatactcgt ttatcatctc agccatttca atcaacaagg gtcctaaatg
      541 cctcatggcc aatagtacat ggggctaccc cttccacgac ggggattatc tcaatgatga
      601 ggccttatgg aacaagtgcc gagagcctct caatgtggtt ccctggaatc tgaccctctt
      661 ctccatcctg ctggtcgtag gaggaatcca gatggttctc tgcgccatcc aggtggtcaa
      721 tggcctcctg gggaccctct gtggggactg ccagtgttgt ggctgctgtg ggggagatgg
      781 acccgtttaa acctccgaga tgagctgctc agactctaca gcatgacgac tacaatttct
      841 tttcataaaa cttcttctct tcttggaatt attaattcct atctgcttcc tagctgataa
      901 agcttagaaa aggcagttat tccttctttc caaccagctt tgctcgagtt agaattttgt
      961 tattttcaaa taaaaaatag tttggccact taacaaattt gatttataaa tctttcaaat
     1021 tagttccttt ttagaattta ccaacaggtt caaagcatac ttttcatgat ttttttatta
     1081 caaatgtaaa atgtataaag tcacatgtac tgccatacta cttctttgta tataaagatg
     1141 tttatatctt tggaagtttt acataaatca aaggaagaaa gcacatttaa aatgagaaac
     1201 taagaccaat ttctgttttt aagaggaaaa agaatgattg atgtatccta agtattgtta
     1261 tttgttgtct ttttttgctg ccttgcttga gttgcttgtg actgatcttt tgaggctgtc
     1321 atcatggcta gggttctttt atgtatgtta aattaaaacc tgaattcaga ggtaacgtaa
     1381 caaagattgt gtgtgtttta ggagggggga caaaacgttg aatgaataac aactcatctt
     1441 ttctacaaat gcttcctttg atcaaacaaa aaaaagtttt taaaaaattg a
//
