LOCUS       NM_005521               2111 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens T cell leukemia homeobox 1 (TLX1), transcript variant
            1, mRNA.
ACCESSION   NM_005521
VERSION     NM_005521.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2111)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2111)
  AUTHORS   Mei,E., Wei,X., Gao,J., Tian,X., Li,W., Liu,L. and Qian,C.
  TITLE     Association of TLX1 gene polymorphisms with the risk of acute
            lymphoblastic leukemia and B lineage acute lymphoblastic leukemia
            in Han Chinese children
  JOURNAL   J Clin Lab Anal 34 (9), e23414 (2020)
   PUBMED   32488880
  REMARK    GeneRIF: Association of TLX1 gene polymorphisms with the risk of
            acute lymphoblastic leukemia and B lineage acute lymphoblastic
            leukemia in Han Chinese children.
REFERENCE   3  (bases 1 to 2111)
  AUTHORS   Verboom,K., Van Loocke,W., Volders,P.J., Decaesteker,B.,
            Cobos,F.A., Bornschein,S., de Bock,C.E., Atak,Z.K., Clappier,E.,
            Aerts,S., Cools,J., Soulier,J., Taghon,T., Van Vlierberghe,P.,
            Vandesompele,J., Speleman,F. and Durinck,K.
  TITLE     A comprehensive inventory of TLX1 controlled long non-coding RNAs
            in T-cell acute lymphoblastic leukemia through polyA+ and total RNA
            sequencing
  JOURNAL   Haematologica 103 (12), e585-e589 (2018)
   PUBMED   29954933
  REMARK    GeneRIF: Data show that among all long non-coding RNAs (lncRNAs),
            82 are differentially regulated upon T cell leukemia homeobox 1
            protein (TLX1) knockdown, of which 30 are directly bound by TLX1.
REFERENCE   4  (bases 1 to 2111)
  AUTHORS   Vanden Bempt,M., Demeyer,S., Broux,M., De Bie,J., Bornschein,S.,
            Mentens,N., Vandepoel,R., Geerdens,E., Radaelli,E.,
            Bornhauser,B.C., Kulozik,A.E., Meijerink,J.P., Bourquin,J.P., de
            Bock,C.E. and Cools,J.
  TITLE     Cooperative Enhancer Activation by TLX1 and STAT5 Drives
            Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic
            Leukemia
  JOURNAL   Cancer Cell 34 (2), 271-285 (2018)
   PUBMED   30107177
  REMARK    GeneRIF: oncogenic kinase NUP214-ABL1, through its downstream
            effector STAT5, directly cooperates with TLX1 at the
            transcriptional level.
REFERENCE   5  (bases 1 to 2111)
  AUTHORS   Dear,T.N., Sanchez-Garcia,I. and Rabbitts,T.H.
  TITLE     The HOX11 gene encodes a DNA-binding nuclear transcription factor
            belonging to a distinct family of homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (10), 4431-4435 (1993)
   PUBMED   8099440
REFERENCE   6  (bases 1 to 2111)
  AUTHORS   Lu,M., Zhang,N. and Ho,A.D.
  TITLE     Genomic organization of the putative human homeobox proto-oncogene
            HOX-11 (TCL-3) and its endogenous expression in T cells
  JOURNAL   Oncogene 7 (7), 1325-1330 (1992)
   PUBMED   1352396
REFERENCE   7  (bases 1 to 2111)
  AUTHORS   Kennedy,M.A., Gonzalez-Sarmiento,R., Kees,U.R., Lampert,F.,
            Dear,N., Boehm,T. and Rabbitts,T.H.
  TITLE     HOX11, a homeobox-containing T-cell oncogene on human chromosome
            10q24
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 8900-8904 (1991)
   PUBMED   1681546
REFERENCE   8  (bases 1 to 2111)
  AUTHORS   Lu,M., Gong,Z.Y., Shen,W.F. and Ho,A.D.
  TITLE     The tcl-3 proto-oncogene altered by chromosomal translocation in
            T-cell leukemia codes for a homeobox protein
  JOURNAL   EMBO J 10 (10), 2905-2910 (1991)
   PUBMED   1717256
REFERENCE   9  (bases 1 to 2111)
  AUTHORS   Hatano,M., Roberts,C.W., Minden,M., Crist,W.M. and Korsmeyer,S.J.
  TITLE     Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell
            leukemia
  JOURNAL   Science 253 (5015), 79-82 (1991)
   PUBMED   1676542
REFERENCE   10 (bases 1 to 2111)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357395.13, BC130530.1,
            M62626.1, S38742.1 and BF514683.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005521.3.
            
            Summary: This gene encodes a nuclear transcription factor that
            belongs to the NK-linked or NK-like (NKL) subfamily of homeobox
            genes. The encoded protein is required for normal development of
            the spleen during embryogenesis. This protein is also involved in
            specification of neuronal cell fates. Ectopic expression of this
            gene due to chromosomal translocations is associated with certain
            T-cell acute lymphoblastic leukemias. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S38742.1, M62626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370196.11/ ENSP00000359215.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL357395.13        35038-35041
            5-1012              BC130530.1         1-1008
            1013-1360           M62626.1           1789-2136
            1361-1621           BC130530.1         1380-1640
            1622-2098           S38742.1           1478-1954
            2099-2111           BF514683.1         17-29               c
FEATURES             Location/Qualifiers
     source          1..2111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.31"
     gene            1..2111
                     /gene="TLX1"
                     /gene_synonym="HOX11; TCL3"
                     /note="T cell leukemia homeobox 1"
                     /db_xref="GeneID:3195"
                     /db_xref="HGNC:HGNC:5056"
                     /db_xref="MIM:186770"
     exon            1..810
                     /gene="TLX1"
                     /gene_synonym="HOX11; TCL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1235
                     /gene="TLX1"
                     /gene_synonym="HOX11; TCL3"
                     /note="isoform 1 is encoded by transcript variant 1; homeo
                     box-11 (T-cell leukemia-3 associated breakpoint,
                     homologous to Drosophila Notch); proto-oncogene TCL-3;
                     homeobox protein Hox-11; T-cell leukemia/lymphoma protein
                     3"
                     /codon_start=1
                     /product="T-cell leukemia homeobox protein 1 isoform 1"
                     /protein_id="NP_005512.1"
                     /db_xref="CCDS:CCDS7510.1"
                     /db_xref="GeneID:3195"
                     /db_xref="HGNC:HGNC:5056"
                     /db_xref="MIM:186770"
                     /translation="MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGE
                     YGLGCLVGGAYTYGGGGSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYN
                     VNMALAGGPGPGGGGGSSGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSV
                     PAMPGVNNLTGLTFPWMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEK
                     RFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILL
                     QLQQEAFQKSLAQPLPADPLCVHNSSLFALQNLQPWSDDSTKITSVTSVASACE"
     exon            811..1012
                     /gene="TLX1"
                     /gene_synonym="HOX11; TCL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..2111
                     /gene="TLX1"
                     /gene_synonym="HOX11; TCL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2090..2095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLX1"
                     /gene_synonym="HOX11; TCL3"
                     /note="hexamer: AATAAA"
     polyA_site      2111
                     /gene="TLX1"
                     /gene_synonym="HOX11; TCL3"
                     /note="major polyA site"
ORIGIN      
        1 gatgtcccag agtcaacagc gagcgagcag ccggagcggg gaagcagaag ccagagaggg
       61 gaagaatacg gcgccccctc tctccctccc ctcccccttc tactttagcc tttctgcgca
      121 cttcgcttcc aagtctccgc gcagccagga gccgctgttg cctcccagcc cctgctagct
      181 gccccccgag ccgagcgcag cgagcgccgc cgcccgggcc ccccggtggg gccagggcca
      241 gcatggagca cctgggtccg caccacctcc acccgggtca cgcagagccc attagcttcg
      301 gcatcgacca gatcctcaac agcccggacc agggtggctg catgggaccc gcctcgcgcc
      361 tccaggacgg agaatacggc cttggctgct tggtcggagg cgcctacact tacggcggcg
      421 ggggctccgc ggccgcgacg ggggctggag gagcgggggc ctatggtact ggaggtcccg
      481 gcggccccgg aggcccggca ggcggcggcg gcgcctgcag catgggtcct ctgaccggct
      541 cctacaacgt gaacatggcc ttggcaggcg gccccggtcc tggcggcggc ggcggcagca
      601 gcggcggtgc cggggcactc agcgctgcgg gggtaatccg ggtgccggca cacaggccgc
      661 tcgccggagc cgtggcccac ccccagcccc tggccaccgg cttgcccacc gtgccctctg
      721 tgcctgccat gccgggcgtc aacaacctca ctggcctcac cttcccctgg atggagagta
      781 accgcagata cacaaaggac aggttcacag gtcaccccta tcagaaccgg acgcccccca
      841 agaagaagaa gccgcgcacg tccttcacac gcctgcagat ctgcgagctg gagaagcgct
      901 tccaccgcca gaagtacctg gcctcggccg agcgcgccgc cctggccaag gcgctcaaaa
      961 tgaccgatgc gcaggtcaaa acctggttcc agaaccggcg gacaaagtgg agacggcaga
     1021 ctgcggagga acgggaggcc gagaggcagc aagcgaaccg catcctcctg cagttgcagc
     1081 aggaggcctt ccagaagagc ctggcacagc cgctgcccgc tgaccctctg tgcgtgcaca
     1141 actcgtcgct cttcgccctg cagaatctgc agccgtggtc tgacgactcg accaaaatca
     1201 ctagcgtcac gtcggtggcg tcggcctgcg agtgagcctg cccattctgc cctgtgggac
     1261 cccaggccca ctcaggggtc actgaggcct gagacccagg actcctcccc accctcctgg
     1321 cctcagactg cacccaggag gggaacactg ccctcgcacg gccccgaagg gcccccacat
     1381 ttgtgccgac actgttctcc cttcggtgga agagctcaag ggacaaggac acgcgccccc
     1441 ctcccagagg cgtcccgcac ctgtctgaac tgttaagaaa tctgtttttg tttatttcat
     1501 tttattttaa tttttaacgt gggattcaga gaaaggcaag ggaggtaagg gaggaggagc
     1561 ttctggggtc cccagggctg tcatctgaat ttgccctggg aaaccccttc tctgtgaccc
     1621 acttctcatc acacacatgg aaacccatag gcccacacac aggtggtgtc actgtccctc
     1681 ctggtgtcac cccagagcca cacatgggca tctatgggag agtgtcaacc agacagaggg
     1741 tcacagtgtt tacactttgg accttacgat caggcacagg tcaggggtga cacagactca
     1801 tcctgaacag catggcactc cctccagcac aaacacaagg tcatggccac actgtgacac
     1861 actacaccac acacaacagc caacagctac aacagcctca cttggtctgc caggccccca
     1921 ccacacatcc cagcccaatc caggtacgca cagacaggtt ttcacataaa tgcagcccat
     1981 ttctccagaa cccatttgag gggtgggggg gtgttaattt atgcacttat aaggtgtttt
     2041 ctgtgtaacc attttataaa gtgcttgtgt aatttatgtg aaaaaaataa ataaaagcct
     2101 ccggatccgg a
//
