LOCUS       NM_022566               4866 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens talin rod domain containing 1 (TLNRD1), mRNA.
ACCESSION   NM_022566
VERSION     NM_022566.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4866)
  AUTHORS   Cowell,A.R., Jacquemet,G., Singh,A.K., Varela,L., Nylund,A.S.,
            Ammon,Y.C., Brown,D.G., Akhmanova,A., Ivaska,J. and Goult,B.T.
  TITLE     Talin rod domain-containing protein 1 (TLNRD1) is a novel
            actin-bundling protein which promotes filopodia formation
  JOURNAL   J Cell Biol 220 (9) (2021)
   PUBMED   34264272
  REMARK    GeneRIF: Talin rod domain-containing protein 1 (TLNRD1) is a novel
            actin-bundling protein which promotes filopodia formation.
REFERENCE   2  (bases 1 to 4866)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4866)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4866)
  AUTHORS   Tatarano,S., Chiyomaru,T., Kawakami,K., Enokida,H., Yoshino,H.,
            Hidaka,H., Nohata,N., Yamasaki,T., Gotanda,T., Tachiwada,T.,
            Seki,N. and Nakagawa,M.
  TITLE     Novel oncogenic function of mesoderm development candidate 1 and
            its regulation by MiR-574-3p in bladder cancer cell lines
  JOURNAL   Int J Oncol 40 (4), 951-959 (2012)
   PUBMED   22179486
  REMARK    GeneRIF: Authors demonstrate that miR-574-3p is a miRNA with tumor
            suppressor function and that MESDC1 (which has a potential
            oncogenic function in BC) may be targeted by miR-574-3p.
REFERENCE   5  (bases 1 to 4866)
  AUTHORS   Gingras,A.R., Bate,N., Goult,B.T., Patel,B., Kopp,P.M., Emsley,J.,
            Barsukov,I.L., Roberts,G.C. and Critchley,D.R.
  TITLE     Central region of talin has a unique fold that binds vinculin and
            actin
  JOURNAL   J Biol Chem 285 (38), 29577-29587 (2010)
   PUBMED   20610383
REFERENCE   6  (bases 1 to 4866)
  AUTHORS   Wines,M.E., Lee,L., Katari,M.S., Zhang,L., DeRossi,C., Shi,Y.,
            Perkins,S., Feldman,M., McCombie,W.R. and Holdener,B.C.
  TITLE     Identification of mesoderm development (mesd) candidate genes by
            comparative mapping and genome sequence analysis
  JOURNAL   Genomics 72 (1), 88-98 (2001)
   PUBMED   11247670
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068870.17, CN370100.1,
            DN995580.1, AY007810.2 and BC084554.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_022566.2.
            
            Summary: This gene encodes a protein that is regulated by micro RNA
            MiR-574-3, and is thought to have an oncogenic function in human
            bladder cancer. A similar gene in mouse is located in a chromosomal
            region critical for differentiation of mesoderm, which affects
            embryo patterning and the formation of heart, muscle, blood,
            skeleton and the urogenital system. The mouse gene is expressed in
            early development, and in the adult. [provided by RefSeq, Nov
            2016].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1163657.283448.1, AY007810.2
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267984.4/ ENSP00000267984.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC068870.17        57397-57427
            32-497              CN370100.1         1-466
            498-709             DN995580.1         54-265
            710-2877            AY007810.2         1-2168
            2878-3082           BC084554.1         1706-1910
            3083-4866           AC068870.17        60479-62262
FEATURES             Location/Qualifiers
     source          1..4866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..4866
                     /gene="TLNRD1"
                     /gene_synonym="MESDC1"
                     /note="talin rod domain containing 1"
                     /db_xref="GeneID:59274"
                     /db_xref="HGNC:HGNC:13519"
                     /db_xref="MIM:615466"
     exon            1..4866
                     /gene="TLNRD1"
                     /gene_synonym="MESDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1350..2438
                     /gene="TLNRD1"
                     /gene_synonym="MESDC1"
                     /note="mesoderm development candidate 1"
                     /codon_start=1
                     /product="talin rod domain-containing protein 1"
                     /protein_id="NP_072088.1"
                     /db_xref="CCDS:CCDS10316.1"
                     /db_xref="GeneID:59274"
                     /db_xref="HGNC:HGNC:13519"
                     /db_xref="MIM:615466"
                     /translation="MASGSAGKPTGEAASPAPASAIGGASSQPRKRLVSVCDHCKGKM
                     QLVADLLLLSSEARPVLFEGPASSGAGAESFEQCRDTIIARTKGLSILTHDVQSQLNM
                     GRFGEAGDSLVELGDLVVSLTECSAHAAYLAAVATPGAQPAQPGLVDRYRVTRCRHEV
                     EQGCAVLRATPLADMTPQLLLEVSQGLSRNLKFLTDACALASDKSRDRFSREQFKLGV
                     KCMSTSASALLACVREVKVAPSELARSRCALFSGPLVQAVSALVGFATEPQFLGRAAA
                     VSAEGKAVQTAILGGAMSVVSACVLLTQCLRDLAQHPDGGAKMSDHRERLRNSACAVS
                     EGCTLLSQALRERSSPRTLPPVNSNSVN"
     regulatory      3060..3065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLNRD1"
                     /gene_synonym="MESDC1"
                     /note="hexamer: ATTAAA"
     polyA_site      3082
                     /gene="TLNRD1"
                     /gene_synonym="MESDC1"
                     /note="major polyA site"
     regulatory      4848..4853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLNRD1"
                     /gene_synonym="MESDC1"
                     /note="hexamer: ATTAAA"
     polyA_site      4866
                     /gene="TLNRD1"
                     /gene_synonym="MESDC1"
ORIGIN      
        1 aaaagatttc tataggctcc agggaggtta cggccgaggc ggcggcggcg gcgagcccgg
       61 gggcgaggcg cggacgggaa caggaaaagc ctccggcagc ccctgcgggc ggcggcgcag
      121 ccacggccgc gctccgaggt gaagccgcgc gcggagagga agcgggtgtt ttcccctctg
      181 cctttcggcc cccgcccttc ctttcagttt ctgcccgctc gctcggaagt tggcggttga
      241 caaaaatggc aggagccggg gcccgggccg gttgccgcag cgccgcgggg accttctgag
      301 ttggcccggt ggcagggaga ctcgtgcagg ggcgtccgat gcgcggggcc cggggcctcg
      361 ggagagctca gctgctgcgg gccccagacg aggcgacagg gatggacttg cgtagacagc
      421 cagcgccggg ccgccgggcg cgcggtctgg gagggcgtgc cgccgcggcg ccgggccgcg
      481 ctctgtgaac cggcgaggcg ggaaggggcc gccgtggtgc tcggcacgcc cgggcgtgtg
      541 gcgggcgggc gagagcttga gcgcgatccg ggcggccgct gtgcgcaatc agtgcaggct
      601 cccgcccgac tctgactcgg cgcggccgcg acagtgccgg ccacaccctc tgccccgctg
      661 ccgccggcgc cgcttcccaa gagctggagg caggagatgc gcccggggcg gccgcgcgtc
      721 ccagagagcc agccccggcc gccgtcgcgg ggaagtgccg cctggtgggg tcacggcgcc
      781 tgaagcccac gtgcgccgcc gagcccgagg tggcctcgag cgcggcggct gacagcacag
      841 cccgcctgag ctgcctcccg cgctcctccc cgaggaaagg attttgattt caaagaaagg
      901 aaggaaggaa ggacaactcc cagcttcccc gtcccgccct ccccgctccg agggccgcgc
      961 caggccatgc ccaagaaggc ggcggcggcg gcgaaccagc agaagggact ttcctggcag
     1021 cccggcgacg aggagcgcgg acagtgagtt tgctctgccc cggttcatgg ttcctgcaag
     1081 ccctctagga ggccgaaagc tgcagcccct ccccttgccc cgaagagcct tccgcgttct
     1141 ctcgccctcg ggcccacccc gcgccgcccg ggctcccgcc gccgcagccc agtgccctct
     1201 gcccgcggcg gtggatggca tgatggtgcg gggaaggcac cgcggccttg gccagctgag
     1261 tcgcgacggc cgccggggcg gcggcagtgg ccgcggcagc ggcggtggta gcgggctccc
     1321 cagcggcatg ccagtgcccc ccgggcgcga tggctagcgg cagcgccggg aagcccactg
     1381 gcgaggcggc ttctccggct cctgcgagcg ccatcggcgg ggccagctcg cagccgcgga
     1441 agaggctggt atccgtctgc gaccactgca agggcaagat gcagctggtg gctgacctgc
     1501 tgctgctgtc gagcgaggcg cggcccgtgc tcttcgaggg ccccgcctcc tctggtgccg
     1561 gcgccgagtc cttcgagcag tgccgggaca ccatcatcgc gcgcaccaag gggctctcca
     1621 tcctcaccca cgacgtgcag agccagctca acatgggccg cttcggggag gcgggggaca
     1681 gcctggtgga gctgggcgac ctggtggtgt cgctgaccga gtgctcggcc cacgcggcct
     1741 atctggccgc tgtggccacg ccgggcgccc agcccgcgca gccgggcctg gtggaccgct
     1801 accgcgtgac gcgatgccgc cacgaggtgg agcagggttg cgccgtgctg cgcgccacgc
     1861 cgctggccga catgacgccg cagctgctgc tggaggtgtc gcagggcctg tcgcgcaacc
     1921 tcaagttcct gacggacgcg tgcgccctgg ccagtgacaa gtcacgggac cgcttttcgc
     1981 gggagcagtt caagctgggc gtcaagtgca tgagcaccag cgcgtcggcg ctgctggcct
     2041 gcgtgcgcga ggtgaaggtg gcgcccagtg agctggcgcg cagccgctgt gcgctcttca
     2101 gcgggcccct ggtgcaggca gtgagcgccc tggtaggctt cgccaccgag ccgcagttcc
     2161 tgggtcgcgc ggcagctgtg agcgccgagg gcaaggcggt gcagaccgcc atcctgggcg
     2221 gcgccatgag cgtggtgtcg gcctgcgtgc tcctgaccca gtgcctcagg gatctggcgc
     2281 agcaccccga cgggggcgcc aagatgtcgg accacaggga gaggctgagg aactcggcct
     2341 gcgccgtgtc tgaaggctgc accctgctat ctcaggcttt aagggagagg tcttcgccca
     2401 ggactttacc gccagtgaat tccaattctg tgaattagca ccccaccccc ataccccttc
     2461 ttccaccccc agactaaagg aagatactta ctctctgccc ctctccattt ataccaaaga
     2521 aatcataggt gaaaccccct accctcccca acgttaaatg ctcgagagga atcttccaca
     2581 aggcagggcc atgcacgcaa cctgcacacg cacttggagg gcccaggtgt ctctccacca
     2641 gcccccatgc agtagggact ggaagatatg tcatctgctg gttgtgttat cactcccacc
     2701 ccctacccca gcccgtcttc cggaatttct caactaaatt tcattattgg gcaggaagga
     2761 ggtcatgggt tcatttcatt tttgtttttt gtgtttttaa ttaaaagaaa ggttacctca
     2821 gttttcactc cttagacatg gatgtagcta cctttttttg tatgtctttt ttttttttaa
     2881 gcaatcgtgt tgaattagga gtatacttgg tgtggaaaga gtatgaattt gccatgtgat
     2941 ttgcaaatgg ggggaagcta ctgtgagcgt gtgttttttt aatttacact atagagtgat
     3001 ttttttttcc cccaacgtca agtttttacc ttgcatgtac tggagtattt atttcatcta
     3061 ttaaaatgtt atgtttctca gatggctttt tgcaattatt gttgattttt caataattgt
     3121 aattttgcat gctgcatgtc atgtatggga agggtctgtg ggaaggctat ttcaatagta
     3181 gtgaggcggg cccccaattc ccagcccttt ctactatttc ctcaagaaaa agtactgctc
     3241 aagaagtact cccttgagca gcctggaact gaagagagga ctatgtgtaa cgttctattt
     3301 taaaaggcag gtgacacaaa tgggattggg ttatgtagag tgcttgggac ggttttgtct
     3361 catttttcct ggaaagtgat ttagctccct ttgtctccac ttacctttcc atcatcatga
     3421 acagtggctc aggctgcttg aattctgatt tgtattctgc ctatcatttt cagattaaat
     3481 cctaatcctg tgtggtatgc cagccttccc aactcagagt ctctggatgg aactctaaaa
     3541 gtactgtaca tcaagtgaga atagttagca tcttttatgt acacaggtct attcagacaa
     3601 gatcctcatg atttcagaaa aaatatagag agggtcctag actgcttaat agaggaaaga
     3661 agtatcctgg aaagcttgtt aagaacgttc tagagccaca acatgattgt aggccaaggg
     3721 cttgtttttg tgaccttgat ctaagataat gccatggttg attgtatgtt ggaagaatct
     3781 ttgattggaa tttggagtaa tattaaggta gtttgtcttt tctgcagaca tttttaggag
     3841 tctttttgtg tgagtggtgg tggagtgtat agttttgttg aacctagtta aattctgaat
     3901 atcttcccac taaaagcaca acaaatctat ttacagtgcc tgaagcctgg gagagccaca
     3961 tgagtaaaaa ctcgtacgtg gtttagattt gttccattta catttttctt gggatttgtt
     4021 gtgcttaaac ctttgcagtt cccacagatc tgaaaagaaa gcatttttca ctgtaataca
     4081 ttaagagaga gagaaaaaag tcatattgac tattttactt gtttgaatcg ctgtttttat
     4141 tacaatgaca tgaaatacaa cgtgtaaaag tctttaacct gtgttgggta agggtaggac
     4201 tgtttcacca ccctgaattt gaaatttgaa aaagtcttaa agtggtaggg tacttaaatt
     4261 tttaaaaaaa tgaccatggg agcagttttt ctctgttaaa tcctggtaaa cttcgggttt
     4321 ttgaagactt taaaagatga aaatgacctt gagcatcttt attcctttcc tctgcccctt
     4381 aatgttggga tggggttcag gatgaaaggg aggtgggatt ctaattcatg tgccagtgac
     4441 aatcctgcat gcatatagaa atttttattt attgaatgta cacaagtaat gatggagttt
     4501 gattatatgg ttcattttca tttatcctat gcagatcaca aagagtaaac tgaaaggaac
     4561 aaacgctaag taaaataagg gccagaaatc tgtaaatttg gtattagatt aagaaaaaaa
     4621 gaattgccag ttttttcctg gactctttcc ttgcagaagc gattttcagg acaactcaag
     4681 ccaattaaaa aaaagaaaat cactttccct atctgtttgg atgaagttaa ctagctagtc
     4741 actaagtgaa ttttgaaacc tcttacctaa atgatagctg ctcttggtgt ttctttatgc
     4801 tctacgtttg gtcatgtaac atgcataatc tctgttctct gaagttgatt aaagttctaa
     4861 acttaa
//
