LOCUS       NM_017442               3352 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens toll like receptor 9 (TLR9), mRNA.
ACCESSION   NM_017442
VERSION     NM_017442.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3352)
  AUTHORS   Obrenovic,M., Supic,G., Miyabe,S., Mladenovic,I., Kozomara,R.,
            Jovic,S., Petkovic Curcin,A., Stefik,D., Stosic,S. and Vukomanovic
            Durdevic,B.
  TITLE     Impact of TLR9 and TLR7 gene polymorphisms on prognosis and
            survival of patients with oral squamous cell carcinoma
  JOURNAL   Biomol Biomed 24 (6), 1682-1691 (2024)
   PUBMED   38850110
  REMARK    GeneRIF: Impact of TLR9 and TLR7 gene polymorphisms on prognosis
            and survival of patients with oral squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3352)
  AUTHORS   Qasim Mohammed,M., Hussein Alwan,A., Amer Almukhtar,A. and Kareem
            Aneed Al-Saedi,M.
  TITLE     Revealing of TLR-9 gene polymorphisms by qPCR HRM technique and
            their influence on TLR-9 serum level in acute myeloid leukemia
            patients: Case-control study
  JOURNAL   Cytokine 182, 156730 (2024)
   PUBMED   39133967
  REMARK    GeneRIF: Revealing of TLR-9 gene polymorphisms by qPCR HRM
            technique and their influence on TLR-9 serum level in acute myeloid
            leukemia patients: Case-control study.
REFERENCE   3  (bases 1 to 3352)
  AUTHORS   Dong,L., Luo,W., Maksym,S., Robson,S.C. and Zavialov,A.V.
  TITLE     Adenosine deaminase 2 regulates the activation of the toll-like
            receptor 9 in response to nucleic acids
  JOURNAL   Front Med 18 (5), 814-830 (2024)
   PUBMED   39078537
  REMARK    GeneRIF: Adenosine deaminase 2 regulates the activation of the
            toll-like receptor 9 in response to nucleic acids.
REFERENCE   4  (bases 1 to 3352)
  AUTHORS   Hatten,H., Colyn,L., Volkert,I., Gassler,N., Lammers,T.,
            Hofmann,U., Hengstler,J.G., Schneider,K.M. and Trautwein,C.
  TITLE     Loss of Toll-like receptor 9 protects from hepatocellular carcinoma
            in murine models of chronic liver disease
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167321 (2024)
   PUBMED   38943920
  REMARK    GeneRIF: Loss of Toll-like receptor 9 protects from hepatocellular
            carcinoma in murine models of chronic liver disease.
REFERENCE   5  (bases 1 to 3352)
  AUTHORS   Emele,R.E., Salim,M.A., Polat,F. and Diler,S.B.
  TITLE     Investigation of TLR2 (-196 to -174del) and TLR9 (T-1486C) Gene
            Polymorphisms Association with Inflammatory Bowel Diseases
  JOURNAL   Asian Pac J Cancer Prev 25 (6), 2003-2010 (2024)
   PUBMED   38918662
  REMARK    GeneRIF: Investigation of TLR2 (-196 to -174del) and TLR9 (T-1486C)
            Gene Polymorphisms Association with Inflammatory Bowel Diseases.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3352)
  AUTHORS   Kadowaki,N., Ho,S., Antonenko,S., Malefyt,R.W., Kastelein,R.A.,
            Bazan,F. and Liu,Y.J.
  TITLE     Subsets of human dendritic cell precursors express different
            toll-like receptors and respond to different microbial antigens
  JOURNAL   J Exp Med 194 (6), 863-869 (2001)
   PUBMED   11561001
REFERENCE   7  (bases 1 to 3352)
  AUTHORS   Hemmi,H., Takeuchi,O., Kawai,T., Kaisho,T., Sato,S., Sanjo,H.,
            Matsumoto,M., Hoshino,K., Wagner,H., Takeda,K. and Akira,S.
  TITLE     A Toll-like receptor recognizes bacterial DNA
  JOURNAL   Nature 408 (6813), 740-745 (2000)
   PUBMED   11130078
  REMARK    Erratum:[Nature 2001 Feb 1;409(6820):646]
REFERENCE   8  (bases 1 to 3352)
  AUTHORS   Chuang,T.H. and Ulevitch,R.J.
  TITLE     Cloning and characterization of a sub-family of human toll-like
            receptors: hTLR7, hTLR8 and hTLR9
  JOURNAL   Eur Cytokine Netw 11 (3), 372-378 (2000)
   PUBMED   11022120
REFERENCE   9  (bases 1 to 3352)
  AUTHORS   Du,X., Poltorak,A., Wei,Y. and Beutler,B.
  TITLE     Three novel mammalian toll-like receptors: gene structure,
            expression, and evolution
  JOURNAL   Eur Cytokine Netw 11 (3), 362-371 (2000)
   PUBMED   11022119
REFERENCE   10 (bases 1 to 3352)
  AUTHORS   Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
  TITLE     A family of human receptors structurally related to Drosophila Toll
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 588-593 (1998)
   PUBMED   9435236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF259262.1, AF245704.1 and
            BC032713.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_017442.3.
            
            Summary: The protein encoded by this gene is a member of the
            Toll-like receptor (TLR) family, which plays a fundamental role in
            pathogen recognition and activation of innate immunity. TLRs are
            highly conserved from Drosophila to humans and share structural and
            functional similarities. They recognize pathogen-associated
            molecular patterns (PAMPs) that are expressed on infectious agents,
            and mediate the production of cytokines necessary for the
            development of effective immunity. Studies in mice and human
            indicate that this receptor mediates cellular response to
            unmethylated CpG dinucleotides in bacterial DNA to mount an innate
            immune response. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032713.1, AF259262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360658.3/ ENSP00000353874.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1750              AF259262.1         519-2268
            1751-2178           AF245704.1         1779-2206
            2179-3352           BC032713.1         2159-3332
FEATURES             Location/Qualifiers
     source          1..3352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..3352
                     /gene="TLR9"
                     /gene_synonym="CD289"
                     /note="toll like receptor 9"
                     /db_xref="GeneID:54106"
                     /db_xref="HGNC:HGNC:15633"
                     /db_xref="MIM:605474"
     exon            1..119
                     /gene="TLR9"
                     /gene_synonym="CD289"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..3215
                     /gene="TLR9"
                     /gene_synonym="CD289"
                     /codon_start=1
                     /product="toll-like receptor 9 precursor"
                     /protein_id="NP_059138.1"
                     /db_xref="CCDS:CCDS2848.1"
                     /db_xref="GeneID:54106"
                     /db_xref="HGNC:HGNC:15633"
                     /db_xref="MIM:605474"
                     /translation="MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVN
                     CNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVG
                     LSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDS
                     ASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNL
                     PSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLH
                     PDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLT
                     QLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPM
                     LQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQP
                     GDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCI
                     SQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGH
                     NFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFF
                     QGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVL
                     DLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTV
                     DHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQG
                     LSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPW
                     RGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWL
                     PGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILS
                     PDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPT
                     AE"
     exon            120..3352
                     /gene="TLR9"
                     /gene_synonym="CD289"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3332..3337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR9"
                     /gene_synonym="CD289"
                     /note="hexamer: AATAAA"
     polyA_site      3352
                     /gene="TLR9"
                     /gene_synonym="CD289"
                     /note="major polyA site"
ORIGIN      
        1 attctctgag ccgctgctgc ccctgtggga agggacctcg agtgtgaagc atccttccct
       61 gtagctgctg tccagtctgc ccgccagacc ctctggagaa gcccctgccc cccagcatgg
      121 gtttctgccg cagcgccctg cacccgctgt ctctcctggt gcaggccatc atgctggcca
      181 tgaccctggc cctgggtacc ttgcctgcct tcctaccctg tgagctccag ccccacggcc
      241 tggtgaactg caactggctg ttcctgaagt ctgtgcccca cttctccatg gcagcacccc
      301 gtggcaatgt caccagcctt tccttgtcct ccaaccgcat ccaccacctc catgattctg
      361 actttgccca cctgcccagc ctgcggcatc tcaacctcaa gtggaactgc ccgccggttg
      421 gcctcagccc catgcacttc ccctgccaca tgaccatcga gcccagcacc ttcttggctg
      481 tgcccaccct ggaagagcta aacctgagct acaacaacat catgactgtg cctgcgctgc
      541 ccaaatccct catatccctg tccctcagcc ataccaacat cctgatgcta gactctgcca
      601 gcctcgccgg cctgcatgcc ctgcgcttcc tattcatgga cggcaactgt tattacaaga
      661 acccctgcag gcaggcactg gaggtggccc cgggtgccct ccttggcctg ggcaacctca
      721 cccacctgtc actcaagtac aacaacctca ctgtggtgcc ccgcaacctg ccttccagcc
      781 tggagtatct gctgttgtcc tacaaccgca tcgtcaaact ggcgcctgag gacctggcca
      841 atctgaccgc cctgcgtgtg ctcgatgtgg gcggaaattg ccgccgctgc gaccacgctc
      901 ccaacccctg catggagtgc cctcgtcact tcccccagct acatcccgat accttcagcc
      961 acctgagccg tcttgaaggc ctggtgttga aggacagttc tctctcctgg ctgaatgcca
     1021 gttggttccg tgggctggga aacctccgag tgctggacct gagtgagaac ttcctctaca
     1081 aatgcatcac taaaaccaag gccttccagg gcctaacaca gctgcgcaag cttaacctgt
     1141 ccttcaatta ccaaaagagg gtgtcctttg cccacctgtc tctggcccct tccttcggga
     1201 gcctggtcgc cctgaaggag ctggacatgc acggcatctt cttccgctca ctcgatgaga
     1261 ccacgctccg gccactggcc cgcctgccca tgctccagac tctgcgtctg cagatgaact
     1321 tcatcaacca ggcccagctc ggcatcttca gggccttccc tggcctgcgc tacgtggacc
     1381 tgtcggacaa ccgcatcagc ggagcttcgg agctgacagc caccatgggg gaggcagatg
     1441 gaggggagaa ggtctggctg cagcctgggg accttgctcc ggccccagtg gacactccca
     1501 gctctgaaga cttcaggccc aactgcagca ccctcaactt caccttggat ctgtcacgga
     1561 acaacctggt gaccgtgcag ccggagatgt ttgcccagct ctcgcacctg cagtgcctgc
     1621 gcctgagcca caactgcatc tcgcaggcag tcaatggctc ccagttcctg ccgctgaccg
     1681 gtctgcaggt gctagacctg tcccacaata agctggacct ctaccacgag cactcattca
     1741 cggagctacc gcgactggag gccctggacc tcagctacaa cagccagccc tttggcatgc
     1801 agggcgtggg ccacaacttc agcttcgtgg ctcacctgcg caccctgcgc cacctcagcc
     1861 tggcccacaa caacatccac agccaagtgt cccagcagct ctgcagtacg tcgctgcggg
     1921 ccctggactt cagcggcaat gcactgggcc atatgtgggc cgagggagac ctctatctgc
     1981 acttcttcca aggcctgagc ggtttgatct ggctggactt gtcccagaac cgcctgcaca
     2041 ccctcctgcc ccaaaccctg cgcaacctcc ccaagagcct acaggtgctg cgtctccgtg
     2101 acaattacct ggccttcttt aagtggtgga gcctccactt cctgcccaaa ctggaagtcc
     2161 tcgacctggc aggaaaccag ctgaaggccc tgaccaatgg cagcctgcct gctggcaccc
     2221 ggctccggag gctggatgtc agctgcaaca gcatcagctt cgtggccccc ggcttctttt
     2281 ccaaggccaa ggagctgcga gagctcaacc ttagcgccaa cgccctcaag acagtggacc
     2341 actcctggtt tgggcccctg gcgagtgccc tgcaaatact agatgtaagc gccaaccctc
     2401 tgcactgcgc ctgtggggcg gcctttatgg acttcctgct ggaggtgcag gctgccgtgc
     2461 ccggtctgcc cagccgggtg aagtgtggca gtccgggcca gctccagggc ctcagcatct
     2521 ttgcacagga cctgcgcctc tgcctggatg aggccctctc ctgggactgt ttcgccctct
     2581 cgctgctggc tgtggctctg ggcctgggtg tgcccatgct gcatcacctc tgtggctggg
     2641 acctctggta ctgcttccac ctgtgcctgg cctggcttcc ctggcggggg cggcaaagtg
     2701 ggcgagatga ggatgccctg ccctacgatg ccttcgtggt cttcgacaaa acgcagagcg
     2761 cagtggcaga ctgggtgtac aacgagcttc gggggcagct ggaggagtgc cgtgggcgct
     2821 gggcactccg cctgtgcctg gaggaacgcg actggctgcc tggcaaaacc ctctttgaga
     2881 acctgtgggc ctcggtctat ggcagccgca agacgctgtt tgtgctggcc cacacggacc
     2941 gggtcagtgg tctcttgcgc gccagcttcc tgctggccca gcagcgcctg ctggaggacc
     3001 gcaaggacgt cgtggtgctg gtgatcctga gccctgacgg ccgccgctcc cgctacgtgc
     3061 ggctgcgcca gcgcctctgc cgccagagtg tcctcctctg gccccaccag cccagtggtc
     3121 agcgcagctt ctgggcccag ctgggcatgg ccctgaccag ggacaaccac cacttctata
     3181 accggaactt ctgccaggga cccacggccg aatagccgtg agccggaatc ctgcacggtg
     3241 ccacctccac actcacctca cctctgcctg cctggtctga ccctcccctg ctcgcctccc
     3301 tcaccccaca cctgacacag agcaggcact caataaatgc taccgaaggc ta
//
