LOCUS       NM_012465               6769 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens tolloid like 2 (TLL2), mRNA.
ACCESSION   NM_012465
VERSION     NM_012465.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6769)
  AUTHORS   Jiang,J., Huang,J., Gu,J., Cai,X., Zhao,H. and Lu,H.
  TITLE     Genomic analysis of a spinal muscular atrophy (SMA) discordant
            family identifies a novel mutation in TLL2, an activator of growth
            differentiation factor 8 (myostatin): a case report
  JOURNAL   BMC Med Genet 20 (1), 204 (2019)
   PUBMED   31888525
  REMARK    GeneRIF: genomic analysis identified compound heterozygous
            mutations at TLL2 on the male patient's genome, and compound
            heterozygous mutations at VPS13A and the de novo mutation at AGAP5
            on female patient's genome
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6769)
  AUTHORS   Xu,Y., Wang,Y., Liu,H., Shi,Q., Zhu,D., Amos,C.I., Fang,S.,
            Lee,J.E., Hyslop,T., Li,X., Han,J. and Wei,Q.
  TITLE     Genetic variants in the metzincin metallopeptidase family genes
            predict melanoma survival
  JOURNAL   Mol Carcinog 57 (1), 22-31 (2018)
   PUBMED   28796414
  REMARK    GeneRIF: Findings suggest that these MMP16 rs10090371, ADAMTS3
            rs788935, TLL2 rs10882807 and MMP9 rs3918251 may be promising
            prognostic biomarkers for cutaneous melanoma specific survival
            (CMSS).
REFERENCE   3  (bases 1 to 6769)
  AUTHORS   de Mooij-van Malsen,J.G., van Lith,H.A., Laarakker,M.C.,
            Brandys,M.K., Oppelaar,H., Collier,D.A., Olivier,B., Breen,G. and
            Kas,M.J.
  TITLE     Cross-species genetics converge to TLL2 for mouse avoidance
            behavior and human bipolar disorder
  JOURNAL   Genes Brain Behav 12 (6), 653-657 (2013)
   PUBMED   23777486
  REMARK    GeneRIF: By means of a cross-species comparative genetic strategy
            we describe an association for TLL2 with bipolar disorder.
REFERENCE   4  (bases 1 to 6769)
  AUTHORS   Mac Sweeney,A., Gil-Parrado,S., Vinzenz,D., Bernardi,A., Hein,A.,
            Bodendorf,U., Erbel,P., Logel,C. and Gerhartz,B.
  TITLE     Structural basis for the substrate specificity of bone
            morphogenetic protein 1/tolloid-like metalloproteases
  JOURNAL   J Mol Biol 384 (1), 228-239 (2008)
   PUBMED   18824173
  REMARK    GeneRIF: The crystal structures of the protease domains of human
            BMP-1 and the closely related Tolloid-like protease 1 (TLL-1), are
            reported.
REFERENCE   5  (bases 1 to 6769)
  AUTHORS   Lesch,K.P., Timmesfeld,N., Renner,T.J., Halperin,R., Roser,C.,
            Nguyen,T.T., Craig,D.W., Romanos,J., Heine,M., Meyer,J.,
            Freitag,C., Warnke,A., Romanos,M., Schafer,H., Walitza,S., Reif,A.,
            Stephan,D.A. and Jacob,C.
  TITLE     Molecular genetics of adult ADHD: converging evidence from
            genome-wide association and extended pedigree linkage studies
  JOURNAL   J Neural Transm (Vienna) 115 (11), 1573-1585 (2008)
   PUBMED   18839057
REFERENCE   6  (bases 1 to 6769)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (bases 1 to 6769)
  AUTHORS   Uzel,M.I., Scott,I.C., Babakhanlou-Chase,H., Palamakumbura,A.H.,
            Pappano,W.N., Hong,H.H., Greenspan,D.S. and Trackman,P.C.
  TITLE     Multiple bone morphogenetic protein 1-related mammalian
            metalloproteinases process pro-lysyl oxidase at the correct
            physiological site and control lysyl oxidase activation in mouse
            embryo fibroblast cultures
  JOURNAL   J Biol Chem 276 (25), 22537-22543 (2001)
   PUBMED   11313359
REFERENCE   8  (bases 1 to 6769)
  AUTHORS   Reynolds,S.D., Zhang,D., Puzas,J.E., O'Keefe,R.J., Rosier,R.N. and
            Reynolds,P.R.
  TITLE     Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal
            tissues
  JOURNAL   Gene 248 (1-2), 233-243 (2000)
   PUBMED   10806368
REFERENCE   9  (bases 1 to 6769)
  AUTHORS   Scott,I.C., Blitz,I.L., Pappano,W.N., Imamura,Y., Clark,T.G.,
            Steiglitz,B.M., Thomas,C.L., Maas,S.A., Takahara,K., Cho,K.W. and
            Greenspan,D.S.
  TITLE     Mammalian BMP-1/Tolloid-related metalloproteinases, including novel
            family member mammalian Tolloid-like 2, have differential enzymatic
            activities and distributions of expression relevant to patterning
            and skeletogenesis
  JOURNAL   Dev Biol 213 (2), 283-300 (1999)
   PUBMED   10479448
REFERENCE   10 (bases 1 to 6769)
  AUTHORS   Scott,I.C., Clark,T.G., Takahara,K., Hoffman,G.G., Eddy,R.L.,
            Haley,L.L., Shows,T.B. and Greenspan,D.S.
  TITLE     Assignment of TLL1 and TLL2, which encode human
            BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33
            and 10q23-->q24 and assignment of murine Tll2 to chromosome 19
  JOURNAL   Cytogenet Cell Genet 86 (1), 64-65 (1999)
   PUBMED   10516436
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA716349.1, AB023149.2, BC112341.1, AL136181.13 and AW452288.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012465.3.
            
            Summary: This gene encodes an astacin-like zinc-dependent
            metalloprotease and is a subfamily member of the metzincin family.
            Unlike other family members, a similar protein in mice does not
            cleave procollagen C-propeptides or chordin. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023149.2, BC112341.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357947.4/ ENSP00000350630.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                DA716349.1         1-84
            85-117              AB023149.2         35-67
            118-3324            BC112341.1         1-3207
            3325-6740           AL136181.13        85031-88446         c
            6741-6769           AW452288.1         20-48               c
FEATURES             Location/Qualifiers
     source          1..6769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..6769
                     /gene="TLL2"
                     /note="tolloid like 2"
                     /db_xref="GeneID:7093"
                     /db_xref="HGNC:HGNC:11844"
                     /db_xref="MIM:606743"
     exon            1..416
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..3289
                     /gene="TLL2"
                     /note="tolloid-like protein 2"
                     /codon_start=1
                     /product="tolloid-like protein 2 precursor"
                     /protein_id="NP_036597.1"
                     /db_xref="CCDS:CCDS7449.1"
                     /db_xref="GeneID:7093"
                     /db_xref="HGNC:HGNC:11844"
                     /db_xref="MIM:606743"
                     /translation="MPRATALGALVSLLLLLPLPRGAGGLGERPDATADYSELDGEEG
                     TEQQLEHYHDPCKAAVFWGDIALDEDDLKLFHIDKARDWTKQTVGATGHSTGGLEEQA
                     SESSPDTTAMDTGTKEAGKDGRENTTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWP
                     GGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYV
                     GRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEY
                     NFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRL
                     SQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLN
                     FTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSN
                     ILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQA
                     FEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINK
                     AGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFI
                     TKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRS
                     GLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDN
                     GGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPS
                     RRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKP
                     DPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYP
                     SEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGP
                     LEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQDALHMKK"
     exon            417..527
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            528..605
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            606..761
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..879
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1058
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1164
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1289
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1405
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1508
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1625
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1771
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1967
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2093
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2254
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2435
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2561
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2689
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2903
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3154
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..6769
                     /gene="TLL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6751..6756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLL2"
                     /note="hexamer: ATTAAA"
     polyA_site      6769
                     /gene="TLL2"
                     /note="major polyA site"
ORIGIN      
        1 acactcgcag ccgccgcagc ctcggccgcc gggcaagtag ctccgagcgg ctgcttcccg
       61 gttgcctcga cgaagacagg gggcgccgcg ctccgcttgc tccgcgcctg agccatgccc
      121 agcagccctg tgtaaccacc gagtcccggc cggagccgac cgacccagtg tgcgccgtct
      181 ttcggccgag ctgagctttc gtgcacgcaa ctccctctgc cccagccggc cccgcgccac
      241 catgccccgg gcgactgcac ttggggccct ggtgtcactg ctgctgctgc tgccgctgcc
      301 tcgcggcgcc gggggactcg gggagcgccc ggacgccacc gcagactact cagagctgga
      361 cggcgaggag ggcacggagc agcagctgga gcattaccac gacccttgca aagccgctgt
      421 cttttgggga gacattgcct tagatgaaga tgacttgaag ctgtttcaca ttgacaaagc
      481 cagagactgg accaagcaga cagtgggggc aacaggacac agcacaggtg ggcttgaaga
      541 gcaggcatct gagagcagcc cagacaccac agccatggac actggcacca aggaagctgg
      601 aaaggatggc cgggagaata ccacactcct gcacagccct gggaccttgc atgccgcagc
      661 caagaccttc tctccccggg tccgaagagc cacaacctca aggacagaga ggatatggcc
      721 tggaggagtc atcccctacg tcattggagg gaacttcact gggagccaga gggccatttt
      781 taagcaggcc atgagacact gggagaagca cacctgtgtg accttcatag aaaggacgga
      841 tgaggaaagc tttattgtat tcagttacag aacctgtggc tgttgctcct atgttgggcg
      901 ccgaggagga ggcccacagg ccatatccat tgggaagaac tgtgacaagt ttggcattgt
      961 ggctcacgag ctgggccatg tggttgggtt ttggcatgaa cacacccggc cagacagaga
     1021 ccaacatgtc accatcatca gggaaaacat ccagccaggt caggagtata atttcttaaa
     1081 aatggaagct ggggaagtga gctctctggg agagacatac gactttgaca gcatcatgca
     1141 ctacgcccgg aacaccttct caagaggagt tttcttagac accatccttc cccgtcaaga
     1201 tgacaatggc gtcaggccaa ccattggcca gcgcgtgcgg ctcagtcagg gagacatagc
     1261 tcaagcccgg aagctgtaca aatgcccagc gtgtggggag accctgcagg acacaacggg
     1321 aaacttttct gcacctggtt tcccaaatgg gtacccatct tactcccact gcgtctggag
     1381 gatctcggtc accccagggg aaaagatcgt attaaacttc acatccatgg atttgtttaa
     1441 aagccgactg tgctggtatg attacgtgga ggtccgggat ggttactgga gaaaagcccc
     1501 ccttttgggc aggttttgtg gcgataagat cccggagccc ctcgtctcca cggacagccg
     1561 gctctgggtg gagttccgca gcagcagcaa catcttgggc aagggcttct ttgcagcgta
     1621 cgaagctacc tgcgggggag acatgaacaa agatgccggt cagattcaat ctcccaacta
     1681 tccggatgac tacagacctt ccaaggaatg tgtctggagg attacggttt cagaggggtt
     1741 tcacgtggga cttaccttcc aagcttttga gattgaaagg cacgacagct gtgcatatga
     1801 ctacctggaa gtccgggatg gccccacgga agagagtgcc ctgatcggcc acttttgtgg
     1861 ctatgagaag ccggaggatg tgaaatcgag ctccaacaga ctgtggatga agtttgtgtc
     1921 cgatggctct atcaataaag cgggctttgc agccaatttt ttcaaggagg tggatgagtg
     1981 ttcctggcca gatcacggcg ggtgcgagca tcgctgtgtg aacacgctgg gcagctacaa
     2041 gtgtgcctgt gaccctggct acgagctggc cgccgataag aagatgtgtg aagtggcctg
     2101 tggcggtttc attaccaagc tgaatggaac catcaccagc cctgggtggc cgaaggagta
     2161 tcccacaaac aaaaactgtg tctggcaggt ggtggccccc gctcagtacc ggatctccct
     2221 tcagtttgaa gtgtttgaac tggaaggcaa tgacgtctgt aagtacgact ttgtagaggt
     2281 gcgcagcggc ctgtcccccg acgccaagct gcacggcagg ttctgcggct ctgagacgcc
     2341 ggaggtcatc acctcgcaga gcaacaacat gcgcgtggag ttcaagtccg acaacaccgt
     2401 ctccaagcgc ggcttcaggg cccacttctt ctcagataag gacgagtgtg ccaaggacaa
     2461 cggcgggtgt cagcatgagt gcgtcaacac cttcgggagc tacctgtgca ggtgcagaaa
     2521 cggctactgg ctccacgaga atgggcatga ctgcaaagag gctggctgtg cacacaagat
     2581 cagcagtgtg gaggggaccc tggcgagccc caactggcct gacaaatacc ccagccggag
     2641 ggagtgtacc tggaacatct cttcgactgc aggccacaga gtgaaactca cctttaatga
     2701 gtttgagatc gagcagcacc aggaatgtgc ctatgaccac ctggaaatgt atgacgggcc
     2761 ggacagcctg gcccccattc tgggccgttt ctgcggcagc aagaaaccag accccacggt
     2821 ggcttccggc agcagtatgt ttctcaggtt ttattcggat gcctcagtgc agaggaaagg
     2881 cttccaggca gtgcacagca cagagtgcgg gggcaggctg aaggctgaag tgcagaccaa
     2941 agagctctat tcccacgccc agtttgggga caacaactac ccgagcgagg cccgctgtga
     3001 ctgggtgatc gtggcagagg acggctacgg cgtggagctg acattccgga cctttgaggt
     3061 tgaggaggag gccgactgcg gctacgacta catggaagcc tacgacggct acgacagctc
     3121 agcgcccagg ctcggccgct tctgtggctc tgggccatta gaagaaatct actctgcagg
     3181 tgattccctg atgattcgat tccgcacaga tgacaccatc aacaagaaag gctttcatgc
     3241 ccgatacacc agcaccaagt tccaggatgc cctgcacatg aagaaatagt gctgatgttc
     3301 ttgaaagaca gaaactgaga attttttttg ttttgttttg tttttaacaa caatagcacc
     3361 ttgaaaatct gccctaaaac agtgtacagt atttttctca aacaaaaact cagaatccag
     3421 ccttagaggt atatatttga atgaaagtct tgtaagtttg gccaacaagg tggagagaaa
     3481 aatgttcttt tgcttctgtc tgcaatgtta tcattcatga actgttaaag tgttaaagat
     3541 taggattgaa gtcactgacc attccggcta tgcttcttca taccattctc cttgtccctt
     3601 gctcctatgt ggcaaaaggt cagccttggg gttggccgtt cctctaatct ggacttgctt
     3661 gcaaaggtgc caggctgtct tctgtccatg ttgggcataa gggatgaaaa cttggccgag
     3721 actaatgtgt ggcccacagc tttggctgga atcattttct ttctctctgc cagggacatg
     3781 tcaaccaaga aacctgaaaa tatggatgga tgtcaggact aaaaaaaggc atcacagtga
     3841 gcagtgagca cagagggagt ttcgagtata agaatcattg tcatgaagtt aggagaccac
     3901 aaagccattt ctcagagtca ttcactctcc ttgtcccttt ggtttccccc cctccctaat
     3961 tgcagtgggg gctaaggcat ccattatgaa tacagcagaa catttgctgg cgagagtcct
     4021 gtctgctgag aagacaatat tgtggctcgt cctgatattt ttttcattca ttgactttga
     4081 gaagactcca cctgtgcttg gaattccatg ggcttcaaag aacatttctt cttttagctt
     4141 tggaggcact tgccgtggca cacctggact ccttgacatc caattcaaac tgcatttgca
     4201 aaatgtgcaa agacctctta tgagggacca attcaggtcc cttatggggt gaacactgtt
     4261 gaagactggt taattataag ttatgtaaga atcatcgcct tgtggaacaa gtcaatcagt
     4321 gactagcttc ctgtagccaa tcaggttaaa gagtgcgttg gtaactttgc tctgattaac
     4381 tagtattcaa tcaccaactt gcaaacagaa ttcataacac ttggcacttg ttctagagaa
     4441 gtgtagagga tgatgtttac ataattttag cacctcaagg tataatttaa acagtgaggt
     4501 agttttgaat ggcatttcat taaggcatct atgggcatta tgagctaaaa gctgtggtat
     4561 gttagcttta aaagagtatt tatgttggaa taatttttaa ataatgttta cataactgta
     4621 agtcctgttt ggttgttgtt ggacgcaggg cggcacatga gtgtttttgg ttagagccaa
     4681 gatagctccc atgcaccgga attcctttgg gatgaatcag catcatttta aacaaagtat
     4741 atgtaaaagg tgaaaggtta tattttttac agatcagaat gtggcaccag aggactgtgt
     4801 ctcattaaag tgattgctgg gagcaaaaac tagaatgata caaagaaagg tcagagaaat
     4861 gcatgggaat attttttcct taaaacagaa aaaaattaaa gtattattaa taatatatgt
     4921 ctgtatatat gtatgtatgt aaaagatcag ctgtcaaagc cttaatcaat gcagtgtgga
     4981 aaatgccaac ccctggtcct cgctttactg tgggccctgc aggactggct ctccatttcc
     5041 tgcctctcct ttcaccaagc tctgttttgg cctttctcgg ccctggactg aggctcagcc
     5101 tacacgctca tattgtgcat atggcagacc ctgcccagcg tgcgctttga tacagcaaat
     5161 ggagcagctg acctcatggc tccaatccca cctgcctgtt agggtagatt ccatttatct
     5221 gatttttgta ttttctgagg ttttatttgg tctcatcttg tctatgagag ttgaaactgg
     5281 aactgggaaa cctaagatgg gtgttatggt tctttctcca aggaaataaa aattctgcag
     5341 ttttaacctt tagaagtcta agcaagatta acaaatttca tagaaaagtg ggagggagtc
     5401 agaaacagag ttggtgctgc tcagcaggac ggtgaaacaa tgatacttct ttttatctct
     5461 ttagtatgaa cattttcaaa aacacacagc ttcaacaatt gtcaccatat ggccaatttg
     5521 caacaatggg actcttatga aaaaccttta tttaggcctt ctgtgtgacg tatccacaga
     5581 aaagagaagc tctgattcag ctggggctag ctgggccgct cctctggaag cccacacttg
     5641 tggggactta ggcatgacac aggttcttgc aaagaaacta gaggctggct tcactagaga
     5701 gagtccattc agcagaaagt cccaggcctc tgccttggtg cttccaatta tcagtgacct
     5761 gcctgcaagc atccccagaa gcaaacagca gaggtagaag atatcactgc agcctgcttt
     5821 gtgctttaat tgggtaccaa gctttgggga tgacagtgag ttgcaagaat agttttagtt
     5881 cagagaattg tcttaggaca acaggctaat gaaggatttg gggtctgggt ttttagcctg
     5941 gctccgttct ggtgtaaccc ggtctagcaa aagctaagcc tggattgcag ggcaggaaaa
     6001 aatctggaat taactttagc cagtggaatt tcttcaaaca gagaaagaga ggctgttcat
     6061 tgatccacta ttccctctat tttcctctaa ggtaaatatt tagaggtatt tacctgtaag
     6121 gtgaagtttc ctttttattt ctactttaca atttctctct aaagcaagct tgtccaaccc
     6181 ttggcccagg acggctttga atatggcccg acacaaattc gtaaactttt taaaaaacat
     6241 tgtaagattc tttctgtgat tttttttttt ctcgtcagct atcgttagtg tattttatgt
     6301 gtggcccaag ataattcttc ttccaatgtg gcccagggaa gccaaaagat gggacacccc
     6361 tgctgtaaag tttcatatca ctcatgaatt gctcagctga tttaaataat ttgtaaaatc
     6421 ctgctaacta gcaaattcac attgagattt tctattgatt gggtcccttt gatagctttc
     6481 agattggtat tgttagcgtt ccatttgtga acaaatgttc ccttggcttt agcagatgtt
     6541 tttaaagttt cttttgtaga ccgaacttct gaagagtaat accaaatgcc taaaatttta
     6601 tttttaaaaa ggaaaattgt ttaaagtatt atatgtaaac atatgggtat tttttatttt
     6661 gtgtaatttt acatttcatg aaatgatgtc agtttcaaag agaaagtgga gaggacctaa
     6721 catatgtctc tacctagaac ggatggtttc attaaagaat gtggattta
//
