LOCUS       NM_138636               4216 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens toll like receptor 8 (TLR8), transcript variant 2,
            mRNA.
ACCESSION   NM_138636
VERSION     NM_138636.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4216)
  AUTHORS   Georges,H.M., Cassin,C., Tong,M. and Abrahams,V.M.
  TITLE     TLR8-activating miR-146a-3p is an intermediate signal contributing
            to fetal membrane inflammation in response to bacterial LPS
  JOURNAL   Immunology 172 (4), 577-587 (2024)
   PUBMED   38631842
  REMARK    GeneRIF: TLR8-activating miR-146a-3p is an intermediate signal
            contributing to fetal membrane inflammation in response to
            bacterial LPS.
REFERENCE   2  (bases 1 to 4216)
  AUTHORS   Liang,J., Wan,Y., Gao,J., Zheng,L., Wang,J., Wu,P., Li,Y., Wang,B.,
            Wang,D., Ma,Y., Shen,B., Lv,X., Wang,D., An,N., Ma,X., Geng,G.,
            Tong,J., Liu,J., Chen,G., Gao,M., Kurita,R., Nakamura,Y., Zhu,P.,
            Yin,H., Zhu,X. and Shi,L.
  TITLE     Erythroid-intrinsic activation of TLR8 impairs erythropoiesis in
            inherited anemia
  JOURNAL   Nat Commun 15 (1), 5678 (2024)
   PUBMED   38971858
  REMARK    GeneRIF: Erythroid-intrinsic activation of TLR8 impairs
            erythropoiesis in inherited anemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4216)
  AUTHORS   Kong,X., Jiang,S., He,Q., Shi,X., Pu,W., Huang,Y., Ma,Y., Liu,Q.,
            Sun,D., Huang,D., Wu,F., Li,P., Tu,W., Zhao,Y., Wang,L., Chen,Y.,
            Wu,W., Tang,Y., Zhao,X., Zhu,Q., Gao,J., Xu,W., Shui,X., Qian,F.
            and Wang,J.
  TITLE     TLR8 aggravates skin inflammation and fibrosis by activating skin
            fibroblasts in systemic sclerosis
  JOURNAL   Rheumatology (Oxford) 63 (6), 1710-1719 (2024)
   PUBMED   37665747
  REMARK    GeneRIF: TLR8 aggravates skin inflammation and fibrosis by
            activating skin fibroblasts in systemic sclerosis.
            Erratum:[Rheumatology (Oxford). 2024 May 3;63(6):1756. doi:
            10.1093/rheumatology/keae193.. PMID: 38545742]
REFERENCE   4  (bases 1 to 4216)
  AUTHORS   Weickert,T.W., Ji,E., Galletly,C., Boerrigter,D., Morishima,Y.,
            Bruggemann,J., Balzan,R., O'Donnell,M., Liu,D., Lenroot,R.,
            Weickert,C.S. and Kindler,J.
  TITLE     Toll-Like Receptor mRNA Levels in Schizophrenia: Association With
            Complement Factors and Cingulate Gyrus Cortical Thinning
  JOURNAL   Schizophr Bull 50 (2), 403-417 (2024)
   PUBMED   38102721
  REMARK    GeneRIF: Toll-Like Receptor mRNA Levels in Schizophrenia:
            Association With Complement Factors and Cingulate Gyrus Cortical
            Thinning.
REFERENCE   5  (bases 1 to 4216)
  AUTHORS   Youness,A., Cenac,C., Faz-Lopez,B., Grunenwald,S., Barrat,F.J.,
            Chaumeil,J., Mejia,J.E. and Guery,J.C.
  TITLE     TLR8 escapes X chromosome inactivation in human monocytes and CD4+
            T cells
  JOURNAL   Biol Sex Differ 14 (1), 60 (2023)
   PUBMED   37723501
  REMARK    GeneRIF: TLR8 escapes X chromosome inactivation in human monocytes
            and CD4[+] T cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4216)
  AUTHORS   Lien,E. and Ingalls,R.R.
  TITLE     Toll-like receptors
  JOURNAL   Crit Care Med 30 (1 Suppl), S1-S11 (2002)
   PUBMED   11782555
  REMARK    Review article
REFERENCE   7  (bases 1 to 4216)
  AUTHORS   Miettinen,M., Sareneva,T., Julkunen,I. and Matikainen,S.
  TITLE     IFNs activate toll-like receptor gene expression in viral
            infections
  JOURNAL   Genes Immun 2 (6), 349-355 (2001)
   PUBMED   11607792
REFERENCE   8  (bases 1 to 4216)
  AUTHORS   Chuang,T.H. and Ulevitch,R.J.
  TITLE     Cloning and characterization of a sub-family of human toll-like
            receptors: hTLR7, hTLR8 and hTLR9
  JOURNAL   Eur Cytokine Netw 11 (3), 372-378 (2000)
   PUBMED   11022120
REFERENCE   9  (bases 1 to 4216)
  AUTHORS   Du,X., Poltorak,A., Wei,Y. and Beutler,B.
  TITLE     Three novel mammalian toll-like receptors: gene structure,
            expression, and evolution
  JOURNAL   Eur Cytokine Netw 11 (3), 362-371 (2000)
   PUBMED   11022119
REFERENCE   10 (bases 1 to 4216)
  AUTHORS   Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
  TITLE     A family of human receptors structurally related to Drosophila Toll
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 588-593 (1998)
   PUBMED   9435236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005859.1, KC877963.1 and
            AC139705.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 17, 2014 this sequence version replaced NM_138636.4.
            
            Summary: The protein encoded by this gene is a member of the
            Toll-like receptor (TLR) family which plays a fundamental role in
            pathogen recognition and activation of innate immunity. TLRs are
            highly conserved from Drosophila to humans and share structural and
            functional similarities. They recognize pathogen-associated
            molecular patterns (PAMPs) that are expressed on infectious agents,
            and mediate the production of cytokines necessary for the
            development of effective immunity. The various TLRs exhibit
            different patterns of expression. This gene is predominantly
            expressed in lung and peripheral blood leukocytes, and lies in
            close proximity to another family member, TLR7, on chromosome X.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in its 5' UTR and 5'
            coding region, compared to variant 1. The encoded isoform (2) has a
            shorter and distinct N-terminus, compared to isoform 2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358296.1, BC101074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000218032.7/ ENSP00000218032.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC005859.1         186400-186489
            91-2568             AC005859.1         198824-201301
            2569-2855           KC877963.1         1-287
            2856-2856           KC877963.1         288-288
            2857-3131           KC877963.1         289-563
            3132-4146           AC005859.1         201865-202879
            4147-4216           AC139705.4         2002-2071
FEATURES             Location/Qualifiers
     source          1..4216
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..4216
                     /gene="TLR8"
                     /gene_synonym="CD288; hTLR8; IMD98; TLR-8"
                     /note="toll like receptor 8"
                     /db_xref="GeneID:51311"
                     /db_xref="HGNC:HGNC:15632"
                     /db_xref="MIM:300366"
     exon            1..90
                     /gene="TLR8"
                     /gene_synonym="CD288; hTLR8; IMD98; TLR-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..3213
                     /gene="TLR8"
                     /gene_synonym="CD288; hTLR8; IMD98; TLR-8"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="toll-like receptor 8 isoform 2 precursor"
                     /protein_id="NP_619542.1"
                     /db_xref="CCDS:CCDS14152.1"
                     /db_xref="GeneID:51311"
                     /db_xref="HGNC:HGNC:15632"
                     /db_xref="MIM:300366"
                     /translation="MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDS
                     VIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQH
                     QNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYN
                     ITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPP
                     KLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASI
                     NIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLT
                     MLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQ
                     LPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRH
                     IRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA
                     CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSH
                     YFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILW
                     NDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWT
                     LLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKH
                     LDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRL
                     VDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDV
                     WFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVL
                     LCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENM
                     DVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRY
                     NNMYVDSIKQY"
     exon            91..4216
                     /gene="TLR8"
                     /gene_synonym="CD288; hTLR8; IMD98; TLR-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3242..3247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR8"
                     /gene_synonym="CD288; hTLR8; IMD98; TLR-8"
                     /note="hexamer: AATAAA"
     polyA_site      3264
                     /gene="TLR8"
                     /gene_synonym="CD288; hTLR8; IMD98; TLR-8"
     regulatory      4194..4199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR8"
                     /gene_synonym="CD288; hTLR8; IMD98; TLR-8"
                     /note="hexamer: AATAAA"
     polyA_site      4216
                     /gene="TLR8"
                     /gene_synonym="CD288; hTLR8; IMD98; TLR-8"
                     /note="major polyA site"
ORIGIN      
        1 agtttctctt ctcggccacc tcctgcatag agggtaccat tctgcgctgc tgcaagttac
       61 ggaatgaaaa attagaacaa cagaaacatg gaaaacatgt tccttcagtc gtcaatgctg
      121 acctgcattt tcctgctaat atctggttcc tgtgagttat gcgccgaaga aaatttttct
      181 agaagctatc cttgtgatga gaaaaagcaa aatgactcag ttattgcaga gtgcagcaat
      241 cgtcgactac aggaagttcc ccaaacggtg ggcaaatatg tgacagaact agacctgtct
      301 gataatttca tcacacacat aacgaatgaa tcatttcaag ggctgcaaaa tctcactaaa
      361 ataaatctaa accacaaccc caatgtacag caccagaacg gaaatcccgg tatacaatca
      421 aatggcttga atatcacaga cggggcattc ctcaacctaa aaaacctaag ggagttactg
      481 cttgaagaca accagttacc ccaaataccc tctggtttgc cagagtcttt gacagaactt
      541 agtctaattc aaaacaatat atacaacata actaaagagg gcatttcaag acttataaac
      601 ttgaaaaatc tctatttggc ctggaactgc tattttaaca aagtttgcga gaaaactaac
      661 atagaagatg gagtatttga aacgctgaca aatttggagt tgctatcact atctttcaat
      721 tctctttcac acgtgccacc caaactgcca agctccctac gcaaactttt tctgagcaac
      781 acccagatca aatacattag tgaagaagat ttcaagggat tgataaattt aacattacta
      841 gatttaagcg ggaactgtcc gaggtgcttc aatgccccat ttccatgcgt gccttgtgat
      901 ggtggtgctt caattaatat agatcgtttt gcttttcaaa acttgaccca acttcgatac
      961 ctaaacctct ctagcacttc cctcaggaag attaatgctg cctggtttaa aaatatgcct
     1021 catctgaagg tgctggatct tgaattcaac tatttagtgg gagaaatagc ctctggggca
     1081 tttttaacga tgctgccccg cttagaaata cttgacttgt cttttaacta tataaagggg
     1141 agttatccac agcatattaa tatttccaga aacttctcta aacttttgtc tctacgggca
     1201 ttgcatttaa gaggttatgt gttccaggaa ctcagagaag atgatttcca gcccctgatg
     1261 cagcttccaa acttatcgac tatcaacttg ggtattaatt ttattaagca aatcgatttc
     1321 aaacttttcc aaaatttctc caatctggaa attatttact tgtcagaaaa cagaatatca
     1381 ccgttggtaa aagatacccg gcagagttat gcaaatagtt cctcttttca acgtcatatc
     1441 cggaaacgac gctcaacaga ttttgagttt gacccacatt cgaactttta tcatttcacc
     1501 cgtcctttaa taaagccaca atgtgctgct tatggaaaag ccttagattt aagcctcaac
     1561 agtattttct tcattgggcc aaaccaattt gaaaatcttc ctgacattgc ctgtttaaat
     1621 ctgtctgcaa atagcaatgc tcaagtgtta agtggaactg aattttcagc cattcctcat
     1681 gtcaaatatt tggatttgac aaacaataga ctagactttg ataatgctag tgctcttact
     1741 gaattgtccg acttggaagt tctagatctc agctataatt cacactattt cagaatagca
     1801 ggcgtaacac atcatctaga atttattcaa aatttcacaa atctaaaagt tttaaacttg
     1861 agccacaaca acatttatac tttaacagat aagtataacc tggaaagcaa gtccctggta
     1921 gaattagttt tcagtggcaa tcgccttgac attttgtgga atgatgatga caacaggtat
     1981 atctccattt tcaaaggtct caagaatctg acacgtctgg atttatccct taataggctg
     2041 aagcacatcc caaatgaagc attccttaat ttgccagcga gtctcactga actacatata
     2101 aatgataata tgttaaagtt ttttaactgg acattactcc agcagtttcc tcgtctcgag
     2161 ttgcttgact tacgtggaaa caaactactc tttttaactg atagcctatc tgactttaca
     2221 tcttcccttc ggacactgct gctgagtcat aacaggattt cccacctacc ctctggcttt
     2281 ctttctgaag tcagtagtct gaagcacctc gatttaagtt ccaatctgct aaaaacaatc
     2341 aacaaatccg cacttgaaac taagaccacc accaaattat ctatgttgga actacacgga
     2401 aacccctttg aatgcacctg tgacattgga gatttccgaa gatggatgga tgaacatctg
     2461 aatgtcaaaa ttcccagact ggtagatgtc atttgtgcca gtcctgggga tcaaagaggg
     2521 aagagtattg tgagtctgga gctaacaact tgtgtttcag atgtcactgc agtgatatta
     2581 tttttcttca cgttctttat caccaccatg gttatgttgg ctgccctggc tcaccatttg
     2641 ttttactggg atgtttggtt tatatataat gtgtgtttag ctaaggtaaa aggctacagg
     2701 tctctttcca catcccaaac tttctatgat gcttacattt cttatgacac caaagatgcc
     2761 tctgttactg actgggtgat aaatgagctg cgctaccacc ttgaagagag ccgagacaaa
     2821 aacgttctcc tttgtctaga ggagagggat tgggacccgg gattggccat catcgacaac
     2881 ctcatgcaga gcatcaacca aagcaagaaa acagtatttg ttttaaccaa aaaatatgca
     2941 aaaagctgga actttaaaac agctttttac ttggctttgc agaggctaat ggatgagaac
     3001 atggatgtga ttatatttat cctgctggag ccagtgttac agcattctca gtatttgagg
     3061 ctacggcagc ggatctgtaa gagctccatc ctccagtggc ctgacaaccc gaaggcagaa
     3121 ggcttgtttt ggcaaactct gagaaatgtg gtcttgactg aaaatgattc acggtataac
     3181 aatatgtatg tcgattccat taagcaatac taactgacgt taagtcatga tttcgcgcca
     3241 taataaagat gcaaaggaat gacatttctg tattagttat ctattgctat gtaacaaatt
     3301 atcccaaaac ttagtggttt aaaacaacac atttgctggc ccacagtttt tgagggtcag
     3361 gagtccaggc ccagcataac tgggtcctct gctcagggtg tctcagaggc tgcaatgtag
     3421 gtgttcacca gagacatagg catcactggg gtcacactca tgtggttgtt ttctggattc
     3481 aattcctcct gggctattgg ccaaaggcta tactcatgta agccatgcga gcctctccca
     3541 caaggcagct tgcttcatca gagctagcaa aaaagagagg ttgctagcaa gatgaagtca
     3601 caatcttttg taatcgaatc aaaaaagtga tatctcatca ctttggccat attctatttg
     3661 ttagaagtaa accacaggtc ccaccagctc catgggagtg accacctcag tccagggaaa
     3721 acagctgaag accaagatgg tgagctctga ttgcttcagt tggtcatcaa ctattttccc
     3781 ttgactgctg tcctgggatg gcctgctatc ttgatgatag attgtgaata tcaggaggca
     3841 gggatcactg tggaccatct tagcagttga cctaacacat cttcttttca atatctaaga
     3901 acttttgcca ctgtgactaa tggtcctaat attaagctgt tgtttatatt tatcatatat
     3961 ctatggctac atggttatat tatgctgtgg ttgcgttcgg ttttatttac agttgctttt
     4021 acaaatattt gctgtaacat ttgacttcta aggtttagat gccatttaag aactgagatg
     4081 gatagctttt aaagcatctt ttacttctta ccatttttta aaagtatgca gctaaattcg
     4141 aagcttttgg tctatattgt taattgccat tgctgtaaat cttaaaatga atgaataaaa
     4201 atgtttcatt ttacaa
//
