LOCUS       NM_006068               6698 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens toll like receptor 6 (TLR6), transcript variant 2,
            mRNA.
ACCESSION   NM_006068
VERSION     NM_006068.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6698)
  AUTHORS   Abdulqadir,R., Al-Sadi,R., Haque,M., Gupta,Y., Rawat,M. and Ma,T.Y.
  TITLE     Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis
            Factor-alpha-Induced Increase in Intestinal Epithelial Tight
            Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6
            Receptor Complex-Dependent Stimulation of Peroxisome
            Proliferator-Activated Receptor gamma and Suppression of NF-kappaB
            p65
  JOURNAL   Am J Pathol 194 (9), 1664-1683 (2024)
   PUBMED   38885924
  REMARK    GeneRIF: Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis
            Factor-alpha-Induced Increase in Intestinal Epithelial Tight
            Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6
            Receptor Complex-Dependent Stimulation of Peroxisome
            Proliferator-Activated Receptor gamma and Suppression of NF-kappaB
            p65.
REFERENCE   2  (bases 1 to 6698)
  AUTHORS   Sato,Y., Wakita,A., Maeda,E., Nagaki,Y., Sasamori,R.,
            Kemuriyama,K., Nozaki,S., Ito,S., Terata,K., Imai,K., Nanjo,H.,
            Nomura,K. and Minamiya,Y.
  TITLE     High TLR6 Expression Status Predicts a More Favorable Prognosis
            after Esophagectomy for Locally Advanced Thoracic Esophageal
            Squamous Cell Carcinoma
  JOURNAL   Curr Oncol 30 (5), 4724-4735 (2023)
   PUBMED   37232814
  REMARK    GeneRIF: High TLR6 Expression Status Predicts a More Favorable
            Prognosis after Esophagectomy for Locally Advanced Thoracic
            Esophageal Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6698)
  AUTHORS   Zhang,M., Chen,G. and He,J.Q.
  TITLE     Variants of Toll-like receptor 6 associated with tuberculosis
            susceptibility in the Chinese Tibetan population
  JOURNAL   Microb Pathog 162, 105208 (2022)
   PUBMED   34563610
  REMARK    GeneRIF: Variants of Toll-like receptor 6 associated with
            tuberculosis susceptibility in the Chinese Tibetan population.
REFERENCE   4  (bases 1 to 6698)
  AUTHORS   Varzari,A., Deyneko,I.V., Tudor,E., Grallert,H. and Illig,T.
  TITLE     Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes
            on the risk of pulmonary tuberculosis in a Moldavian population
  JOURNAL   Innate Immun 27 (5), 365-376 (2021)
   PUBMED   34275341
  REMARK    GeneRIF: Synergistic effect of genetic polymorphisms in TLR6 and
            TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian
            population.
REFERENCE   5  (bases 1 to 6698)
  AUTHORS   Bulut,Y., Faure,E., Thomas,L., Equils,O. and Arditi,M.
  TITLE     Cooperation of Toll-like receptor 2 and 6 for cellular activation
            by soluble tuberculosis factor and Borrelia burgdorferi outer
            surface protein A lipoprotein: role of Toll-interacting protein and
            IL-1 receptor signaling molecules in Toll-like receptor 2 signaling
  JOURNAL   J Immunol 167 (2), 987-994 (2001)
   PUBMED   11441107
REFERENCE   6  (bases 1 to 6698)
  AUTHORS   Hajjar,A.M., O'Mahony,D.S., Ozinsky,A., Underhill,D.M., Aderem,A.,
            Klebanoff,S.J. and Wilson,C.B.
  TITLE     Cutting edge: functional interactions between toll-like receptor
            (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
  JOURNAL   J Immunol 166 (1), 15-19 (2001)
   PUBMED   11123271
REFERENCE   7  (bases 1 to 6698)
  AUTHORS   Ozinsky,A., Underhill,D.M., Fontenot,J.D., Hajjar,A.M., Smith,K.D.,
            Wilson,C.B., Schroeder,L. and Aderem,A.
  TITLE     The repertoire for pattern recognition of pathogens by the innate
            immune system is defined by cooperation between toll-like receptors
  JOURNAL   Proc Natl Acad Sci U S A 97 (25), 13766-13771 (2000)
   PUBMED   11095740
REFERENCE   8  (bases 1 to 6698)
  AUTHORS   Xu,Y., Tao,X., Shen,B., Horng,T., Medzhitov,R., Manley,J.L. and
            Tong,L.
  TITLE     Structural basis for signal transduction by the Toll/interleukin-1
            receptor domains
  JOURNAL   Nature 408 (6808), 111-115 (2000)
   PUBMED   11081518
REFERENCE   9  (bases 1 to 6698)
  AUTHORS   Brightbill,H.D., Libraty,D.H., Krutzik,S.R., Yang,R.B.,
            Belisle,J.T., Bleharski,J.R., Maitland,M., Norgard,M.V.,
            Plevy,S.E., Smale,S.T., Brennan,P.J., Bloom,B.R., Godowski,P.J. and
            Modlin,R.L.
  TITLE     Host defense mechanisms triggered by microbial lipoproteins through
            toll-like receptors
  JOURNAL   Science 285 (5428), 732-736 (1999)
   PUBMED   10426995
REFERENCE   10 (bases 1 to 6698)
  AUTHORS   Takeuchi,O., Kawai,T., Sanjo,H., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Takeda,K. and Akira,S.
  TITLE     TLR6: A novel member of an expanding toll-like receptor family
  JOURNAL   Gene 231 (1-2), 59-65 (1999)
   PUBMED   10231569
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108044.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 23, 2020 this sequence version replaced NM_006068.4.
            
            Summary: The protein encoded by this gene is a member of the
            Toll-like receptor (TLR) family which plays a fundamental role in
            pathogen recognition and activation of innate immunity. TLRs are
            highly conserved from Drosophila to humans and share structural and
            functional similarities. They recognize pathogen-associated
            molecular patterns (PAMPs) that are expressed on infectious agents,
            and mediate the production of cytokines necessary for the
            development of effective immunity. The various TLRs exhibit
            different patterns of expression. This receptor functionally
            interacts with toll-like receptor 2 to mediate cellular response to
            bacterial lipoproteins. A Ser249Pro polymorphism in the
            extracellular domain of the encoded protein may be associated with
            an increased of asthma is some populations.[provided by RefSeq, Jan
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313618.1, SRR14038197.485640.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000508254.6/ ENSP00000424718.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC108044.5         76981-77037         c
            58-6698             AC108044.5         43117-49757         c
FEATURES             Location/Qualifiers
     source          1..6698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..6698
                     /gene="TLR6"
                     /gene_synonym="CD286"
                     /note="toll like receptor 6"
                     /db_xref="GeneID:10333"
                     /db_xref="HGNC:HGNC:16711"
                     /db_xref="MIM:605403"
     exon            1..57
                     /gene="TLR6"
                     /gene_synonym="CD286"
                     /inference="alignment:Splign:2.1.0"
     exon            58..6698
                     /gene="TLR6"
                     /gene_synonym="CD286"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2512
                     /gene="TLR6"
                     /gene_synonym="CD286"
                     /EC_number="3.2.2.6"
                     /codon_start=1
                     /product="toll-like receptor 6 precursor"
                     /protein_id="NP_006059.2"
                     /db_xref="CCDS:CCDS3446.1"
                     /db_xref="GeneID:10333"
                     /db_xref="HGNC:HGNC:16711"
                     /db_xref="MIM:605403"
                     /translation="MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLI
                     HVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDL
                     EYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQK
                     LDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVN
                     TLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPK
                     PVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIM
                     MLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDL
                     FKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPP
                     RIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVS
                     HPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYKCDYPES
                     YRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQT
                     RRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKEDIQICLHERNFVPGK
                     SIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIP
                     QNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNMKLTLVTENNDVKS"
     regulatory      2972..2977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR6"
                     /gene_synonym="CD286"
                     /note="hexamer: TATAAA"
     polyA_site      2993
                     /gene="TLR6"
                     /gene_synonym="CD286"
                     /note="major polyA site"
     regulatory      6676..6681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR6"
                     /gene_synonym="CD286"
                     /note="hexamer: AATAAA"
     polyA_site      6698
                     /gene="TLR6"
                     /gene_synonym="CD286"
                     /note="major polyA site"
ORIGIN      
        1 aattgtattt ccgttcattt acaagttatt ttctcttctt ctgaaaaaga gatcttgaat
       61 ttggactcat atcaagatgc tctgaagaag aacaaccctt taggatagcc actgcaacat
      121 catgaccaaa gacaaagaac ctattgttaa aagcttccat tttgtttgcc ttatgatcat
      181 aatagttgga accagaatcc agttctccga cggaaatgaa tttgcagtag acaagtcaaa
      241 aagaggtctt attcatgttc caaaagacct accgctgaaa accaaagtct tagatatgtc
      301 tcagaactac atcgctgagc ttcaggtctc tgacatgagc tttctatcag agttgacagt
      361 tttgagactt tcccataaca gaatccagct acttgattta agtgttttca agttcaacca
      421 ggatttagaa tatttggatt tatctcataa tcagttgcaa aagatatcct gccatcctat
      481 tgtgagtttc aggcatttag atctctcatt caatgatttc aaggccctgc ccatctgtaa
      541 ggaatttggc aacttatcac aactgaattt cttgggattg agtgctatga agctgcaaaa
      601 attagatttg ctgccaattg ctcacttgca tctaagttat atccttctgg atttaagaaa
      661 ttattatata aaagaaaatg agacagaaag tctacaaatt ctgaatgcaa aaacccttca
      721 ccttgttttt cacccaacta gtttattcgc tatccaagtg aacatatcag ttaatacttt
      781 agggtgctta caactgacta atattaaatt gaatgatgac aactgtcaag ttttcattaa
      841 atttttatca gaactcacca gaggttcaac cttactgaat tttaccctca accacataga
      901 aacgacttgg aaatgcctgg tcagagtctt tcaatttctt tggcccaaac ctgtggaata
      961 tctcaatatt tacaatttaa caataattga aagcattcgt gaagaagatt ttacttattc
     1021 taaaacgaca ttgaaagcat tgacaataga acatatcacg aaccaagttt ttctgttttc
     1081 acagacagct ttgtacaccg tgttttctga gatgaacatt atgatgttaa ccatttcaga
     1141 tacacctttt atacacatgc tgtgtcctca tgcaccaagc acattcaagt ttttgaactt
     1201 tacccagaac gttttcacag atagtatttt tgaaaaatgt tccacgttag ttaaattgga
     1261 gacacttatc ttacaaaaga atggattaaa agaccttttc aaagtaggtc tcatgacgaa
     1321 ggatatgcct tctttggaaa tactggatgt tagctggaat tctttggaat ctggtagaca
     1381 taaagaaaac tgcacttggg ttgagagtat agtggtgtta aatttgtctt caaatatgct
     1441 tactgactct gttttcagat gtttacctcc caggatcaag gtacttgatc ttcacagcaa
     1501 taaaataaag agcgttccta aacaagtcgt aaaactggaa gctttgcaag aactcaatgt
     1561 tgctttcaat tctttaactg accttcctgg atgtggcagc tttagcagcc tttctgtatt
     1621 gatcattgat cacaattcag tttcccaccc atcggctgat ttcttccaga gctgccagaa
     1681 gatgaggtca ataaaagcag gggacaatcc attccaatgt acctgtgagc taagagaatt
     1741 tgtcaaaaat atagaccaag tatcaagtga agtgttagag ggctggcctg attcttataa
     1801 gtgtgactac ccagaaagtt atagaggaag cccactaaag gactttcaca tgtctgaatt
     1861 atcctgcaac ataactctgc tgatcgtcac catcggtgcc accatgctgg tgttggctgt
     1921 gactgtgacc tccctctgca tctacttgga tctgccctgg tatctcagga tggtgtgcca
     1981 gtggacccag actcggcgca gggccaggaa cataccctta gaagaactcc aaagaaacct
     2041 ccagtttcat gcttttattt catatagtga acatgattct gcctgggtga aaagtgaatt
     2101 ggtaccttac ctagaaaaag aagatataca gatttgtctt catgagagaa actttgtccc
     2161 tggcaagagc attgtggaaa atatcatcaa ctgcattgag aagagttaca agtccatctt
     2221 tgttttgtct cccaactttg tccagagtga gtggtgccat tacgaactct attttgccca
     2281 tcacaatctc tttcatgaag gatctaataa cttaatcctc atcttactgg aacccattcc
     2341 acagaacagc attcccaaca agtaccacaa gctgaaggct ctcatgacgc agcggactta
     2401 tttgcagtgg cccaaggaga aaagcaaacg tgggctcttt tgggctaaca ttagagccgc
     2461 ttttaatatg aaattaacac tagtcactga aaacaatgat gtgaaatctt aaaaaaattt
     2521 aggaaattca acttaagaaa ccattattta cttggatgat ggtgaatagt acagtcgtaa
     2581 gtaactgtct ggaggtgcct ccattatcct catgccttca ggaaagactt aacaaaaaca
     2641 atgtttcatc tggggaactg agctaggcgg tgaggttagc ctgccagtta gagacagccc
     2701 agtctcttct ggtttaatca ttatgtttca aattgaaaca gtctcttttg agtaaatgct
     2761 cagtttttca gctcctctcc actctgcttt cccaaatgga ttctgttgtg agcaagagtt
     2821 tatatggctt catggcagca agggaacagt caacttcagc atcatatgca ccagtcctcg
     2881 gagtgccctg tgaatcatat tggtctttgg gtcagtgtca tcattctctt caagtctggg
     2941 gcttggggaa aaaattagat cagctacggc atataaaaaa gtcttttgtt tcacatatgt
     3001 gtaatagctt atttaatttt ttatcctgct acacaaatat gtaattaacc aatgaggact
     3061 catgacttga tagtgtatgt atgtaaaggg atatatggac ttaatcataa gctgttgagg
     3121 tgaaagacgt ggatccacct gctttccaag aaaactcggc caaatttatt tgcagctgga
     3181 tattgaatgg gacttttctg gttgtcttag aattctggct aaaggctcaa agctgacgaa
     3241 agacagtaac tgcaccaaca tgatactaga cacagccagt ctggacttat caaaagagca
     3301 gaaagagacc aatgactccc agtccgtatt atccatctct agaagactag agtcaaaagc
     3361 gtgattaaag agtcattaag cggaggttct aggccatagg gagattgctt tgaatttctt
     3421 gcagacaagt gtgagggact cagcatggta gaaggtagcc tggcatccca ctccaagact
     3481 gaaagcttgc agagtaacag gagcacacag gttcagtgca gcagatgtgg tgtggcttga
     3541 gaattcttgg aagagcttga tgagtgtttg ctggagtccg agggtgggca ctgggaacac
     3601 agagactggt aaatagtgtt tggcaaatac aagtgcttga tgaatatttg ttgaatgaat
     3661 agatgagttc ttcccccctg gggaattcag gaggtgaaag gttggcttga gcacccaaaa
     3721 tggcaggatg agagaagaga agcactgata gcaacctgcc ctcccattat tgacatggta
     3781 aaaggatgtg aatttcttca catggctttg actatggaag agtagctggg cttgcattgt
     3841 catgacggga tatcagccaa cagggtagcc tgttgtgcaa agaaactata gcagtaagag
     3901 gacacggggt taggcagaag aggggtttgg ggtggaggtt gctgcaagag gtcagccaga
     3961 taatgtggcc ctgcatcatg gaactgtgca atgtggggta cactcaaggc cctccaataa
     4021 ctcacagatg tgccctatga aaaagccagc atttggactc tgccatagca gctggcagga
     4081 tcatgctggc ctgtctgcct tattcaatag ttaactacag gaagatctgc tcctctttgt
     4141 gtaataccct cttcccttgc aatggcatag ggacatctag aatatagaga agacagagac
     4201 aatggaggaa gagtaaagaa actgactata tgccttcgtc atttcactgc aaggaaggcc
     4261 aagcagattt ttgaatgagg tgtgagattg ctgttaaatt ggactggcct ggacatttta
     4321 atcccttaaa tagaggtgca atgactaaag tgagatttgt cactaaaatt tatggtatct
     4381 gcccaagatt caggagtgat gatgggagga gatccaacag aactttgttg taaggcaatg
     4441 gttagagaaa aatgaagccc tcgctttctg gacttagttc attcaataaa ccagtttcgg
     4501 ccaggcacgt tggctcacat ctataatccc agtactgtgg gaggctgagg caggtggatc
     4561 acttgaggtc aggagttcga gaccagcctg gccaacatgg tgaaaccctg tctgtactaa
     4621 aaatacaaaa attagccggg tgtggtggtg tgcacctgta gtcccagcta ctcgggaggc
     4681 tgaggcagga aaatcacttg aacctgggag acagaggctg tagtgagctg agacagcgct
     4741 actgtactcc ccgctgggca acagagtgag actccatctc aaaaaagtta aaagaaaaaa
     4801 aatctggttt cataatagct gtaacgaaat aagccttaat gatattttat tagcatcatc
     4861 ttctgtctgc attagccctt ccttgctctt caggagaaca acatttgttt tcctccctag
     4921 gctctatccc aaacggcaca ttcttccaca acccctgttg aacagatttt ttaaactgtt
     4981 gcctaatcta aaaacaataa aaacaacaaa caaccacagt aacaacaacg acaaaaaaaa
     5041 ctgccacaga ttctaaataa tcagatcttt ttaaatggta tcaatgtttc ccacaaaata
     5101 ttgttgacat tgaaaatata gaattttagc attaattttg ttaaacctac atcccctcgg
     5161 cagaggggcc tccctgcatc ccagtggaaa gtaggttcct cacagtcctc tccgtcacat
     5221 tcttcccatt tcttttcttc acagaacaca tcactgtcta aaattatctt gtttgcttag
     5281 ttgcttactc atcttcttct tctctcctct gaagtctaag ctccaggaaa aagggagact
     5341 tctccacctg ttccctgcct ctccccagtg ccgaggggac actgtgcacc ccattgtaga
     5401 tgcgcagtaa aaactcgtgg gatgagcaaa tgactctgaa acggtcccat gcgggaaatg
     5461 tccatgaagt cctggatttt atctaaaaag cccaggcagg ggggggcggg ggcggcgggg
     5521 ctacagttcc acgctgagct gcctcctggc cgctcgtccc cgccgcagtg cctgggcggc
     5581 ccgggcgccc gaccttggcc gtggacacct tcgcggtggg tgctgctcct ccccatctgc
     5641 cactggaaga tgctggggcg acccggctcc aggtttagca ggacactgag aaaagggaat
     5701 ggctgccttt cggaggctgg gtgagccctt ctctgtgcct cacctgcccg ccccacagcg
     5761 gccctgcacc tcgtcccacg gggcccattg ccccggtagg atgcgcgctt ttgttttgag
     5821 ggtcaggcat cttccctgcc gtcgtttctg ggaggttgaa aaattgatcc agaaagacct
     5881 aaaacaaaaa acaaagaaaa acaaaaaagc gaaaaggagg caaaacaaaa caaaaatcca
     5941 tacaaataaa gtatctcctc catccatgtt tgcactattc cttctcattc ccccgtccaa
     6001 tgccacaatt tggtaagttt gcctcaacac gttttcagtt cttaacactg tgataagaat
     6061 aaacaataga tcccgtagta agatgacctg ttaaaaggaa tggggcatgg cagagatgag
     6121 tttggatgag gaaaggtgtc agtccgtttg ggctgctcta actaagttct gagatgtgtg
     6181 ttaggtaatt ttgactttgg ttgaacatca tagagtgcac tcacacagac atagatgaca
     6241 tagcttacta cacacctagg cttatggtat agcctgttgc ttctaggtga ttgtaacaca
     6301 atgcttagta tttgtgtatc caaacatatc taaacatagc aagggtatgg taaaaatatg
     6361 gtaaagaaga taaaaaatgg tacacctgta tagggcactg atgtgggttg gctgtgtccc
     6421 cacccaaatc tcatcttgaa ttcccacgtg ttgtgggagg gacccagtgg gaggtgattg
     6481 catcatgggg gcgggtcttt tcctgtgctg ttctcctgtt agcgaatggg tctcatgaaa
     6541 tctgatggtt ctttaagggg gagtttccct gcacaagttc tctctcttcc ctgctgacat
     6601 gtaagatgtg acttgctcct ccttgccttc tgccatgatt gtgaggcttc cccagctctg
     6661 tggaactgta ggtccaataa acctctttct tttgtgaa
//
