LOCUS       NM_138461               1026 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens transmembrane 4 L six family member 19 (TM4SF19),
            transcript variant 1, mRNA.
ACCESSION   NM_138461 XM_942636 XM_946172 XM_946174
VERSION     NM_138461.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1026)
  AUTHORS   Shin,E., Kwon,Y., Jung,E., Kim,Y.J., Kim,C., Hong,S. and Kim,J.
  TITLE     TM4SF19 controls GABP-dependent YAP transcription in head and neck
            cancer under oxidative stress conditions
  JOURNAL   Proc Natl Acad Sci U S A 121 (7), e2314346121 (2024)
   PUBMED   38315837
  REMARK    GeneRIF: TM4SF19 controls GABP-dependent YAP transcription in head
            and neck cancer under oxidative stress conditions.
REFERENCE   2  (bases 1 to 1026)
  AUTHORS   Park,S., Heo,J.S., Mizuno,S., Kim,M., An,H., Hong,E., Kang,M.G.,
            Kim,J., Yun,R., Park,H., Noh,E.H., Lee,M.J., Yoon,K., Kim,P.,
            Son,M., Pang,K., Lee,J., Park,J., Ooshima,A., Kim,T.J., Park,J.Y.,
            Yang,K.M., Myung,S.J., Bae,H., Lee,K.M., Letterio,J., Park,S.H.,
            Takahashi,S. and Kim,S.J.
  TITLE     Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents
            bone loss
  JOURNAL   Metabolism 151, 155746 (2024)
   PUBMED   38016540
REFERENCE   3  (bases 1 to 1026)
  AUTHORS   Luo,M., Xie,L., Su,Y., Zhang,K., Liang,R., Ma,Z. and Li,Y.
  TITLE     TM4SF19-AS1 facilitates the proliferation of lung squamous cell
            carcinoma by recruiting WDR5 to mediate TM4SF19
  JOURNAL   Mol Cell Probes 65, 101849 (2022)
   PUBMED   35987447
  REMARK    GeneRIF: TM4SF19-AS1 facilitates the proliferation of lung squamous
            cell carcinoma by recruiting WDR5 to mediate TM4SF19.
REFERENCE   4  (bases 1 to 1026)
  AUTHORS   Ding,L., Li,L.M., Hu,B., Wang,J.L., Lu,Y.B., Zhang,R.Y., He,X.,
            Shi,C., Wu,L.M., Wu,C.M., Yang,B., Zheng,L., Ping,B.H., Hu,Y.W. and
            Wang,Q.
  TITLE     TM4SF19 aggravates LPS-induced attenuation of vascular endothelial
            cell adherens junctions by suppressing VE-cadherin expression
  JOURNAL   Biochem Biophys Res Commun 533 (4), 1204-1211 (2020)
   PUBMED   33059922
  REMARK    GeneRIF: TM4SF19 aggravates LPS-induced attenuation of vascular
            endothelial cell adherens junctions by suppressing VE-cadherin
            expression.
REFERENCE   5  (bases 1 to 1026)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA489370.1, BC146985.1,
            AF192910.1 and CA430273.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_138461.3.
            
            Summary: The protein encoded by this gene is a member of the
            four-transmembrane L6 superfamily. Members of this family function
            in various cellular processes including cell proliferation,
            motility, and adhesion via their interactions with integrins. In
            human brain tissue, this gene is expressed at high levels in the
            parietal lobe, occipital lobe, hippocampus, pons, white matter,
            corpus callosum, and cerebellum. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF192910.1, SRR5189658.16745.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2156670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273695.4/ ENSP00000273695.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                CA489370.1         33-99
            68-801              BC146985.1         1-734
            802-1022            AF192910.1         790-1010
            1023-1026           CA430273.1         20-23               c
FEATURES             Location/Qualifiers
     source          1..1026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..1026
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /note="transmembrane 4 L six family member 19"
                     /db_xref="GeneID:116211"
                     /db_xref="HGNC:HGNC:25167"
                     /db_xref="MIM:620845"
     exon            1..125
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            126..327
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..756
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane 4 L6 family member 19; tetraspan membrane
                     protein OCTM4; osteoclast maturation-associated gene 4
                     protein"
                     /codon_start=1
                     /product="transmembrane 4 L6 family member 19 isoform 1"
                     /protein_id="NP_612470.2"
                     /db_xref="CCDS:CCDS3316.1"
                     /db_xref="GeneID:116211"
                     /db_xref="HGNC:HGNC:25167"
                     /db_xref="MIM:620845"
                     /translation="MVSSPCTQASSRTCSRILGLSLGTAALFAAGANVALLLPNWDVT
                     YLLRGLLGRHAMLGTGLWGGGLMVLTAAILISLMGWRYGCFSKSGLCRSVLTALLSGG
                     LALLGALICFVTSGVALKDGPFCMFDVSSFNQTQAWKYGYPFKDLHSRNYLYDRSLWN
                     SVCLEPSAAVVWHVSLFSALLCISLLQLLLVVVHVINSLLGLFCSLCEK"
     exon            328..405
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            406..575
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            576..1026
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      842..847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /note="hexamer: AACAAA"
     polyA_site      862
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /note="major polyA site"
     regulatory      873..878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /note="hexamer: AATAAT"
     polyA_site      897
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
     regulatory      962..967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /note="hexamer: GATAAA"
     polyA_site      984
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
     regulatory      1005..1010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /note="hexamer: CATAAA"
     polyA_site      1026
                     /gene="TM4SF19"
                     /gene_synonym="OCTM4"
                     /note="major polyA site"
ORIGIN      
        1 aaagagtcct ggaaagacaa ccttcaggtc cagccctgga gctggaggag tggagcccca
       61 ctctgaagac gcagcctttc tccaggttct gtctctccca ttctgattct tgacaccaga
      121 tgcaggatgg tgtcctctcc ctgcacgcag gcaagctcac ggacttgctc ccgtatcctg
      181 ggactgagcc ttgggactgc agccctgttt gctgctgggg ccaacgtggc actcctcctt
      241 cctaactggg atgtcaccta cctgttgagg ggcctccttg gcaggcatgc catgctggga
      301 actgggctct ggggaggagg cctcatggta ctcactgcag ctatcctcat ctccttgatg
      361 ggctggagat acggctgctt cagtaagagt gggctctgtc gaagcgtgct tactgctctg
      421 ttgtcaggtg gcctggcttt acttggagcc ctgatttgct ttgtcacttc tggagttgct
      481 ctgaaagatg gtcctttttg catgtttgat gtttcatcct tcaatcagac acaagcttgg
      541 aaatatggtt acccattcaa agacctgcat agtaggaatt atctgtatga ccgttcgctc
      601 tggaactccg tctgcctgga gccctctgca gctgttgtct ggcacgtgtc cctcttctcc
      661 gcccttctgt gcatcagcct gctccagctt ctcctggtgg tcgttcatgt catcaacagc
      721 ctcctgggcc ttttctgcag cctctgcgag aagtgacagg cagaaccttc acttgcaagc
      781 atgggtgttt tcatcatcgg ctgtcttgaa tcctttctac aaggagtggg tacgaattat
      841 aaacaaactt cccctttagg tatccctgga gtaataatga caacaaaatt cactgcaggt
      901 cggtggaatg atagaatgca ttttaaatca cattgtaaac ttccaggtga tccatggata
      961 ggataaataa ctaagttatt ataattgttt aggaatttat agtccataaa atatcctcca
     1021 gccagg
//
