LOCUS       NM_003268               4235 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens toll like receptor 5 (TLR5), mRNA.
ACCESSION   NM_003268
VERSION     NM_003268.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4235)
  AUTHORS   Pearson,J.A., Hu,Y., Peng,J., Wong,F.S. and Wen,L.
  TITLE     TLR5-deficiency controls dendritic cell subset development in an
            autoimmune diabetes-susceptible model
  JOURNAL   Front Immunol 15, 1333967 (2024)
   PUBMED   38482010
  REMARK    GeneRIF: TLR5-deficiency controls dendritic cell subset development
            in an autoimmune diabetes-susceptible model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4235)
  AUTHORS   Raghibi,M., Raghibi,M., Morovvati,A., Shakib,P., Aflatoonian,R. and
            Dirbaiyan,A.
  TITLE     Expression of mRNA-TLR-5 Gene in Patients with Endometriosis using
            Real-time PCR in Tehran, Iran
  JOURNAL   Recent Adv Antiinfect Drug Discov 19 (4), 300-306 (2024)
   PUBMED   38213148
  REMARK    GeneRIF: Expression of mRNA-TLR-5 Gene in Patients with
            Endometriosis using Real-time PCR in Tehran, Iran.
REFERENCE   3  (bases 1 to 4235)
  AUTHORS   Wang,L., Mao,Z. and Shao,F.
  TITLE     Identification of toll-like receptor 5 and acyl-CoA synthetase long
            chain family member 1 as hub genes are correlated with the severe
            forms of COVID-19 by Weighted gene co-expression network analysis
  JOURNAL   IET Syst Biol 17 (6), 327-335 (2023)
   PUBMED   37823415
  REMARK    GeneRIF: Identification of toll-like receptor 5 and acyl-CoA
            synthetase long chain family member 1 as hub genes are correlated
            with the severe forms of COVID-19 by Weighted gene co-expression
            network analysis.
REFERENCE   4  (bases 1 to 4235)
  AUTHORS   Demirci,F.Y., Manzi,S., Ramsey-Goldman,R., Kenney,M., Shaw,P.S.,
            Dunlop-Thomas,C.M., Kao,A.H., Rhew,E.Y., Bontempo,F., Kammerer,C.
            and Kamboh,M.I.
  TITLE     Association study of Toll-like receptor 5 (TLR5) and Toll-like
            receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus
  JOURNAL   J Rheumatol 34 (8), 1708-1711 (2007)
   PUBMED   17516623
  REMARK    GeneRIF: Our results do not indicate a major influence of these
            putative functional TLR5 and TLR9 single nucleotide polymorphisms
            on the susceptibility to (or protection from) systemic lupus
            erythematosus.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 4235)
  AUTHORS   Hawn,T.R., Wu,H., Grossman,J.M., Hahn,B.H., Tsao,B.P. and Aderem,A.
  TITLE     A stop codon polymorphism of Toll-like receptor 5 is associated
            with resistance to systemic lupus erythematosus
  JOURNAL   Proc Natl Acad Sci U S A 102 (30), 10593-10597 (2005)
   PUBMED   16027372
  REMARK    GeneRIF: A stop codon polymorphism of Toll-like receptor 5 is
            associated with resistance to systemic lupus erythematosus.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4235)
  AUTHORS   Hawn,T.R., Verbon,A., Lettinga,K.D., Zhao,L.P., Li,S.S., Laws,R.J.,
            Skerrett,S.J., Beutler,B., Schroeder,L., Nachman,A., Ozinsky,A.,
            Smith,K.D. and Aderem,A.
  TITLE     A common dominant TLR5 stop codon polymorphism abolishes flagellin
            signaling and is associated with susceptibility to legionnaires'
            disease
  JOURNAL   J Exp Med 198 (10), 1563-1572 (2003)
   PUBMED   14623910
REFERENCE   7  (bases 1 to 4235)
  AUTHORS   Moser,K.L., Neas,B.R., Salmon,J.E., Yu,H., Gray-McGuire,C.,
            Asundi,N., Bruner,G.R., Fox,J., Kelly,J., Henshall,S., Bacino,D.,
            Dietz,M., Hogue,R., Koelsch,G., Nightingale,L., Shaver,T.,
            Abdou,N.I., Albert,D.A., Carson,C., Petri,M., Treadwell,E.L.,
            James,J.A. and Harley,J.B.
  TITLE     Genome scan of human systemic lupus erythematosus: evidence for
            linkage on chromosome 1q in African-American pedigrees
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14869-14874 (1998)
   PUBMED   9843982
REFERENCE   8  (bases 1 to 4235)
  AUTHORS   Chaudhary,P.M., Ferguson,C., Nguyen,V., Nguyen,O., Massa,H.F.,
            Eby,M., Jasmin,A., Trask,B.J., Hood,L. and Nelson,P.S.
  TITLE     Cloning and characterization of two Toll/Interleukin-1
            receptor-like genes TIL3 and TIL4: evidence for a multi-gene
            receptor family in humans
  JOURNAL   Blood 91 (11), 4020-4027 (1998)
   PUBMED   9596645
REFERENCE   9  (bases 1 to 4235)
  AUTHORS   Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
  TITLE     A family of human receptors structurally related to Drosophila Toll
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 588-593 (1998)
   PUBMED   9435236
REFERENCE   10 (bases 1 to 4235)
  AUTHORS   Tsao,B.P., Cantor,R.M., Kalunian,K.C., Chen,C.J., Badsha,H.,
            Singh,R., Wallace,D.J., Kitridou,R.C., Chen,S.L., Shen,N.,
            Song,Y.W., Isenberg,D.A., Yu,C.L., Hahn,B.H. and Rotter,J.I.
  TITLE     Evidence for linkage of a candidate chromosome 1 region to human
            systemic lupus erythematosus
  JOURNAL   J Clin Invest 99 (4), 725-731 (1997)
   PUBMED   9045876
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB060695.1, DB448079.1,
            AB445645.1, AL929091.28 and BQ025528.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003268.5.
            
            Summary: This gene encodes a member of the toll-like receptor (TLR)
            family, which plays a fundamental role in pathogen recognition and
            activation of innate immune responses. These receptors recognize
            distinct pathogen-associated molecular patterns that are expressed
            on infectious agents. The protein encoded by this gene recognizes
            bacterial flagellin, the principal component of bacterial flagella
            and a virulence factor. The activation of this receptor mobilizes
            the nuclear factor NF-kappaB, which in turn activates a host of
            inflammatory-related target genes. Mutations in this gene have been
            associated with both resistance and susceptibility to systemic
            lupus erythematosus, and susceptibility to Legionnaire
            disease.[provided by RefSeq, Dec 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF051151.2, AB060695.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000642603.2/ ENSP00000496355.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AB060695.1         97-284
            189-439             DB448079.1         100-350
            440-1938            AB060695.1         536-2034
            1939-1939           AB445645.1         1332-1332
            1940-3334           AB060695.1         2036-3430
            3335-3718           AL929091.28        65570-65953         c
            3719-4233           BQ025528.1         19-533              c
            4234-4235           AL929091.28        65053-65054         c
FEATURES             Location/Qualifiers
     source          1..4235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..4235
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /note="toll like receptor 5"
                     /db_xref="GeneID:7100"
                     /db_xref="HGNC:HGNC:11851"
                     /db_xref="MIM:603031"
     exon            1..53
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /inference="alignment:Splign:2.1.0"
     exon            54..169
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /inference="alignment:Splign:2.1.0"
     exon            170..255
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /inference="alignment:Splign:2.1.0"
     exon            256..438
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /inference="alignment:Splign:2.1.0"
     exon            439..603
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /inference="alignment:Splign:2.1.0"
     exon            604..4235
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             608..3184
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /note="toll/interleukin-1 receptor-like protein 3;
                     systemic lupus erythematosus susceptibility 1"
                     /codon_start=1
                     /product="toll-like receptor 5 precursor"
                     /protein_id="NP_003259.2"
                     /db_xref="CCDS:CCDS31033.1"
                     /db_xref="GeneID:7100"
                     /db_xref="HGNC:HGNC:11851"
                     /db_xref="MIM:603031"
                     /translation="MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQV
                     LNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDL
                     GSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSL
                     YLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGK
                     CMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKD
                     PDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYG
                     LDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLR
                     DNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHL
                     QILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLY
                     LNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPD
                     VFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSL
                     STEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDH
                     PQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENR
                     IANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQY
                     QLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVAT
                     IS"
     regulatory      3309..3314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /note="hexamer: CATAAA"
     polyA_site      3334
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /note="major polyA site"
     regulatory      3372..3377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /note="hexamer: AATAGA"
     polyA_site      3397
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /note="major polyA site"
     regulatory      4078..4083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /note="hexamer: ATTAAA"
     polyA_site      4099
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
     regulatory      4212..4217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
                     /note="hexamer: AATGAA"
     polyA_site      4235
                     /gene="TLR5"
                     /gene_synonym="MELIOS; SLE1; SLEB1; TIL3"
ORIGIN      
        1 gcgtccggga ggagccaacc gtggcgcagg cggcgcgggg aggcgtccca gagtctcact
       61 ctgccgccca ggctggactg cagtgacaca atctcggctg actgcaacca ctgcctccag
      121 ggttcaagcg attctcttgc ctcagcctcc caagtagctg ggattacaga ttgatgttca
      181 tgttcctgac actactacaa gattcatact cctgatgcta ctgacaacgt ggcttctcca
      241 cagtcaccaa accagggatg ctatactgga cttccctact ctcatctgct ccagccccct
      301 gaccttatag ttgcccagct ttcctggcaa ttgactttgc ccatcaatac acaggattta
      361 gcatccaggg aagatgtcgg agcctcagat gttaattttc taattgagaa tgttggcgct
      421 gtccgaacct ggagacagga aaacaaaaag tcctttctcc tgattcacca aaaaataaaa
      481 tactgactac catcactgtg atgagattcc tatagtctca ggaactgaag tctttaaaca
      541 accagggacc ctctgcccct agaataagaa catactagaa gtcccttctg ctaggacaac
      601 gaggatcatg ggagaccacc tggaccttct cctaggagtg gtgctcatgg ccggtcctgt
      661 gtttggaatt ccttcctgct cctttgatgg ccgaatagcc ttttatcgtt tctgcaacct
      721 cacccaggtc ccccaggtcc tcaacaccac tgagaggctc ctgctgagct tcaactatat
      781 caggacagtc actgcttcat ccttcccctt tctggaacag ctgcagctgc tggagctcgg
      841 gagccagtat acccccttga ctattgacaa ggaggccttc agaaacctgc ccaaccttag
      901 aatcttggac ctgggaagta gtaagatata cttcttgcat ccagatgctt ttcagggact
      961 gttccatctg tttgaactta gactgtattt ctgtggtctc tctgatgctg tattgaaaga
     1021 tggttatttc agaaatttaa aggctttaac tcgcttggat ctatccaaaa atcagattcg
     1081 tagcctttac cttcatcctt catttgggaa gttgaattcc ttaaagtcca tagatttttc
     1141 ctccaaccaa atattccttg tatgtgaaca tgagctcgag cccctacaag ggaaaacgct
     1201 ctcctttttt agcctcgcag ctaatagctt gtatagcaga gtctcagtgg actggggaaa
     1261 atgtatgaac ccattcagaa acatggtgct ggagatacta gatgtttctg gaaatggctg
     1321 gacagtggac atcacaggaa actttagcaa tgccatcagc aaaagccagg ccttctcttt
     1381 gattcttgcc caccacatca tgggtgccgg gtttggcttc cataacatca aagatcctga
     1441 ccagaacaca tttgctggcc tggccagaag ttcagtgaga cacctggatc tttcacatgg
     1501 gtttgtcttc tccctgaact cacgagtctt tgagacactc aaggatttga aggttctgaa
     1561 ccttgcctac aacaagataa ataagattgc agatgaagca ttttacggac ttgacaacct
     1621 ccaagttctc aatttgtcat ataaccttct gggggaactt tacagttcga atttctatgg
     1681 actacctaag gtagcctaca ttgatttgca aaagaatcac attgcaataa ttcaagacca
     1741 aacattcaaa ttcctggaaa aattacagac cttggatctc cgagacaatg ctcttacaac
     1801 cattcatttt attccaagca tacccgatat cttcttgagt ggcaataaac tagtgacttt
     1861 gccaaagatc aaccttacag cgaacctcat ccacttatca gaaaacaggc tagaaaatct
     1921 agatattctc tactttctcc tacgggtacc tcatctccag attctcattt taaatcaaaa
     1981 tcgcttctcc tcctgtagtg gagatcaaac cccttcagag aatcccagct tagaacagct
     2041 tttccttgga gaaaatatgt tgcaacttgc ctgggaaact gagctctgtt gggatgtttt
     2101 tgagggactt tctcatcttc aagttctgta tttgaatcat aactatctta attcccttcc
     2161 accaggagta tttagccatc tgactgcatt aaggggacta agcctcaact ccaacaggct
     2221 gacagttctt tctcacaatg atttacctgc taatttagag atcctggaca tatccaggaa
     2281 ccagctccta gctcctaatc ctgatgtatt tgtatcactt agtgtcttgg atataactca
     2341 taacaagttc atttgtgaat gtgaacttag cacttttatc aattggctta atcacaccaa
     2401 tgtcactata gctgggcctc ctgcagacat atattgtgtg taccctgact cgttctctgg
     2461 ggtttccctc ttctctcttt ccacggaagg ttgtgatgaa gaggaagtct taaagtccct
     2521 aaagttctcc cttttcattg tatgcactgt cactctgact ctgttcctca tgaccatcct
     2581 cacagtcaca aagttccggg gcttctgttt tatctgttat aagacagccc agagactggt
     2641 gttcaaggac catccccagg gcacagaacc tgatatgtac aaatatgatg cctatttgtg
     2701 cttcagcagc aaagacttca catgggtgca gaatgctttg ctcaaacacc tggacactca
     2761 atacagtgac caaaacagat tcaacctgtg ctttgaagaa agagactttg tcccaggaga
     2821 aaaccgcatt gccaatatcc aggatgccat ctggaacagt agaaagatcg tttgtcttgt
     2881 gagcagacac ttccttagag atggctggtg ccttgaagcc ttcagttatg cccagggcag
     2941 gtgcttatct gaccttaaca gtgctctcat catggtggtg gttgggtcct tgtcccagta
     3001 ccagttgatg aaacatcaat ccatcagagg ctttgtacag aaacagcagt atttgaggtg
     3061 gcctgaggat ctccaggatg ttggctggtt tcttcataaa ctctctcaac agatactaaa
     3121 gaaagaaaaa gaaaagaaga aagacaataa cattccgttg caaactgtag caaccatctc
     3181 ctaatcaaag gagcaatttc caacttatct caagccacaa ataactcttc actttgtatt
     3241 tgcaccaagt tatcattttg gggtcctctc tggaggtttt ttttttcttt ttgctactat
     3301 gaaaacaaca taaatctctc aattttcgta tcaacaccat gttctgtctc actaacctcc
     3361 aaatggaaaa taatagatct agaaaattgc aactgccctt agaggtttcc agtctccatt
     3421 gattttcttt cagatccaat aataccgttc tgtcctgctg tgttgattat ggaatgtatc
     3481 ctaatcatgg gaagggcacc ttgggagaag ttgcagatgg ctgacgtgct ttctctagca
     3541 ttcagctaaa aaatgggatg gtccatgatt ctgcgttctc tgtgttctgc aaaacaacat
     3601 taagtagaaa acaaacagaa gcagaggcac atttccttct tttgccacag aaacaatgcc
     3661 actgttgagt gcaagtcaca ctttgtctca tagataagag gtggccccaa agaagctggg
     3721 atgaatgagt cactacctgt cttgtgactg tactgcactt catgttctta ccttcggctt
     3781 ctccaggtct cgccctagtg agccaagaac tttctctcac atgctgcctt tatttaagcc
     3841 tggccttcaa gaccttccat gatttatcac caacctacct tttcagcttt gtttcctagc
     3901 acacctcatt gatcagctgc tcaggctgtt gcatgaagaa catggacttt gcacacagat
     3961 cctgggttga gttctgagtc agctgtgtat tagccatgta accttggcct tggtatgccc
     4021 ttgctggacc tacattttct cacgtaacag catctatgtc atagaattcc tgtgaaaatt
     4081 aaattggcca aggatgtcag ggcttctcag atcttttcct tcgttgccct aatgaccaca
     4141 agagaacaca tacactgaag gcctcctggg gggcagttgc aatttcactg aagttgtatt
     4201 tttttatctt aaatgaaatc tatgtgtatt ttcca
//
