LOCUS       NM_006289               8623 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens talin 1 (TLN1), mRNA.
ACCESSION   NM_006289
VERSION     NM_006289.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8623)
  AUTHORS   Kliche,J., Simonetti,L., Krystkowiak,I., Kuss,H., Diallo,M.,
            Rask,E., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Proteome-scale characterisation of motif-based interactome rewiring
            by disease mutations
  JOURNAL   Mol Syst Biol 20 (9), 1025-1048 (2024)
   PUBMED   39009827
REFERENCE   2  (bases 1 to 8623)
  AUTHORS   Xu,D., Yuan,X., Li,Z. and Mu,R.
  TITLE     Integrin activating molecule-talin1 promotes skin fibrosis in
            systemic sclerosis
  JOURNAL   Front Immunol 15, 1400819 (2024)
   PUBMED   38863696
  REMARK    GeneRIF: Integrin activating molecule-talin1 promotes skin fibrosis
            in systemic sclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8623)
  AUTHORS   Terri,M., Sandoval,P., Bontempi,G., Montaldo,C., Tomero-Sanz,H., de
            Turris,V., Trionfetti,F., Pascual-Anton,L., Clares-Pedrero,I.,
            Battistelli,C., Valente,S., Zwergel,C., Mai,A., Rosano,L., Del
            Pozo,M.A., Sanchez-Alvarez,M., Cabanas,C., Tripodi,M.,
            Lopez-Cabrera,M. and Strippoli,R.
  TITLE     HDAC1/2 control mesothelium/ovarian cancer adhesive interactions
            impacting on Talin-1-alpha5beta1-integrin-mediated actin
            cytoskeleton and extracellular matrix protein remodeling
  JOURNAL   J Exp Clin Cancer Res 43 (1), 27 (2024)
   PUBMED   38254102
  REMARK    GeneRIF: HDAC1/2 control mesothelium/ovarian cancer adhesive
            interactions impacting on Talin-1-alpha5beta1-integrin-mediated
            actin cytoskeleton and extracellular matrix protein remodeling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8623)
  AUTHORS   Li,J., Chen,S., Qin,R., Liu,X., Fan,L., Wei,M., Wei,J., Lin,J. and
            Zheng,F.
  TITLE     Talin1 regulates glucose metabolism and endometrial receptivity via
            GLUT-4 in patients with polycystic ovary syndrome and insulin
            resistance
  JOURNAL   Gynecol Endocrinol 39 (1), 2231085 (2023)
   PUBMED   37395213
  REMARK    GeneRIF: Talin1 regulates glucose metabolism and endometrial
            receptivity via GLUT-4 in patients with polycystic ovary syndrome
            and insulin resistance.
REFERENCE   5  (bases 1 to 8623)
  AUTHORS   Xu,C., Yang,K., Xuan,Z., Li,J., Liu,Y., Zhao,Y., Zheng,Z., Bai,Y.,
            Shi,Z., Shao,C., Zhang,L. and Sun,H.
  TITLE     BCKDK regulates breast cancer cell adhesion and tumor metastasis by
            inhibiting TRIM21 ubiquitinate talin1
  JOURNAL   Cell Death Dis 14 (7), 445 (2023)
   PUBMED   37460470
  REMARK    GeneRIF: BCKDK regulates breast cancer cell adhesion and tumor
            metastasis by inhibiting TRIM21 ubiquitinate talin1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8623)
  AUTHORS   Gilmore,A.P., Ohanian,V., Spurr,N.K. and Critchley,D.R.
  TITLE     Localisation of the human gene encoding the cytoskeletal protein
            talin to chromosome 9p
  JOURNAL   Hum Genet 96 (2), 221-224 (1995)
   PUBMED   7635475
REFERENCE   7  (bases 1 to 8623)
  AUTHORS   Salgia,R., Li,J.L., Lo,S.H., Brunkhorst,B., Kansas,G.S.,
            Sobhany,E.S., Sun,Y., Pisick,E., Hallek,M., Ernst,T. et al.
  TITLE     Molecular cloning of human paxillin, a focal adhesion protein
            phosphorylated by P210BCR/ABL
  JOURNAL   J Biol Chem 270 (10), 5039-5047 (1995)
   PUBMED   7534286
REFERENCE   8  (bases 1 to 8623)
  AUTHORS   Luna,E.J. and Hitt,A.L.
  TITLE     Cytoskeleton--plasma membrane interactions
  JOURNAL   Science 258 (5084), 955-964 (1992)
   PUBMED   1439807
  REMARK    Review article
REFERENCE   9  (bases 1 to 8623)
  AUTHORS   Kupfer,A., Burn,P. and Singer,S.J.
  TITLE     The PMA-induced specific association of LFA-1 and talin in intact
            cloned T helper cells
  JOURNAL   J Mol Cell Immunol 4 (6), 317-325 (1990)
   PUBMED   2150484
REFERENCE   10 (bases 1 to 8623)
  AUTHORS   Gogstad,G.O., Hagen,I., Korsmo,R. and Solum,N.O.
  TITLE     Characterization of the proteins of isolated human platelet
            alpha-granules. Evidence for a separate alpha-granule-pool of the
            glycoproteins IIb and IIIa
  JOURNAL   Biochim Biophys Acta 670 (2), 150-162 (1981)
   PUBMED   6457647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB028950.2 and AL133410.32.
            
            On Nov 22, 2018 this sequence version replaced NM_006289.3.
            
            Summary: This gene encodes a cytoskeletal protein that is
            concentrated in areas of cell-substratum and cell-cell contacts.
            The encoded protein plays a significant role in the assembly of
            actin filaments and in spreading and migration of various cell
            types, including fibroblasts and osteoclasts. It codistributes with
            integrins in the cell surface membrane in order to assist in the
            attachment of adherent cells to extracellular matrices and of
            lymphocytes to other cells. The N-terminus of this protein contains
            elements for localization to cell-extracellular matrix junctions.
            The C-terminus contains binding sites for proteins such as
            beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028950.2, BC042923.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314888.10/ ENSP00000316029.9
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8097              AB028950.2         176-8272
            8098-8623           AL133410.32        16829-17354         c
FEATURES             Location/Qualifiers
     source          1..8623
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..8623
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /note="talin 1"
                     /db_xref="GeneID:7094"
                     /db_xref="HGNC:HGNC:11845"
                     /db_xref="MIM:186745"
     exon            1..121
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            122..284
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..7780
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /codon_start=1
                     /product="talin-1"
                     /protein_id="NP_006280.3"
                     /db_xref="CCDS:CCDS35009.1"
                     /db_xref="GeneID:7094"
                     /db_xref="HGNC:HGNC:11845"
                     /db_xref="MIM:186745"
                     /translation="MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPP
                     SDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMV
                     DDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEK
                     LKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQ
                     ARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGE
                     RKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITK
                     ECVMRVDEKTKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLI
                     AGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALP
                     AIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQA
                     AQATLDDFDTLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPA
                     ETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLR
                     SAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALMQLAKAVASAAAAL
                     VLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAG
                     RLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRY
                     DQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKL
                     LSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLV
                     QRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQIPLLVQGVRG
                     SQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTA
                     LAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGETMEKCT
                     QDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPA
                     VQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLP
                     GQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRG
                     TPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAK
                     ALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLE
                     NPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGF
                     TEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSA
                     ATIVAKHTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTE
                     ENRAQCRAATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESA
                     GGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAAL
                     NSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQ
                     LGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGG
                     NPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGP
                     MGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEA
                     KPAAVAAENEEIGSHIKHRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVS
                     EKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHR
                     EGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDP
                     ETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTV
                     KAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAV
                     AAGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYL
                     ELLDHVLLTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAE
                     NELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAAS
                     AAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQE
                     KLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAF
                     EEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELR
                     DEH"
     exon            285..382
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            383..512
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            513..665
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            666..808
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            809..936
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            937..997
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1102
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1258
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1360
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1437
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1618
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1732
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1841
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2050
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2149
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2317
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2612
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2779
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2908
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3025
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3139
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3274
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            3275..3403
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3506
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3715
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3835
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            3836..4033
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            4034..4173
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            4174..4267
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            4268..4357
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            4358..4480
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            4481..4624
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            4625..4786
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            4787..4927
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            4928..5109
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            5110..5242
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            5243..5344
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            5345..5515
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            5516..5665
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            5666..5767
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            5768..5887
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            5888..6034
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            6035..6201
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            6202..6385
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            6386..6511
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            6512..6628
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            6629..6814
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            6815..6922
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            6923..7028
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            7029..7153
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            7154..7279
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            7280..7342
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            7343..7525
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            7526..7654
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            7655..8623
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8212..8217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /note="hexamer: AATAAA"
     polyA_site      8234
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
                     /note="major polyA site"
     polyA_site      8313
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
     polyA_site      8623
                     /gene="TLN1"
                     /gene_synonym="ILWEQ; talin-1; TLN"
ORIGIN      
        1 gttcccagga cggaagtggc cgagagagtg tcgaagggag ggcgaggccg gagcccgagg
       61 gcgacccgag aagcggcggg gcggcgggcc ggcgggcggg gcgcagagcc aggcagcgca
      121 ggtatagcca ggctggagaa aagaagctgc caccatggtt gcactttcac tgaagatcag
      181 cattgggaat gtggtgaaga cgatgcagtt tgagccgtct accatggtgt acgacgcctg
      241 ccgcatcatt cgtgagcgga tcccagaggc cccagctggt cctcccagcg actttgggct
      301 ctttctgtca gatgatgacc ccaaaaaggg tatatggctg gaggctggga aagctttgga
      361 ctactacatg ctccgaaatg gggacactat ggagtacagg aagaaacaga gacccctgaa
      421 gatccgtatg ctggatggaa ctgtgaagac gatcatggtg gatgactcta agactgtcac
      481 tgacatgctc atgaccatct gtgcccgcat tggcatcacc aatcatgatg aatattcatt
      541 ggttcgagag ctgatggaag agaaaaagga ggaaataaca gggaccttaa gaaaggacaa
      601 gacattgctg cgagatgaaa agaagatgga gaaactaaag cagaaattgc acacagatga
      661 tgagttgaac tggctggacc atggtcggac actgagggag cagggtgtag aggagcacga
      721 gacgctgctg ctgcggagga agttctttta ctcagaccag aatgtggatt cccgggaccc
      781 tgtacagctg aacctcctgt atgtgcaggc acgagatgac atcctgaatg gctcccaccc
      841 tgtctccttt gacaaggcct gtgagtttgc tggcttccaa tgccagatcc agtttgggcc
      901 ccacaatgag cagaagcaca aggctggctt ccttgacctg aaggacttcc tgcccaagga
      961 gtatgtgaag cagaagggag agcgtaagat cttccaggca cacaagaatt gtgggcagat
     1021 gagtgagatt gaggccaagg tccgctacgt gaagctagcc cgttctctca agacttacgg
     1081 tgtctccttc ttcctggtga aggaaaaaat gaaagggaag aacaagctag tgcccaggct
     1141 tctgggcatc accaaggagt gtgtgatgcg agtggatgag aagaccaagg aagtgatcca
     1201 ggagtggaac ctcaccaaca tcaaacgctg ggctgcgtct cccaaaagct tcaccctgga
     1261 ttttggagat taccaagatg gctattactc agtacagaca actgaagggg agcagattgc
     1321 acagctcatt gccggctaca tcgatatcat cctgaagaag aaaaaaagca aggatcactt
     1381 tgggctggaa ggagatgagg agtctactat gctggaggac tcagtgtccc ccaaaaagtc
     1441 aacagtcctg cagcagcaat acaaccgggt ggggaaagtg gagcatggct ctgtggccct
     1501 gcctgccatc atgcgctctg gagcctctgg tcctgagaat ttccaggtgg gcagcatgcc
     1561 ccctgcccag cagcagatta ccagcggcca gatgcaccga ggacacatgc ctcctctgac
     1621 ttcagcccag caggcactca ctggaaccat taactccagc atgcaggccg tgcaggctgc
     1681 ccaggccacc ctggatgact ttgacactct gccgcctctt ggccaggatg ctgcctctaa
     1741 ggcctggcgt aaaaacaaga tggatgaatc aaagcatgag atccactctc aggtagatgc
     1801 catcacagct ggtactgcgt ctgtggtgaa cctgacagca ggggaccctg ctgagacaga
     1861 ctataccgca gtgggctgtg cagtcaccac aatctcctcc aacctgacgg agatgtcccg
     1921 tggggtgaag ctgctggctg ccttgctgga ggacgaaggc ggcagtggtc ggcccctgtt
     1981 gcaggcagca aagggccttg cgggagcagt gtcagaactg ctgcgcagtg cccaaccagc
     2041 cagtgctgag ccccgtcaga acctgctgca agcagctggg aacgtgggcc aggccagtgg
     2101 ggagctgttg caacaaattg gggaaagtga tactgacccc cacttccagg atgcgctaat
     2161 gcagctcgcc aaagctgtgg caagtgctgc agctgccctg gtcctcaagg ccaagagtgt
     2221 ggcccagcgg acagaggact cgggacttca gacccaagtt attgctgcag caacacagtg
     2281 tgccctatcc acttcccaac tagtggcctg tactaaggtg gtggcaccta caatcagctc
     2341 acctgtctgc caagagcaac tggtggaggc tggacgactg gtagccaaag ccgtggaggg
     2401 ctgtgtgtct gcctcccagg cagctacaga ggatgggcaa ctgttgcgag gggtaggagc
     2461 agcagccaca gctgtcaccc aggccctaaa tgagctgctg cagcatgtga aagcccatgc
     2521 cacaggggct gggcctgctg gccgttatga ccaggctact gacaccatcc taaccgtcac
     2581 tgagaacatc tttagctcca tgggtgatgc tggggagatg gtgcgacagg cccgcatcct
     2641 ggcccaagcc acatctgacc tggtcaatgc catcaaggct gatgctgagg gggaaagtga
     2701 tctggagaac tcccgcaagc tcttaagtgc tgccaagatc ctagctgatg ccacagccaa
     2761 gatggtagag gctgccaagg gagcagctgc ccaccctgac agtgaggagc agcagcagcg
     2821 gctgcgggag gcagctgagg ggctgcgcat ggccaccaat gcagctgcgc agaatgccat
     2881 caagaaaaag ctggtgcagc gcctggagca tgcagccaag caggctgcag cctcagccac
     2941 acagaccatc gctgcagctc agcacgcagc ctctaccccc aaggcctctg ccggccccca
     3001 gcccctgctg gtgcagagct gcaaggcagt ggcagagcag attccactgc tggtgcaggg
     3061 cgtccgagga agccaagccc agcctgacag ccccagcgct cagcttgccc tcattgctgc
     3121 cagccagagc ttcctgcagc caggtgggaa gatggtggca gctgcaaagg cctcagtgcc
     3181 aacgattcag gaccaggctt cagccatgca gctgagtcag tgtgccaaga acctgggcac
     3241 cgcgctggct gaactccgga cggctgccca gaaggctcag gaagcatgtg gacctttgga
     3301 gatggattct gcactgagtg tggtacagaa tctagagaaa gatctacagg aagtgaaggc
     3361 agcagctcga gatggcaagc ttaaaccctt acctggggag acaatggaga agtgtaccca
     3421 ggacctgggc aacagcacca aagccgtgag ctcagccatc gcccagctac tgggagaggt
     3481 tgcccagggc aatgagaatt atgcaggtat tgcagctcgg gatgtggcag gtgggctgcg
     3541 gtcactggcc caggccgcta ggggagtcgc tgcactgacg tcagatcctg cagtgcaggc
     3601 cattgtactt gatacggcca gtgatgtgct ggacaaggcc agcagcctca ttgaggaggc
     3661 gaaaaaggca gctggccatc caggggaccc tgagagccag cagcggcttg cccaggtggc
     3721 taaagcagtg acccaggctc tgaaccgctg tgtcagctgc ctacctggcc agcgcgatgt
     3781 ggataatgcc ctgagggcag ttggagatgc cagcaagcga ctcctgagtg actcgcttcc
     3841 tcctagcact gggacatttc aagaagctca gagccggttg aatgaagctg ctgctgggct
     3901 gaatcaggca gccacagaac tggtgcaggc ctctcgggga acccctcagg acctggctcg
     3961 agcctcaggc cgatttggac aggacttcag caccttcctg gaagctggtg tggagatggc
     4021 aggccaggct ccgagccagg aggaccgagc ccaagttgtg tccaacttga agggcatctc
     4081 catgtcttca agcaaacttc ttctggctgc caaggccctg tccacggacc ctgctgcccc
     4141 taacctcaag agtcagctgg ctgcagctgc cagggcagta actgacagca tcaatcagct
     4201 catcactatg tgcacccagc aggcacccgg ccagaaggag tgtgataacg ccctgcggga
     4261 attggagacg gtccgggaac tcctggagaa cccagtccag cccatcaatg acatgtccta
     4321 ctttggttgc ctggacagtg taatggagaa ctcaaaggtg ctgggcgagg ccatgactgg
     4381 catctcccaa aatgccaaga acggaaacct gccagagttt ggagatgcca tttccacagc
     4441 ctcaaaggca ctttgtggct tcaccgaggc agctgcacag gctgcatatc tggttggtgt
     4501 ctctgacccc aatagccaag ctggacagca agggctagtg gagcccacac agtttgcccg
     4561 tgcaaaccag gcaattcaga tggcctgcca gagtttggga gagcctggct gtacccaggc
     4621 ccaggtgctc tctgcagcca ccattgtggc taaacacacc tctgcactgt gtaacagctg
     4681 tcgcctggct tctgcccgta ccaccaatcc tactgccaag cgccagtttg tacagtcagc
     4741 caaggaggtg gccaacagca cagctaatct tgtcaagacc atcaaggcgc tagatggggc
     4801 cttcacagag gagaaccgtg cccagtgccg agcagcaaca gcccctctgc tggaggctgt
     4861 ggacaatctg agtgcctttg cgtccaaccc tgagttctcc agcattcctg cccagatcag
     4921 ccctgagggt cgggctgcca tggagcccat tgtgatctct gccaagacaa tgttagagag
     4981 tgccggggga ctcatccaga cagcccgggc cctcgcagtc aatccccggg accccccgag
     5041 ctggtcggtg ctggccggcc actcccgtac tgtctcagac tccatcaaga agctaattac
     5101 aagcatgagg gacaaggctc cagggcagct ggagtgtgaa acggccattg cagctctgaa
     5161 cagttgtcta cgggacctag accaggcttc cctcgctgca gtcagccagc agcttgctcc
     5221 ccgtgaggga atctctcaag aggccttgca cactcagatg ctcactgcag tccaagagat
     5281 ctcccatctc attgagccgc tggccaatgc tgcccgggct gaagcctccc agctgggaca
     5341 caaggtgtcc cagatggcgc agtactttga gccgctcacc ctggctgcag tgggtgctgc
     5401 ctccaagacc ctgagccacc cgcagcagat ggcactcctg gaccagacta aaacattggc
     5461 agagtctgcc ctgcagttgc tatacactgc caaggaggct ggtggtaacc caaagcaagc
     5521 agctcacacc caggaagccc tggaggaggc tgtgcagatg atgaccgagg ccgtagagga
     5581 cctgacaaca accctcaacg aggcagccag tgctgctggg gtcgtgggtg gcatggtgga
     5641 ctccatcacc caggccatca accagctaga tgaaggacca atgggtgaac cagaaggttc
     5701 cttcgtggat taccaaacaa ctatggtgcg gacagccaag gccattgcag tgaccgttca
     5761 ggagatggtt accaagtcaa acaccagccc agaggagctg ggccctcttg ctaaccagct
     5821 gaccagtgac tatggccgtc tggcctcgga ggccaagcct gcagcggtgg ctgctgaaaa
     5881 tgaagagata ggttcccata tcaaacaccg ggtacaggag ctgggccatg gctgtgccgc
     5941 tctggtcacc aaggcaggcg ccctgcagtg cagccccagt gatgcctaca ccaagaagga
     6001 gctcatagag tgtgcccgga gagtctctga gaaggtctcc cacgtcctgg ctgcgctcca
     6061 ggctgggaat cgtggcaccc aggcctgcat cacagcagcc agcgctgtgt ctggtatcat
     6121 tgctgacctc gacaccacca tcatgttcgc cactgctggc acgctcaatc gtgagggtac
     6181 tgaaactttc gctgaccacc gggagggcat cctgaagact gcgaaggtgc tggtggagga
     6241 caccaaggtc ctggtgcaaa acgcagctgg gagccaggag aagttggcgc aggctgccca
     6301 gtcctccgtg gcgaccatca cccgcctcgc tgatgtggtc aagctgggtg cagccagcct
     6361 gggagctgag gaccctgaga cccaggtggt actaatcaac gcagtgaaag atgtagccaa
     6421 agccctggga gacctcatca gtgcaacgaa ggctgcagct ggcaaagttg gagatgaccc
     6481 tgctgtgtgg cagctaaaga actctgccaa ggtgatggtg accaatgtga catcattgct
     6541 taagacagta aaagccgtgg aagatgaggc caccaaaggc actcgggccc tggaggcaac
     6601 cacagaacac atacggcagg agctggcggt tttctgttcc ccagagccac ctgccaagac
     6661 ctctacccca gaagacttca tccgaatgac caagggtatc accatggcaa ccgccaaggc
     6721 cgttgctgct ggcaattcct gtcgccagga agatgtcatt gccacagcca atctgagccg
     6781 ccgtgctatt gcagatatgc ttcgggcttg caaggaagca gcttaccacc cagaagtggc
     6841 ccctgatgtg cggcttcgag ccctgcacta tggccgggag tgtgccaatg gctacctgga
     6901 actgctggac catgtactgc tgaccctgca gaagccaagc ccagaactga agcagcagtt
     6961 gacaggacat tcaaagcgtg tggctggttc cgtcactgag ctcatccagg ctgctgaagc
     7021 catgaaggga acagaatggg tagacccaga ggaccccaca gtcattgctg agaatgagct
     7081 cctgggagct gcagccgcca ttgaggctgc agccaaaaag ctagagcagc tgaagccccg
     7141 ggccaaaccc aaggaggcag atgagtcctt gaactttgag gagcagatac tagaagctgc
     7201 caagtccatt gcagcagcca ccagtgcact ggtaaaggct gcgtcggctg cccagagaga
     7261 actagtggcc caagggaagg tgggtgccat tccagccaat gcactggacg atgggcagtg
     7321 gtcccagggc ctcatttctg ctgcccggat ggtggctgcg gccaccaaca atctgtgtga
     7381 ggcagccaat gcagctgtac aaggccatgc cagccaggag aagctcatct catcagccaa
     7441 gcaggtagct gcctccacag cccagctcct tgtggcctgc aaggtcaagg ctgaccagga
     7501 ctcggaggca atgaaacgac ttcaggctgc tggcaacgca gtgaagcgag cctcagataa
     7561 tctggtgaaa gcagcacaga aggctgcagc ctttgaagag caggagaatg agacagtggt
     7621 ggtgaaagag aagatggttg gcggcattgc ccagatcatc gcagcacagg aagaaatgct
     7681 tcggaaggaa cgagagctgg aagaggcgcg gaagaaactg gcccagatcc ggcagcagca
     7741 gtacaagttt ctgccttcag agcttcgaga tgagcactaa agaagcctct tctatttaat
     7801 gcagacccgg cccagagact gtgcgtgcca ctaccaaagc cttctgggct gtcggggccc
     7861 aacctgccca accccagcac tccccaaagt gcctgccaaa ccccagggcc tggccccgcc
     7921 cagtcccgca gtacatcccc tgtcccctcc ccaaccccaa gtgccttcat gccctagggc
     7981 cccccaagtg cctgcccctc cccagagtat taacgctcca agagtattat taacgctgct
     8041 gtacctcgat ctgaatctgc cggggcccca gcccactcca ccctgccagc agcttccggc
     8101 cagtccccac agcctcatca gctctcttca ccgttttttg atactatctt cccccacccc
     8161 cagctaccca taggggctgc agagttataa gccccaaaca ggtcatgctc caataaaaat
     8221 gattctacct acaacctctg cctggcttca agggagatac aagttttctc ccagggcagt
     8281 aggagagaca gtggggttga attctgtcac ccagcttgat ccagcttgaa atgggagagg
     8341 ggaagactgg cagtctgcac ctgaggtccc ttcctccttg cacccggacc ctaaagttat
     8401 ccaatgggga agttgtgcct gagaagtcat actcctgtta tcctcacctc cctggccagc
     8461 acctaagcct cacaaagtgt cgttctgctg ctgctgggac agcagctacc acagttcctt
     8521 gtggctacca ggacattctg ttcttcatag ctactcaggg tatgtcaaca aatccagtcc
     8581 ttgaccaaat tcaaattttc aaaagaagct ttgctaaaaa taa
//
