LOCUS       NM_012464               7291 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens tolloid like 1 (TLL1), transcript variant 1, mRNA.
ACCESSION   NM_012464
VERSION     NM_012464.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7291)
  AUTHORS   Fu,S., Karim,D., Prieto,J., Balderramo,D., Ferrer,J.D.,
            Mattos,A.Z., Arrese,M., Carrera,E., Oliveira,J., Debes,J.D. and
            Boonstra,A.
  TITLE     Assessment of TLL1 variant and risk of hepatocellular carcinoma in
            Latin Americans and Europeans
  JOURNAL   Ann Hepatol 29 (2), 101181 (2024)
   PUBMED   37981236
  REMARK    GeneRIF: Assessment of TLL1 variant and risk of hepatocellular
            carcinoma in Latin Americans and Europeans.
REFERENCE   2  (bases 1 to 7291)
  AUTHORS   Liu,J., Zhang,S., Pei,H., Tu,F., Liu,B., Yan,J. and Lin,X.
  TITLE     Klebsiella pneumoniae activates the TGF-beta signaling pathway to
            adhere to and invade intestinal epithelial cells via enhancing TLL1
            expression
  JOURNAL   Int J Med Microbiol 312 (6), 151561 (2022)
   PUBMED   36087399
  REMARK    GeneRIF: Klebsiella pneumoniae activates the TGF-beta signaling
            pathway to adhere to and invade intestinal epithelial cells via
            enhancing TLL1 expression.
REFERENCE   3  (bases 1 to 7291)
  AUTHORS   Agwa,S.H.A., Kamel,M.M., Elghazaly,H., Abd Elsamee,A.M., Hafez,H.,
            Girgis,S.A., Ezz Elarab,H., Ebeid,F.S.E., Sayed,S.M., Sherif,L. and
            Matboli,M.
  TITLE     Association between Interferon-Lambda-3 rs12979860, TLL1 rs17047200
            and DDR1 rs4618569 Variant Polymorphisms with the Course and
            Outcome of SARS-CoV-2 Patients
  JOURNAL   Genes (Basel) 12 (6), 830 (2021)
   PUBMED   34071309
  REMARK    GeneRIF: Association between Interferon-Lambda-3 rs12979860, TLL1
            rs17047200 and DDR1 rs4618569 Variant Polymorphisms with the Course
            and Outcome of SARS-CoV-2 Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7291)
  AUTHORS   McCoy,J.C., Goebel,E.J. and Thompson,T.B.
  TITLE     Characterization of tolloid-mediated cleavage of the GDF8
            procomplex
  JOURNAL   Biochem J 478 (9), 1733-1747 (2021)
   PUBMED   33876824
  REMARK    GeneRIF: Characterization of tolloid-mediated cleavage of the GDF8
            procomplex.
REFERENCE   5  (bases 1 to 7291)
  AUTHORS   Mangoud,N.O.M., Ali,S.A., El Kassas,M. and Soror,S.H.
  TITLE     Chitinase 3-like-1, Tolloid-like protein 1, and intergenic gene
            polymorphisms are predictors for hepatocellular carcinoma
            development after hepatitis C virus eradication by direct-acting
            antivirals
  JOURNAL   IUBMB Life 73 (2), 474-482 (2021)
   PUBMED   33347699
  REMARK    GeneRIF: Chitinase 3-like-1, Tolloid-like protein 1, and intergenic
            gene polymorphisms are predictors for hepatocellular carcinoma
            development after hepatitis C virus eradication by direct-acting
            antivirals.
REFERENCE   6  (bases 1 to 7291)
  AUTHORS   Uzel,M.I., Scott,I.C., Babakhanlou-Chase,H., Palamakumbura,A.H.,
            Pappano,W.N., Hong,H.H., Greenspan,D.S. and Trackman,P.C.
  TITLE     Multiple bone morphogenetic protein 1-related mammalian
            metalloproteinases process pro-lysyl oxidase at the correct
            physiological site and control lysyl oxidase activation in mouse
            embryo fibroblast cultures
  JOURNAL   J Biol Chem 276 (25), 22537-22543 (2001)
   PUBMED   11313359
REFERENCE   7  (bases 1 to 7291)
  AUTHORS   Scott,I.C., Imamura,Y., Pappano,W.N., Troedel,J.M., Recklies,A.D.,
            Roughley,P.J. and Greenspan,D.S.
  TITLE     Bone morphogenetic protein-1 processes probiglycan
  JOURNAL   J Biol Chem 275 (39), 30504-30511 (2000)
   PUBMED   10896944
REFERENCE   8  (bases 1 to 7291)
  AUTHORS   Scott,I.C., Blitz,I.L., Pappano,W.N., Imamura,Y., Clark,T.G.,
            Steiglitz,B.M., Thomas,C.L., Maas,S.A., Takahara,K., Cho,K.W. and
            Greenspan,D.S.
  TITLE     Mammalian BMP-1/Tolloid-related metalloproteinases, including novel
            family member mammalian Tolloid-like 2, have differential enzymatic
            activities and distributions of expression relevant to patterning
            and skeletogenesis
  JOURNAL   Dev Biol 213 (2), 283-300 (1999)
   PUBMED   10479448
REFERENCE   9  (bases 1 to 7291)
  AUTHORS   Scott,I.C., Clark,T.G., Takahara,K., Hoffman,G.G., Eddy,R.L.,
            Haley,L.L., Shows,T.B. and Greenspan,D.S.
  TITLE     Assignment of TLL1 and TLL2, which encode human
            BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33
            and 10q23-->q24 and assignment of murine Tll2 to chromosome 19
  JOURNAL   Cytogenet Cell Genet 86 (1), 64-65 (1999)
   PUBMED   10516436
REFERENCE   10 (bases 1 to 7291)
  AUTHORS   Takahara,K., Brevard,R., Hoffman,G.G., Suzuki,N. and Greenspan,D.S.
  TITLE     Characterization of a novel gene product (mammalian tolloid-like)
            with high sequence similarity to mammalian tolloid/bone
            morphogenetic protein-1
  JOURNAL   Genomics 34 (2), 157-165 (1996)
   PUBMED   8661043
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097502.3, U91963.1,
            AC097507.2, AC093874.3, BC144085.1, AF282732.1, AK021908.1 and
            BU753788.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_012464.4.
            
            Summary: This gene encodes an astacin-like, zinc-dependent,
            metalloprotease that belongs to the peptidase M12A family. This
            protease processes procollagen C-propeptides, such as chordin,
            pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that
            this gene plays multiple roles in the development of mammalian
            heart, and is essential for the formation of the interventricular
            septum. Allelic variants of this gene are associated with atrial
            septal defect type 6. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.51262.1,
                                           SRR1803617.258053.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000061240.7/ ENSP00000061240.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC097502.3         124865-124885
            22-3091             U91963.1           1-3070
            3092-3092           AC097507.2         163386-163386
            3093-3211           U91963.1           3072-3190
            3212-3212           AC093874.3         11571-11571
            3213-3310           U91963.1           3192-3289
            3311-3311           AC093874.3         11670-11670
            3312-4860           BC144085.1         3270-4818
            4861-5530           AF282732.1         4444-5113
            5531-6160           AK021908.1         543-1172
            6161-7017           AC093874.3         23669-24525
            7018-7291           BU753788.1         15-288              c
FEATURES             Location/Qualifiers
     source          1..7291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3"
     gene            1..7291
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /note="tolloid like 1"
                     /db_xref="GeneID:7092"
                     /db_xref="HGNC:HGNC:11843"
                     /db_xref="MIM:606742"
     exon            1..837
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     CDS             669..3710
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /EC_number="3.4.24.-"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tolloid-like protein 1"
                     /codon_start=1
                     /product="tolloid-like protein 1 isoform 1 precursor"
                     /protein_id="NP_036596.3"
                     /db_xref="CCDS:CCDS3811.1"
                     /db_xref="GeneID:7092"
                     /db_xref="HGNC:HGNC:11843"
                     /db_xref="MIM:606742"
                     /translation="MGLGTLSPRMLVWLVASGIVFYGELWVCAGLDYDYTFDGNEEDK
                     TETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTTGGLGDHAMS
                     KKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGG
                     VIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGR
                     RGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNF
                     LKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSK
                     GDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFT
                     TMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWV
                     GKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFE
                     IERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAG
                     FAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTK
                     LNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGL
                     SSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGG
                     CQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRK
                     ECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDP
                     LVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQ
                     VDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPE
                     EIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK"
     exon            838..948
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1029
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1182
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1300
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1479
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1585
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1710
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1826
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1929
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2046
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2192
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2388
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2514
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2675
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2856
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2982
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3110
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3324
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3575
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..7291
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5597..5602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /note="hexamer: AATACA"
     polyA_site      5615
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
     regulatory      6709..6714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /note="hexamer: ATTAAA"
     polyA_site      6731
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /note="major polyA site"
     regulatory      7269..7274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
                     /note="hexamer: AATATA"
     polyA_site      7291
                     /gene="TLL1"
                     /gene_synonym="ASD6; TLL"
ORIGIN      
        1 caaacagtgc atccccaaat cctcacactt ttgctctctt gcagtcagtt gctttgctgg
       61 cttctgcagg cttttaaggt ctcgcggcgt agaaatgcct ggcccccacc cccttcctcg
      121 gtctcccctt tcaattcaga tgtgctgatg tgcagaccgg attcatcttc tcggagctgc
      181 ggcggcggct ttgggctcag gcggcggcgg ctcgcgctcg gccgcggagt cctggcagca
      241 gcggggacgc ggcgcgggag tccgagctct ggtggcagct gagcccgcgg ggcgccgctc
      301 gccgagccgc ggccgcggga agttcggcag ccagaaggac gacctggcag gctgcgagcg
      361 ccagcgccgc cagagccgag tttgcctgcg ccctccccgc ctccgagtgc agagttcctt
      421 acctgccctc cgcccacccg tgggccccta gccaacttct ccctgcgact gggggtaaca
      481 ggcagtgctt gccctctcta ctgtcccggc ggcatccaca tgtttccgga cacctgagca
      541 ccccggtccc gccgaggagc ctccgggtgg ggagaagagc accggtgccc ctagccccgc
      601 acatcagcgc ggaccgcggc tgcctaacct ctgggtcccg tcccctcctt ttcctccggg
      661 ggaggaggat ggggttggga acgctttccc cgaggatgct cgtgtggctg gtggcctcgg
      721 ggattgtttt ctacggggag ctatgggtct gcgctggcct cgattatgat tacacttttg
      781 atgggaacga agaggataaa acagagacta tagattacaa ggacccgtgt aaagccgctg
      841 tattttgggg cgatattgcc ttagatgatg aagacttaaa tatctttcaa atagatagga
      901 caattgacct tacgcagaac ccctttggaa accttggaca taccacaggt ggacttggag
      961 accatgctat gtcaaagaag cgaggggccc tctaccaact tatagacagg ataagaagaa
     1021 ttggctttgg cttggagcaa aacaacacag ttaagggaaa agtacctcta caattctcag
     1081 ggcaaaatga gaaaaatcga gttcccagag ccgctacatc aagaacggaa agaatatggc
     1141 ctggaggcgt tattccttat gttataggag gaaacttcac tggcagccag agagccatgt
     1201 tcaagcaggc catgaggcac tgggaaaagc acacatgtgt gactttcata gaaagaagtg
     1261 atgaagagag ttacattgta ttcacctata ggccttgtgg atgctgctcc tatgtaggtc
     1321 ggcgaggaaa tggacctcag gcaatctcta tcggcaagaa ctgtgataaa tttgggattg
     1381 ttgttcatga attgggtcat gtgataggct tttggcatga acacacaaga ccagatcgag
     1441 ataaccacgt aactatcata agagaaaaca tccagccagg tcaagagtac aattttctga
     1501 agatggagcc tggagaagta aactcacttg gagaaagata tgatttcgac agtatcatgc
     1561 actatgccag gaacaccttc tcaaggggga tgtttctgga taccattctc ccctcccgtg
     1621 atgataatgg catacgtcct gcaattggtc agcgaacccg tctaagcaaa ggagatatcg
     1681 cacaggcaag aaagctgtat agatgtccag catgtggaga aactctacaa gaatccaatg
     1741 gcaacctttc ctctccagga tttcccaatg gctacccttc ttacacacac tgcatctgga
     1801 gagtttctgt gaccccaggg gagaagattg ttttaaattt tacaacgatg gatctataca
     1861 agagtagttt gtgctggtat gactatattg aagtaagaga cgggtactgg agaaaatcac
     1921 ctctccttgg tagattctgt ggggacaaat tgcctgaagt tcttacttct acagacagca
     1981 gaatgtggat tgagtttcgt agcagcagta attgggtagg aaaaggcttt gcagctgtct
     2041 atgaagcgat ctgtggaggt gagatacgta aaaatgaagg acagattcag tctcccaatt
     2101 atcctgatga ctatcgcccg atgaaagaat gtgtgtggaa aataacagtg tctgagagct
     2161 accacgtcgg gctgaccttt cagtcctttg agattgaaag acatgacaat tgtgcttatg
     2221 actacctgga agttagagat ggaaccagtg aaaatagccc tttgataggg cgtttctgtg
     2281 gttatgacaa acctgaagac ataagatcta cctccaatac tttgtggatg aagtttgttt
     2341 ctgacggaac tgtgaacaaa gcagggtttg ctgctaactt ttttaaagag gaagatgagt
     2401 gtgccaaacc tgaccgtgga ggctgtgagc agcgatgtct gaacactctg ggcagttacc
     2461 agtgtgcctg tgagcctggc tatgagctgg gcccagacag aaggagctgt gaagctgctt
     2521 gtggtggact tcttaccaaa cttaacggca ccataaccac ccctggctgg cccaaggagt
     2581 accctcctaa taagaactgt gtgtggcaag tggttgcacc aacccagtac agaatttctg
     2641 tgaagtttga gttttttgaa ttggaaggca atgaagtttg caaatatgat tatgtggaga
     2701 tctggagtgg tctttcctct gagtctaaac tgcatggcaa attctgtggc gctgaagtgc
     2761 ctgaagtgat cacatcccag ttcaacaata tgagaattga attcaaatct gacaatactg
     2821 tatccaagaa gggcttcaaa gcacattttt tctcagacaa agatgaatgc tctaaggata
     2881 atggtggatg tcagcacgaa tgtgtcaaca cgatggggag ctacatgtgt caatgccgta
     2941 atggatttgt gctacatgac aataaacatg attgcaagga agctgagtgt gaacagaaga
     3001 tccacagtcc aagtggcctc atcaccagtc ccaactggcc agacaagtac ccaagcagga
     3061 aagaatgcac ttgggaaatc agcgccactc ctggccaccg aatcaaatta gcctttagtg
     3121 aatttgagat tgagcagcat caagaatgtg cttatgacca cttagaagta tttgatggag
     3181 aaacagaaaa gtcaccgatt cttggacgac tgtgtggcaa caagatacca gatccccttg
     3241 tggctactgg aaataaaatg tttgttcggt ttgtttctga tgcatctgtt caaagaaaag
     3301 gctttcaagc tacacattct acagagtgtg gcggacgatt gaaagcagaa tcaaaaccaa
     3361 gagatctgta ctcacatgct cagtttggtg ataacaacta cccaggacag gttgactgtg
     3421 aatggctatt agtatcagaa cggggctctc gacttgaatt atccttccag acatttgaag
     3481 tggaggaaga agcagactgt ggctatgact atgtggagct ctttgatggt cttgattcaa
     3541 cagctgtggg gcttggtcga ttctgtggat ccgggccacc agaagagatt tattcaattg
     3601 gagattcagt tttaattcat ttccacactg atgacacaat caacaagaag ggatttcata
     3661 taagatacaa aagcataaga tatccagata ccacacatac caaaaaataa caccaaaacc
     3721 tctgtcagaa cacaaaggaa tgtgcataat ggagagaaga catatttttt ttaaaactga
     3781 agatattggc acaaatgttt tatacaaaga gtttgaacaa aaaatccctg taagaccaga
     3841 attatctttg tactaaaaga gaagtttcca gcaaaaccct catcagcatt acaaggatat
     3901 ttgaactcca tgcttgatgg tattaataaa gctggtgaaa gggcatcata tacttcaagg
     3961 aagactctac aagcttttgt tcacagcttg aaatagatgc ctcacaattc agacagttta
     4021 attcaggaac tgtgaccctg cagtgttctt tttgacaatt tgtcaagatt tagggacata
     4081 aaatgatctt gcaggtcgta aactggaaaa cagtattttg gttgtcttag gataattgct
     4141 gactttgtat cttggataca gtgtaaacca gatccatata aggtgaatgt gaaatgggag
     4201 tcttctgagg gtgatttgta ctttccatgt gtatgtgtgt gtctggtgtt tggaaactgg
     4261 gatatttcag cttcattatt tccacttgca ggccagctta acctctgaaa cacaaatgat
     4321 cttgagacca ctttagtgta cttacattta gatgagtttg aaatctcaat ggtgtctaat
     4381 tattgcagtt aaattctaga catcagttct ttaagtctca gaaaacgccc agtgaattgg
     4441 taaacttagt tctttttttt ggaagtgctg ccttttcaca ccaaatccaa gaagcctgtg
     4501 atgtcttatg aaccttatga gaaaactccg aagaggtgtg agcaggattc ttctgaatga
     4561 ctgtctggat ggttcattac tcaagttact gctgctgcta ttgtctttcc tttgttgtcg
     4621 atctgttatt gttgtattat tattgttgat gttgtcatgg ttaatctatt ttttaaaatt
     4681 gaaatgaagc agaagtaggc cttgtgagaa ctgaaaggtc tctttcattt ttctcttcct
     4741 gggattcatt ttttcaaaac acaatgctgg aaaaaaaaga tttgtttctg aaagacttct
     4801 tatggtgcta ttccataaac tttttttcaa acaagttttt gacctttgag ccaacccacc
     4861 cgtagactac gaatgtctcc ctatggctgg tagcatttga agactaaaga cttgtcaaat
     4921 atatcaagag tatatcattg caagggcagc acttgtcctg tggaacaact acttataatg
     4981 ccttagaatt cctgcacatg atcaaacaga tcctcctaaa acacaccttt tgaaatgttg
     5041 aacataatag tgtatgttaa ttaacagctc tatgaagaaa atccatttcc atgactgaag
     5101 cattggatat aaatatggtg tcctgctttt tttgtagaaa atgtaatttg aggatgaatt
     5161 ttctgcttta aaggcatgtg tgtttttaaa attaatgaat gtagatgtgt gattgtctga
     5221 gtgagtgaaa ctacaagagg taaaaaataa tgggtggttg aaaagttaaa atgtatgtgc
     5281 caagttctac tagaattcca tttgaaatag caccttcctt aggtttcatg gacaaataat
     5341 gggaacttct aattttgatc aatcccatta aaaaaaggct ctttccttta gagaaactct
     5401 attttgatgt caatatagat tactgtatga agtagctttg tgtctgttac ctgtccatga
     5461 gcatacaaca ttgaatacaa ttgggtgtat tctttcagtt ttacacaatt aaagtataca
     5521 cacagatgta gcttatctgt ttttttctta aattgttgcc ctgaaaaaat ttcttgcata
     5581 tgaattgtaa aatgtaaata catttttata accaatgttt tgatcttatt gaatgttact
     5641 ttgaaaatgt ataactattg cctgcaatgt agatgagcct tttagtagag ctgatttatt
     5701 ccagtaactt cttccatatt ttctcactaa tctcccgtta gccaaaatat gccagaaatg
     5761 ggaaagagag gagaaaaagt cattaacatt aacacctata ctgttctata ctactcctac
     5821 ccgtgtgcta ggaatgtgca ctagctcttt ttaaattcca tgctacactt tgaggactgt
     5881 catcatgttc tcgttttgta gttcagaaag tgaggctcaa agaatttatg taaccttccc
     5941 agagtcacag tgtaaagtta gatgttgaaa cccagtttat cttatacaaa tgagcctctg
     6001 cttgttctac aaaggtagta gaatcaatct cgacctatat aaatagtaga ttttttatgg
     6061 tgaaactttc ccacataaag taaattttag gggtgaatta gagtaaaact tacaggataa
     6121 gcattttgct ctttttaaga acagcatgaa atttagaata ccaatgatag ctatctttaa
     6181 gaatcagaat tagtactaga aatttaaaaa accctatagt ttggagttag tatgagcctt
     6241 ttgtgaaaat aaatatatta aattattttg cctgatgtgg taggggaaat gtattgctct
     6301 atattaagaa atattctgga tattctgatt gacatcttat taggccatag tgagctatgc
     6361 tctgcacaac tgagaaatta ggtatttaga aggcatatag agatgttgtc ataactaggt
     6421 cttcaacgtg aaaattaatt tttattgtat catgtcaagt atcagtttac cacatattat
     6481 ttttatatta attcaacatt tgccttaagt gtgttgttaa atgaaagtac agacagcttc
     6541 attgttgtat tgttaataat tgttacttac tgctccaggc attttattaa attaattttt
     6601 taaattattt tccaccctac atcagtatat tggttgtgct ttatatttgc caaagtccta
     6661 actgactata catagaaaaa aaaaaaaaca ctgttctcac ttgattttat taaattattt
     6721 ttaaaagtca attttgaaaa taactgtatt ttattaagga gatcgtgact taacttaaat
     6781 ggacaaaata actttttaaa agaaatggat gagaagtaat tgtgtttcca aaaccctcaa
     6841 atatcccatt cctatactgg ctggattttt gctacctgtc gctcatttta atatgtcaca
     6901 gtatgagatt caaattctgt ttaactttgt tttaaaatag cttggtctct tttatttggt
     6961 ttgtaatact gctgtatttt tggtggtaag cttcaaatat caaattttgt tctgccatgt
     7021 agaaaaatct ctaaaagcat caaatgacta attttatttt tgcaaggtta aaatttattt
     7081 ttaaaagaaa cattaaatta tatctttatg tagatttaga aggactgcaa ccctatgtga
     7141 cattataact tacttaaaac agttatcaaa tatttggaaa ctattgttta ctaataagaa
     7201 taagacttgc cttatggaaa atttttgata ccacttgtta aatcaggcat gggaggagga
     7261 gagcagaaaa tataattgcc ttctaaagat a
//
