LOCUS       NM_014220               1555 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens transmembrane 4 L six family member 1 (TM4SF1),
            transcript variant 1, mRNA.
ACCESSION   NM_014220
VERSION     NM_014220.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Jin,Y., Eum,D.Y., Lee,C., Park,S.Y., Shim,J.W., Choi,Y.J.,
            Choi,S.H., Kim,J.G., Heo,K. and Park,S.J.
  TITLE     Breast cancer malignancy is governed by regulation of the
            macroH2A2/TM4SF1 axis, the AKT/NF-kappaB pathway, and elevated
            MMP13 expression
  JOURNAL   Mol Carcinog 63 (4), 714-727 (2024)
   PUBMED   38251858
  REMARK    GeneRIF: Breast cancer malignancy is governed by regulation of the
            macroH2A2/TM4SF1 axis, the AKT/NF-kappaB pathway, and elevated
            MMP13 expression.
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Yang,S.B., Zhou,Z.H., Lei,J., Li,X.W., Chen,Q., Li,B., Zhang,Y.W.,
            Ge,Y.Z. and Zuo,S.
  TITLE     TM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote
            cancer stemness and lenvatinib resistance in HCC
  JOURNAL   Biol Direct 18 (1), 18 (2023)
   PUBMED   37069693
  REMARK    GeneRIF: TM4SF1 upregulates MYH9 to activate the NOTCH pathway to
            promote cancer stemness and lenvatinib resistance in HCC.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Hong,J., Wong,B., Huynh,C., Tang,B., Ruffenach,G., Li,M., Umar,S.,
            Yang,X. and Eghbali,M.
  TITLE     Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in
            Pulmonary Arterial Hypertension
  JOURNAL   Am J Respir Cell Mol Biol 68 (4), 381-394 (2023)
   PUBMED   36252184
  REMARK    GeneRIF: Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in
            Pulmonary Arterial Hypertension.
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   Cai,R., Zhao,F., Zhou,H., Wang,Z., Lin,D., Huang,L., Xie,W.,
            Chen,J., Zhou,L., Zhang,N. and Huang,C.
  TITLE     A tumor-associated autoantibody panel for the detection of
            non-small cell lung cancer
  JOURNAL   Front Oncol 12, 1056572 (2022)
   PUBMED   36531074
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1555)
  AUTHORS   Wei,Y., Yin,L., Xie,X., Wu,Z., Zhang,J., Gao,Y. and Tang,J.
  TITLE     MicroRNA-501-3p targeting TM4SF1 facilitates tumor-related
            behaviors of gastric cancer cells via EMT signaling pathway
  JOURNAL   Mutat Res 825, 111802 (2022)
   PUBMED   36274500
  REMARK    GeneRIF: MicroRNA-501-3p targeting TM4SF1 facilitates tumor-related
            behaviors of gastric cancer cells via EMT signaling pathway.
REFERENCE   6  (bases 1 to 1555)
  AUTHORS   Borrell-Pages,M., Fernandez-Larrea,J., Borroto,A., Rojo,F.,
            Baselga,J. and Arribas,J.
  TITLE     The carboxy-terminal cysteine of the tetraspanin L6 antigen is
            required for its interaction with SITAC, a novel PDZ protein
  JOURNAL   Mol Biol Cell 11 (12), 4217-4225 (2000)
   PUBMED   11102519
REFERENCE   7  (bases 1 to 1555)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   8  (bases 1 to 1555)
  AUTHORS   Marken,J.S., Bajorath,J., Edwards,C.P., Farr,A.G., Schieven,G.L.,
            Hellstrom,I., Hellstrom,K.E. and Aruffo,A.
  TITLE     Membrane topology of the L6 antigen and identification of the
            protein epitope recognized by the L6 monoclonal antibody
  JOURNAL   J Biol Chem 269 (10), 7397-7401 (1994)
   PUBMED   7510285
REFERENCE   9  (bases 1 to 1555)
  AUTHORS   Virtaneva,K.I., Emi,N., Marken,J.S., Aruffo,A., Jones,C.,
            Spurr,N.K. and Schroder,J.P.
  TITLE     Chromosomal localization of three human genes coding for A15, L6,
            and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of
            proteins
  JOURNAL   Immunogenetics 39 (5), 329-334 (1994)
   PUBMED   8168850
REFERENCE   10 (bases 1 to 1555)
  AUTHORS   Marken,J.S., Schieven,G.L., Hellstrom,I., Hellstrom,K.E. and
            Aruffo,A.
  TITLE     Cloning and expression of the tumor-associated antigen L6
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3503-3507 (1992)
   PUBMED   1565644
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK130271.1, AC108751.10 and
            AC073522.19.
            
            On Nov 22, 2018 this sequence version replaced NM_014220.2.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            This encoded protein is a cell surface antigen and is highly
            expressed in different carcinomas. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK130271.1, SRR3476690.169890.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305366.8/ ENSP00000304277.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               AK130271.1         127-632
            507-515             AC108751.10        3289-3297           c
            516-696             AC073522.19        33715-33895         c
            697-1525            AC073522.19        31080-31908         c
            1526-1555           AK130271.1         1652-1681
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..1555
                     /gene="TM4SF1"
                     /gene_synonym="H-L6; L6; M3S1; TAAL6"
                     /note="transmembrane 4 L six family member 1"
                     /db_xref="GeneID:4071"
                     /db_xref="HGNC:HGNC:11853"
                     /db_xref="MIM:191155"
     exon            1..279
                     /gene="TM4SF1"
                     /gene_synonym="H-L6; L6; M3S1; TAAL6"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..711
                     /gene="TM4SF1"
                     /gene_synonym="H-L6; L6; M3S1; TAAL6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane 4 superfamily member 1; tumor-associated
                     antigen L6; membrane component, chromosome 3, surface
                     marker 1; transmembrane 4 L6 family member 1"
                     /codon_start=1
                     /product="transmembrane 4 L6 family member 1 isoform 1"
                     /protein_id="NP_055035.1"
                     /db_xref="CCDS:CCDS3143.1"
                     /db_xref="GeneID:4071"
                     /db_xref="HGNC:HGNC:11853"
                     /db_xref="MIM:191155"
                     /translation="MCYGKCARCIGHSLVGLALLCIAANILLYFPNGETKYASENHLS
                     RFVWFFSGIVGGGLLMLLPAFVFIGLEQDDCCGCCGHENCGKRCAMLSSVLAALIGIA
                     GSGYCVIVAALGLAEGPLCLDSLGQWNYTFASTEGQYLLDTSTWSECTEPKHIVEWNV
                     SLFSILLALGGIEFILCLIQVINGVLGGICGFCCSHQQQYDC"
     exon            280..369
                     /gene="TM4SF1"
                     /gene_synonym="H-L6; L6; M3S1; TAAL6"
                     /inference="alignment:Splign:2.1.0"
     exon            370..515
                     /gene="TM4SF1"
                     /gene_synonym="H-L6; L6; M3S1; TAAL6"
                     /inference="alignment:Splign:2.1.0"
     exon            516..696
                     /gene="TM4SF1"
                     /gene_synonym="H-L6; L6; M3S1; TAAL6"
                     /inference="alignment:Splign:2.1.0"
     exon            697..1555
                     /gene="TM4SF1"
                     /gene_synonym="H-L6; L6; M3S1; TAAL6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1537..1542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM4SF1"
                     /gene_synonym="H-L6; L6; M3S1; TAAL6"
                     /note="hexamer: AATAAA"
     polyA_site      1555
                     /gene="TM4SF1"
                     /gene_synonym="H-L6; L6; M3S1; TAAL6"
                     /note="major polyA site"
ORIGIN      
        1 agtggtgttt gctttctcca ccagaagggc acactttcat ctaatttggg gtatcactga
       61 gctgaagaca aagagaaggg ggagaaaacc tagcagacca ccatgtgcta tgggaagtgt
      121 gcacgatgca tcggacattc tctggtgggg ctcgccctcc tgtgcatcgc ggctaatatt
      181 ttgctttact ttcccaatgg ggaaacaaag tatgcctccg aaaaccacct cagccgcttc
      241 gtgtggttct tttctggcat cgtaggaggt ggcctgctga tgctcctgcc agcatttgtc
      301 ttcattgggc tggaacagga tgactgctgt ggctgctgtg gccatgaaaa ctgtggcaaa
      361 cgatgtgcga tgctttcttc tgtattggct gctctcattg gaattgcagg atctggctac
      421 tgtgtcattg tggcagccct tggcttagca gaaggaccac tatgtcttga ttccctcggc
      481 cagtggaact acacctttgc cagcactgag ggccagtacc ttctggatac ctccacatgg
      541 tccgagtgca ctgaacccaa gcacattgtg gaatggaatg tatctctgtt ttctatcctc
      601 ttggctcttg gtggaattga attcatcttg tgtcttattc aagtaataaa tggagtgctt
      661 ggaggcatat gtggcttttg ctgctctcac caacagcaat atgactgcta aaagaaccaa
      721 cccaggacag agccacaatc ttcctctatt tcattgtaat ttatatattt cacttgtatt
      781 catttgtaaa actttgtatt agtgtaacat actccccaca gtctactttt acaaacgcct
      841 gtaaagactg gcatcttcac aggatgtcag tgtttaaatt tagtaaactt cttttttgtt
      901 tgtttatttg tttttgtttt tttttaagga atgaggaaac aaaccaccct ctgggggtaa
      961 tttacagact gagtgacagt actcagtata tctgagataa actctataat gttttggata
     1021 aaaataacat tccaatcact attgtatata tgtgcatgta ttttttaaat taaagatgtc
     1081 tagttgcttt ttataagacc aagaaggaga aaatccgaca acctggaaag atttttgttt
     1141 tcactgcttg tatgatgttt cccattcata cacctataaa tctctaacaa gaggcccttt
     1201 gaactgcctt gtgttctgtg agaaacaaat atttacttag agtggaagga ctgattgaga
     1261 atgttccaat ccaaatgaat gcatcacaac ttacaatgct gctcattgtt gtgagtacta
     1321 tgagattcaa atttttctaa catatggaaa gccttttgtc ctccaaagat gagtactagg
     1381 gatcatgtgt ttaaaaaaag aaaggctacg atgactgggc aagaagaaag atgggaaact
     1441 gaataaagca gttgatcagc atcattggaa catggggacg agtgacggca ggaggaccac
     1501 gaggaaatac cctcaaaact aacttgttta caacaaaata aagtattcac tacca
//
