LOCUS       NM_138786               3727 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane 4 L six family member 18 (TM4SF18),
            transcript variant 1, mRNA.
ACCESSION   NM_138786
VERSION     NM_138786.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3727)
  AUTHORS   Qin,X., Chen,Y., Ma,S., Shen,L. and Ju,S.
  TITLE     Immune-related gene TM4SF18 could promote the metastasis of gastric
            cancer cells and predict the prognosis of gastric cancer patients
  JOURNAL   Mol Oncol 16 (22), 4043-4059 (2022)
   PUBMED   36209368
  REMARK    GeneRIF: Immune-related gene TM4SF18 could promote the metastasis
            of gastric cancer cells and predict the prognosis of gastric cancer
            patients.
REFERENCE   2  (bases 1 to 3727)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3727)
  AUTHORS   Singhal,M., Khatibeghdami,M., Principe,D.R., Mancinelli,G.E.,
            Schachtschneider,K.M., Schook,L.B., Grippo,P.J. and Grimaldo,S.R.
  TITLE     TM4SF18 is aberrantly expressed in pancreatic cancer and regulates
            cell growth
  JOURNAL   PLoS One 14 (3), e0211711 (2019)
   PUBMED   30897168
  REMARK    GeneRIF: TM4SF18 is highly expressed in pancreatic ductal
            adenocarcinoma (PDAC) tumor epithelium, expressed in normal acinar
            tissue and weakly expressed in normal ducts. Although there is
            minimal expression in normal ducts, study observed increased
            TM4SF18 levels in preneoplastic ducts and tumor epithelium.
            Knockdown of the TM4SF18 protein led to a significant decrease in
            Capan-1 cell growth.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3727)
  AUTHORS   Wright,M.D., Ni,J. and Rudy,G.B.
  TITLE     The L6 membrane proteins--a new four-transmembrane superfamily
  JOURNAL   Protein Sci 9 (8), 1594-1600 (2000)
   PUBMED   10975581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB282139.1, BC014339.1 and AC093001.2.
            
            On Nov 22, 2018 this sequence version replaced NM_138786.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.184605.1,
                                           SRR1803612.177289.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296059.7/ ENSP00000296059.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DB282139.1         126-129
            5-1157              BC014339.1         6-1158
            1158-3727           AC093001.2         140059-142628       c
FEATURES             Location/Qualifiers
     source          1..3727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..3727
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
                     /note="transmembrane 4 L six family member 18"
                     /db_xref="GeneID:116441"
                     /db_xref="HGNC:HGNC:25181"
     exon            1..124
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
                     /inference="alignment:Splign:2.1.0"
     exon            125..318
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..747
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
                     /codon_start=1
                     /product="transmembrane 4 L6 family member 18"
                     /protein_id="NP_620141.1"
                     /db_xref="CCDS:CCDS3142.1"
                     /db_xref="GeneID:116441"
                     /db_xref="HGNC:HGNC:25181"
                     /translation="MGSRKCGGCLSCLLIPLALWSIIVNILLYFPNGQTSYASSNKLT
                     NYVWYFEGICFSGIMMLIVTTVLLVLENNNNYKCCQSENCSKKYVTLLSIIFSSLGIA
                     FSGYCLVISALGLVQGPYCRTLDGWEYAFEGTAGRFLTDSSIWIQCLEPAHVVEWNII
                     LFSILITLSGLQVIICLIRVVMQLSKILCGSYSVIFQPGII"
     exon            319..408
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
                     /inference="alignment:Splign:2.1.0"
     exon            409..551
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
                     /inference="alignment:Splign:2.1.0"
     exon            552..732
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
                     /inference="alignment:Splign:2.1.0"
     exon            733..3727
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1180..1185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
                     /note="hexamer: AATAAA"
     polyA_site      1206
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
                     /note="major polyA site"
     regulatory      3705..3710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
                     /note="hexamer: AATAAA"
     polyA_site      3727
                     /gene="TM4SF18"
                     /gene_synonym="L6D"
ORIGIN      
        1 gatcattgtc tattgttctc caaacagtaa accagtattt cacactgaga ttgtcggctg
       61 cgggtatatt ccaattcccc gtctcctcat gaatatgaag tgaagggctc tgaccctgga
      121 agtggttcta agcagggcaa aatggggtct cggaagtgtg gaggctgcct aagttgtttg
      181 ctgattccgc ttgcactttg gagtataatc gtgaacatat tattgtattt cccgaatggg
      241 caaacttcct atgcatccag caataaactc accaactacg tgtggtattt tgaaggaatc
      301 tgtttctcag gcatcatgat gcttatagta acaacagttc ttctggtact ggagaataat
      361 aacaactata aatgttgcca gagtgaaaac tgcagcaaaa aatatgtgac actgctgtca
      421 attatctttt cttccctcgg aattgctttt tctggatact gcctggtcat ctctgccttg
      481 ggtcttgtcc aagggccata ttgccgcacc cttgatggct gggagtatgc ttttgaaggc
      541 actgctggac gtttccttac agattctagc atatggattc agtgcctgga acctgcacat
      601 gttgtggagt ggaacatcat tttattttcc attctcataa ccctcagtgg gcttcaagtg
      661 atcatctgcc tcatcagagt agtcatgcaa ctatccaaga tactgtgtgg aagctattca
      721 gtgatcttcc agcctggaat catttgaata aggacaaaat gttttccatt atcaagacat
      781 ggccatctat ctaaatatta tatcaactgt gtagacttga gggcaatatt gaaatgatgg
      841 tgctttctgc atttggtgtt tatttgtaaa aaatttgcag tcctcactgc acatgcaagt
      901 ataccaccct tccatttagt atgtttttta agtaatatgc atcagaaact tcagaaatac
      961 ttctgccctt tgatcaaaca aatccatttc caagaatctg tactagggaa gtaaataaga
     1021 atatgagaga aacctttatg caaatatgta tattgcaaca ttatttaata ttctggaaaa
     1081 ttggaaacac cccaaaattc taaactcaga ggaaggatta agtaaagagt ggtacatact
     1141 gtaaatgttt tctgatatta aaaaaaaaat taaataaaaa ataaagagta ctacatggtt
     1201 gtaaaattac agtcattaca aatgatgttt ttaaaattat gaataatgct acatcaaaaa
     1261 gcaggttaca aattcatgtt tactatataa ctatttaaag caaatgaaac actaatagtc
     1321 aaagtttagg atgaaaacta aatctaaaag gaaatataac aaaatgccaa ttatgcttgg
     1381 tttggggcat tgatgaccct tcttcccact tttctatatt ttccaagatt tctttattga
     1441 atatgtttta ctataaatat tttctaaact catattttca ctattaaaat ttttttattt
     1501 ttccaaactt taaggcatat gctctttcca cattcctcaa cattatttgc aaacatcatg
     1561 aaatgacact tccatcaaca ttcaatgagg aaagtagtga tatagatgag ccaaaaagag
     1621 ttttatataa acttatacaa tctaaactct tgctcttcct ttctgactcc tgagggtgag
     1681 tgtgatggac tagaagaggt agccttaaaa taagtgagca gctagggaac atgctcaatg
     1741 ggcaagagaa aatgaccact gaccagtcaa tacctgtgtc agggggagtt accagtacct
     1801 atatttattt ttaaagtaat taaaaagtag aacacttaca aattttccac ctatacatgc
     1861 catgtcttcc tcggggacag tagccacatc ttatatattt cccaccatgc ataggaccca
     1921 gcacacagtg aagccagtag gcactcagtg ttgaatgctc ataccaggtt ttctgcttcc
     1981 tgtagttacc ctgctgagca ctgcttccat cacaggtgca ctgggcctca acacttctgc
     2041 catttcccca tttgtctcct ccatggacac tgtcaacaat ggtctgtcaa cacctgctct
     2101 gtgccaaagc cagggagtag gctgggggga tacggaagag aatatctttc tccttgatgc
     2161 ctgctgtgcc aacagccccc tttaagcctt gttcacagcc tttgctgaaa caagcatctt
     2221 gaaagcaagc catgttatac accgcatgac cttcatgctc tgggcccagc tgactgaact
     2281 ggggcaggcc ccagagtcat gggcagccta ttgtcttgct aatggcctct gacttagcct
     2341 ggagtaaaac actgtccaaa caagactggt ggttattcaa gcataagaat ttgaactagg
     2401 aagccaagaa tgaagcaacc ggaccattac catcaaaaaa tgattaaagg atgaagaagg
     2461 aagccaacat tcagagagta tctggttcat gttaataatg gtatcatatt aaaaggaaga
     2521 tacatgaact tctactccaa aagctcctaa aactgccttt gcccacaatg aacagtgtac
     2581 cctaggcctg gtttctgttc ttggattcct agatagtctt tcttctttgt cactgtgctg
     2641 atcatttcag taaacccccg actaaatcag tgcagctctg tttattgcaa ctaaaacgat
     2701 ccaaatgaag tctccctttt ctagatgttg ggttggaggg atgctaagac aaagatgctt
     2761 aggctccaga gttttacaga gcttcattca ataacactct actttccaaa gaacttaaat
     2821 atgaggtctg aaggacttgg accaagaggc aaacccaagc tacagacacc atgttgtact
     2881 cagagtgacc tctcccctct gacagcccag gatttctcta tcaagtccat aagctagtca
     2941 tatctaggac catcttgtta aaaattctct caaagtctcc tcagccctct tgtaaacaga
     3001 cttctggaag gtccacttca tcagtttgtt atatactttc agactgtcta tctcttgttt
     3061 agattcagca tggcaccgta cgttgaatgg actgttaata gatgtttgct gaatgactcc
     3121 accacagcat tggacacatc aggggtacag ccaaatgcag catgatacct ctatcaggaa
     3181 aattaaattt taacacagcc accaaatatt ctatatttga agagtatatg ctaatcatgc
     3241 aattttaagt aaaaaaaagc tgaatacaaa aaaagctgaa tatgtgtttt atatcctcgt
     3301 gaattcaaag taaaaaggaa aaaaaactca aaaaccaaat atatgtatgc agtttgagcc
     3361 caaattttta attaagtaac catataatta catgtagaca tgtataaacc ttgagatatg
     3421 taaagaccag aaaaatattt aaaagttaat agttacatca tctgtggtca caacaccctg
     3481 aaaatgccta atattggaaa cttaagcagg attgatccag gttattactt ggatgggaga
     3541 ccagatgcta taggctgaaa aaagaaagca taagtacgca caagttaata cttaataatt
     3601 atctcctaat gataggacta taagttctat ctcttttctt tacattgttc agtattttca
     3661 aatttccctt tgaaaatgtg ttatgtactt gaattattag aaaaaataaa tgtcatttaa
     3721 aaagcaa
//
