LOCUS       NM_030956               3991 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens toll like receptor 10 (TLR10), transcript variant 1,
            mRNA.
ACCESSION   NM_030956
VERSION     NM_030956.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3991)
  AUTHORS   Deb,P., Singh,S., Kalyoussef,E., Hess,N.J., Tapping,R.I. and
            Fitzgerald-Bocarsly,P.
  TITLE     TLR10 (CD290) Is a Regulator of Immune Responses in Human
            Plasmacytoid Dendritic Cells
  JOURNAL   J Immunol 213 (5), 577-587 (2024)
   PUBMED   38995177
  REMARK    GeneRIF: TLR10 (CD290) Is a Regulator of Immune Responses in Human
            Plasmacytoid Dendritic Cells.
REFERENCE   2  (bases 1 to 3991)
  AUTHORS   Lee,K.M., Baris,D., Zhang,Y., Hosgood,H.D. 3rd, Menashe,I.,
            Yeager,M., Zahm,S.H., Wang,S.S., Purdue,M.P., Chanock,S., Zheng,T.,
            Rothman,N. and Lan,Q.
  TITLE     Common single nucleotide polymorphisms in immunoregulatory genes
            and multiple myeloma risk among women in Connecticut
  JOURNAL   Am J Hematol 85 (8), 560-563 (2010)
   PUBMED   20568250
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3991)
  AUTHORS   Guan,Y., Ranoa,D.R., Jiang,S., Mutha,S.K., Li,X., Baudry,J. and
            Tapping,R.I.
  TITLE     Human TLRs 10 and 1 share common mechanisms of innate immune
            sensing but not signaling
  JOURNAL   J Immunol 184 (9), 5094-5103 (2010)
   PUBMED   20348427
  REMARK    GeneRIF: Analysis of chimeric receptors containing the TLR10
            extracellular recognition domain indicates that human TLR10
            cooperates with TLR2 in sensing of microbes and fungi but possesses
            a signaling function distinct from that of other TLR2 subfamily
            members.
REFERENCE   4  (bases 1 to 3991)
  AUTHORS   Georgel,P., Macquin,C. and Bahram,S.
  TITLE     The heterogeneous allelic repertoire of human toll-like receptor
            (TLR) genes
  JOURNAL   PLoS One 4 (11), e7803 (2009)
   PUBMED   19924287
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3991)
  AUTHORS   Nakajima,T., Ohtani,H., Satta,Y., Uno,Y., Akari,H., Ishida,T. and
            Kimura,A.
  TITLE     Natural selection in the TLR-related genes in the course of primate
            evolution
  JOURNAL   Immunogenetics 60 (12), 727-735 (2008)
   PUBMED   18810425
REFERENCE   6  (bases 1 to 3991)
  AUTHORS   Nyman,T., Stenmark,P., Flodin,S., Johansson,I., Hammarstrom,M. and
            Nordlund,P.
  TITLE     The crystal structure of the human toll-like receptor 10
            cytoplasmic domain reveals a putative signaling dimer
  JOURNAL   J Biol Chem 283 (18), 11861-11865 (2008)
   PUBMED   18332149
  REMARK    GeneRIF: The TLR10 structure is in good agreement with available
            biochemical data on TLR receptors and is likely to provide a good
            model for the physiological dimer.
REFERENCE   7  (bases 1 to 3991)
  AUTHORS   Dasari,P., Nicholson,I.C. and Zola,H.
  TITLE     Toll-like receptors
  JOURNAL   J Biol Regul Homeost Agents 22 (1), 17-26 (2008)
   PUBMED   18394314
  REMARK    Review article
REFERENCE   8  (bases 1 to 3991)
  AUTHORS   Lien,E. and Ingalls,R.R.
  TITLE     Toll-like receptors
  JOURNAL   Crit Care Med 30 (1 Suppl), S1-S11 (2002)
   PUBMED   11782555
  REMARK    Review article
REFERENCE   9  (bases 1 to 3991)
  AUTHORS   Chuang,T. and Ulevitch,R.J.
  TITLE     Identification of hTLR10: a novel human Toll-like receptor
            preferentially expressed in immune cells
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 157-161 (2001)
   PUBMED   11267672
REFERENCE   10 (bases 1 to 3991)
  AUTHORS   Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F.
  TITLE     A family of human receptors structurally related to Drosophila Toll
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 588-593 (1998)
   PUBMED   9435236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA643313.1, DB226380.1,
            AF296673.1, AY358300.1 and AC118137.3.
            
            On Nov 22, 2018 this sequence version replaced NM_030956.3.
            
            Summary: The protein encoded by this gene is a member of the
            Toll-like receptor (TLR) family which plays a fundamental role in
            pathogen recognition and activation of innate immunity. TLRs are
            highly conserved from Drosophila to humans and share structural and
            functional similarities. They recognize pathogen-associated
            molecular patterns (PAMPs) that are expressed on infectious agents,
            and mediate the production of cytokines necessary for the
            development of effective immunity. The various TLRs exhibit
            different patterns of expression. This gene is most highly
            expressed in lymphoid tissues such as spleen, lymph node, thymus,
            and tonsil. Multiple alternatively spliced transcript variants
            which encode different protein isoforms have been found for this
            gene. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-4 encode the same protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.1011504.1,
                                           SRR14243140.5243797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308973.9/ ENSP00000308925.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                DA643313.1         1-70
            71-560              DB226380.1         71-560
            561-2322            AF296673.1         409-2170
            2323-3990           AY358300.1         1795-3462
            3991-3991           AC118137.3         34077-34077         c
FEATURES             Location/Qualifiers
     source          1..3991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..3991
                     /gene="TLR10"
                     /gene_synonym="CD290"
                     /note="toll like receptor 10"
                     /db_xref="GeneID:81793"
                     /db_xref="HGNC:HGNC:15634"
                     /db_xref="MIM:606270"
     exon            1..70
                     /gene="TLR10"
                     /gene_synonym="CD290"
                     /inference="alignment:Splign:2.1.0"
     exon            71..387
                     /gene="TLR10"
                     /gene_synonym="CD290"
                     /inference="alignment:Splign:2.1.0"
     exon            388..576
                     /gene="TLR10"
                     /gene_synonym="CD290"
                     /inference="alignment:Splign:2.1.0"
     exon            577..3991
                     /gene="TLR10"
                     /gene_synonym="CD290"
                     /inference="alignment:Splign:2.1.0"
     CDS             639..3074
                     /gene="TLR10"
                     /gene_synonym="CD290"
                     /EC_number="3.2.2.6"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="toll-like receptor 10 isoform a precursor"
                     /protein_id="NP_112218.2"
                     /db_xref="CCDS:CCDS3445.1"
                     /db_xref="GeneID:81793"
                     /db_xref="HGNC:HGNC:15634"
                     /db_xref="MIM:606270"
                     /translation="MRLIRNIYIFCSIVMTAEGDAPELPEERELMTNCSNMSLRKVPA
                     DLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLD
                     LSNNRLKSVTWYLLAGLRYLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQ
                     KIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILE
                     MTNIDGKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQI
                     RNVTFGGKAYLDHNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTIS
                     NAQMPHMLFPNYPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGNKLETLSLVSC
                     FANNTPLEHLDLSQNLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDL
                     NNNQIQTVPKETIHLMALRELNIAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFV
                     QSCQEVKTLNAGRNPFRCTCELKNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKD
                     VHLHELSCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTT
                     QEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENI
                     VSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPT
                     RYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAINVNVLATREMYELQTFTELNEES
                     RGSTISLMRTDCL"
     regulatory      3968..3973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLR10"
                     /gene_synonym="CD290"
                     /note="hexamer: AATAAA"
     polyA_site      3991
                     /gene="TLR10"
                     /gene_synonym="CD290"
                     /note="major polyA site"
ORIGIN      
        1 agccaattct gaccgtgtca acgaatcatc cacgcacctg cagctctgct gagagagtgc
       61 aagccgtggg aattcagcag ctgaatatca agacctttga attcaacaag aagttaagac
      121 atttatagtt gtctaacaac agactgaaga ttgtggcttg gtattcactg gcaggtttca
      181 gacatttaga tctttctttt aatgactaac accatgccta tctgtggaga agctggcaac
      241 atgtcacacc tggaaattgt ttttcaacat taatactatt atttggcagt aatccagatt
      301 gcttttgcca ccaacctgaa gacatataga ggcagaagga caggaataat tctatttgtt
      361 tcctgttttg aaacttccat ctgtaaggct atcaaaagga gatgtgagag agggtattga
      421 gtctggcctg acaatgcagt tcttaaacca aaggtccatt atgcttctcc tctctgagaa
      481 tcctgactta cctcaacaac ggagacatgg cacagtagcc agcttggaga cttctcagcc
      541 aatgctctga gatcaagtcg aagacccaat atacagggtt ttgagctcat cttcatcatt
      601 catatgagga aataagtggt aaaatccttg gaaatacaat gagactcatc agaaacattt
      661 acatattttg tagtattgtt atgacagcag agggtgatgc tccagagctg ccagaagaaa
      721 gggaactgat gaccaactgc tccaacatgt ctctaagaaa ggttcccgca gacttgaccc
      781 cagccacaac gacactggat ttatcctata acctcctttt tcaactccag agttcagatt
      841 ttcattctgt ctccaaactg agagttttga ttctatgcca taacagaatt caacagctgg
      901 atctcaaaac ctttgaattc aacaaggagt taagatattt agatttgtct aataacagac
      961 tgaagagtgt aacttggtat ttactggcag gtctcaggta tttagatctt tcttttaatg
     1021 actttgacac catgcctatc tgtgaggaag ctggcaacat gtcacacctg gaaatcctag
     1081 gtttgagtgg ggcaaaaata caaaaatcag atttccagaa aattgctcat ctgcatctaa
     1141 atactgtctt cttaggattc agaactcttc ctcattatga agaaggtagc ctgcccatct
     1201 taaacacaac aaaactgcac attgttttac caatggacac aaatttctgg gttcttttgc
     1261 gtgatggaat caagacttca aaaatattag aaatgacaaa tatagatggc aaaagccaat
     1321 ttgtaagtta tgaaatgcaa cgaaatctta gtttagaaaa tgctaagaca tcggttctat
     1381 tgcttaataa agttgattta ctctgggacg accttttcct tatcttacaa tttgtttggc
     1441 atacatcagt ggaacacttt cagatccgaa atgtgacttt tggtggtaag gcttatcttg
     1501 accacaattc atttgactac tcaaatactg taatgagaac tataaaattg gagcatgtac
     1561 atttcagagt gttttacatt caacaggata aaatctattt gcttttgacc aaaatggaca
     1621 tagaaaacct gacaatatca aatgcacaaa tgccacacat gcttttcccg aattatccta
     1681 cgaaattcca atatttaaat tttgccaata atatcttaac agacgagttg tttaaaagaa
     1741 ctatccaact gcctcacttg aaaactctca ttttgaatgg caataaactg gagacacttt
     1801 ctttagtaag ttgctttgct aacaacacac ccttggaaca cttggatctg agtcaaaatc
     1861 tattacaaca taaaaatgat gaaaattgct catggccaga aactgtggtc aatatgaatc
     1921 tgtcatacaa taaattgtct gattctgtct tcaggtgctt gcccaaaagt attcaaatac
     1981 ttgacctaaa taataaccaa atccaaactg tacctaaaga gactattcat ctgatggcct
     2041 tacgagaact aaatattgca tttaattttc taactgatct ccctggatgc agtcatttca
     2101 gtagactttc agttctgaac attgaaatga acttcattct cagcccatct ctggattttg
     2161 ttcagagctg ccaggaagtt aaaactctaa atgcgggaag aaatccattc cggtgtacct
     2221 gtgaattaaa aaatttcatt cagcttgaaa catattcaga ggtcatgatg gttggatggt
     2281 cagattcata cacctgtgaa taccctttaa acctaagggg aactaggtta aaagacgttc
     2341 atctccacga attatcttgc aacacagctc tgttgattgt caccattgtg gttattatgc
     2401 tagttctggg gttggctgtg gccttctgct gtctccactt tgatctgccc tggtatctca
     2461 ggatgctagg tcaatgcaca caaacatggc acagggttag gaaaacaacc caagaacaac
     2521 tcaagagaaa tgtccgattc cacgcattta tttcatacag tgaacatgat tctctgtggg
     2581 tgaagaatga attgatcccc aatctagaga aggaagatgg ttctatcttg atttgccttt
     2641 atgaaagcta ctttgaccct ggcaaaagca ttagtgaaaa tattgtaagc ttcattgaga
     2701 aaagctataa gtccatcttt gttttgtctc ccaactttgt ccagaatgag tggtgccatt
     2761 atgaattcta ctttgcccac cacaatctct tccatgaaaa ttctgatcat ataattctta
     2821 tcttactgga acccattcca ttctattgca ttcccaccag gtatcataaa ctgaaagctc
     2881 tcctggaaaa aaaagcatac ttggaatggc ccaaggatag gcgtaaatgt gggcttttct
     2941 gggcaaacct tcgagctgct attaatgtta atgtattagc caccagagaa atgtatgaac
     3001 tgcagacatt cacagagtta aatgaagagt ctcgaggttc tacaatctct ctgatgagaa
     3061 cagattgtct ataaaatccc acagtccttg ggaagttggg gaccacatac actgttggga
     3121 tgtacattga tacaaccttt atgatggcaa tttgacaata tttattaaaa taaaaaatgg
     3181 ttattccctt catatcagtt tctagaagga tttctaagaa tgtatcctat agaaacacct
     3241 tcacaagttt ataagggctt atggaaaaag gtgttcatcc caggattgtt tataatcatg
     3301 aaaaatgtgg ccaggtgcag tggctcactc ttgtaatccc agcactatgg gaggccaagg
     3361 tgggtgaccc acgaggtcaa gagatggaga ccatcctggc caacatggtg aaaccctgtc
     3421 tctactaaaa atacaaaaat tagctgggcg tgatggtgca cgcctgtagt cccagctact
     3481 tgggaggctg aggcaggaga atcgcttgaa cccgggaggt ggcagttgca gtgagctgag
     3541 atcgagccac tgcactccag cctggtgaca gagcgagact ccatctcaaa aaaaagaaaa
     3601 aaaaaaaaga aaaaaatgga aaacatcctc atggccacaa aataaggtct aattcaataa
     3661 attatagtac attaatgtaa tataatatta catgccacta aaaagaataa ggtagctgta
     3721 tatttcctgg tatggaaaaa acatattaat atgttataaa ctattaggtt ggtgcaaaac
     3781 taattgtggt ttttgccatt gaaatggcat tgaaataaaa gtgtaaagaa atctatacca
     3841 gatgtagtaa cagtggtttg ggtctgggag gttggattac agggagcatt tgatttctat
     3901 gttgtgtatt tctataatgt ttgaattgtt tagaatgaat ctgtatttct tttataagta
     3961 gaaaaaaaat aaagatagtt tttacagcct a
//
