LOCUS       XM_047435181            5155 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens tousled like kinase 2 (TLK2), transcript
            variant X19, mRNA.
ACCESSION   XM_047435181
VERSION     XM_047435181.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..5155
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /note="tousled like kinase 2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 62 ESTs, 595 long SRA reads, 1 Protein, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:11011"
                     /db_xref="HGNC:HGNC:11842"
                     /db_xref="MIM:608439"
     CDS             35..2239
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /codon_start=1
                     /product="serine/threonine-protein kinase tousled-like 2
                     isoform X14"
                     /protein_id="XP_047291137.1"
                     /db_xref="GeneID:11011"
                     /db_xref="HGNC:HGNC:11842"
                     /db_xref="MIM:608439"
                     /translation="MGEAQAAPAWDWGRRPEERRGPPGSWRPRQPPGRPREPALPSSV
                     TAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEK
                     KQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQ
                     HSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGL
                     CFTFVSANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQD
                     RLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAM
                     GQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERL
                     ERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYV
                     AVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEY
                     CEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGT
                     ACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKV
                     DVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRR
                     CLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN"
ORIGIN      
        1 gagggctgcg ggtcgctgag gggccgggca gaagatgggg gaggcccagg cggccccggc
       61 ctgggattgg ggccggcggc cggaggagag acgggggccc ccaggcagct ggaggcctcg
      121 gcagcctccc gggcgccccc gagagccggc cctcccttcc tccgtgacag cagaaatgat
      181 ggaagaattg catagcctgg acccacgacg gcaggaatta ttggaggcca ggtttactgg
      241 agtaggtgtt agtaagggac cacttaatag tgagtcttcc aaccagagct tgtgcagcgt
      301 cggatccttg agtgataaag aagtagagac tcccgagaaa aagcagaatg accagcgaaa
      361 tcggaaaaga aaagctgaac catatgaaac tagccaaggg aaaggcactc ctaggggaca
      421 taaaattagt gattactttg agtttgctgg gggaagcgcg ccaggaacca gccctggcag
      481 aagtgttcca ccagttgcac gatcctcacc gcaacattcc ttatccaatc ccttaccgcg
      541 acgagtagaa cagcccctct atggtttaga tggcagtgct gcaaaggagg caacggagga
      601 gcagtctgct ctgccaaccc tcatgtcagt gatgctagca aaacctcggc ttgacacaga
      661 gcagctggcg caaaggggag ctggcctctg cttcactttt gtttcagcca actgtgattt
      721 gagacggcag attgatgaac agcaaaagat gctagagaaa tacaaggaac gattaaatag
      781 atgtgtgaca atgagcaaga aactccttat agaaaagtca aaacaagaga agatggcgtg
      841 tagagataag agcatgcaag accgcttgag actgggccac tttactactg tccgacacgg
      901 agcctcattt actgaacagt ggacagatgg ttatgctttt cagaatctta tcaagcaaca
      961 ggaaaggata aattcacaga gggaagagat agaaagacaa cggaaaatgt tagcaaagcg
     1021 gaaacctcct gccatgggtc aggcccctcc tgcaaccaat gagcagaaac agcggaaaag
     1081 caagaccaat ggagctgaaa atgaaacgtt aacgttagca gaataccatg aacaagaaga
     1141 aatcttcaaa ctcagattag gtcatcttaa aaaggaggaa gcagagatcc aggcagagct
     1201 ggagagacta gaaagggtta gaaatctaca tatcagggaa ctaaaaagga tacataatga
     1261 agataattca caatttaaag atcatccaac gctaaatgac agatatttgt tgttacatct
     1321 tttgggtaga ggaggtttca gtgaagttta caaggcattt gatctaacag agcaaagata
     1381 cgtagctgtg aaaattcacc agttaaataa aaactggaga gatgagaaaa aggagaatta
     1441 ccacaagcat gcatgtaggg aataccggat tcataaagag ctggatcatc ccagaatagt
     1501 taagctgtat gattactttt cactggatac tgactcgttt tgtacagtat tagaatactg
     1561 tgagggaaat gatctggact tctacctgaa acagcacaaa ttaatgtcgg agaaagaggc
     1621 ccggtccatt atcatgcaga ttgtgaatgc tttaaagtac ttaaatgaaa taaaacctcc
     1681 catcatacac tatgacctca aaccaggtaa tattctttta gtaaatggta cagcgtgtgg
     1741 agagataaaa attacagatt ttggtctttc gaagatcatg gatgatgata gctacaattc
     1801 agtggatggc atggagctaa catcacaagg tgctggtact tattggtatt taccaccaga
     1861 gtgttttgtg gttgggaaag aaccaccaaa gatctcaaat aaagttgatg tgtggtcggt
     1921 gggtgtgatc ttctatcagt gtctttatgg aaggaagcct tttggccata accagtctca
     1981 gcaagacatc ctacaagaga atacgattct taaagctact gaagtgcagt tcccgccaaa
     2041 gccagtagta acacctgaag caaaggcgtt tattcgacga tgcttggcct accgaaagga
     2101 ggaccgcatt gatgtccagc agctggcctg tgatccctac ttgttgcctc acatccgaaa
     2161 gtcagtctct acaagtagcc ctgctggagc tgctattgca tcaacctctg gggcgtccaa
     2221 taacagttct tctaattgag actgactcca aggccacaaa ctgttcaaca cacacaaagt
     2281 ggacaaatgg cgttcagcag cgggtttgga acatagcgaa tccgaatgga tctgatgaaa
     2341 cctgtaccag gtgcttttat tttcttgctt ttttcccatc catagagcat gacagcatcg
     2401 attctcattg aggagaaacc ttgggcagct ccggccaggc cttgtaggaa aaggccccgc
     2461 ccgaggttcc agcgtcaacg gccactgtgt gtggctgctc tgagtgagga aaaaattaaa
     2521 aagaaaaact ggttccatgt actgtgaact tgaaaacttg cagactcagg ggggtccctg
     2581 atgcagtgct tcagatgaag aatgtggact tgaaaataca gactgggcta gtccagtgtc
     2641 tatatttaaa cttgttcttt tcttttaata aagtttaggt aacatctcct gaaaagcttg
     2701 tagcacaaag gctcagctgg ggatggtgtt tgacttcgga ggaaaaaagt tgctattgcc
     2761 cgttaaaggc actagagtta gtgttttatc cctaaataat ttcaattttt aaaaacatgc
     2821 agcttccctc tccccttttt tatttttgaa agaatacatt tggtcataaa gtgaaacccg
     2881 tattagcaag tacgtggcaa tgttcattcc aatcagatgc agctttctcc tccgtctggt
     2941 ctcctgtttg caattgcttc cctcatctca gtagggaaaa aattgagtgg gagtactgag
     3001 atgtgtgggt ttttgccatt ggacaaagaa tgaggttaga agactgcagc ttggagtctc
     3061 tctaggtttt caactatttc ttcacaattt gaacacttga cggttgtccc ttttaattta
     3121 tttgaagtgc tattttttta aataaaggtt catctgtcca tgcagtcctc ttggattctc
     3181 tgaatgtagt aactatgaag ctatgccaaa ggtaggcaga aaatgggctt gggagccaga
     3241 cactccaggg atcagtagtt cctacccata gtctttgtgt gcttgctaaa tggtgtacat
     3301 ttcttgttaa ccacgttatt aaaacttgat cagcacataa gctttcttct gttagatctt
     3361 ttggcagcaa acaaccttcc ccccaagcct ctgaattttg tgggtgtgtg gtggtgtgtg
     3421 tctgtgtgtg catgtacaca cacactttgt ctagctcact ttaaaagatt catcaaatgg
     3481 aattttaaaa ataatctgaa aagaaataga tatttcaggc cgggcctggt ggttcacgcc
     3541 tgtaatccca gcactttggg aggccgaggt gggtggatca cgaggtcggg agttcgagat
     3601 cagtctggtc aacatggtga aacgccatct ctactaaaaa tataaaaatt agcctggcgt
     3661 ggtggcgtgt gcctctagtc ccagctaccc gggaggctga ggcaggagaa tttctggaac
     3721 ccaggaggcg gaggttgcag tgagccgaga tggcaccact gcaatccagc ctaggcaaca
     3781 gaatgagact ctgtctcaga aaaaaaaaaa aaaaaaaaag gagaaataga tgtttcaaat
     3841 atgaacattc ttttggcacc aattttcttt tttaatttgg ttgtttctga gatgtatgat
     3901 caactgaaga tggagctgaa atgggagacg ggtggcccca ccgtgccctt gaaacagcag
     3961 agcactcctc agtagagagg gagggagcca agagcctgaa catgtggtcg ccagcttgga
     4021 atgttactga catatgtggc gagggcttag ccagaaatat ttaaagatgt agtattccgg
     4081 cctgtgagtt gtctgggcag ggagggggag tcagaaaggg tagagagctc tcaaataact
     4141 catgactcta gtgttccttt cacatgtgaa cagtgtcact gatgacacat tttctaggac
     4201 cttcgtttgt tttgtggacc tgcctcagtc tcctcagtat caggcgatct taagggaaga
     4261 tggagtgttt caaattggag agaagttcat gggtaggtat cgtcctgtgg aattctgaat
     4321 gcaaggaagt caaccccaga ggccttggta cccccagctt tctaaaacta ctttattaca
     4381 atttatatgt atatacacat gcacatataa acgtgtgcat ttatgtatgt gtgtatagta
     4441 ccttttttaa aaaaacattt cctccaagct gctaagcaaa gggtctcaca ggtcgagcac
     4501 agtgctgaga ggatggtgtc tgcataatga agacatggat gaagctgaga ccgtgttcaa
     4561 actcactgaa aacaatgaag ttctattcct tttttcttcc tctccaatga tcttgcagtt
     4621 gatttgtttg ttttttaatt ttttaacatt tttttaacgt tgaaaaaatg ctgcgtcttt
     4681 ctttaagcct tcccagtaac ttcctgcctt ttttttcccc gtgggctttt aagtgaagct
     4741 gcaggatttt atctttcaat ctgccctttc tacccttgtc ctattgaaag gatgccctct
     4801 tcccttgctt ttttggtcta gggcctgttt ggagctaact aggcttggct gagtccgggc
     4861 aagaccttct tccgaggcat ggacaagccc cagagaacat gcagaacatt gacctttcca
     4921 ttgactgtct ttcaagcagc cagtgaaatc actaagtggg gttcttccat gacatatttt
     4981 gttaatatgg gtttcacttt ttccaagaat agtcccttgt tgccacaatg ttgatttact
     5041 ttacacaatg acagtatgta ttaatttgta attaaaccca tccagattgt tttagccttt
     5101 tcccaatggg gtgggggagg gaagaaggat attaaaataa gttttaagaa gcaaa
//
