LOCUS       NM_078473               3239 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens TM2 domain containing 2 (TM2D2), transcript variant 1,
            mRNA.
ACCESSION   NM_078473
VERSION     NM_078473.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3239)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3239)
  AUTHORS   Kajkowski,E.M., Lo,C.F., Ning,X., Walker,S., Sofia,H.J., Wang,W.,
            Edris,W., Chanda,P., Wagner,E., Vile,S., Ryan,K.,
            McHendry-Rinde,B., Smith,S.C., Wood,A., Rhodes,K.J., Kennedy,J.D.,
            Bard,J., Jacobsen,J.S. and Ozenberger,B.A.
  TITLE     beta -Amyloid peptide-induced apoptosis regulated by a novel
            protein containing a g protein activation module
  JOURNAL   J Biol Chem 276 (22), 18748-18756 (2001)
   PUBMED   11278849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG424960.1, AF353991.1 and AC108863.4.
            
            On Nov 23, 2018 this sequence version replaced NM_078473.2.
            
            Summary: The protein encoded by this gene contains a structural
            module related to that of the seven transmembrane domain G
            protein-coupled receptor superfamily. This protein has sequence and
            structural similarities to the beta-amyloid binding protein (BBP),
            but, unlike BBP, it does not regulate a response to beta-amyloid
            peptide. This protein may have regulatory roles in cell death or
            proliferation signal cascades. This gene has multiple alternatively
            spliced transcript variants which encode two different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.245642.1,
                                           SRR1803611.159917.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000456397.7/ ENSP00000416050.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               BG424960.1         14-310
            298-715             AF353991.1         281-698
            716-3239            AC108863.4         93709-96232         c
FEATURES             Location/Qualifiers
     source          1..3239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.22"
     gene            1..3239
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
                     /note="TM2 domain containing 2"
                     /db_xref="GeneID:83877"
                     /db_xref="HGNC:HGNC:24127"
                     /db_xref="MIM:610081"
     exon            1..297
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..715
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; BBP-like protein 1; TM2 domain-containing
                     protein 2; beta-amyloid-binding protein-like protein 1"
                     /codon_start=1
                     /product="TM2 domain-containing protein 2 isoform a
                     precursor"
                     /protein_id="NP_510882.1"
                     /db_xref="CCDS:CCDS6111.1"
                     /db_xref="GeneID:83877"
                     /db_xref="HGNC:HGNC:24127"
                     /db_xref="MIM:610081"
                     /translation="MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSQNATAEPEL
                     TSAGAAQPEGPGGAASWEYGDPHSPVILCSYLPDEFIECEDPVDHVGNATASQELGYG
                     CLKFGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFL
                     GCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY"
     exon            298..385
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..501
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            502..3239
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1223..1228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
                     /note="hexamer: AATAAA"
     polyA_site      1243
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
                     /note="major polyA site"
     regulatory      1498..1503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
                     /note="hexamer: AATAAA"
     polyA_site      1520
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
     regulatory      3214..3219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
                     /note="hexamer: AATAAA"
     polyA_site      3239
                     /gene="TM2D2"
                     /gene_synonym="BLP1"
ORIGIN      
        1 agttcttggg tctgtgctgc tggcctgggg ttgtggttga ggccgggtct ccgctcctgt
       61 gcccgggaag atggtgctag gtggttgccc ggttagttac ttacttctgt gcggccaggc
      121 ggctttgctg ctggggaatt tacttctgct gcattgtgtg tctcggagcc actcgcaaaa
      181 tgcgaccgct gagcctgagc tcacatccgc tggcgccgcc cagccggagg gccccggggg
      241 tgctgcgagc tgggaatatg gcgaccccca ctctccggtc atcctctgct cttacctacc
      301 tgatgaattt atagaatgtg aagacccagt ggatcatgtt ggaaatgcaa ctgcatccca
      361 ggaacttggt tatggttgtc tcaagttcgg cggtcaggcc tacagcgacg tggaacacac
      421 ttcagtccag tgccatgcct tagatggaat tgagtgtgcc agtcctagga cctttctacg
      481 agaaaataaa ccttgtataa agtataccgg acactacttc ataaccactt tactctactc
      541 cttcttcctg ggatgttttg gtgtggatcg attctgtttg ggacacactg gcactgcagt
      601 agggaagctg ttgacgcttg gaggacttgg gatttggtgg tttgttgacc ttattttgct
      661 aattactgga gggctgatgc caagtgatgg cagcaactgg tgcactgttt actaagaaga
      721 gctgccatca tggcccaggg aggcgggtga aagctccgtc ttctgaattc atctctacag
      781 gctcaaaact cctctttgat atcagacctg atgttatttt ccttcttttg gagggcattt
      841 gtttggttaa gaaggcttct ttggactttg gaatttcaac ccagatttta ccttgcagac
      901 ggaatgacaa gcaaaaagtg ttgtggggaa tcaaatttgt tcctttcctc atgcacaaaa
      961 cataaaggat agtggcgagt ttacaagctg tggatgggtt tccatagtct tcctttctgt
     1021 acattgctat atcttcagtc ctttggagca agtggaccta acaagttgag caaaatgaat
     1081 atttggatcc atgttcctct tgtgaccctg agtcttcatg caaggagatc tgaagctgaa
     1141 caatgaaaat cttcagcaga aatagaaatg gccgtggatt gtaatacaca ctgaaattct
     1201 gactttctga atttaaatgt agaataaatt ttaccaactt ggagtactgt atgagtattt
     1261 tcagtagggg gaataaactc aaaattatat ttgttttgca gaaacctagt catttgaaat
     1321 gagccatcct attaagccct cttttgtctc cattatgttc cagaggcagt atatgcagtg
     1381 caataatttt ttcattccac ttatgttttg aaagccagcg gcatcagatg tgtgagttga
     1441 gctattcctc ctggcagaat tgtccaatct aaaaatcagc gtttaccagc ccatgctaat
     1501 aaaattaaga tttcatacaa gtttctgtaa aactattctt catgattagc tctccctgtg
     1561 ggctgcagca gtcagaaaga gataacagcc acacctctgc attccccggt caccaggaat
     1621 aaaaggaaat gttccagatt gtaagtggtt ttaaaaactc agttctcatc gtttgcaatc
     1681 taagttgaaa gaactattaa atataaaatc aaaggtgggc aatgtggcca agtcaatgga
     1741 agaggcttta ctcagaataa cttacaaatt ctagaaacaa ggtagaactc actcagttta
     1801 cctaataata attgaattta agaccaaata tcacagttga aataacttcc ctggatacat
     1861 tctatcattt tgtagctttc ctaagaattt cttgctttat cattcctgat taatcactgt
     1921 ttttacatta ttaaaggtgg caattttctg taaaaaattt aaaacagatg atcctattct
     1981 gtcttgaaag ttctgtacca cactgacctt aaccttgctt ataacataac aattggtaaa
     2041 cttttaattc ataatcttta taccctaaga tagtatttat taaattttta tgggtcatga
     2101 agaaactaga ccctctcccc agaaaaatct acatacacag aatttacata gaacttgggt
     2161 tcatctacac aatttatgca tgaaataaaa ttgtactggt accctataaa tttatacaaa
     2221 taaaagagtt taagggagtt caaggatgcc atatgtatat tttaaaaaaa tttctaaggg
     2281 aagtctaaaa aacataaatt ataatattac ccaaaataag atgctacttt tcacctaacc
     2341 aagtcctgcc tcatttcaca ctttaacctc ctaagtatat tcataaccct accaaaagtt
     2401 gttttcttta aaaaataaga aactttaggg ccagcgcaat ggtgcaagcc tgtaatccct
     2461 gcactttggg aggccgaggc aggtgaatcc tttaaggtca ggagttcgag accagcctgg
     2521 ccaacatggt gagacacact cccccacccc cgcccagtct ctagtaaaaa tgcaaaaatt
     2581 agccgggcgt ggtggcgtgc acctgtaatc ccagctactc gggaggctga ggtaagagaa
     2641 tcacttgaac tgaggaggca gagattgcag tgagccgaga tcctgccact gcacttcagc
     2701 ctgggcaaca gagtgagact ctgaccaaaa aagaaatttt gcagctccaa ggcttgaagt
     2761 catttatgtt gccaggggta agagcttggt tgaagggcta aaagactaga aactactgaa
     2821 gatgcccttc ttactgtcag taaagctgct ggagacaaaa gaagttgttc tcgctgctag
     2881 agtggtaatt tgagaatcat cagtattcct atgtgacaat ccaaaattac tggttttcat
     2941 ttgacttgta aatgacaccc atcatccatc tgcccacaaa cctggccaaa tgtgatacaa
     3001 cctgaaaacc tgatggacta aaggagtact atttaacaat tgattgcctt tgcactttat
     3061 tcaggttgtt tcttaaattt tggtagacag atccatttgt atatgtgtgt gttatatcta
     3121 gtttatggct atagagaagg tttaaaatac tacagtgtcc ttccctcaag gttaaattag
     3181 aagctgcctg ccttttagtt gtttcttgcc tttaataaaa tgttatcagt tcccccaga
//
