LOCUS       NM_003265               6015 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens toll like receptor 3 (TLR3), mRNA.
ACCESSION   NM_003265
VERSION     NM_003265.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6015)
  AUTHORS   Tachizaki,M., Kobori,Y., Kawaguchi,S., Seya,K., Tanaka,H. and
            Imaizumi,T.
  TITLE     Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress
            TLR3-mediated CCL5 expression in human renal proximal tubular
            epithelial cells
  JOURNAL   Mol Biol Rep 51 (1), 974 (2024)
   PUBMED   39259342
  REMARK    GeneRIF: Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress
            TLR3-mediated CCL5 expression in human renal proximal tubular
            epithelial cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6015)
  AUTHORS   Soumbara,T., Bonnet,C., Hamed,C.T., Veten,F., Hemeyine,M.,
            Fall-Malick,F.Z., El Yezid,M.M., Diallo,A., Mounah,M.M. and
            Houmeida,A.
  TITLE     Genetic variation of TLR3 gene is associated with the outcome of
            hepatitis b infection in mauritanian patients: case control study
  JOURNAL   BMC Infect Dis 24 (1), 616 (2024)
   PUBMED   38907187
  REMARK    GeneRIF: Genetic variation of TLR3 gene is associated with the
            outcome of hepatitis b infection in mauritanian patients: case
            control study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6015)
  AUTHORS   Karabatic Knezovic,S., Knezovic,D., Matana,A., Puizina Ivic,N. and
            Drmic Hofman,I.
  TITLE     Strong association of TLR2 and TLR3 polymorphisms with
            keratoacanthoma and common warts: a case-control study
  JOURNAL   Croat Med J 65 (3), 232-238 (2024)
   PUBMED   38868969
  REMARK    GeneRIF: Strong association of TLR2 and TLR3 polymorphisms with
            keratoacanthoma and common warts: a case-control study.
REFERENCE   4  (bases 1 to 6015)
  AUTHORS   Braga,M., Shiga,M.A.S., Silva,P.E.S., Yamanaka,A.H.U., Souza,V.H.,
            Grava,S., Simao,A.N.C., Neves,J.S.F., de Lima Neto,Q.A.,
            Zacarias,J.M.V. and Visentainer,J.E.L.
  TITLE     Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes
            and covid-19 severity in Southern Brazil
  JOURNAL   Expert Rev Mol Diagn 24 (6), 525-531 (2024)
   PUBMED   38864429
  REMARK    GeneRIF: Association between polymorphisms in TLR3, TICAM1 and
            IFNA1 genes and covid-19 severity in Southern Brazil.
REFERENCE   5  (bases 1 to 6015)
  AUTHORS   Peng,L., Chen,J.W., Chen,Y.Z., Zhang,C., Shen,S.H., Liu,M.Z.,
            Fan,Y., Yang,S.Q., Zhang,X.Z., Wang,W., Gao,X.S., Di,X.P., Ma,Y.C.,
            Zeng,X., Shen,H., Jin,X. and Luo,D.Y.
  TITLE     UPK3A+ umbrella cell damage mediated by TLR3-NR2F6 triggers
            programmed destruction of urothelium in Hunner-type interstitial
            cystitis/painful bladder syndrome
  JOURNAL   J Pathol 263 (2), 203-216 (2024)
   PUBMED   38551071
  REMARK    GeneRIF: UPK3A[+] umbrella cell damage mediated by TLR3-NR2F6
            triggers programmed destruction of urothelium in Hunner-type
            interstitial cystitis/painful bladder syndrome.
REFERENCE   6  (bases 1 to 6015)
  AUTHORS   Kadowaki,N., Ho,S., Antonenko,S., Malefyt,R.W., Kastelein,R.A.,
            Bazan,F. and Liu,Y.J.
  TITLE     Subsets of human dendritic cell precursors express different
            toll-like receptors and respond to different microbial antigens
  JOURNAL   J Exp Med 194 (6), 863-869 (2001)
   PUBMED   11561001
REFERENCE   7  (bases 1 to 6015)
  AUTHORS   Muzio,M., Bosisio,D., Polentarutti,N., D'amico,G., Stoppacciaro,A.,
            Mancinelli,R., van't Veer,C., Penton-Rol,G., Ruco,L.P., Allavena,P.
            and Mantovani,A.
  TITLE     Differential expression and regulation of toll-like receptors (TLR)
            in human leukocytes: selective expression of TLR3 in dendritic
            cells
  JOURNAL   J Immunol 164 (11), 5998-6004 (2000)
   PUBMED   10820283
REFERENCE   8  (bases 1 to 6015)
  AUTHORS   Brightbill,H.D., Libraty,D.H., Krutzik,S.R., Yang,R.B.,
            Belisle,J.T., Bleharski,J.R., Maitland,M., Norgard,M.V.,
            Plevy,S.E., Smale,S.T., Brennan,P.J., Bloom,B.R., Godowski,P.J. and
            Modlin,R.L.
  TITLE     Host defense mechanisms triggered by microbial lipoproteins through
            toll-like receptors
  JOURNAL   Science 285 (5428), 732-736 (1999)
   PUBMED   10426995
REFERENCE   9  (bases 1 to 6015)
  AUTHORS   Lee,R.J., Albanese,C., Stenger,R.J., Watanabe,G., Inghirami,G.,
            Haines,G.K. 3rd, Webster,M., Muller,W.J., Brugge,J.S., Davis,R.J.
            and Pestell,R.G.
  TITLE     pp60(v-src) induction of cyclin D1 requires collaborative
            interactions between the extracellular signal-regulated kinase,
            p38, and Jun kinase pathways. A role for cAMP response
            element-binding protein and activating transcription factor-2 in
            pp60(v-src) signaling in breast cancer cells
  JOURNAL   J Biol Chem 274 (11), 7341-7350 (1999)
   PUBMED   10066798
REFERENCE   10 (bases 1 to 6015)
  AUTHORS   Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
  TITLE     A family of human receptors structurally related to Drosophila Toll
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 588-593 (1998)
   PUBMED   9435236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA374150.1, BC096333.1,
            U88879.1, BU624267.1 and AC104070.3.
            
            On Nov 21, 2019 this sequence version replaced NM_003265.2.
            
            Summary: The protein encoded by this gene is a member of the
            Toll-like receptor (TLR) family which plays a fundamental role in
            pathogen recognition and activation of innate immunity. TLRs are
            highly conserved from Drosophila to humans and share structural and
            functional similarities. They recognize pathogen-associated
            molecular patterns (PAMPs) that are expressed on infectious agents,
            and mediate the production of cytokines necessary for the
            development of effective immunity. The various TLRs exhibit
            different patterns of expression. This receptor is most abundantly
            expressed in placenta and pancreas, and is restricted to the
            dendritic subpopulation of the leukocytes. It recognizes dsRNA
            associated with viral infection, and induces the activation of
            NF-kappaB and the production of type I interferons. It thus plays a
            role in host defense against multiple viruses. [provided by RefSeq,
            Jul 2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094737.1, AK314208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000296795.8/ ENSP00000296795.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                DA374150.1         2-94
            94-2986             BC096333.1         72-2964
            2987-3037           U88879.1           2960-3010
            3038-3040           BU624267.1         17-19               c
            3041-6015           AC104070.3         73222-76196
FEATURES             Location/Qualifiers
     source          1..6015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..6015
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /note="toll like receptor 3"
                     /db_xref="GeneID:7098"
                     /db_xref="HGNC:HGNC:11849"
                     /db_xref="MIM:603029"
     exon            1..93
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /inference="alignment:Splign:2.1.0"
     exon            94..541
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2815
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /codon_start=1
                     /product="toll-like receptor 3 precursor"
                     /protein_id="NP_003256.1"
                     /db_xref="CCDS:CCDS3846.1"
                     /db_xref="GeneID:7098"
                     /db_xref="HGNC:HGNC:11849"
                     /db_xref="MIM:603029"
                     /translation="MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQ
                     VPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLK
                     VLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLS
                     STKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFH
                     AIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNL
                     TMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFT
                     KQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTS
                     LRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQ
                     EWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNL
                     TILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHI
                     LNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITS
                     VEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPH
                     YHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHR
                     VLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVF
                     ELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIP
                     DYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKNSVH"
     exon            542..733
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /inference="alignment:Splign:2.1.0"
     exon            734..2586
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..6015
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3019..3024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /note="hexamer: AATAAA"
     polyA_site      3040
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /note="major polyA site"
     regulatory      4557..4562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /note="hexamer: AATAAA"
     polyA_site      4585
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
     regulatory      4639..4644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /note="hexamer: AATAAA"
     polyA_site      4666
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
     regulatory      5988..5993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
                     /note="hexamer: ATTAAA"
     polyA_site      6015
                     /gene="TLR3"
                     /gene_synonym="CD283; IIAE2; IMD83"
ORIGIN      
        1 actttcgaga gtgccgtcta tttgccacac acttccctga tgaaatgtct ggatttggac
       61 taaagaaaaa aggaaaggct agcagtcatc caacagaatc atgagacaga ctttgccttg
      121 tatctacttt tgggggggcc ttttgccctt tgggatgctg tgtgcatcct ccaccaccaa
      181 gtgcactgtt agccatgaag ttgctgactg cagccacctg aagttgactc aggtacccga
      241 tgatctaccc acaaacataa cagtgttgaa ccttacccat aatcaactca gaagattacc
      301 agccgccaac ttcacaaggt atagccagct aactagcttg gatgtaggat ttaacaccat
      361 ctcaaaactg gagccagaat tgtgccagaa acttcccatg ttaaaagttt tgaacctcca
      421 gcacaatgag ctatctcaac tttctgataa aacctttgcc ttctgcacga atttgactga
      481 actccatctc atgtccaact caatccagaa aattaaaaat aatccctttg tcaagcagaa
      541 gaatttaatc acattagatc tgtctcataa tggcttgtca tctacaaaat taggaactca
      601 ggttcagctg gaaaatctcc aagagcttct attatcaaac aataaaattc aagcgctaaa
      661 aagtgaagaa ctggatatct ttgccaattc atctttaaaa aaattagagt tgtcatcgaa
      721 tcaaattaaa gagttttctc cagggtgttt tcacgcaatt ggaagattat ttggcctctt
      781 tctgaacaat gtccagctgg gtcccagcct tacagagaag ctatgtttgg aattagcaaa
      841 cacaagcatt cggaatctgt ctctgagtaa cagccagctg tccaccacca gcaatacaac
      901 tttcttggga ctaaagtgga caaatctcac tatgctcgat ctttcctaca acaacttaaa
      961 tgtggttggt aacgattcct ttgcttggct tccacaacta gaatatttct tcctagagta
     1021 taataatata cagcatttgt tttctcactc tttgcacggg cttttcaatg tgaggtacct
     1081 gaatttgaaa cggtctttta ctaaacaaag tatttccctt gcctcactcc ccaagattga
     1141 tgatttttct tttcagtggc taaaatgttt ggagcacctt aacatggaag ataatgatat
     1201 tccaggcata aaaagcaata tgttcacagg attgataaac ctgaaatact taagtctatc
     1261 caactccttt acaagtttgc gaactttgac aaatgaaaca tttgtatcac ttgctcattc
     1321 tcccttacac atactcaacc taaccaagaa taaaatctca aaaatagaga gtgatgcttt
     1381 ctcttggttg ggccacctag aagtacttga cctgggcctt aatgaaattg ggcaagaact
     1441 cacaggccag gaatggagag gtctagaaaa tattttcgaa atctatcttt cctacaacaa
     1501 gtacctgcag ctgactagga actcctttgc cttggtccca agccttcaac gactgatgct
     1561 ccgaagggtg gcccttaaaa atgtggatag ctctccttca ccattccagc ctcttcgtaa
     1621 cttgaccatt ctggatctaa gcaacaacaa catagccaac ataaatgatg acatgttgga
     1681 gggtcttgag aaactagaaa ttctcgattt gcagcataac aacttagcac ggctctggaa
     1741 acacgcaaac cctggtggtc ccatttattt cctaaagggt ctgtctcacc tccacatcct
     1801 taacttggag tccaacggct ttgacgagat cccagttgag gtcttcaagg atttatttga
     1861 actaaagatc atcgatttag gattgaataa tttaaacaca cttccagcat ctgtctttaa
     1921 taatcaggtg tctctaaagt cattgaacct tcagaagaat ctcataacat ccgttgagaa
     1981 gaaggttttc gggccagctt tcaggaacct gactgagtta gatatgcgct ttaatccctt
     2041 tgattgcacg tgtgaaagta ttgcctggtt tgttaattgg attaacgaga cccataccaa
     2101 catccctgag ctgtcaagcc actacctttg caacactcca cctcactatc atgggttccc
     2161 agtgagactt tttgatacat catcttgcaa agacagtgcc ccctttgaac tctttttcat
     2221 gatcaatacc agtatcctgt tgatttttat ctttattgta cttctcatcc actttgaggg
     2281 ctggaggata tctttttatt ggaatgtttc agtacatcga gttcttggtt tcaaagaaat
     2341 agacagacag acagaacagt ttgaatatgc agcatatata attcatgcct ataaagataa
     2401 ggattgggtc tgggaacatt tctcttcaat ggaaaaggaa gaccaatctc tcaaattttg
     2461 tctggaagaa agggactttg aggcgggtgt ttttgaacta gaagcaattg ttaacagcat
     2521 caaaagaagc agaaaaatta tttttgttat aacacaccat ctattaaaag acccattatg
     2581 caaaagattc aaggtacatc atgcagttca acaagctatt gaacaaaatc tggattccat
     2641 tatattggtt ttccttgagg agattccaga ttataaactg aaccatgcac tctgtttgcg
     2701 aagaggaatg tttaaatctc actgcatctt gaactggcca gttcagaaag aacggatagg
     2761 tgcctttcgt cataaattgc aagtagcact tggatccaaa aactctgtac attaaattta
     2821 tttaaatatt caattagcaa aggagaaact ttctcaattt aaaaagttct atggcaaatt
     2881 taagttttcc ataaaggtgt tataatttgt ttattcatat ttgtaaatga ttatattcta
     2941 tcacaattac atctcttcta ggaaaatgtg tctccttatt tcaggcctat ttttgacaat
     3001 tgacttaatt ttacccaaaa taaaacatat aagcacgtaa gaacattgtc tactgattaa
     3061 tatacaatca gccactgagc ctatgacagc ttaaggagtt tgaaaacatt cctcatttta
     3121 agaaaagtta gaggtatatg agggtttgtg atgatctttt tgtattttgg atgcacttag
     3181 aatgaaagat aattgtttca atgggtataa tgctatttcc tttgtaaaag agtaaaatat
     3241 atacccatat ttttaacaag tttaattaca gtattttttc aatggaaaaa ctttgtattt
     3301 tagtaagtac ttgtctcagt gttgactttg ttaaatgtta aatatttttt aatatacata
     3361 cccaagggca gaaaacattt gcaattcatt tttattagtt aatgagatga ttatttgaat
     3421 gaatattgac ttgtattttc ctgagattat gagtttctgc tgtgggaggg tggaaacaat
     3481 tctcttacta aaagtattgt aggcaggctt gctttctgaa ggctaatcac tatttggctt
     3541 tgtggaaaca gaactttcct cccatggtca cagactcagg agatggcgtt ggcaaaatca
     3601 cttggtccca ctgggattct ttgactcctg atcttgaaaa ttatgataat aaatgcatct
     3661 tagatattcc tatgtaatta gtgatgatga tcgctgtata atatattcaa aggaatgtat
     3721 tattttacca taaaataatg tgctacgcat aaggtagtcc ttatctagaa agactatttt
     3781 tatttttgtt tttttgtttg tttgtttttt atttgtttgt ttttgagaca gagtctggct
     3841 ctgtcgccca ggctggagtt cagtggtcca acctcggccc accgcaacct ccacctctga
     3901 gttcaagcta ttctcctgcc tcagccaccc gagtagctgg gattacaggc acatgccacc
     3961 atgcctggct aatttttgta tttttagtag agatggggtt tcaccatgtt ggccaggctg
     4021 gtcttgaact cctgacctca agtgatcctc tcgccttggc ctcccaaagt gctaggatta
     4081 caggtgtgag ccaccgcgcc ccgccttttt attttgtttt acaatacaac aaaaaatttt
     4141 tagttttaca ataaaagaga atctgattat tggaaataga cctgaatagc tttttgaaat
     4201 atttatagtt ctagtattta aagagaaacc tgaaattata aagctgagtt aatttctata
     4261 cctgaaatgt tcatttgtct gctgaattca gggagcattt gagatgtcac attttggaac
     4321 tttgatttaa atagttcagt attcccaagg ctgagttcca tgaccctgga atgagaaata
     4381 tccactgtac ctctggttct gaagagtcta tagtcggcca acactgtgaa tgtgtggagg
     4441 actaattgtc actttcatgt tatttgccac cctgacagct gagacactgc ttttcagcat
     4501 tttagttaag atttgctttt taactgtgca ataatcattt tattttggca ttataaaata
     4561 aaaatcacaa cttctgcttt tcttatatgc tttgtgtgtt atcacacaaa tattctcaaa
     4621 tattcataag atattttaaa taaatcattg tgaattagtc aatatatcaa gttgcttaat
     4681 atgtcatata tcaatgctat ttaatatata atatctatat ttaatatatt gatatgttac
     4741 tggtggagag tgtccaggtt cttggtgctt tgaacaagga attggacaaa atgcacaaag
     4801 aatgaggcga caaaagcaga ggtttattga aaacgaaagc acaccccgca gggtgggagc
     4861 ggcccgagca agcagctcaa aagccgggtt acaggatttt ctggggttta aatactctct
     4921 agaggtttcc attggttact tggtttatgc cctatgtaaa tgaagaggct aaagtgaaat
     4981 tacaaagtta tttacttgtt gtgcacccta cgcaaatgaa tagctgtcac agctgaggta
     5041 gagttacagt gatttacttg gtggtagaat gttgggattt ttccatttga ttgagttcta
     5101 ggaagccttt agtttccctg cctgcagacc ccattctcct gcctcagata tatcaatgac
     5161 atattcaata catcattaag ttgcttaata tttaagaggt taagatgcac aggtaatgac
     5221 ctctaaatga atgccaataa aaatagtaaa aggtgtaaac tctgactcct atctgaccta
     5281 ggtaggaagt aacatccaga acttctgcag gctgtcctgt gtaattgttc tccggaggaa
     5341 cccttgtccc tggggtttga gagaagggga tcgaggaaaa ggatgtttgt ctgagctctt
     5401 gtttgatttg cccaagtgac ttgacttgtt tgaatcctct cagggtgcca tcatgtaatc
     5461 tgtccactcc aacttcttcc tgtttttcac attgcaaaac aaaacccaac tgaatcgaca
     5521 ctgagtttaa aataaatctt ggtatttagg ttgtacctaa aaatgataac ttttagactg
     5581 taatcagagg tagatgctat caatttgtta gtgaggaggg gaggagtttt cgatgccact
     5641 tagtttacaa tgtctaattg ttcaaatata catctaggtt gtaaaggaga ctcaacggta
     5701 agttatagtg accattgaaa aatgtaaagg ggcttcaaat caagaactta gaaggaattt
     5761 cttgcaatct attgagacac aaagcagatg agtggttgtc tgggcctagg aacaggaatg
     5821 gggagtggct gcaaataggt ggaagagacc ttttttgggt gatgaaagtg ctctataatt
     5881 gggttatggt aataattgta caactatgta aatttactga aagtcattga gttggacact
     5941 taaaacaggt gaattttatg atatgtaaat tatatattca caaagccatt aaaaattgta
     6001 ttttttgagc agcta
//
