LOCUS       NM_001318789            3596 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens toll like receptor 2 (TLR2), transcript variant 2,
            mRNA.
ACCESSION   NM_001318789 XM_005263194
VERSION     NM_001318789.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3596)
  AUTHORS   Ghali,R.M., Zaied,S., Daldoul,A., Kanabekova,P. and Almawi,W.Y.
  TITLE     Association between Toll-like receptor 2 rs4696483 and rs1898830
            polymorphisms and the risk of triple-negative breast cancer
  JOURNAL   Gene 928, 148773 (2024)
   PUBMED   39029768
  REMARK    GeneRIF: Association between Toll-like receptor 2 rs4696483 and
            rs1898830 polymorphisms and the risk of triple-negative breast
            cancer.
REFERENCE   2  (bases 1 to 3596)
  AUTHORS   Lin,Q., Zhang,C., Huang,H., Bai,Z., Liu,J., Zhang,Y., Li,X. and
            Wang,G.
  TITLE     TLR2 reprograms glucose metabolism in CD4+ T cells of rheumatoid
            arthritis patients to mediate cell hyperactivation and TNF-alpha
            secretion
  JOURNAL   Clin Rheumatol 43 (11), 3537-3549 (2024)
   PUBMED   39356380
  REMARK    GeneRIF: TLR2 reprograms glucose metabolism in CD4[+] T cells of
            rheumatoid arthritis patients to mediate cell hyperactivation and
            TNF-alpha secretion.
REFERENCE   3  (bases 1 to 3596)
  AUTHORS   Dinice,L., Esposito,G., Cacciamani,A., Balzamino,B.O., Cosimi,P.,
            Cafiero,C., Ripandelli,G. and Micera,A.
  TITLE     TLR2 and TLR4 Are Expressed in Epiretinal Membranes: Possible Links
            with Vitreous Levels of Complement Fragments and DAMP-Related
            Proteins
  JOURNAL   Int J Mol Sci 25 (14), 7732 (2024)
   PUBMED   39062973
  REMARK    GeneRIF: TLR2 and TLR4 Are Expressed in Epiretinal Membranes:
            Possible Links with Vitreous Levels of Complement Fragments and
            DAMP-Related Proteins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3596)
  AUTHORS   Jin,M.S., Kim,S.E., Heo,J.Y., Lee,M.E., Kim,H.M., Paik,S.G., Lee,H.
            and Lee,J.O.
  TITLE     Crystal structure of the TLR1-TLR2 heterodimer induced by binding
            of a tri-acylated lipopeptide
  JOURNAL   Cell 130 (6), 1071-1082 (2007)
   PUBMED   17889651
  REMARK    GeneRIF: Propose that formation of the TLR1-TLR2 heterodimer brings
            the intracellular TIR domains close to each other to promote
            dimerization and initiate signaling.
REFERENCE   5  (bases 1 to 3596)
  AUTHORS   Haehnel,V., Schwarzfischer,L., Fenton,M.J. and Rehli,M.
  TITLE     Transcriptional regulation of the human toll-like receptor 2 gene
            in monocytes and macrophages
  JOURNAL   J Immunol 168 (11), 5629-5637 (2002)
   PUBMED   12023360
REFERENCE   6  (bases 1 to 3596)
  AUTHORS   Aliprantis,A.O., Yang,R.B., Mark,M.R., Suggett,S., Devaux,B.,
            Radolf,J.D., Klimpel,G.R., Godowski,P. and Zychlinsky,A.
  TITLE     Cell activation and apoptosis by bacterial lipoproteins through
            toll-like receptor-2
  JOURNAL   Science 285 (5428), 736-739 (1999)
   PUBMED   10426996
REFERENCE   7  (bases 1 to 3596)
  AUTHORS   Yoshimura,A., Lien,E., Ingalls,R.R., Tuomanen,E., Dziarski,R. and
            Golenbock,D.
  TITLE     Cutting edge: recognition of Gram-positive bacterial cell wall
            components by the innate immune system occurs via Toll-like
            receptor 2
  JOURNAL   J Immunol 163 (1), 1-5 (1999)
   PUBMED   10384090
REFERENCE   8  (bases 1 to 3596)
  AUTHORS   Yang,R.B., Mark,M.R., Gray,A., Huang,A., Xie,M.H., Zhang,M.,
            Goddard,A., Wood,W.I., Gurney,A.L. and Godowski,P.J.
  TITLE     Toll-like receptor-2 mediates lipopolysaccharide-induced cellular
            signalling
  JOURNAL   Nature 395 (6699), 284-288 (1998)
   PUBMED   9751057
REFERENCE   9  (bases 1 to 3596)
  AUTHORS   Chaudhary,P.M., Ferguson,C., Nguyen,V., Nguyen,O., Massa,H.F.,
            Eby,M., Jasmin,A., Trask,B.J., Hood,L. and Nelson,P.S.
  TITLE     Cloning and characterization of two Toll/Interleukin-1
            receptor-like genes TIL3 and TIL4: evidence for a multi-gene
            receptor family in humans
  JOURNAL   Blood 91 (11), 4020-4027 (1998)
   PUBMED   9596645
REFERENCE   10 (bases 1 to 3596)
  AUTHORS   Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
  TITLE     A family of human receptors structurally related to Drosophila Toll
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 588-593 (1998)
   PUBMED   9435236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF424051.1, BC033756.1,
            AK125659.1, CB528396.1, AW614989.1 and BQ017238.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001318789.1.
            
            Summary: The protein encoded by this gene is a member of the
            Toll-like receptor (TLR) family which plays a fundamental role in
            pathogen recognition and activation of innate immunity. TLRs are
            highly conserved from Drosophila to humans and share structural and
            functional similarities. This protein is a cell-surface protein
            that can form heterodimers with other TLR family members to
            recognize conserved molecules derived from microorganisms known as
            pathogen-associated molecular patterns (PAMPs). Activation of TLRs
            by PAMPs leads to an up-regulation of signaling pathways to
            modulate the host's inflammatory response. This gene is also
            thought to promote apoptosis in response to bacterial lipoproteins.
            This gene has been implicated in the pathogenesis of several
            autoimmune diseases. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-8 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.175271.1,
                                           SRR1660803.67281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000642700.2/ ENSP00000494425.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AF424051.1         29-265
            238-839             BC033756.1         145-746
            840-840             AK125659.1         2001-2001
            841-2788            BC033756.1         748-2695
            2789-3029           CB528396.1         21-261              c
            3030-3427           AW614989.1         15-412              c
            3428-3596           BQ017238.1         16-184              c
FEATURES             Location/Qualifiers
     source          1..3596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..3596
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /note="toll like receptor 2"
                     /db_xref="GeneID:7097"
                     /db_xref="HGNC:HGNC:11848"
                     /db_xref="MIM:603028"
     exon            1..81
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /inference="alignment:Splign:2.1.0"
     exon            82..227
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /inference="alignment:Splign:2.1.0"
     exon            228..3596
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2598
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /EC_number="3.2.2.6"
                     /note="toll/interleukin-1 receptor-like protein 4"
                     /codon_start=1
                     /product="toll-like receptor 2 precursor"
                     /protein_id="NP_001305718.1"
                     /db_xref="CCDS:CCDS3784.1"
                     /db_xref="GeneID:7097"
                     /db_xref="HGNC:HGNC:11848"
                     /db_xref="MIM:603028"
                     /translation="MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLN
                     SIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSL
                     EHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMD
                     TFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFV
                     DVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQI
                     SGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSL
                     TERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTL
                     ILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHS
                     VTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISR
                     NAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDS
                     PSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAW
                     LQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPG
                     KWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPI
                     EKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS"
     regulatory      2722..2727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /note="hexamer: ACTAAA"
     polyA_site      2743
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /note="major polyA site"
     regulatory      2764..2769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /note="hexamer: TATAAA"
     polyA_site      2788
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /note="major polyA site"
     regulatory      3015..3020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /note="hexamer: AATACA"
     polyA_site      3038
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /note="major polyA site"
     regulatory      3563..3568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
                     /note="hexamer: AATAAA"
     polyA_site      3596
                     /gene="TLR2"
                     /gene_synonym="CD282; TIL4"
ORIGIN      
        1 aggccggctc ggaggcagcg agaaagcgca gccaggcggc tgctcggcgt tctctcaggt
       61 gactgctcgg agttctccca gtttctcttt taacagtgtt tggtgttgca agcaggatcc
      121 aaaggagacc tatagtgact cccaggagct cttagtgacc aagtgaaggt acctgtgggg
      181 ctcattgtgc ccattgctct ttcactgctt tcaactggta gttgtgggtt gaagcactgg
      241 acaatgccac atactttgtg gatggtgtgg gtcttggggg tcatcatcag cctctccaag
      301 gaagaatcct ccaatcaggc ttctctgtct tgtgaccgca atggtatctg caagggcagc
      361 tcaggatctt taaactccat tccctcaggg ctcacagaag ctgtaaaaag ccttgacctg
      421 tccaacaaca ggatcaccta cattagcaac agtgacctac agaggtgtgt gaacctccag
      481 gctctggtgc tgacatccaa tggaattaac acaatagagg aagattcttt ttcttccctg
      541 ggcagtcttg aacatttaga cttatcctat aattacttat ctaatttatc gtcttcctgg
      601 ttcaagcccc tttcttcttt aacattctta aacttactgg gaaatcctta caaaacccta
      661 ggggaaacat ctcttttttc tcatctcaca aaattgcaaa tcctgagagt gggaaatatg
      721 gacaccttca ctaagattca aagaaaagat tttgctggac ttaccttcct tgaggaactt
      781 gagattgatg cttcagatct acagagctat gagccaaaaa gtttgaagtc aattcagaat
      841 gtaagtcatc tgatccttca tatgaagcag catattttac tgctggagat ttttgtagat
      901 gttacaagtt ccgtggaatg tttggaactg cgagatactg atttggacac tttccatttt
      961 tcagaactat ccactggtga aacaaattca ttgattaaaa agtttacatt tagaaatgtg
     1021 aaaatcaccg atgaaagttt gtttcaggtt atgaaacttt tgaatcagat ttctggattg
     1081 ttagaattag agtttgatga ctgtaccctt aatggagttg gtaattttag agcatctgat
     1141 aatgacagag ttatagatcc aggtaaagtg gaaacgttaa caatccggag gctgcatatt
     1201 ccaaggtttt acttatttta tgatctgagc actttatatt cacttacaga aagagttaaa
     1261 agaatcacag tagaaaacag taaagttttt ctggttcctt gtttactttc acaacattta
     1321 aaatcattag aatacttgga tctcagtgaa aatttgatgg ttgaagaata cttgaaaaat
     1381 tcagcctgtg aggatgcctg gccctctcta caaactttaa ttttaaggca aaatcatttg
     1441 gcatcattgg aaaaaaccgg agagactttg ctcactctga aaaacttgac taacattgat
     1501 atcagtaaga atagttttca ttctatgcct gaaacttgtc agtggccaga aaagatgaaa
     1561 tatttgaact tatccagcac acgaatacac agtgtaacag gctgcattcc caagacactg
     1621 gaaattttag atgttagcaa caacaatctc aatttatttt ctttgaattt gccgcaactc
     1681 aaagaacttt atatttccag aaataagttg atgactctac cagatgcctc cctcttaccc
     1741 atgttactag tattgaaaat cagtaggaat gcaataacta cgttttctaa ggagcaactt
     1801 gactcatttc acacactgaa gactttggaa gctggtggca ataacttcat ttgctcctgt
     1861 gaattcctct ccttcactca ggagcagcaa gcactggcca aagtcttgat tgattggcca
     1921 gcaaattacc tgtgtgactc tccatcccat gtgcgtggcc agcaggttca ggatgtccgc
     1981 ctctcggtgt cggaatgtca caggacagca ctggtgtctg gcatgtgctg tgctctgttc
     2041 ctgctgatcc tgctcacggg ggtcctgtgc caccgtttcc atggcctgtg gtatatgaaa
     2101 atgatgtggg cctggctcca ggccaaaagg aagcccagga aagctcccag caggaacatc
     2161 tgctatgatg catttgtttc ttacagtgag cgggatgcct actgggtgga gaaccttatg
     2221 gtccaggagc tggagaactt caatcccccc ttcaagttgt gtcttcataa gcgggacttc
     2281 attcctggca agtggatcat tgacaatatc attgactcca ttgaaaagag ccacaaaact
     2341 gtctttgtgc tttctgaaaa ctttgtgaag agtgagtggt gcaagtatga actggacttc
     2401 tcccatttcc gtctttttga tgagaacaat gatgctgcca ttctcattct tctggagccc
     2461 attgagaaaa aagccattcc ccagcgcttc tgcaagctgc ggaagataat gaacaccaag
     2521 acctacctgg agtggcccat ggacgaggct cagcgggaag gattttgggt aaatctgaga
     2581 gctgcgataa agtcctaggt tcccatattt aagaccagtc tttgtctagt tgggatcttt
     2641 atgtcactag ttatagttaa gttcattcag acataattat ataaaaacta cgtggatgta
     2701 ccgtcatttg aggacttgct tactaaaact acaaaacttc aaattttgtc tggggtgctg
     2761 ttttataaac atatgccaga tttaaaaatt ggtttttggt ttttcttttt tctatgagat
     2821 aaccatgatc ataagtctat tactgatatc tgaatatagt cccttggtat ccaagggaat
     2881 tggttgcagg atcctcgtgg atatcaaaat tcatagatga tcaagtccct tataagagtg
     2941 gcatagtatt tgcatataac ctgtgtacat tctcctgtat actttaaatc atctctagat
     3001 tacttatgat acccaataca atgtaaatac tatgtaaata gttgtactgt ctttttattt
     3061 atattattat tgttattttt tattttcaaa atttttaaaa catacttttg atccacagtt
     3121 ggttgacttc atggatgcag aacccatgga tatagagggc caactgtaat ctgtagcaac
     3181 tggcttagtt cattaggaaa cagcacaaat gaacttaaga ttctcaatga ctgtgtcatt
     3241 ctttcttcct gctaagagac tcctctgtgg ccacaaaagg cattctctgt cctacctagc
     3301 tgtcacttct ctgtgcagct gatctcaaga gcaacaaggc aaagtatttg gggcactccc
     3361 caaaacttgt tgctattcct agaaaaaagt gctgtgtatt tcctattaaa ctttacagga
     3421 tgagaaatac tagagggtgt attttcatgt gatctggatc tgtctttctg gctattagat
     3481 aggtttctcc agccatagtt acttgagaga gtgagtacac agtgcaaggt acagtaaatt
     3541 atgtatttct gtaatttaac aaaataaata ctcagtttag gagaatttga aagaca
//
