LOCUS       NM_032027                969 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens TM2 domain containing 1 (TM2D1), transcript variant 1,
            mRNA.
ACCESSION   NM_032027
VERSION     NM_032027.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 969)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 969)
  AUTHORS   Cam,J.A., Zerbinatti,C.V., Knisely,J.M., Hecimovic,S., Li,Y. and
            Bu,G.
  TITLE     The low density lipoprotein receptor-related protein 1B retains
            beta-amyloid precursor protein at the cell surface and reduces
            amyloid-beta peptide production
  JOURNAL   J Biol Chem 279 (28), 29639-29646 (2004)
   PUBMED   15126508
  REMARK    GeneRIF: These findings reveal that low density lipoprotein
            receptor-related protein 1B is a novel binding partner of
            beta-amyloid precursor protein (APP) that functions to decrease APP
            processing to amyloid beta peptides.
REFERENCE   3  (bases 1 to 969)
  AUTHORS   Lee,Y., Chang,D.J., Lee,Y.S., Chang,K.A., Kim,H., Yoon,J.S.,
            Lee,S., Suh,Y.H. and Kaang,B.K.
  TITLE     Beta-amyloid peptide binding protein does not couple to G protein
            in a heterologous Xenopus expression system
  JOURNAL   J Neurosci Res 73 (2), 255-259 (2003)
   PUBMED   12836168
  REMARK    GeneRIF: A two-electrode voltage-clamp technique is used to
            determine that BBP is not directly coupled to G alpha(i/o), G
            alpha(s), or G alpha(q) proteins and that BBP may need a component
            other than amyloid precursor protein to exert its toxic effect with
            A beta.
REFERENCE   4  (bases 1 to 969)
  AUTHORS   Kirfel,G., Borm,B., Rigort,A. and Herzog,V.
  TITLE     The secretory beta-amyloid precursor protein is a motogen for human
            epidermal keratinocytes
  JOURNAL   Eur J Cell Biol 81 (12), 664-676 (2002)
   PUBMED   12553667
  REMARK    GeneRIF: sAPP increased the proportion of migrating keratinocytes
            and their directional persistence. sAPP appeared to operate
            synergistically with fibronectin with respect to its motogenic
            effect.
REFERENCE   5  (bases 1 to 969)
  AUTHORS   Kajkowski,E.M., Lo,C.F., Ning,X., Walker,S., Sofia,H.J., Wang,W.,
            Edris,W., Chanda,P., Wagner,E., Vile,S., Ryan,K.,
            McHendry-Rinde,B., Smith,S.C., Wood,A., Rhodes,K.J., Kennedy,J.D.,
            Bard,J., Jacobsen,J.S. and Ozenberger,B.A.
  TITLE     beta -Amyloid peptide-induced apoptosis regulated by a novel
            protein containing a g protein activation module
  JOURNAL   J Biol Chem 276 (22), 18748-18756 (2001)
   PUBMED   11278849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099791.2.
            
            On Nov 30, 2018 this sequence version replaced NM_032027.2.
            
            Summary: The protein encoded by this gene is a beta-amyloid
            peptide-binding protein. It contains a structural module related to
            that of the seven transmembrane domain G protein-coupled receptor
            superfamily and known to be important in heterotrimeric G protein
            activation. Beta-amyloid peptide has been established to be a
            causative factor in neuron death and the consequent diminution of
            cognitive abilities observed in Alzheimer's disease. This protein
            may be a target of neurotoxic beta-amyloid peptide, and may mediate
            cellular vulnerability to beta-amyloid peptide toxicity through a G
            protein-regulated program of cell death. Several transcript
            variants have been found for this gene. [provided by RefSeq, Feb
            2016].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029486.1, BI464436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000606498.5/ ENSP00000475700.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC099791.2         222352-222536       c
            186-259             AC099791.2         221108-221181       c
            260-368             AC099791.2         206724-206832       c
            369-460             AC099791.2         198329-198420       c
            461-534             AC099791.2         192092-192165       c
            535-664             AC099791.2         180812-180941       c
            665-969             AC099791.2         178441-178745       c
FEATURES             Location/Qualifiers
     source          1..969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..969
                     /gene="TM2D1"
                     /gene_synonym="BBP"
                     /note="TM2 domain containing 1"
                     /db_xref="GeneID:83941"
                     /db_xref="HGNC:HGNC:24142"
                     /db_xref="MIM:610080"
     exon            1..185
                     /gene="TM2D1"
                     /gene_synonym="BBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..645
                     /gene="TM2D1"
                     /gene_synonym="BBP"
                     /note="TM2 domain-containing protein 1; hBBP;
                     beta-amyloid-binding protein; amyloid-beta-binding
                     protein; Beta-amyloid peptide binding protein"
                     /codon_start=1
                     /product="TM2 domain-containing protein 1 precursor"
                     /protein_id="NP_114416.1"
                     /db_xref="CCDS:CCDS65554.1"
                     /db_xref="GeneID:83941"
                     /db_xref="HGNC:HGNC:24142"
                     /db_xref="MIM:610080"
                     /translation="MAAAWPSGPSAPEAVTARLVGVLWFVSVTTGPWGAVATSAGGEE
                     SLKCEDLKVGQYICKDPKINDATQEPVNCTNYTAHVSCFPAPNITCKDSSGNETHFTG
                     NEVGFFKPISCRNVNGYSYKVAVALSLFLGWLGADRFYLGYPALGLLKFCTVGFCGIG
                     SLIDFILISMQIVGPSDGSSYIIDYYGTRLTRLSITNETFRKTQLYP"
     exon            186..259
                     /gene="TM2D1"
                     /gene_synonym="BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            260..368
                     /gene="TM2D1"
                     /gene_synonym="BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            369..460
                     /gene="TM2D1"
                     /gene_synonym="BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            461..534
                     /gene="TM2D1"
                     /gene_synonym="BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            535..664
                     /gene="TM2D1"
                     /gene_synonym="BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            665..969
                     /gene="TM2D1"
                     /gene_synonym="BBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      947..952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TM2D1"
                     /gene_synonym="BBP"
                     /note="hexamer: AATAAA"
     polyA_site      969
                     /gene="TM2D1"
                     /gene_synonym="BBP"
                     /note="major polyA site"
ORIGIN      
        1 gagaaagtgt cggtctccaa gatggcggcc gcctggccgt ctggtccgtc tgctccggag
       61 gccgtgacgg ccagactcgt tggtgtcctg tggttcgtct cagtcactac aggaccctgg
      121 ggggctgttg ccacctccgc cgggggcgag gagtcgctta agtgcgagga cctcaaagtg
      181 ggacaatata tttgtaaaga tccaaaaata aatgacgcta cgcaagaacc agttaactgt
      241 acaaactaca cagctcatgt ttcctgtttt ccagcaccca acataacttg taaggattcc
      301 agtggcaatg aaacacattt tactgggaac gaagttggtt ttttcaagcc catatcttgc
      361 cgaaatgtaa atggctattc ctacaaagtg gcagtcgcat tgtctctttt tcttggatgg
      421 ttgggagcag atcgatttta ccttggatac cctgctttgg gtttgttaaa gttttgcact
      481 gtagggtttt gtggaattgg gagcctaatt gatttcattc ttatttcaat gcagattgtt
      541 ggaccttcag atggaagtag ttacattata gattactatg gaaccagact tacaagactg
      601 agtattacta atgaaacatt tagaaaaacg caattatatc cataaatatt ttttaaaaga
      661 aacagatttg agcctccttg attttaatag agaacttcta gtgtatggat ttaaagattt
      721 ctctttttca ttcatatacc attttatgag ttctgtataa ttttttgtgg tttttgtttt
      781 gttgagttaa agtatattat tgtgagattt atttaatagg acttcctttg aaagctgtat
      841 aatagtgttt ctcgggcttc tgtctctatg agagatagct tattactctg atactcttta
      901 atcttttaca aaggcaagtt gccacttgtc atttttgttt ctgaaaaata aaagtataac
      961 ttattcaca
//
