LOCUS       NM_016562               5003 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens toll like receptor 7 (TLR7), mRNA.
ACCESSION   NM_016562
VERSION     NM_016562.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5003)
  AUTHORS   Obrenovic,M., Supic,G., Miyabe,S., Mladenovic,I., Kozomara,R.,
            Jovic,S., Petkovic Curcin,A., Stefik,D., Stosic,S. and Vukomanovic
            Durdevic,B.
  TITLE     Impact of TLR9 and TLR7 gene polymorphisms on prognosis and
            survival of patients with oral squamous cell carcinoma
  JOURNAL   Biomol Biomed 24 (6), 1682-1691 (2024)
   PUBMED   38850110
  REMARK    GeneRIF: Impact of TLR9 and TLR7 gene polymorphisms on prognosis
            and survival of patients with oral squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5003)
  AUTHORS   Boos,J., van der Made,C.I., Ramakrishnan,G., Coughlan,E.,
            Asselta,R., Loscher,B.S., Valenti,L.V.C., de Cid,R., Bujanda,L.,
            Julia,A., Pairo-Castineira,E., Baillie,J.K., May,S., Zametica,B.,
            Heggemann,J., Albillos,A., Banales,J.M., Barretina,J., Blay,N.,
            Bonfanti,P., Buti,M., Fernandez,J., Marsal,S., Prati,D.,
            Ronzoni,L., Sacchi,N., Schultze,J.L., Riess,O., Franke,A.,
            Rawlik,K., Ellinghaus,D., Hoischen,A., Schmidt,A. and Ludwig,K.U.
  CONSRTM   Spanish/Italian Severe COVID-19 Sequencing group; GenOMICC
            Investigators
  TITLE     Stratified analyses refine association between TLR7 rare variants
            and severe COVID-19
  JOURNAL   HGG Adv 5 (4), 100323 (2024)
   PUBMED   38944683
  REMARK    GeneRIF: Stratified analyses refine association between TLR7 rare
            variants and severe COVID-19.
REFERENCE   3  (bases 1 to 5003)
  AUTHORS   Padmanaban,V., Keller,I., Seltzer,E.S., Ostendorf,B.N., Kerner,Z.
            and Tavazoie,S.F.
  TITLE     Neuronal substance P drives metastasis through an extracellular
            RNA-TLR7 axis
  JOURNAL   Nature 633 (8028), 207-215 (2024)
   PUBMED   39112700
  REMARK    GeneRIF: Neuronal substance P drives metastasis through an
            extracellular RNA-TLR7 axis.
REFERENCE   4  (bases 1 to 5003)
  AUTHORS   Pawar,K., Kawamura,T. and Kirino,Y.
  TITLE     The tRNAVal half: A strong endogenous Toll-like receptor 7 ligand
            with a 5'-terminal universal sequence signature
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2319569121 (2024)
   PUBMED   38683985
  REMARK    GeneRIF: The tRNA[Val] half: A strong endogenous Toll-like receptor
            7 ligand with a 5'-terminal universal sequence signature.
REFERENCE   5  (bases 1 to 5003)
  AUTHORS   Kalita,S., Kalita,M.J., Talukdar,A.J., Das,P.P., Dutta,K.,
            Hazarika,G., Dutta,S., Das,P., Idris,G., Kaur,H. and Medhi,S.
  TITLE     Altered TLR7 Expression-Mediated Immune Modulation Is Supportive of
            Persistent Replication and Intrauterine Transmission of HBV
  JOURNAL   Viral Immunol 37 (3), 149-158 (2024)
   PUBMED   38573237
  REMARK    GeneRIF: Altered TLR7 Expression-Mediated Immune Modulation Is
            Supportive of Persistent Replication and Intrauterine Transmission
            of HBV.
REFERENCE   6  (bases 1 to 5003)
  AUTHORS   Kaisho,T. and Akira,S.
  TITLE     Toll-like receptors as adjuvant receptors
  JOURNAL   Biochim Biophys Acta 1589 (1), 1-13 (2002)
   PUBMED   11909637
  REMARK    Review article
REFERENCE   7  (bases 1 to 5003)
  AUTHORS   Lien,E. and Ingalls,R.R.
  TITLE     Toll-like receptors
  JOURNAL   Crit Care Med 30 (1 Suppl), S1-S11 (2002)
   PUBMED   11782555
  REMARK    Review article
REFERENCE   8  (bases 1 to 5003)
  AUTHORS   Chuang,T.H. and Ulevitch,R.J.
  TITLE     Cloning and characterization of a sub-family of human toll-like
            receptors: hTLR7, hTLR8 and hTLR9
  JOURNAL   Eur Cytokine Netw 11 (3), 372-378 (2000)
   PUBMED   11022120
REFERENCE   9  (bases 1 to 5003)
  AUTHORS   Du,X., Poltorak,A., Wei,Y. and Beutler,B.
  TITLE     Three novel mammalian toll-like receptors: gene structure,
            expression, and evolution
  JOURNAL   Eur Cytokine Netw 11 (3), 362-371 (2000)
   PUBMED   11022119
REFERENCE   10 (bases 1 to 5003)
  AUTHORS   Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
  TITLE     A family of human receptors structurally related to Drosophila Toll
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 588-593 (1998)
   PUBMED   9435236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005859.1, BC033651.1 and
            AF240467.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016562.3.
            
            Summary: The protein encoded by this gene is a member of the
            Toll-like receptor (TLR) family which plays a fundamental role in
            pathogen recognition and activation of innate immunity. TLRs are
            highly conserved from Drosophila to humans and share structural and
            functional similarities. The human TLR family comprises 11 members.
            They recognize pathogen-associated molecular patterns (PAMPs) that
            are expressed on infectious agents, and mediate the production of
            cytokines necessary for the development of effective immunity. For
            the recognition of structural components in foreign microorganisms,
            the various TLRs exhibit different patterns of expression as well;
            in this way for example, TLR-3, -7, and -8 are essential in the
            recognition of single-stranded RNA viruses. TLR7 senses
            single-stranded RNA oligonucleotides containing guanosine- and
            uridine-rich sequences from RNA viruses, a recognition occuring in
            the endosomes of plasmacytoid dendritic cells and B cells. This
            gene is predominantly expressed in lung, placenta, and spleen, and
            is phylogenetically related and lies in close proximity to another
            family member, TLR8, on chromosome X. [provided by RefSeq, Aug
            2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313858.1, AF240467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000380659.4/ ENSP00000370034.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC005859.1         146852-146862
            12-15               BC033651.1         12-15
            16-5003             AF240467.1         1-4988
FEATURES             Location/Qualifiers
     source          1..5003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..5003
                     /gene="TLR7"
                     /gene_synonym="IMD74; SLEB17; TLR7-like"
                     /note="toll like receptor 7"
                     /db_xref="GeneID:51284"
                     /db_xref="HGNC:HGNC:15631"
                     /db_xref="MIM:300365"
     exon            1..52
                     /gene="TLR7"
                     /gene_synonym="IMD74; SLEB17; TLR7-like"
                     /inference="alignment:Splign:2.1.0"
     exon            53..153
                     /gene="TLR7"
                     /gene_synonym="IMD74; SLEB17; TLR7-like"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..3300
                     /gene="TLR7"
                     /gene_synonym="IMD74; SLEB17; TLR7-like"
                     /note="toll-like receptor 7-like"
                     /codon_start=1
                     /product="toll-like receptor 7 precursor"
                     /protein_id="NP_057646.1"
                     /db_xref="CCDS:CCDS14151.1"
                     /db_xref="GeneID:51284"
                     /db_xref="HGNC:HGNC:15631"
                     /db_xref="MIM:300365"
                     /translation="MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPK
                     NHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVP
                     IPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNI
                     FSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTA
                     VPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNN
                     SPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAK
                     FLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSP
                     LHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNART
                     SVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFV
                     KSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELH
                     KLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTL
                     EFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSL
                     AKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTK
                     YFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWV
                     NHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVM
                     MTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVA
                     KLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFY
                     LSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLK
                     NALATDNHVAYSQVFKETV"
     exon            154..5003
                     /gene="TLR7"
                     /gene_synonym="IMD74; SLEB17; TLR7-like"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4373..4378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR7"
                     /gene_synonym="IMD74; SLEB17; TLR7-like"
                     /note="hexamer: AGTAAA"
     polyA_site      4392
                     /gene="TLR7"
                     /gene_synonym="IMD74; SLEB17; TLR7-like"
                     /note="major polyA site"
     regulatory      4715..4720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR7"
                     /gene_synonym="IMD74; SLEB17; TLR7-like"
                     /note="hexamer: TATAAA"
     polyA_site      4742
                     /gene="TLR7"
                     /gene_synonym="IMD74; SLEB17; TLR7-like"
     regulatory      4982..4987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR7"
                     /gene_synonym="IMD74; SLEB17; TLR7-like"
                     /note="hexamer: ATTAAA"
     polyA_site      5003
                     /gene="TLR7"
                     /gene_synonym="IMD74; SLEB17; TLR7-like"
ORIGIN      
        1 acttcatctc agaagactcc agatatagga tcactccatg ccatcaagaa agttgatgct
       61 attgggccca tctcaagctg atcttggcac ctctcatgct ctgctctctt caaccagacc
      121 tctacattcc attttggaag aagactaaaa atggtgtttc caatgtggac actgaagaga
      181 caaattctta tcctttttaa cataatccta atttccaaac tccttggggc tagatggttt
      241 cctaaaactc tgccctgtga tgtcactctg gatgttccaa agaaccatgt gatcgtggac
      301 tgcacagaca agcatttgac agaaattcct ggaggtattc ccacgaacac cacgaacctc
      361 accctcacca ttaaccacat accagacatc tccccagcgt cctttcacag actggaccat
      421 ctggtagaga tcgatttcag atgcaactgt gtacctattc cactggggtc aaaaaacaac
      481 atgtgcatca agaggctgca gattaaaccc agaagcttta gtggactcac ttatttaaaa
      541 tccctttacc tggatggaaa ccagctacta gagataccgc agggcctccc gcctagctta
      601 cagcttctca gccttgaggc caacaacatc ttttccatca gaaaagagaa tctaacagaa
      661 ctggccaaca tagaaatact ctacctgggc caaaactgtt attatcgaaa tccttgttat
      721 gtttcatatt caatagagaa agatgccttc ctaaacttga caaagttaaa agtgctctcc
      781 ctgaaagata acaatgtcac agccgtccct actgttttgc catctacttt aacagaacta
      841 tatctctaca acaacatgat tgcaaaaatc caagaagatg attttaataa cctcaaccaa
      901 ttacaaattc ttgacctaag tggaaattgc cctcgttgtt ataatgcccc atttccttgt
      961 gcgccgtgta aaaataattc tcccctacag atccctgtaa atgcttttga tgcgctgaca
     1021 gaattaaaag ttttacgtct acacagtaac tctcttcagc atgtgccccc aagatggttt
     1081 aagaacatca acaaactcca ggaactggat ctgtcccaaa acttcttggc caaagaaatt
     1141 ggggatgcta aatttctgca ttttctcccc agcctcatcc aattggatct gtctttcaat
     1201 tttgaacttc aggtctatcg tgcatctatg aatctatcac aagcattttc ttcactgaaa
     1261 agcctgaaaa ttctgcggat cagaggatat gtctttaaag agttgaaaag ctttaacctc
     1321 tcgccattac ataatcttca aaatcttgaa gttcttgatc ttggcactaa ctttataaaa
     1381 attgctaacc tcagcatgtt taaacaattt aaaagactga aagtcataga tctttcagtg
     1441 aataaaatat caccttcagg agattcaagt gaagttggct tctgctcaaa tgccagaact
     1501 tctgtagaaa gttatgaacc ccaggtcctg gaacaattac attatttcag atatgataag
     1561 tatgcaagga gttgcagatt caaaaacaaa gaggcttctt tcatgtctgt taatgaaagc
     1621 tgctacaagt atgggcagac cttggatcta agtaaaaata gtatattttt tgtcaagtcc
     1681 tctgattttc agcatctttc tttcctcaaa tgcctgaatc tgtcaggaaa tctcattagc
     1741 caaactctta atggcagtga attccaacct ttagcagagc tgagatattt ggacttctcc
     1801 aacaaccggc ttgatttact ccattcaaca gcatttgaag agcttcacaa actggaagtt
     1861 ctggatataa gcagtaatag ccattatttt caatcagaag gaattactca tatgctaaac
     1921 tttaccaaga acctaaaggt tctgcagaaa ctgatgatga acgacaatga catctcttcc
     1981 tccaccagca ggaccatgga gagtgagtct cttagaactc tggaattcag aggaaatcac
     2041 ttagatgttt tatggagaga aggtgataac agatacttac aattattcaa gaatctgcta
     2101 aaattagagg aattagacat ctctaaaaat tccctaagtt tcttgccttc tggagttttt
     2161 gatggtatgc ctccaaatct aaagaatctc tctttggcca aaaatgggct caaatctttc
     2221 agttggaaga aactccagtg tctaaagaac ctggaaactt tggacctcag ccacaaccaa
     2281 ctgaccactg tccctgagag attatccaac tgttccagaa gcctcaagaa tctgattctt
     2341 aagaataatc aaatcaggag tctgacgaag tattttctac aagatgcctt ccagttgcga
     2401 tatctggatc tcagctcaaa taaaatccag atgatccaaa agaccagctt cccagaaaat
     2461 gtcctcaaca atctgaagat gttgcttttg catcataatc ggtttctgtg cacctgtgat
     2521 gctgtgtggt ttgtctggtg ggttaaccat acggaggtga ctattcctta cctggccaca
     2581 gatgtgactt gtgtggggcc aggagcacac aagggccaaa gtgtgatctc cctggatctg
     2641 tacacctgtg agttagatct gactaacctg attctgttct cactttccat atctgtatct
     2701 ctctttctca tggtgatgat gacagcaagt cacctctatt tctgggatgt gtggtatatt
     2761 taccatttct gtaaggccaa gataaagggg tatcagcgtc taatatcacc agactgttgc
     2821 tatgatgctt ttattgtgta tgacactaaa gacccagctg tgaccgagtg ggttttggct
     2881 gagctggtgg ccaaactgga agacccaaga gagaaacatt ttaatttatg tctcgaggaa
     2941 agggactggt taccagggca gccagttctg gaaaaccttt cccagagcat acagcttagc
     3001 aaaaagacag tgtttgtgat gacagacaag tatgcaaaga ctgaaaattt taagatagca
     3061 ttttacttgt cccatcagag gctcatggat gaaaaagttg atgtgattat cttgatattt
     3121 cttgagaagc cctttcagaa gtccaagttc ctccagctcc ggaaaaggct ctgtgggagt
     3181 tctgtccttg agtggccaac aaacccgcaa gctcacccat acttctggca gtgtctaaag
     3241 aacgccctgg ccacagacaa tcatgtggcc tatagtcagg tgttcaagga aacggtctag
     3301 cccttctttg caaaacacaa ctgcctagtt taccaaggag aggcctggct gtttaaattg
     3361 ttttcatata tatcacacca aaagcgtgtt ttgaaattct tcaagaaatg agattgccca
     3421 tatttcaggg gagccaccaa cgtctgtcac aggagttgga aagatggggt ttatataatg
     3481 catcaagtct tctttcttat ctctctgtgt ctctatttgc acttgagtct ctcacctcag
     3541 ctcctgtaaa agagtggcaa gtaaaaaaca tggggctctg attctcctgt aattgtgata
     3601 attaaatata cacacaatca tgacattgag aagaactgca tttctaccct taaaaagtac
     3661 tggtatatac agaaataggg ttaaaaaaaa ctcaagctct ctctatatga gaccaaaatg
     3721 tactagagtt agtttagtga aataaaaaac cagtcagctg gccgggcatg gtggctcatg
     3781 cttgtaatcc cagcactttg ggaggccgag gcaggtggat cacgaggtca ggagtttgag
     3841 accagtctgg ccaacatggt gaaaccccgt ctgtactaaa aatacaaaaa ttagctgggc
     3901 gtggtggtgg gtgcctgtaa tcccagctac ttgggaggct gaggcaggag aatcgcttga
     3961 acccgggagg tggaggtggc agtgagccga gatcacgcca ctgcaatgca gcccgggcaa
     4021 cagagctaga ctgtctcaaa agaacaaaaa aaaaaaaaca caaaaaaact cagtcagctt
     4081 cttaaccaat tgcttccgtg tcatccaggg ccccattctg tgcagattga gtgtgggcac
     4141 cacacaggtg gttgctgctt cagtgcttcc tgctcttttt ccttgggcct gcttctgggt
     4201 tccataggga aacagtaaga aagaaagaca catccttacc ataaatgcat atggtccacc
     4261 tacaaataga aaaatattta aatgatctgc ctttatacaa agtgatattc tctacctttg
     4321 ataatttacc tgcttaaatg tttttatctg cactgcaaag tactgtatcc aaagtaaaat
     4381 ttcctcatcc aatatctttc aaactgtttt gttaactaat gccatatatt tgtaagtatc
     4441 tgcacacttg atacagcaac gttagatggt tttgatggta aaccctaaag gaggactcca
     4501 agagtgtgta tttatttata gttttatcag agatgacaat tatttgaatg ccaattatat
     4561 ggattccttt cattttttgc tggaggatgg gagaagaaac caaagtttat agaccttcac
     4621 attgagaaag cttcagtttt gaacttcagc tatcagattc aaaaacaaca gaaagaacca
     4681 agacattctt aagatgcctg tactttcagc tgggtataaa ttcatgagtt caaagattga
     4741 aacctgacca atttgcttta tttcatggaa gaagtgatct acaaaggtgt ttgtgccatt
     4801 tggaaaacag cgtgcatgtg ttcaagcctt agattggcga tgtcgtattt tcctcacgtg
     4861 tggcaatgcc aaaggcttta ctttacctgt gagtacacac tatatgaatt atttccaacg
     4921 tacatttaat caataagggt cacaaattcc caaatcaatc tctggaataa atagagaggt
     4981 aattaaattg ctggagccaa cta
//
